Zonisamide therapy for refractory idiopathic epilepsy in dogs

Journal of the American Animal Hospital Association

Volumn 40, Issue 4, 2004, Pages 285-291

  Dewey, Curtis W ^a   Guiliano, Rose ^a   Boothe, Dawn M ^b   Berg, Jason M ^c   Kortz, Gregg D ^d   Joseph, Richard J ^c   Budsberg, Steven C ^e  

^a Long Island Veterinary Specialists ^*  (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c County Animal Specialty Group ^*  (United States)

^d California Veterinary Neurology and Neurosurgery Specialists   (United States)

^e UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLORAZEPATE; FELBAMATE; GABAPENTIN; PHENOBARBITAL; POTASSIUM BROMIDE; ZONISAMIDE;

ARTICLE; ATAXIA; DISEASE SEVERITY; DOG DISEASE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG METABOLISM; DRUG TOLERABILITY; EPILEPSY; FEMALE; IDIOPATHIC DISEASE; MALE; NONHUMAN; OPEN STUDY; POLYURIA; PROSPECTIVE STUDY; SEDATION; VOMITING;

ATAXIA; CANIS FAMILIARIS;

EID: 6444236922     PISSN: 15473317     EISSN: 15473317     Source Type: Journal    
DOI: 10.5326/0400285     Document Type: Article

References (28)

1. Thomas WB. Seizures and narcolepsy. In: Dewey CW, ed. A Practical Guide to Canine and Feline Neurology. Ames: Iowa State Press, 2003:193-212.
2. Boothe DM. Anticonvulsant therapy in small animals. Vet Clin North Am Small Anim Pract 1998;28:411-447.
3. Podell M, Fenner WR. Bromide therapy in refractory canine idiopathic epilepsy. J Vet Intern Med 1993;7:318-327.
4. Adusumalli VE, Gilchrist JR, Wichmann JY, et al. Pharmacokinetics of felbamate in pediatric and adult beagle dogs. Epilepsia 1992;33:955-960.
5. Vollmer KO, von Hodenberg A, Kolle EU. Pharmacokinetics and metabolism of gabapentin in rat, dog and man. Drug Res 1986;36:830-839.
6. Radulovic LL, Turck D, von Hodenberg A, et al. Disposition of gabapentin (neurontin) in mice, rats, dogs, and monkeys. Drug Metab Disposition 1995;23:441-448.
7. Oommen KJ, Mathews S. Zonisamide: a new antiepileptic drug. Clin Neuropharm 1999;22:192-200.
8. Leppik IE. Zonisamide. Epilepsia 1999;40(Suppl 5):S23-S29.
9. Mori A, Noda Y, Packer L. The anticonvulsant zonisamide scavenges free radicals. Epilepsy Research 1998;30:153-158.
10. Blum DE. New drugs for persons with epilepsy. In: French J, Leppik I, Dichter MA, eds. Antiepileptic Drug Development. Advances in Neurology 1998;76:57-87.
11. Perucca E. Is there a role for therapeutic drug monitoring of new anticonvulsants? Clin Pharmacokinet 2000;38:191-204.
12. Ketter TA, Frye MA, Cora-Locatelli G, et al. Metabolism and excretion of mood stabilizers and new anticonvulsants. Cell Molec Neurobiol 1999;19:511-532.
13. Faught E, Ayala R, Montouris GG, et al. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures. Neurology 2001;57:1774-1779.
14. Leppik IE, Willmore LJ, Homan RW, et al. Efficacy and safety of zonisamide: results of a multicenter study. Epilepsy Research 1993;14:165-173.
15. Walker RM, DiFonzo CJ, Barsoum NJ, et al. Chronic toxicity of the anticonvulsant zonisamide in beagle dogs. Fund Appl Toxicology 1988;11:333-342.
16. 14C] methyl)-1,2-benzisoxazole (AD-810) in rats, dogs and monkeys and of AD-810 in men. Drug Res 1983; 33:961-968.
17. Nakamura M, Hirade K, Sugiyama T, et al. High-performance liquid chromatographic assay of zonisamide in human plasma using a nonporous silica column. J Chromatography 2001;755:337-341.
18. Marson AG, Kadir ZA, Hutton JL, et al. The new antiepileptic drugs: a systematic review of their efficacy and tolerability. Epilepsia 1997;38:859-880.
19. Charles CL, Stoesz L, Tollefson G. Zonisamide-induced mania. Psychosomatics 1990;31:214-217.
20. Kimura S. Zonisamide-induced behavior disorder in two children. Epilepsia 1994;35:403-405.
21. McElroy SL, Keck PE. Pharmacologic agents for the treatment of acute bipolar mania. Biol Psychiatry 2000;48:539-557.
22. Cribb AE. Idiosyncratic reactions to sulfonamides in dogs. J Am Vet Med Assoc 1989;195:1612-1614.
23. Wilkie DA, Wolf ED. Sulfonamides and keratoconjunctivitis sicca. J Am Vet Med Assoc 1990;196:521-522.
24. Berger SL, Scagliotti RH, Lund EM. A quantitative study of the effects of tribrissen on canine tear production. J Am Anim Hosp Assoc 1995;31:236-241.
25. Giger U, Werner LL, Millichamp NJ, et al. Sulfadiazine-induced allergy in six doberman pinschers. J Am Vet Med Assoc 1985;186:179-484.
26. Perucca E. The clinical pharmacokinetics of the new antiepileptic drugs. Epilepsia 1999;40(Suppl 9):S7-S13.
27. Gatti G, Bonomi I, Jannuzzi G, et al. The new antiepileptic drugs: pharmacological and clinical aspects. Curr Pharmaceut Design 2000;6:839-860.
28. Shinoda M, Akita M, Hasegawa M, et al. The necessity of adjusting the dosage of zonisamide when coadministered with other antiepileptic drugs. Biol Pharm Bull 1996;19:1090-1092.