Long-term protection of brain tissue from cerebral ischemia by peripherally administered peptidomimetic caspase inhibitors

Drug Development Research

Volumn 52, Issue 4, 2001, Pages 579-586

  Deckwerth, Thomas L ^a   Adams, Lisa M ^a   Wiessner, Christoph ^b   Allegrini, Peter R ^b   Rudin, Markus ^b   Sauter, Andre ^b   Hengerer, Bastian ^b   Sayers, Robert O ^a   Rovelli, Giorgio ^b   Aja, Teresa ^a   May, Rachel ^b   Nalley, Kip ^a   Linton, Steve ^a   Karanewsky, Donald S ^a   Wu, Joe C ^a   Roggo, Silvio ^b   Schmitz, Albert ^b   Contreras, Patricia C ^a   Tomaselli, Kevin J ^a  

^a PFIZER INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; Infarct; Middle cerebral artery; Neuroprotection; Stroke

Indexed keywords

[3 (5 BENZYLOXYCARBONYLAMINO 1,2,4,5,6,7 HEXAHYDRO 4 OXOAZEPINO[3,2,1 HI]INDOLE 2 CARBONYL)AMINO] 5 FLUORO 4 OXOPENTANOIC ACID; AZEPINE DERIVATIVE; CASPASE INHIBITOR; CGP 82630; IDN 3866; IDN 5370; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL SURVIVAL; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; HIPPOCAMPUS; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN DEGRADATION; RAT; TRANSIENT ISCHEMIC ATTACK;

EID: 0034944956     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1161     Document Type: Article

References (1)

1. Allegrini PR, Sauer D. 1992. Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis. Magn Reson Imaging 10:773-778.