Cancer metastasis as disrupted developmental phenotype

Current Genomics

Volumn 9, Issue 1, 2008, Pages 25-28

  Ishii, Hideshi ^a,b   Saito, Toshiyuki ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Bmp; Cancer; Metastasis; Notch; SHH

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CYCLOPAMINE; MYC PROTEIN; NOTCH RECEPTOR; PROTEIN P53; PROTEIN PATCHED; RAS PROTEIN; RETINOBLASTOMA PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SONIC HEDGEHOG PROTEIN; UVOMORULIN; VIMENTIN;

BREAST CANCER; CANCER GENETICS; CANCER INHIBITION; CANCER INVASION; CANCER SURVIVAL; DEVELOPMENTAL BIOLOGY; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE EXPRESSION REGULATION; HUMAN; METASTASIS; NONHUMAN; OVARY CANCER; PANCREAS CANCER; PHENOTYPE; PROTEIN SYNTHESIS INHIBITION; REVIEW; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TUMOR CELL;

EID: 41549157310     PISSN: 13892029     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920208783884919     Document Type: Review

References (48)

1. Sporn, M.B. The war on cancer. Lancet, 1996, 347: 1377-81.
2. Weidner, N., Semple, J.P., Welch, W.R., Folkman, J. Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. New Engl. J. Med., 1991, 324: 1-8.
3. Bailey, J.M., Singh, P.K., Hollingsworth, M.A. Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. J. Cell. Biochem., 2007, 102: 829-839.
4. Hay, E.D. An overview of epithelio-mesenchymal transformation. Acta Anat. (Bascl), 1995, 154: 8-20.
5. Hugo, H.A., M.L., Blick, T., Lawrence, M.G., Clements, J.A., Williams, E.D., Thompson, E.W. Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J. Cell. Physiol., 2007, 213: 374-383.
6. Kahn, L.B., Uys, C.J., Dale, J., Rutherfoord, S. Carcinoma of the breast with metaplasia to chondrosarcoma: A light and electron microscopic study. Histopathology, 1978, 2: 93-106.
7. Ishikawa, S., Kaneko, H., Sumida, T., Sekiya, M. Ultrastructure of mesodermalmixed tumor of the uterus. Acta Pathol. Jpn., 1979, 29: 801-809.
8. Krug, E.L., Mjaatvedt, C.H., Markwald, R.R. Extracellular matrix from embryonic myocardium elicits an early morphogenetic event in cardiac endothelial differentiation. Dev. Biol., 1987, 120: 348-355.
9. Thiery, J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell. Biol., 2003, 15: 740-746.
10. Grunert, S., Jechlinger, M., Beug, H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat. Rev. Mol. Cell. Biol., 2003, 4: 657-665.
11. Buijs, J.T., Henriquez, N.V., van Overveld, P.G., van der Horst, G., Que, I., Schwaninger, R., Rentsch, C., Ten Dijke, P., Cleton-Jansen, A.M., Driouch, K., Lidereau, R., Bachelier, R., Vukicevic, S., Clézardin, P., Papapoulos, S.E., Cecchini, M.G., Löwik, C.W., van der Pluijm, G. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res., 2007, 67: 8742-8751.
12. Thiery, J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer, 2002, 2: 442-454.
13. Nowell, P.C. Chromosomes and cancer: the evolution of an idea. Adv. Cancer Res., 1993, 62: 1-17.
14. Vogelstein, B., Kinzler, K.W. The multistep nature of cancer. Trends Genet., 1993, 9: 138-141.
15. Hickman, E.S., Moroni, M.C., Helin, K. The role of p53 and pRB in apoptosis and cancer. Curr. Opin. Genet. Dev., 2002, 12: 60-66.
16. Malumbres, M., Barbacid, M. RAS oncogenes: the first 30 years. Nat. Rev. Cancer, 2003, 3: 459-465.
17. Calin, G.A., Croce, C.M. MicroRNAs and chromosomal abnormalities in cancer cells. Oncogene, 2006, 25: 6202-6210.
18. Sancar, A., Lindsey-Boltz, L.A., Unsal-Kacmaz, K., Linn, S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem., 2004, 73: 39-85.
19. Fearon, E., Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 1990, 61: 759-767.
20. Ince, T.A., Richardson, A.L., Bell, G.W., Saitoh, M., Godar, S., Karnoub, A.E., Iglehart, J.D., Weinberg, R.A. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell, 2007, 12: 160-170.
21. Bray, S. Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol., 2006, 7: 678-689.
22. Bolos, V., Grego-Bessa, J., de la Pompa, J.L. Notchsignaling in development and cancer. Endocr. Rev., 2007, 28: 339-363.
23. Artavanis-Tsakonas, S., Rand, M.D., Lake, R.J. Notch signaling: Cell fate control and signal integration in development. Science, 1999, 284: 770-776.
24. Lewis, J. Notch signalling and the control of cell fate choices in vertebrates. Semin. Cell. Dev. Biol., 1998, 9: 583-589.
25. Timmerman, L.A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J.M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisua-Belmonte, J.C., de la Pompa, J.L. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev., 2004. 18: 99-115.
26. Krebs, L.T., Xue, Y., Norton, C.R., Shutter, J.R., Maguire, M., Sundberg, J.P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., Smith, G.H., Stark, K.L., Gridley, T. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev., 2000, 14: 1343-1352.
27. Shi, W., Harris, A.L. Notch signaling in breast cancer and tumor angiogenesis: cross-talk and therapeutic potentials. J. Mammary Gland Biol. Neoplasia, 2006, 11: 41-52.
28. Miele, L., Golde, T., Osborne, B. Notch signaling in cancer. Curr. Mol. Med., 2006, 6: 905-918.
29. Efstratiadis, A., Szabolcs, M., Klinakis, A. Notch, Myc and breast cancer. Cell Cycle, 2007, 6: 418-429.
30. Hu, C., Dievart, A., Lupien, M., Calvo, E., Tremblay, G.., Jolicocur, P. Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors. Am. J. Pathol., 2006, 168: 973-990.
31. Radtke, F., Raj, K. The role of Notch in tumorigenesis: Oncogene or tumour suppressor? Nat. Rev. Cancer, 2003, 3: 756-767.
32. Paget, S. The distribution of secondary growths in cancer of the breast. Lancet, 1889, 1: 571-573.
33. Fidler, I. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat. Rev. Cancer, 2003, 3: 453-458.
34. Koenig, B.B., Cook, J.S., Wolsing, D.H., Ting, J., Tiesman, J.P., Correa, P.E., Olson, C.A., Pecquet, A.L., Ventura, F., Grant, R.A. Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol. Cell. Biol., 1994, 14: 5961-5974.
35. ten Dijke, P., Yamashita, H., Sampath, T.K., Reddi, A.H., Estevez, M., Riddle, D.L., Ichijo, H., Heldin, C.H., Miyazono, K. Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem., 1994, 269: 16985-16988.
36. Ma, L., Lu, M.F., Schwartz, R.J., Martin, J.F. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development, 2005, 132: 5601-5611.
37. Theriault, B.L., Shepherd, T.G., Mujoomdar, M.L., Nachtigal, M.W. BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis, 2007, 28: 1153-1162.
38. Dudley, A.T., Lyons, K.M., Robertson, E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev., 1995, 9: 2795-2807.
39. Luo, G., Hofmann, C., Bronckers, A.L., Sohocki, M., Bradley, A., Karsenty, G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev., 1995, 9: 2808-2820.
40. Vukicevic, S., Kopp, J.B., Luyten, F.P., Sampath, T.K. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc. Natl. Acad. Sci. USA, 1996, 93: 9021-9026.
41. Zeisberg, M., Hanai, J., Sugimoto, H., Mammoto, T., Charytan, D., Strutz, F., Kalluri, R. BMP-7 counteracts TGF-betal-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat. Med., 2003, 9: 964-968.
42. Simic, P., Vukicevic, S. Bone morphogenetic proteins in development and homeostasis of kidney. Cytokine Growth Factor Rev., 2005, 16: 299-308.
43. Zeisberg, M., Shah, A.A., Kalluri, R. Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney. J. Biol. Chem., 2005, 280: 8094-8100.
44. Ingham, P.W., McMahon, A.P. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev., 2001, 15: 3059-3087.
45. Pepinsky, R.B., Rayhorn, P., Day, E.S., Dergay, A., Williams, K.P., Galdes, A., Taylor, F.R., Boriack-Sjodin, P.A., Garber, E.A. Mapping sonic hedgehog-receptor interactions by steric interference. J. Biol. Chem., 2000, 275: 10995-11001.
46. Murone, M., Rosenthal, A., de Sauvage, F.J. Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr. Biol., 1999, 9: 76-84.
47. Corbit, K.C., Aanstad, P., Singla, V., Norman, A.R., Stainier, D.Y., Reiter, J.F. Vertebrate Smoothened functions at the primary cilium. Nature, 2005, 437: 1018-1021.
48. Feldmann, G., Dhara, S., Fendrich, V., Bedja, D., Beaty, R., Mullendore, M., Karikari, C., Alvarez, H., Iacobuzio-Donahue, C., Jimeno, A., Gabrielson, K.L., Matsui, W., Maitra, A. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers. Cancer Res., 2007, 67: 2187-2196.