HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 4, 2008, Pages

  Venkatakrishnan, C D ^a   Dunsmore, Kathy ^c,d   Wong, Hector ^c,d   Roy, Sashwathi ^b   Sen, Chandan K ^b   Wani, Altaf ^a   Zweier, Jay L ^a   Ilangovan, Govindasamy ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cell survival; DNA repair; Oxidative stress; Redox signaling

Indexed keywords

ANTHRACYCLINE DERIVATIVE; DOXORUBICIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK FACTOR 1; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 27; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ARTICLE; CANCER PATIENT; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; EMBRYO; FIBROBLAST; FLOW CYTOMETRY; HEART PROTECTION; IMMUNOPRECIPITATION; IN VITRO STUDY; KNOCKOUT MOUSE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METAPHASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BENZOTHIAZOLES; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; FIBROBLASTS; FLOW CYTOMETRY; G2 PHASE; HEAT-SHOCK PROTEINS; IMMUNOPRECIPITATION; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYOCYTES, CARDIAC; NEOPLASM PROTEINS; PROTEIN BINDING; RATS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TOLUENE; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 41749103345     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.91507.2007     Document Type: Article

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