-
1
-
-
0033006836
-
Cancer statistics, 1999
-
Landis S.H., Murray T., Bolden S., et al. Cancer statistics, 1999. CA Cancer J Clin 49 1 (1999) 8-31
-
(1999)
CA Cancer J Clin
, vol.49
, Issue.1
, pp. 8-31
-
-
Landis, S.H.1
Murray, T.2
Bolden, S.3
-
2
-
-
0032714136
-
American gastroenterological association medical position statement: epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma
-
American gastroenterological association medical position statement: epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. Gastroenterology 117 6 (1999) 1463-1484
-
(1999)
Gastroenterology
, vol.117
, Issue.6
, pp. 1463-1484
-
-
-
3
-
-
22844448456
-
Molecular markers of early pancreatic cancer
-
Goggins M. Molecular markers of early pancreatic cancer. J Clin Oncol 23 20 (2005) 4524-4531
-
(2005)
J Clin Oncol
, vol.23
, Issue.20
, pp. 4524-4531
-
-
Goggins, M.1
-
4
-
-
33745845817
-
Increasing survival rates of patients with pancreatic cancer by earlier identification
-
Greenhalf W., and Neoptolemos J.P. Increasing survival rates of patients with pancreatic cancer by earlier identification. Nat Clin Pract Oncol 3 7 (2006) 346-347
-
(2006)
Nat Clin Pract Oncol
, vol.3
, Issue.7
, pp. 346-347
-
-
Greenhalf, W.1
Neoptolemos, J.P.2
-
5
-
-
23244467796
-
Probability of pancreatic cancer following diabetes: a population-based study
-
Chari S.T., Leibson C.L., Rabe K.G., et al. Probability of pancreatic cancer following diabetes: a population-based study. Gastroenterology 129 2 (2005) 504-511
-
(2005)
Gastroenterology
, vol.129
, Issue.2
, pp. 504-511
-
-
Chari, S.T.1
Leibson, C.L.2
Rabe, K.G.3
-
6
-
-
10744233747
-
Clinical and genetic characteristics of hereditary pancreatitis in Europe
-
Howes N., Lerch M.M., Greenhalf W., et al. Clinical and genetic characteristics of hereditary pancreatitis in Europe. Clin Gastroenterol Hepatol 2 3 (2004) 252-261
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, Issue.3
, pp. 252-261
-
-
Howes, N.1
Lerch, M.M.2
Greenhalf, W.3
-
7
-
-
0034046621
-
Hereditary pancreatic adenocarcinoma. A clinical perspective
-
Brand R.E., and Lynch H.T. Hereditary pancreatic adenocarcinoma. A clinical perspective. Med Clin North Am 84 3 (2000) 665-675
-
(2000)
Med Clin North Am
, vol.84
, Issue.3
, pp. 665-675
-
-
Brand, R.E.1
Lynch, H.T.2
-
8
-
-
0026503664
-
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium
-
Chang K., Pastan I., and Willingham M.C. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer 50 3 (1992) 373-381
-
(1992)
Int J Cancer
, vol.50
, Issue.3
, pp. 373-381
-
-
Chang, K.1
Pastan, I.2
Willingham, M.C.3
-
9
-
-
0035674996
-
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
-
Argani P., Iacobuzio-Donahue C., Ryu B., et al. Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE). Clin Cancer Res 7 12 (2001) 3862-3868
-
(2001)
Clin Cancer Res
, vol.7
, Issue.12
, pp. 3862-3868
-
-
Argani, P.1
Iacobuzio-Donahue, C.2
Ryu, B.3
-
10
-
-
11144353917
-
Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers
-
Koopmann J., Buckhaults P., Brown D.A., et al. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res 10 7 (2004) 2386-2392
-
(2004)
Clin Cancer Res
, vol.10
, Issue.7
, pp. 2386-2392
-
-
Koopmann, J.1
Buckhaults, P.2
Brown, D.A.3
-
11
-
-
0035866352
-
Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations
-
Jones J.B., Song J.J., Hempen P.M., et al. Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations. Cancer Res 61 4 (2001) 1299-1304
-
(2001)
Cancer Res
, vol.61
, Issue.4
, pp. 1299-1304
-
-
Jones, J.B.1
Song, J.J.2
Hempen, P.M.3
-
12
-
-
2442720182
-
The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection
-
Maitra A., Cohen Y., Gillespie S.E., et al. The Human MitoChip: a high-throughput sequencing microarray for mitochondrial mutation detection. Genome Res 14 5 (2004) 812-819
-
(2004)
Genome Res
, vol.14
, Issue.5
, pp. 812-819
-
-
Maitra, A.1
Cohen, Y.2
Gillespie, S.E.3
-
13
-
-
33745627069
-
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
-
Peng D.F., Kanai Y., Sawada M., et al. DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis 27 6 (2006) 1160-1168
-
(2006)
Carcinogenesis
, vol.27
, Issue.6
, pp. 1160-1168
-
-
Peng, D.F.1
Kanai, Y.2
Sawada, M.3
-
14
-
-
33645294070
-
Oncomirs-microRNAs with a role in cancer
-
Esquela-Kerscher A., and Slack F.J. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 6 4 (2006) 259-269
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.4
, pp. 259-269
-
-
Esquela-Kerscher, A.1
Slack, F.J.2
-
15
-
-
34247862190
-
MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
-
Bloomston M., Frankel W.L., Petrocca F., et al. MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 297 17 (2007) 1901-1908
-
(2007)
JAMA
, vol.297
, Issue.17
, pp. 1901-1908
-
-
Bloomston, M.1
Frankel, W.L.2
Petrocca, F.3
-
16
-
-
0033887693
-
Progression model for pancreatic cancer
-
Hruban R.H., Goggins M., Parsons J., et al. Progression model for pancreatic cancer. Clin Cancer Res 6 8 (2000) 2969-2972
-
(2000)
Clin Cancer Res
, vol.6
, Issue.8
, pp. 2969-2972
-
-
Hruban, R.H.1
Goggins, M.2
Parsons, J.3
-
17
-
-
0034092011
-
Tumor angiogenesis: past, present and the near future
-
Kerbel R.S. Tumor angiogenesis: past, present and the near future. Carcinogenesis 21 3 (2000) 505-515
-
(2000)
Carcinogenesis
, vol.21
, Issue.3
, pp. 505-515
-
-
Kerbel, R.S.1
-
18
-
-
0036334059
-
Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials
-
Bloomston M., Zervos E.E., and Rosemurgy II A.S. Matrix metalloproteinases and their role in pancreatic cancer: a review of preclinical studies and clinical trials. Ann Surg Oncol 9 7 (2002) 668-674
-
(2002)
Ann Surg Oncol
, vol.9
, Issue.7
, pp. 668-674
-
-
Bloomston, M.1
Zervos, E.E.2
Rosemurgy II, A.S.3
-
19
-
-
0037100983
-
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
-
Bramhall S.R., Schulz J., Nemunaitis J., et al. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 87 2 (2002) 161-167
-
(2002)
Br J Cancer
, vol.87
, Issue.2
, pp. 161-167
-
-
Bramhall, S.R.1
Schulz, J.2
Nemunaitis, J.3
-
20
-
-
0035424135
-
Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial
-
Bramhall S.R., Rosemurgy A., Brown P.D., et al. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 19 15 (2001) 3447-3455
-
(2001)
J Clin Oncol
, vol.19
, Issue.15
, pp. 3447-3455
-
-
Bramhall, S.R.1
Rosemurgy, A.2
Brown, P.D.3
-
21
-
-
0032710567
-
BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity
-
Gatto C., Rieppi M., Borsotti P., et al. BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activity. Clin Cancer Res 5 11 (1999) 3603-3607
-
(1999)
Clin Cancer Res
, vol.5
, Issue.11
, pp. 3603-3607
-
-
Gatto, C.1
Rieppi, M.2
Borsotti, P.3
-
22
-
-
0035071939
-
Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566
-
Erlichman C., Adjei A.A., Alberts S.R., et al. Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566. Ann Oncol 12 3 (2001) 389-395
-
(2001)
Ann Oncol
, vol.12
, Issue.3
, pp. 389-395
-
-
Erlichman, C.1
Adjei, A.A.2
Alberts, S.R.3
-
23
-
-
17944370745
-
Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors
-
Heath E.I., O'Reilly S., Humphrey R., et al. Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors. Cancer Chemother Pharmacol 48 4 (2001) 269-274
-
(2001)
Cancer Chemother Pharmacol
, vol.48
, Issue.4
, pp. 269-274
-
-
Heath, E.I.1
O'Reilly, S.2
Humphrey, R.3
-
24
-
-
0032907687
-
Vascular endothelial growth factor (VEGF) and its receptors
-
Neufeld G., Cohen T., Gengrinovitch S., et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13 1 (1999) 9-22
-
(1999)
FASEB J
, vol.13
, Issue.1
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
-
25
-
-
0030754056
-
Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
-
Itakura J., Ishiwata T., Friess H., et al. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res 3 8 (1997) 1309-1316
-
(1997)
Clin Cancer Res
, vol.3
, Issue.8
, pp. 1309-1316
-
-
Itakura, J.1
Ishiwata, T.2
Friess, H.3
-
26
-
-
0034657029
-
High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
-
Seo Y., Baba H., Fukuda T., et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 88 10 (2000) 2239-2245
-
(2000)
Cancer
, vol.88
, Issue.10
, pp. 2239-2245
-
-
Seo, Y.1
Baba, H.2
Fukuda, T.3
-
27
-
-
0035253739
-
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
Gordon M.S., Margolin K., Talpaz M., et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol 19 3 (2001) 843-850
-
(2001)
J Clin Oncol
, vol.19
, Issue.3
, pp. 843-850
-
-
Gordon, M.S.1
Margolin, K.2
Talpaz, M.3
-
28
-
-
0035253586
-
Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data
-
Margolin K., Gordon M.S., Holmgren E., et al. Phase Ib trial of intravenous recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J Clin Oncol 19 3 (2001) 851-856
-
(2001)
J Clin Oncol
, vol.19
, Issue.3
, pp. 851-856
-
-
Margolin, K.1
Gordon, M.S.2
Holmgren, E.3
-
29
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
Kabbinavar F., Hurwitz H.I., Fehrenbacher L., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21 1 (2003) 60-65
-
(2003)
J Clin Oncol
, vol.21
, Issue.1
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
-
30
-
-
41049116938
-
-
Hurwitz H, Fehrenbacher L, Cartwright T. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
Hurwitz H, Fehrenbacher L, Cartwright T. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
-
-
-
31
-
-
41049098142
-
-
Kindler HL, Lester E. Bevacizumab (B) plus gemcitabine (G) in patients (pts) with advanced pancreatic cancer (PC). Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
Kindler HL, Lester E. Bevacizumab (B) plus gemcitabine (G) in patients (pts) with advanced pancreatic cancer (PC). Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
-
-
-
32
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
-
Burris III H.A., Moore M.J., Andersen J., et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol 15 6 (1997) 2403-2413
-
(1997)
J Clin Oncol
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris III, H.A.1
Moore, M.J.2
Andersen, J.3
-
33
-
-
33644968548
-
Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer
-
Crane C.H., Ellis L.M., Abbruzzese J.L., et al. Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer. J Clin Oncol 24 7 (2006) 1145-1151
-
(2006)
J Clin Oncol
, vol.24
, Issue.7
, pp. 1145-1151
-
-
Crane, C.H.1
Ellis, L.M.2
Abbruzzese, J.L.3
-
34
-
-
6544295983
-
Overexpression of cyclooxygenase-2 in carcinoma of the pancreas
-
Okami J., Yamamoto H., Fujiwara Y., et al. Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res 5 8 (1999) 2018-2024
-
(1999)
Clin Cancer Res
, vol.5
, Issue.8
, pp. 2018-2024
-
-
Okami, J.1
Yamamoto, H.2
Fujiwara, Y.3
-
35
-
-
41049103690
-
-
Xiong H, Plunkett W, Wolff R. Pharmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer. Paper Presented at the Annual Meeting of the American Cancer Society. Orlando (FL), May 18-21, 2002.
-
Xiong H, Plunkett W, Wolff R. Pharmacology study of celecoxib in combination with gemcitabine for advanced pancreatic cancer. Paper Presented at the Annual Meeting of the American Cancer Society. Orlando (FL), May 18-21, 2002.
-
-
-
-
36
-
-
41049106802
-
-
Smith S, Burris H, Loehrer P. Preliminary report of a phase II trial of gemcitabine combined with celecoxib for advanced pancreatic cancer. Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
Smith S, Burris H, Loehrer P. Preliminary report of a phase II trial of gemcitabine combined with celecoxib for advanced pancreatic cancer. Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Chicago, May 31-June 3, 2003.
-
-
-
-
37
-
-
22444448481
-
Cardiovascular risk associated with celecoxib
-
author reply 2648-50
-
Brophy J.M. Cardiovascular risk associated with celecoxib. N Engl J Med 352 25 (2005) 2648-2650 author reply 2648-50
-
(2005)
N Engl J Med
, vol.352
, Issue.25
, pp. 2648-2650
-
-
Brophy, J.M.1
-
38
-
-
0036728051
-
Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway
-
Tong W.G., Ding X.Z., Witt R.C., et al. Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway. Mol Cancer Ther 1 11 (2002) 929-935
-
(2002)
Mol Cancer Ther
, vol.1
, Issue.11
, pp. 929-935
-
-
Tong, W.G.1
Ding, X.Z.2
Witt, R.C.3
-
39
-
-
41049109077
-
-
Schwartz G, Budman D, Endres S, et al. Phase I and pharmacokinetic study of LY293111, an orally available small molecule known to be an LTB4 receptor antagonist, 5-lipoxygenase inhibitor and peroxisome proliferator activated receptor-gamma agonist (PPARc) (abstract 343). Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Orlando (FL), May 18-21, 2002.
-
Schwartz G, Budman D, Endres S, et al. Phase I and pharmacokinetic study of LY293111, an orally available small molecule known to be an LTB4 receptor antagonist, 5-lipoxygenase inhibitor and peroxisome proliferator activated receptor-gamma agonist (PPARc) (abstract 343). Paper Presented at the Annual Meeting of the American Society of Clinical Oncology. Orlando (FL), May 18-21, 2002.
-
-
-
-
41
-
-
0003460126
-
Thalidomide and analogues
-
Teicher B.A. (Ed), Humana Press, Totowa (NJ)
-
Udagawa T., Verheul H.M., and D'Amato R.J. Thalidomide and analogues. In: Teicher B.A. (Ed). Antiangiogenic agents in cancer therapy (1999), Humana Press, Totowa (NJ) 263-274
-
(1999)
Antiangiogenic agents in cancer therapy
, pp. 263-274
-
-
Udagawa, T.1
Verheul, H.M.2
D'Amato, R.J.3
-
42
-
-
0001867498
-
Thalidomide: a prodrug that inhibits angiogenesis
-
Teicher B.A. (Ed), Humana Press, Totowa (NJ)
-
Figg W.D., Reed E., Green S., et al. Thalidomide: a prodrug that inhibits angiogenesis. In: Teicher B.A. (Ed). Antiangiogenic agents in cancer therapy (1999), Humana Press, Totowa (NJ) 407-422
-
(1999)
Antiangiogenic agents in cancer therapy
, pp. 407-422
-
-
Figg, W.D.1
Reed, E.2
Green, S.3
-
43
-
-
33644978679
-
A phase I/II trial of weekly gemcitabine with celecoxib and thalidomide for patients with advanced pancreatic cancer
-
Densmore J., Fox J., Kannarkat G., et al. A phase I/II trial of weekly gemcitabine with celecoxib and thalidomide for patients with advanced pancreatic cancer. J Clin Oncol 23 Suppl (2005) 4241
-
(2005)
J Clin Oncol
, vol.23
, Issue.SUPPL
, pp. 4241
-
-
Densmore, J.1
Fox, J.2
Kannarkat, G.3
-
44
-
-
0037010091
-
Epidermal growth factor receptor-targeted therapy for pancreatic cancer
-
Xiong H.Q., and Abbruzzese J.L. Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Semin Oncol 29 5 Suppl 14 (2002) 31-37
-
(2002)
Semin Oncol
, vol.29
, Issue.5 SUPPL. 14
, pp. 31-37
-
-
Xiong, H.Q.1
Abbruzzese, J.L.2
-
45
-
-
6044241807
-
The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma
-
Ueda S., Ogata S., Tsuda H., et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 29 1 (2004) E1-E8
-
(2004)
Pancreas
, vol.29
, Issue.1
-
-
Ueda, S.1
Ogata, S.2
Tsuda, H.3
-
46
-
-
33144481184
-
Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer
-
Robert F., Blumenschein G., Herbst R.S., et al. Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer. J Clin Oncol 23 36 (2005) 9089-9096
-
(2005)
J Clin Oncol
, vol.23
, Issue.36
, pp. 9089-9096
-
-
Robert, F.1
Blumenschein, G.2
Herbst, R.S.3
-
47
-
-
33745519512
-
Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
-
Bourhis J., Rivera F., Mesia R., et al. Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 24 18 (2006) 2866-2872
-
(2006)
J Clin Oncol
, vol.24
, Issue.18
, pp. 2866-2872
-
-
Bourhis, J.1
Rivera, F.2
Mesia, R.3
-
48
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial
-
Xiong H.Q., Rosenberg A., LoBuglio A., et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol 22 13 (2004) 2610-2616
-
(2004)
J Clin Oncol
, vol.22
, Issue.13
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
-
49
-
-
41049091258
-
-
Available at: http://www.cancer.gov.
-
Available at: http://www.cancer.gov.
-
-
-
-
50
-
-
33646504884
-
Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer
-
Graeven U., Kremer B., Sudhoff T., et al. Phase I study of the humanised anti-EGFR monoclonal antibody matuzumab (EMD 72000) combined with gemcitabine in advanced pancreatic cancer. Br J Cancer 94 9 (2006) 1293-1299
-
(2006)
Br J Cancer
, vol.94
, Issue.9
, pp. 1293-1299
-
-
Graeven, U.1
Kremer, B.2
Sudhoff, T.3
-
51
-
-
41049091604
-
-
Strumberg D, Scheulen ME, Hilger RA, et al. Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, as monotherapy in patients with locally advanced or metastatic pancreatic cancer (PC). 2006 ASCO Annual Meeting Proceedings, Part I. J Clin Oncol 2006;24(Suppl 18):12504.
-
Strumberg D, Scheulen ME, Hilger RA, et al. Safety, efficacy and pharmacokinetics of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, as monotherapy in patients with locally advanced or metastatic pancreatic cancer (PC). 2006 ASCO Annual Meeting Proceedings, Part I. J Clin Oncol 2006;24(Suppl 18):12504.
-
-
-
-
52
-
-
0035884231
-
The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
-
Arteaga C.L. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 19 Suppl 18 (2001) 32S-40S
-
(2001)
J Clin Oncol
, vol.19
, Issue.SUPPL. 18
-
-
Arteaga, C.L.1
-
53
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M., Siu L.L., Nemunaitis J., et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 19 13 (2001) 3267-3279
-
(2001)
J Clin Oncol
, vol.19
, Issue.13
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
-
54
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore M.J., Goldstein D., Hamm J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25 15 (2007) 1960-1966
-
(2007)
J Clin Oncol
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
55
-
-
33144463315
-
A phase II study of erlotinib in combination with capecitabine in previously treated patients with metastatic pancreatic cancer. 2005 ASCO Annal Meedint Proceedings
-
Blaszkowsky L.S., Kulke R.H., Ryan D.P., et al. A phase II study of erlotinib in combination with capecitabine in previously treated patients with metastatic pancreatic cancer. 2005 ASCO Annal Meedint Proceedings. J Clin Oncol 23 Suppl 16 (2005) 4099
-
(2005)
J Clin Oncol
, vol.23
, Issue.SUPPL. 16
, pp. 4099
-
-
Blaszkowsky, L.S.1
Kulke, R.H.2
Ryan, D.P.3
-
56
-
-
29044433659
-
Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study
-
Iannitti D., Dipetrillo T., Akerman P., et al. Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I study. Am J Clin Oncol 28 6 (2005) 570-575
-
(2005)
Am J Clin Oncol
, vol.28
, Issue.6
, pp. 570-575
-
-
Iannitti, D.1
Dipetrillo, T.2
Akerman, P.3
-
57
-
-
0242349249
-
MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac
-
Yip-Schneider M.T., and Schmidt C.M. MEK inhibition of pancreatic carcinoma cells by U0126 and its effect in combination with sulindac. Pancreas 27 4 (2003) 337-344
-
(2003)
Pancreas
, vol.27
, Issue.4
, pp. 337-344
-
-
Yip-Schneider, M.T.1
Schmidt, C.M.2
-
58
-
-
19644388719
-
Pharmacologic inhibition of RAF->MEK->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
-
Gysin S., Lee S.H., Dean N.M., et al. Pharmacologic inhibition of RAF->MEK->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res 65 11 (2005) 4870-4880
-
(2005)
Cancer Res
, vol.65
, Issue.11
, pp. 4870-4880
-
-
Gysin, S.1
Lee, S.H.2
Dean, N.M.3
-
59
-
-
0242468891
-
CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)
-
Allen L.F., Sebolt-Leopold J., and Meyer M.B. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol 30 5 Suppl 16 (2003) 105-116
-
(2003)
Semin Oncol
, vol.30
, Issue.5 SUPPL. 16
, pp. 105-116
-
-
Allen, L.F.1
Sebolt-Leopold, J.2
Meyer, M.B.3
-
60
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
Rinehart J., Adjei A.A., Lorusso P.M., et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol 22 22 (2004) 4456-4462
-
(2004)
J Clin Oncol
, vol.22
, Issue.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
Lorusso, P.M.3
-
61
-
-
34247857540
-
Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors
-
Strumberg D., Clark J.W., Awada A., et al. Safety, pharmacokinetics, and preliminary antitumor activity of sorafenib: a review of four phase I trials in patients with advanced refractory solid tumors. Oncologist 12 4 (2007) 426-437
-
(2007)
Oncologist
, vol.12
, Issue.4
, pp. 426-437
-
-
Strumberg, D.1
Clark, J.W.2
Awada, A.3
-
62
-
-
31544460436
-
Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer
-
Siu L.L., Awada A., Takimoto C.H., et al. Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer. Clin Cancer Res 12 1 (2006) 144-151
-
(2006)
Clin Cancer Res
, vol.12
, Issue.1
, pp. 144-151
-
-
Siu, L.L.1
Awada, A.2
Takimoto, C.H.3
-
63
-
-
26444574802
-
Development of farnesyl transferase inhibitors: a review
-
Appels N.M., Beijnen J.H., and Schellens J.H. Development of farnesyl transferase inhibitors: a review. Oncologist 10 8 (2005) 565-578
-
(2005)
Oncologist
, vol.10
, Issue.8
, pp. 565-578
-
-
Appels, N.M.1
Beijnen, J.H.2
Schellens, J.H.3
-
64
-
-
0036605562
-
Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer
-
Crul M., de Klerk G.J., Swart M., et al. Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol 20 11 (2002) 2726-2735
-
(2002)
J Clin Oncol
, vol.20
, Issue.11
, pp. 2726-2735
-
-
Crul, M.1
de Klerk, G.J.2
Swart, M.3
-
65
-
-
23844517889
-
A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study
-
Macdonald J.S., McCoy S., Whitehead R.P., et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study. Invest New Drugs 23 5 (2005) 485-487
-
(2005)
Invest New Drugs
, vol.23
, Issue.5
, pp. 485-487
-
-
Macdonald, J.S.1
McCoy, S.2
Whitehead, R.P.3
-
66
-
-
0142061051
-
Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes
-
Cortes J. Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes. Clin Lymphoma 4 Suppl 1 (2003) S30-S35
-
(2003)
Clin Lymphoma
, vol.4
, Issue.SUPPL. 1
-
-
Cortes, J.1
-
67
-
-
22544467757
-
Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma
-
Kim E.S., Kies M.S., Fossella F.V., et al. Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma. Cancer 104 3 (2005) 561-569
-
(2005)
Cancer
, vol.104
, Issue.3
, pp. 561-569
-
-
Kim, E.S.1
Kies, M.S.2
Fossella, F.V.3
-
68
-
-
11144354579
-
Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 given as a 1-hour intravenous infusion in patients with advanced solid tumors
-
Ryan D.P., Eder Jr. J.P., Puchlaski T., et al. Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 given as a 1-hour intravenous infusion in patients with advanced solid tumors. Clin Cancer Res 10 7 (2004) 2222-2230
-
(2004)
Clin Cancer Res
, vol.10
, Issue.7
, pp. 2222-2230
-
-
Ryan, D.P.1
Eder Jr., J.P.2
Puchlaski, T.3
-
69
-
-
3042857537
-
The influence of Ras pathway signaling on tumor radiosensitivity
-
Kim I.A., Fernandes A.T., Gupta A.K., et al. The influence of Ras pathway signaling on tumor radiosensitivity. Cancer Metastasis Rev 23 3-4 (2004) 227-236
-
(2004)
Cancer Metastasis Rev
, vol.23
, Issue.3-4
, pp. 227-236
-
-
Kim, I.A.1
Fernandes, A.T.2
Gupta, A.K.3
-
70
-
-
2142686613
-
Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor
-
Matsui Y., Goto M., Iwakawa M., et al. Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor. Oncol Rep 10 5 (2003) 1525-1528
-
(2003)
Oncol Rep
, vol.10
, Issue.5
, pp. 1525-1528
-
-
Matsui, Y.1
Goto, M.2
Iwakawa, M.3
-
71
-
-
33751116803
-
Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against RAS mutated cell lines
-
Cengel K.A., Deutsch E., Stephens T.C., et al. Radiosensitizing effects of the prenyltransferase inhibitor AZD3409 against RAS mutated cell lines. Cancer Biol Ther 5 9 (2006) 1206-1210
-
(2006)
Cancer Biol Ther
, vol.5
, Issue.9
, pp. 1206-1210
-
-
Cengel, K.A.1
Deutsch, E.2
Stephens, T.C.3
-
72
-
-
4143060341
-
A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer
-
Martin N.E., Brunner T.B., Kiel K.D., et al. A phase I trial of the dual farnesyltransferase and geranylgeranyltransferase inhibitor L-778,123 and radiotherapy for locally advanced pancreatic cancer. Clin Cancer Res 10 16 (2004) 5447-5454
-
(2004)
Clin Cancer Res
, vol.10
, Issue.16
, pp. 5447-5454
-
-
Martin, N.E.1
Brunner, T.B.2
Kiel, K.D.3
-
73
-
-
33745593715
-
Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin
-
Wobser M., Keikavoussi P., Kunzmann V., et al. Complete remission of liver metastasis of pancreatic cancer under vaccination with a HLA-A2 restricted peptide derived from the universal tumor antigen survivin. Cancer Immunol Immunother 55 10 (2006) 1294-1298
-
(2006)
Cancer Immunol Immunother
, vol.55
, Issue.10
, pp. 1294-1298
-
-
Wobser, M.1
Keikavoussi, P.2
Kunzmann, V.3
-
74
-
-
0037280283
-
HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes
-
Gjertsen M.K., Saeterdal I., Saeboe-Larssen S., et al. HLA-A3 restricted mutant ras specific cytotoxic T-lymphocytes induced by vaccination with T-helper epitopes. J Mol Med 81 1 (2003) 43-50
-
(2003)
J Mol Med
, vol.81
, Issue.1
, pp. 43-50
-
-
Gjertsen, M.K.1
Saeterdal, I.2
Saeboe-Larssen, S.3
-
75
-
-
23344445706
-
MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer
-
Yamamoto K., Ueno T., Kawaoka T., et al. MUC1 peptide vaccination in patients with advanced pancreas or biliary tract cancer. Anticancer Res 25 5 (2005) 3575-3579
-
(2005)
Anticancer Res
, vol.25
, Issue.5
, pp. 3575-3579
-
-
Yamamoto, K.1
Ueno, T.2
Kawaoka, T.3
-
76
-
-
33646468422
-
Development of the PANVAC-VF vaccine for pancreatic cancer
-
Petrulio C.A., and Kaufman H.L. Development of the PANVAC-VF vaccine for pancreatic cancer. Expert Rev Vaccines 5 1 (2006) 9-19
-
(2006)
Expert Rev Vaccines
, vol.5
, Issue.1
, pp. 9-19
-
-
Petrulio, C.A.1
Kaufman, H.L.2
-
77
-
-
25144436016
-
Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer
-
Yamamoto K., Mine T., Katagiri K., et al. Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer. Oncol Rep 13 5 (2005) 874-883
-
(2005)
Oncol Rep
, vol.13
, Issue.5
, pp. 874-883
-
-
Yamamoto, K.1
Mine, T.2
Katagiri, K.3
-
78
-
-
20344407571
-
Immunotherapy for pancreatic cancer-science driving clinical progress
-
Laheru D., and Jaffee E.M. Immunotherapy for pancreatic cancer-science driving clinical progress. Nat Rev Cancer 5 6 (2005) 459-467
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.6
, pp. 459-467
-
-
Laheru, D.1
Jaffee, E.M.2
-
79
-
-
34147128639
-
Immunological evaluation of personalized peptide vaccination with gemcitabine for pancreatic cancer
-
Yanagimoto H., Mine T., Yamamoto K., et al. Immunological evaluation of personalized peptide vaccination with gemcitabine for pancreatic cancer. Cancer Sci 98 4 (2007) 605-611
-
(2007)
Cancer Sci
, vol.98
, Issue.4
, pp. 605-611
-
-
Yanagimoto, H.1
Mine, T.2
Yamamoto, K.3
-
80
-
-
3543060047
-
Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients
-
Thomas A.M., Santarsiero L.M., Lutz E.R., et al. Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. J Exp Med 200 3 (2004) 297-306
-
(2004)
J Exp Med
, vol.200
, Issue.3
, pp. 297-306
-
-
Thomas, A.M.1
Santarsiero, L.M.2
Lutz, E.R.3
-
81
-
-
33845219775
-
A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors
-
Hung C.F., Calizo R., Tsai Y.C., et al. A DNA vaccine encoding a single-chain trimer of HLA-A2 linked to human mesothelin peptide generates anti-tumor effects against human mesothelin-expressing tumors. Vaccine 25 1 (2007) 127-135
-
(2007)
Vaccine
, vol.25
, Issue.1
, pp. 127-135
-
-
Hung, C.F.1
Calizo, R.2
Tsai, Y.C.3
-
82
-
-
0037108933
-
Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer
-
Brett B.T., Smith S.C., Bouvier C.V., et al. Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J Clin Oncol 20 20 (2002) 4225-4231
-
(2002)
J Clin Oncol
, vol.20
, Issue.20
, pp. 4225-4231
-
-
Brett, B.T.1
Smith, S.C.2
Bouvier, C.V.3
-
83
-
-
33847699242
-
G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy
-
Gilliam A.D., and Watson S.A. G17DT: an antigastrin immunogen for the treatment of gastrointestinal malignancy. Expert Opin Biol Ther 7 3 (2007) 397-404
-
(2007)
Expert Opin Biol Ther
, vol.7
, Issue.3
, pp. 397-404
-
-
Gilliam, A.D.1
Watson, S.A.2
|