Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2

Molecular and Cellular Biology

Volumn 16, Issue 2, 1996, Pages 538-547

  Yang, Beom Seok ^a   Hauser, Craig A ^b   Henkel, Gregory ^b   Colman, Michael S ^a   Van Beveren, Charles ^c   Stacey, Katryn J ^d   Hume, David A ^d   Maki, Richard A ^b   Ostrowski, Michael C ^a,e  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b BURNHAM INSTITUTE   (United States)

^c SIDNEY KIMMEL CANCER CENTER   (United States)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; GENE MUTATION; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0030048767     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.2.538     Document Type: Article

References (56)

1. Alvarez, E., I. C. Northwood, F. A. Gonzalez, D. A. Latour, A. Seth, C. Abate, T. Curran, and R. J. Davis. 1991. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266:15277-15285.
2. Aoyama, A., and R. Klemenz. 1993. Oncogene-mediated effects on cellular gene expression. Crit Rev. Oncogenesis 4:53-94.
3. Barbacid, M. 1987. ras genes. Annu. Rev. Biochem. 56:779-827.
4. Binetruy, B., T. Smeal, and M. Karin. 1991 Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature (London) 351:122-127.
5. Bortner, D. M., S. J. Langer, and M. C. Ostrowski. 1993. Non-nuclear oncogenes and the regulation of gene expression in transformed cells. Crit. Rev. Oncogenesis 4:137-160.
6. Boyle, W. J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201:110-149.
7. Bradford, A. P., K. E. Conrad, C. Wasylyk, B. Wasylyk, and A. Gutierrez-Hartmann. 1995. Functional interaction of c-Ets-1 and GHF-1/Pit-1 mediates Ras activation of pituitary-specific gene expression. mapping of the essential c-Ets-1 domain Mol. Cell. Biol. 15:2849-2857
8. Brunner, D., K. Ducker, N. Oellers, E. Hafen, H. Scholz, and C. Klambt. 1994. The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature (London) 370:386-389.
9. Chambers, A. F., and A. B. Tuck. 1993. Ras-responsive genes and tumor metastasis. Crit Rev. Oncogenesis 4:95-114.
10. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
11. Dalton, S., and R. Treisman. 1992 Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. Cell 68:597-612.
12. Deng, T., and M. Karin. 1994. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature (London) 371:171-175.
13. Dent, P., W. Haser, T. A. Haystead, L. A. Vincent, T. M. Roberts, and T. W. Sturgill. 1992 Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro Science 257:1404-1407.
14. Dent, P., J. Wu, G. Romero, L. A. Vincent, D. Castle, and T. W. Sturgill. 1993. Activation of the mitogen-activated protein kinase pathway in Triton X-100 disrupted NIH-3T3 cells by p21 ras and in vitro by plasma membranes from NIH 3T3 cells. Mol Biol. Cell 4:483-493
15. Derijard, B., M. Hibi, I. H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
16. Derijard, B., J. Raingeaud, T. Barrett, I. H. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685
17. Egan, S. E. W. 1993. The pathway to signal achievement Nature (London) 361:781-783.
18. Galang, C. K., C. J. Der, and C. A. Hauser. 1994. Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene 9:2913-2921.
19. Ginty, D. D., A. Bonni, and M. E. Greenberg. 1994 Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 77:713-725.
20. Gutman, A., and B. Wasylyk. 1991. Nuclear targets for transcription regulation by oncogenes. Trends Genet. 7:49-54.
21. Hauser, C. A., J. K. Westwick, and L. A. Quilliam. 1995 Ras-mediated transcription regulation: analysis by transient co-transfection assays. Methods Enzymol. 255:412-426.
22. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148.
23. Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211
24. Howe, L. R., S. J. Leevers, N. Gomez, S. Nakielny, P. Cohen, and C. J. Marshall. 1992. Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335-342.
25. Jin, D. I., S. B. Jameson, M. A. Reddy, D. Schenkman, and M. C. Ostrowski, 1995. Alterations in differentiation and behavior of monocytic phagocytes in transgenic mice that express dominant suppressors of ras signaling. Mol. Cell. Biol. 15:693-703.
26. Karim, F. D., L. D. Urness, C. S. Thummel, M. J. Klemsz, S. R. McKercher, A. Celada, C. Van Beveren, R. A. Maki, C. V. Gunther, J. A. Nye, et al. 1990. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes Dev. 4:1451-1453.
27. Karin, M. 1994. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin. Cell Biol. 6:415-424
28. Klaes, A., T. Menne, A. Stollewerk, H. Scholz, and C. Klambt. 1994. The Ets transcription factors encoded by the Drosophila gene pointed direct glial cell differentiation in the embryonic CNS. Cell 78:149-160
29. Klambt, C. 1993 The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells Development 117:163-176.
30. Klemsz, M. J., R. A. Maki, T. Papayannopoulou, J. Moore, and R. Hromas. 1993. Characterization of the ets oncogene family member, fli-1. J. Biol. Chem. 268:5769-5773.
31. Kodaki, T., R. Woscholski, B, Hallberg, P. Rodriguez-Viciana, J. Downward, and P. J. Parker. 1994. The activation of phosphatidylinositol 3-kinase by Ras. Curr. Biol. 4:798-806.
32. Langer, S. J., D. M. Bortner, M. F. Roussel, C. J. Sherr, and M. C. Ostrowski. 1992. Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression. Mol Cell. Biol. 12:5355-5362.
33. Leiden, J. M., C. Y. Wang, B. Petryniak, D. M. Markovitz, G. J. Nabel, and C. B. Thompson. 1992. A novel Eis-related transcription factor. Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells. J. Virol. 66:5890-5897
34. Lloyd, A., N. Yancheva, and B. Wasylyk. 1991. Transformation suppressor activity of a Jun transcription factor lacking its activation domain. Nature (London) 352:635-638.
35. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381-393.
36. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 80:179-185.
37. Minden, A., A. Lin, M. Mcmahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science 266:1719-1723.
38. O'Neill, E. M., I. Rebay, R. Tjian, and G. M. Rubin. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
39. Reddy, M. A., S. J. Langer, M. S. Colman, and M. C. Ostrowski. 1992. An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. Mol. Endocrinol. 6:1051-1060.
40. Reddy, M. A., B. S. Yang, X. Yue, C. J. Barnett, I. L. Russ, M. J. Sweet, D. A. Hume, and M.C. Ostrowski. 1994. Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes. J Exp Med. 180:2309-2319
41. Rorth, P., C. Nerlov, F. Blasi, and M. Johnsen. 1990. Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbol-ester. Nucleic Acids Res 18:5009-5017.
42. Ross, I. L., T. L. Dunn, X. Yue, S. Roy, C. J. Barnett, and D. A. Hume. 1994 Comparison of the expression and function of the transcription factor PU.1 (Spi-1 proto-oncogene) between murine macrophages and B lymphocytes. Oncogene 9:121-132.
43. Simon, M. A., D. D. Bowtell, G. S. Dodson, T. R. Laverty, and G. M. Rubin. 1991 Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase Cell 67: 701-716
44. Smeal, T., B. Binetruy, D. A. Mercola, M. Birrer, and M. Karin. 1991. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature (London) 354:494-496
45. Stacey, D. W. 1988. The ras pathway: a model for the control of proliferation m animal cells. Adv. Exp. Med Biol. 234:141-167
46. Stacey, K. J., L. F. Fowles, M. S. Colman, M. C. Ostrowski, and D. A. Hume. 1995 Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor. Mol. Cell. Biol. 15:3430-3441.
47. Vojtek, A. B., S. M. Hollenberg, and J. A. Cooper. 1993. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214
48. Warne, P. H., P. R. Viciana, and J. Downward. 1993. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature (London) 364:352-355
49. Wasylyk, B., C. Wasylyk, P. Flores, A. Begue, D. Leprince, and D. Stehelin. 1990. The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation. Nature (London) 346: 191-193.
50. Wasylyk, C., A. Gutman, R. Nicholson, and B. Wasylyk. 1991 The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J 10:1127-1134
51. Wasylyk, C., S. M. Maira, P. Sobieszcznk, and B. Wasylyk. 1994. Reversion of Ras transformed cells by EtS transdominant mutants Oncogene 9:3665-3673
52. Watson, D. K., M. J. McWilliams, P. Lapis, J. A. Lautenberger, C. W. Schweinfest, and T. S. Papas. 1988. Mammalian ets-1 and cts-2 genes encode highly conserved proteins. Proc. Natl. Acad. Sci. USA 85:7862-7866.
53. Wu, H., K. Moulton, A. Horvai, S. Parik, and C. K. Glass. 1994. Combinatorial interactions between AP-1 and Ets domain proteins contribute to the developmental regulation of the macrophage scavenger receptor gene. Mol. Cell. Biol 14:2129-2139.
54. Xin, J. H., A. Cowie, P. Lachance, and J. A. Hassell. 1992. Molecular cloning and characterization of PEA3, a new member of the Ets oncogene family that is differentially expressed in mouse embryonic cells. Genes Dev 6:481-496.
55. Yang, B.-S., C. A. Hauser, and M. C. Ostrowski. Unpublished observations.
56. Zhang, X. F., J. Settleman, J. M. Kyriakis, E. Takeuchi-Suzuki, S. J. Elledge, M. S. Marshall, J. T. Bruder, U. R. Rapp, and J. Avruch. 1993 Normal and oncogenic p21ras proteins bind to the amino-termmal regulatory domain of c-Raf-1. Nature (London) 364:308-313