Small-molecule inhibitors of Bcl-2 family proteins are able to induce tumor regression in a mouse model of pre-B-cell acute lymphocytic lymphoma

DNA and Cell Biology

Volumn 27, Issue 3, 2008, Pages 133-142

  Turner, Brian C ^a   Eves, Taylor ^a   Refaeli, Yosef ^a,b,c  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; PROTEIN BCL 2; PUMA PROTEIN;

ACUTE LYMPHOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; TUMOR REGRESSION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BIOMIMETICS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR WEIGHT; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; REMISSION INDUCTION; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MURINAE; MUS;

EID: 41449099497     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.2007.0675     Document Type: Article

References (35)

1. Adams, J.M. (2003). Ways of dying: multiple pathways to apoptosis. Genes Dev 17, 2482-2495.
2. Adams, J.M., Harris, A.W., Pinkert, C.A., Corcoran, L.M., Alexander, W.S., Cory, S., Palmitter, R.D., and Brinster, R.L. (1985). The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533-538.
3. Amundson, S.A., Myers, T.G., Scudiero, D., Kitada, S., Reed, J.C., and Fornace, A.J., Jr. (2000). As informatics approach to identifying markers of chemosensitivity in human cancer cell lines. Cancer Res 60, 6101-6110.
4. Bonnet, D., and Dick, J.E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3, 730-737.
5. Chen, L., Willis, S.N., Wei, A., Smith, B.J., Fletcher, J.I., Hinds, M.G., Colman, P.M., Day, C.L., Adams, J.M., and Huang, D.C. (2005). Differential targeting of pro-survival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17, 393-403.
6. Cory, S., and Adams, J.M. (2002). The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2, 647-656.
7. Danial, N.N., and Korsmeyer, S.J. (2004). Cell death: critical control point. Cell 116, 205-219.
8. Degterev, A., Lugovskoy, A., Cardone, M., Mulley, B., Wagner, G., Mitchison, T., and Yuan, J. (2001). Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-XL. Nat Cell Biol 3, 173-182.
9. Deng, J., Carlson, N., Takeyama, K., Dal Cin, P., Shipp, M., and Letai, A. (2007). BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents. Cancer Cell 12, 171-185.
10. Dick, J.E. (2005). Acute myeloid leukemia stem cells. Ann NY Acad Sci 1044, 1-5.
11. Egle, A., Harris, A.W., Bouillet, P., and Cory, S. (2004). Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci USA 101, 6164-6169.
12. Fesik, S.W. (2005). Promoting apoptosis as a strategy for cancer drug discovery. Nat Rev Cancer 5, 876-885.
13. Green, D.R. (2005). Apoptotic pathways: ten minutes to dead. Cell 121, 671-674.
14. Harris, A.W., Strasser, A., Bath, M.L., Elefanty, A.G., and Cory, S. (1997). Lymphomas and plasmacytomas in transgenic mice involving bcl2, myc and v-abl. Curr Top Microbiol Immunol 224, 221-230.
15. Hemann, M.T., Bric, A., Teruya-Feldstein, J., Herbst, A., Nilsson, J.A., Cordon-Cardo, C., and Lowe, S. (2005). Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 436, 807-811.
16. Hemann, M.T., Zilfou, J.T., Zhao, Z., Burgess, D.J., Hannon, G.J., and Lowe, S.W. (2004). Suppression of tumorigenesis by the p53 target Puma. Proc Natl Acad Sci USA 101, 9333-9338.
17. Hinds, M.G., and Day, C.L. (2005). Regulation of apoptosis: uncovering the binding determinants. Curr Opin Struct Biol 15, 690-699.
18. Huang, D.C.S., and Strasser, A. (2000). BH3-only proteins - essential initiators of apoptotic cell death. Cell 103, 839-842.
19. Konopoleva, M., Contractor, R., Tsao, T., Samudio, I., Ruvolo, P.P., Kitada, S., Deng, X., Zhai, D., Shi, Y.X., Sneed, T., Verhaegen, M., Soengas, M., Ruvolo, V.R., McQueen, T., Schober, W.D., Watt, J.C., Jiffar, T., Ling, X., Marini, F.C., Harris, D., Dietrich, M., Estrov, Z., McCubrey, J., May, W.S., Reed, J.C., and Andreef, M. (2006). Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 10, 375-388.
20. Langdon, W.Y., Harris, A.W., Cory, S., and Adams, J.M. (1986). The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 47, 11-18.
21. Liu, X., Dai, S., Zhu, Y., Marrack, P., and Kappler, J.W. (2003). The structure of Bcl-XL/Bim fragment complex: implications for Bim function. Immunity 19, 341-352.
22. Olderdorf, T., Elmore, S.W., Shoemaker, A.R., Armstrong, R.C., Augeri, D.J., Belli, B.A., Bruncko, M., Deckwerth, T.L., Dinges, J., Hajduk, P.J., Joseph, M.K., Kitada, S., Korsmeyer, S.J., Kunzer, A.R., Letai, A., Li, C., Mitten, M.J., Nettesheim, D.G., Ng, S., Nimmer, P.M., O'Connor, J.M., Oleksijew, A., Petros, A.M., Reed, J.C., Shen, W., Tahir, S.K., Thonpson, C.B., Tomaselli, K.J., Wang, B., Wendt, M.D., Zhang, H., Fesik, S.W., and Rosenberg, S.H. (2005). An inhibitor of Bcl-2 family proteins induced regression of solid tumours. Nature 435, 677-681.
23. Refaeli, Y., van Parijs, L., Alexander, S.I., and Abbas, A.K. (2002). Interferon gamma is required for activation-induced cell death of T lymphocytes. J Exp Med 196, 999-1005.
24. Refaeli, Y., van Parijs, L., London, C.A., Tschopp, J., and Abbas, A.K. (1998). Biochemical mechanisms of IL-2-regulated Fasmediated T cell apoptosis. Immunity 8, 615-623.
25. Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W.S., and Khovorova, A. (2004). Rational siRNA design for RNA interference. Nat Biotechnol 22, 326.
26. Rubinson, D.A., Dillon, C.P., Kwiatkowski, A.V., Sievers, C., Yang, L., Kopinja, J., Rooney, D.L., Ihrig, M.M., McManus, M.T., Gertler, F.B., Scott, M.L., and van Parijs, L. (2003). A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet 33, 401-406.
27. Sadowsky, J.D., Schmitt, M.A., Lee, H.S., Umezawa, N., Wang, S., Tomita, Y., and Gellman, S.H. (2005). Chimaeric (alpha/beta +alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc 127, 11966-11968.
28. Trumpp, A., Refaeli, Y., Oskarsson, T., Gasser, S., Murphy, M., Martin, G.R., and Bishop, J.M. (2001). c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature 414, 768-773.
29. Van Parijs, L., Refaeli, Y., Abbas, A.K., and Baltimore, D. (1999). Autoimmunity as a consequence of retrovirus-mediated expression of c-FLIP. Immunity 11, 763-770.
30. Vaux, D.L., Cory, S., and Adams, J.M. (1988). Bcl-2 gene promotes haematopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440-442.
31. Ventura, A., Meissner, A., Dillon, C.P., McManus, M., Sharp, P.A., van Parijs, L., Jaenisch, R., and Jacks, T. (2004). Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci USA 101, 10380-10385.
32. Vousden, K.H., and Lu, X. (2002). Live or let die: the cell's response to p53. Nat Rev Cancer 2, 594-604.
33. Walensky, L.D., Kung, A.L., Escher, I., Malia, T.J., Barbuto, S., Wright, R.D., Wagner, G., Verdine, G.L., and Korsmeyer, S.J. (2004). Activation of apoptosis in vivo by a hydrocarbonstapled BH3 helix. Science 305, 1466-1470.
34. Wang, J.L., Zhang, Z.J., Shan, S., Han, X., Srinivasula, S.M., Croce, C.M., Alnemri, E.S., and Huang, Z. (2000). Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 97, 7124-7129.
35. Zufferey, R., Dull, T., Mandel, R.J., Bukovsky, A., Quiroz, D., Naldini, L., and Trono, D. (1998). Self-inactivating lentivirus for safe and efficient in vivo gene delivery. J Virol 72, 9873-9880.