Overexpression of PHGPx and HSP60/10 protects against ischemia/ reoxygenation injury

Free Radical Biology and Medicine

Volumn 35, Issue 7, 2003, Pages 742-751

  Hollander, John M ^a   Lin, Kurt M ^b   Scott, Brian T ^a   Dillmann, Wolfgang H ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Apoptosis; Free radical scavenger; Free radicals; Ischemia; Reperfusion

Indexed keywords

ADENOVIRUS VECTOR; CREATINE KINASE; CYTOCHROME C; DNA FRAGMENT; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 10; HEAT SHOCK PROTEIN 60; HISTONE; LACTATE DEHYDROGENASE; MITOCHONDRIAL ENZYME; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME RELEASE; GENE OVEREXPRESSION; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REOXYGENATION; REPERFUSION INJURY; VIRUS INFECTION;

EID: 0142258709     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(03)00400-3     Document Type: Article

References (46)

1. Ji L.L., Fu R.G., Waldrop T.G., Liu K.J., Swartz H.M. Myocardial response to regional ischemia and reperfusion in vivo in rat heart. Can. J. Physiol. Pharmacol. 71:1993;811-817.
2. Sevanian A., McLeod L.L. Lipid peroxidation and modification of lipid composition in an endothelial cell model of ischemia and reperfusion. Free Radic. Biol. Med. 23:1997;680-694.
3. Bluhm W.F., Martin J.L., Mestril R., Dillmann W.H. Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes. Am. J. Physiol. 275:1998;H2243-H2249.
4. Park Y., Kanekal S., Kehrer J.P. Oxiative changes in hypoxic rat heart tissue. Am. J. Physiol. 260:1992;H1395-H1405.
5. Simpson P.J., Lucchesi B.R. Free radicals and myocardial ischemia and reperfusion injury. J. Lab. Clin. Med. 110:1987;95-100.
6. Suzuki S., Kaneko M., Chapman D.C., Dhalla N.S. Alterations in cardiac contractile proteins due to oxygen free radicals. Biochim. Biophys. Acta. 1074:1991;95-100.
7. Nohl H. The biochemical mechanism of the formation of reactive oxygen species in heart mitochondria. Caldarera C.M., Harris P. Advances in studies on heart metabolism. 1982;413-421 Cooperative Libraria Universitaria Editrice, Bologna.
8. Guarnieri C., Ceconi C., Muscari C., Flamigni F. Influence of oxygen radicals on heart metabolism. Caldarera C.M., Harris P. Advances in studies on heart metabolism. 1982;423-431 Cooperative Libraria Universitaria Editrice, Bologna.
9. Ferrari R., Ceconi C., Curello S., Cargnoni A., De Giuli F., Visioli O. Occurrence of oxidative stress during myocardial reperfusion. Mol. Cell. Biochem. 111:1992;61-69.
10. Ferrari R., Ceconi C., Curello S., Guarnieri G., Caldarera C.M., Albertini A., Visioli O. Oxygen-mediated myocardial damage during ischemia and reperfusion role of the cellular defense against oxygen toxicity . J. Mol. Cell. Cardiol. 17:1985;937-945.
11. Dhaliwal H., Kirshenbaum L.A., Randhawa A.K., Singal P.K. Correlation between antioxidant changes during hypoxia and recovery on reoxygenation. Am. J. Physiol. 261:1991;H632-H638.
12. Ji L.L., Hollander J. Free Radicals in exercise and aging. Radak Z. Antioxidant defense. 2001;25-47 Human Kinetics Publishing, Champaign, IL.
13. Arai M., Imai H., Koumura T., Yoshida M., Emoto K., Umeda M., Chiba N., Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells. J. Biol. Chem. 274:1999;4924-4933.
14. Ursini F., Maiorino M., Gregolin C. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim. Biophys. Acta. 839:1985;62-70.
15. Ursini F., Maiorino M., Brigelius-Flohe R., Aumann K.D., Rovery A., Schomburg D., Flohe L. Diversity of glutathione peroxidases. Methods Enzymol. 252:1995;38-83.
16. Schnurr K., Belkner J., Ursini F., Schewe T., Kuhn H. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase controls the activity of the 15-lipoxygenase with complex substrates and preserves the specificity of the oxygenation products. J. Biol. Chem. 271:1996;4653-4658.
17. Thomas J.P., Maiorino M., Ursini F., Girotti A.W. Protective action of phospholipid hydroperoxide glutathione peroxidase against membrane-damaging lipid peroxidation. J. Biol. Chem. 265:1990;454-461.
18. Nomura K., Imai H., Koumura T., Arai M., Nakagawa Y. Mitochondrial phospholipid hydroperoxide glutathione peroxidase suppresses apoptosis mediated by a mitochondrial death pathway. J. Biol. Chem. 274:1999;29294-29302.
19. Yant L.J., Ran Q., Rao L., Van Remmen H., Shibatani T., Belter J.G., Motta L., Richardson A., Prolla T.A. The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic. Biol. Med. 34:2003;496-502.
20. Mestril R., Chi S.H., Sayen M.R., O'Reilly K., Dillmann W.H. Expression of inducible stress protein 70 in rat myogenic cells confers protection against simulated ischemia-induced injury. J. Clin. Invest. 93:1994;759-767.
21. Lau S., Patnaik N., Sayen R., Mestril R. Simultaneous overexpression of two stress proteins in rat cardiomyocytes and myogenic cells confers protection against ischemia-induced injury. Circulation. 96:1997;2287-2294.
22. Martin J.L., Mestril R., Hilal-Dandan R., Brunton L.L., Dillmann W.H. Small heat shock protein and protection against ischemic injury in cardiac myocytes. Circulation. 96:1997;4343-4348.
23. Trost S.U., Omens J.H., Karlon W.J., Meyer M., Mestril R., Covell J.W., Dillmann W.H. Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70. J. Clin. Invest. 101:1998;855-862.
24. Welch W.J., Mizzen L.A., Arrigo A.P. Structure and function of mammalian stress proteins. Pardue M.L., Feramisco J.R., Lindquist S. Stress-induced proteins. 1989;187-202 Alan R. Liss, Inc. New York.
25. Polla B.S., Kantengwa S., Francois D., Salvioli S., Franceschi C., Marsae C., Cossarizza A. Mitochondria are selective targets for the protective effects of heat shock against oxidative injury. Proc. Natl. Acad. Sci. USA. 93:1996;6458-6463.
26. Mehlan P., Preville X., Chareyron P., Briolay J., Klemenz R., Arrigo A.P. Constitutive expression of human hsp27, Drosophila hsp27, or human α B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts. J. Immunol. 154:1995;363-374.
27. Mehlen P., Preville X., Kretz-Remy C., Arrigo A.-P. Human hsp27, Drosophila hsp27, and human α B-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNF-induced cell death. EMBO J. 15:1996;2695-2706.
28. Mehlen P., Hickey E., Weber L.A., Arrigo A.-P. Large unphosphorylated aggregates as the active germ of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNF in NIH-3T3-ras cells. Biochem. Biophys. Res. Commun. 241:1997;187-192.
29. Lin K.M., Lin B., Lian I.Y., Mestril R., Scheffler I.E., Dillmann W.H. Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation. 103:2001;1787-1792.
30. Iwaki K., Chi S.H., Dillmann W.H. Mestril R. Induction of HSP70 in cultured rat neonatal cardiomyocytes by hypoxia and metabolic stress. Circulation. 87:1993;2023-2032.
31. Graham F.L., Prevec L. Manipulation of adenovirus vectors. Murray E.J. Methods in molecular biology. 1991;109-128 Humana Press, Clifton, NJ.
32. Seip W.F., Evans G.L. Atmospheric analysis and redox potentials of culture media in the GasPak system. J. Clin. Microbiol. 11:1980;226-233.
33. Bradford M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:1976;248-256.
34. Maiorino M., Gregolin C., Ursini F. Phospholipid hydroperoxide glutathione peroxidase. Methods Enzymol. 186:1990;448-457.
35. Lei X.G., Evenson J.K., Thompson K.M., Sunde R.A. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J. Nutr. 125:1995;1438-1446.
36. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
37. Hofhaus G., Shakeley R.M., Attardi G. Use of polarography to detect respiration defects in cell cultures. Methods Enzymol. 264:1996;476-483.
38. Griffin D.S., Segall H.J. Role of cellular calcium homeostasis in toxic liver injury induced by the pyrrolizidine alkaloid senecionine and the alkenal trans-4-OH-2hexenal. J. Biochem. Toxicol. 2:1987;155-167.
39. Koster J.F., Slee R.G., Montfoort A., Lang J., Esterbauer H. Comparison of the inactivation of microsomal glucose-6-phosphatase by in situ lipid peroxidation-derived 4-hydroxynonenal. Free Radic. Res. Commun. 1:1986;273-287.
40. McCord J.M. Free radicals and myocardial ischemia overview and outlook . Free Radic. Biol. Med. 4:1988;9-14.
41. Bindoli A., Cavallini L., Rigobello M.P., Coassin M., Di Lisa F. Modification of the xanthine-converting enzyme of perfused rat heart during ischemia and oxidative stress. Free Radic. Biol. Med. 4:1988;163-170.
42. Esterbauer H., Schaur R.J., Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde, and related aldehydes. Free Radic. Biol. Med. 11:1991;81-128.
43. Poot M., Verkerk A., Koster J.F., Esterbauer H., Jongkind J.F. Reversible inhibition of DNA and protein synthesis by cumene hydroperoxide and 4-hydroxynonenal. Mech. Ageing Dev. 43:1988;1-9.
44. Chen J., Henderson G.I., Freeman G.L. Role of 4-hydroxynonenal in modification of cytochrome c oxidase in ischemia/reperfused rat heart. J. Mol. Cell. Cardiol. 33:2001;1919-1927.
45. Lucas D.T., Szweda L.I. Declines in mitochondrial respiration during cardiac reperfusion age-dependent inactivation of α-ketoglutarate dehydrogenase . Proc. Natl. Acad. Sci. USA. 96:1999;6689-6693.
46. Hendrick J.P., Hartl F.U. The role of molecular chaperones in protein folding. FASEB J. 9:1995;1559-1569.