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Volumn 7, Issue 3, 2007, Pages 397-404

G17DT: An antigastrin immunogen for the treatment of gastrointestinal malignancy

Author keywords

Angiogenesis; Apoptosis; Colorectal cancer; G17DT; Gastric cancer; Gastrin; Pancreatic cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; CISPLATIN; EXATECAN; FLUOROURACIL; G 17DT; GASTRAZOLE; GASTRIMMUNE; GASTRIN 17; GASTRIN 17 ANTIBODY; GEMCITABINE; HORMONE ANTIBODY; IMMUNOLOGIC AGENT; IRINOTECAN; JB 95008; UNCLASSIFIED DRUG;

EID: 33847699242     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.7.3.397     Document Type: Review
Times cited : (37)

References (26)
  • 2
    • 0032934334 scopus 로고    scopus 로고
    • Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor
    • MIYAZAKI Y, SHINOMURA Y, TSUTSUI S et al.: Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor. Gastroenterology (1999) 116:78-89.
    • (1999) Gastroenterology , vol.116 , pp. 78-89
    • MIYAZAKI, Y.1    SHINOMURA, Y.2    TSUTSUI, S.3
  • 3
    • 0036107819 scopus 로고    scopus 로고
    • Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor
    • VARRO A, NOBLE PJ, WROBLEWSKI LE, BISHOP L, DOCKRAY GJ: Gastrin-cholecystokinin(B) receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor. Gut (2002) 50:827-833.
    • (2002) Gut , vol.50 , pp. 827-833
    • VARRO, A.1    NOBLE, P.J.2    WROBLEWSKI, L.E.3    BISHOP, L.4    DOCKRAY, G.J.5
  • 4
    • 0037230016 scopus 로고    scopus 로고
    • Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways
    • NOBLE PJ, WILDE G, WHITE MR et al.: Stimulation of gastrin-CCKB receptor promotes migration of gastric AGS cells via multiple paracrine pathways. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) 284:G75-G84.
    • (2003) Am. J. Physiol. Gastrointest. Liver Physiol , vol.284
    • NOBLE, P.J.1    WILDE, G.2    WHITE, M.R.3
  • 5
    • 0031761368 scopus 로고    scopus 로고
    • Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats
    • FUKUI H, KINOSHITA Y, MAEKAWA T et al.: Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Gastroenterology (1998) 115:1483-1493.
    • (1998) Gastroenterology , vol.115 , pp. 1483-1493
    • FUKUI, H.1    KINOSHITA, Y.2    MAEKAWA, T.3
  • 6
    • 0037073757 scopus 로고    scopus 로고
    • Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor
    • GUO YS, CHENG JZ, JIN GF et al.: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. J. Biol. Chem. (2002) 277:48755-48763.
    • (2002) J. Biol. Chem , vol.277 , pp. 48755-48763
    • GUO, Y.S.1    CHENG, J.Z.2    JIN, G.F.3
  • 7
    • 0034789948 scopus 로고    scopus 로고
    • Glycine-extended gastrin promotes the invasiveness of human colon cancer cells
    • KERMORGANT S, LEHY T: Glycine-extended gastrin promotes the invasiveness of human colon cancer cells, Biochem. Biophys. Res. Commun. (2001) 285:136-141.
    • (2001) Biochem. Biophys. Res. Commun , vol.285 , pp. 136-141
    • KERMORGANT, S.1    LEHY, T.2
  • 8
    • 4143116933 scopus 로고    scopus 로고
    • The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas
    • HARRIS JC, GILLIAM AD, MCKENZIE AJ et al.: The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas. Cancer Res. (2004) 64:5624-5631.
    • (2004) Cancer Res , vol.64 , pp. 5624-5631
    • HARRIS, J.C.1    GILLIAM, A.D.2    MCKENZIE, A.J.3
  • 9
    • 0030722875 scopus 로고    scopus 로고
    • Clinical response benefit in patients with advanced pancreatic cancer. Role of gemcitabine
    • CARMICHAEL J: Clinical response benefit in patients with advanced pancreatic cancer. Role of gemcitabine. Digestion (1997) 58:503-507.
    • (1997) Digestion , vol.58 , pp. 503-507
    • CARMICHAEL, J.1
  • 10
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • BURRIS HA 3RD, MOORE MJ, ANDERSEN J et al.: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J. Clin. Oncol. (1997) 15:2403-2413.
    • (1997) J. Clin. Oncol , vol.15 , pp. 2403-2413
    • BURRIS 3RD, H.A.1    MOORE, M.J.2    ANDERSEN, J.3
  • 11
    • 16444383237 scopus 로고    scopus 로고
    • GemOx (gemcitabine + oxaliplatin) versus Gem (gemcitabine) in non-resectable pancreatic andenocarcinoma: Final results of the GERCOR/GISCAD Intergroup Phase III
    • Abstract 4008
    • LOUVET C, LABIANCA R, HAMMEL P et al.: GemOx (gemcitabine + oxaliplatin) versus Gem (gemcitabine) in non-resectable pancreatic andenocarcinoma: final results of the GERCOR/GISCAD Intergroup Phase III. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 4008.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • LOUVET, C.1    LABIANCA, R.2    HAMMEL, P.3
  • 12
    • 16444384413 scopus 로고    scopus 로고
    • A randomized Phase III trial of DX-8951f (exatecan mesylate;DX) and gemcitabine (GEM) versus gemcitabine alone in advanced pancreatic cancer (APC)
    • Abstract 4006
    • O'REILLY M, ABOU-ALFA GK, LETOURNEAU R et al.: A randomized Phase III trial of DX-8951f (exatecan mesylate;DX) and gemcitabine (GEM) versus gemcitabine alone in advanced pancreatic cancer (APC). Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 4006.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • O'REILLY, M.1    ABOU-ALFA, G.K.2    LETOURNEAU, R.3
  • 13
    • 16444372799 scopus 로고    scopus 로고
    • A randomized Phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer
    • Abstract 4007
    • RICHARDS DA, KINDLER HL, OETTLE H et al.: A randomized Phase III study comparing gemcitabine + pemetrexed versus gemcitabine in patients with locally advanced and metastatic pancreas cancer. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 4007.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • RICHARDS, D.A.1    KINDLER, H.L.2    OETTLE, H.3
  • 14
    • 33646155340 scopus 로고    scopus 로고
    • Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: Results from two randomised controlled trials
    • CHAU I, CUNNINGHAM D, RUSSELL C et al.: Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials. Br. J. Cancer (2006) 94:1107-1115.
    • (2006) Br. J. Cancer , vol.94 , pp. 1107-1115
    • CHAU, I.1    CUNNINGHAM, D.2    RUSSELL, C.3
  • 15
    • 33745987278 scopus 로고    scopus 로고
    • G17DT - a new weapon in the therapeutic armoury for gastrointestinal malignancy
    • WATSON SA, GILLIAM AD: G17DT - a new weapon in the therapeutic armoury for gastrointestinal malignancy. Expert Opin. Biol. Ther. (2001) 1:309-317.
    • (2001) Expert Opin. Biol. Ther , vol.1 , pp. 309-317
    • WATSON, S.A.1    GILLIAM, A.D.2
  • 16
    • 33847756426 scopus 로고    scopus 로고
    • GILLIAM AD, HENWOOD M, WATSON SA et al.: G17DT - A study to detemine the safety, tolerance and antibody response in patients with advanced pancreatic carcinoma. J. Clin. Oncol. (2001) 120:1350.
    • GILLIAM AD, HENWOOD M, WATSON SA et al.: G17DT - A study to detemine the safety, tolerance and antibody response in patients with advanced pancreatic carcinoma. J. Clin. Oncol. (2001) 120:1350.
  • 17
    • 0032445725 scopus 로고    scopus 로고
    • Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer
    • SMITH JP, VERDERAME MF, ZAGON IS: Antisense oligonucleotides to gastrin inhibit growth of human pancreatic cancer. Cancer Lett. (1999) 135:107-112.
    • (1999) Cancer Lett , vol.135 , pp. 107-112
    • SMITH, J.P.1    VERDERAME, M.F.2    ZAGON, I.S.3
  • 18
    • 18744374426 scopus 로고    scopus 로고
    • Randomised, double blind, placebo-controlled, multi-centre, group-sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy
    • Abstract 2511
    • GILLIAM AD, TOPUZOV EG, GARIN AM et al.: Randomised, double blind, placebo-controlled, multi-centre, group-sequential trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 2511.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • GILLIAM, A.D.1    TOPUZOV, E.G.2    GARIN, A.M.3
  • 19
    • 32944474394 scopus 로고    scopus 로고
    • The effect of jaundice on the generation of anti-gastrin antibodies in G17DT immunized patients with advanced pancreatic cancer
    • TAKHAR AS, GILLIAM AD, WATSON SA et al.: The effect of jaundice on the generation of anti-gastrin antibodies in G17DT immunized patients with advanced pancreatic cancer. Eur. J. Surg. Oncol. (2006) 32:197-200.
    • (2006) Eur. J. Surg. Oncol , vol.32 , pp. 197-200
    • TAKHAR, A.S.1    GILLIAM, A.D.2    WATSON, S.A.3
  • 20
    • 0037108933 scopus 로고    scopus 로고
    • Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer
    • BRETT BT, SMITH SC, BOUVIER CV et al.: Phase II study of anti-gastrin-17 antibodies, raised to G17DT, in advanced pancreatic cancer. J. Clin. Oncol. (2002) 20:4225-4231.
    • (2002) J. Clin. Oncol , vol.20 , pp. 4225-4231
    • BRETT, B.T.1    SMITH, S.C.2    BOUVIER, C.V.3
  • 22
    • 21344435796 scopus 로고    scopus 로고
    • A multi-centre Phase II study of irinotecan in comabination with G17DT immunogen in subjects with metastatic colorectal adenocarcinoma (CRC) refractory to previous irinotecan-based chemotherapy
    • Abstract 3573
    • ROCHA LIMA CM, BUCK RD, MEYER K et al.: A multi-centre Phase II study of irinotecan in comabination with G17DT immunogen in subjects with metastatic colorectal adenocarcinoma (CRC) refractory to previous irinotecan-based chemotherapy. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 3573.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • ROCHA LIMA, C.M.1    BUCK, R.D.2    MEYER, K.3
  • 23
    • 21344450377 scopus 로고    scopus 로고
    • Final data of the multicener Phase II study of cisplatin (CDDP) and 5-fluorouracil (5-FU) in combination with G17DT immunogen in chemonaive patients with locally recurrent or metastatic gastric and gastroesophageal cancer
    • Abstract 4048
    • MICHAELI D, HECHT JR, OORTGIESEN M et al.: Final data of the multicener Phase II study of cisplatin (CDDP) and 5-fluorouracil (5-FU) in combination with G17DT immunogen in chemonaive patients with locally recurrent or metastatic gastric and gastroesophageal cancer. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 4048.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • MICHAELI, D.1    HECHT, J.R.2    OORTGIESEN, M.3
  • 24
    • 33847753945 scopus 로고    scopus 로고
    • Immune response to gastrin-17 is an independent covariate in determination of survival in colorectal, gastric and pancreatic cancers
    • Abstract 4073
    • BROOME P, BUCK RD, MICHAELI D: Immune response to gastrin-17 is an independent covariate in determination of survival in colorectal, gastric and pancreatic cancers. Proc. Am. Soc. Clin. Oncol. (2004) 22(Suppl.):Abstract 4073.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , Issue.SUPPL.
    • BROOME, P.1    BUCK, R.D.2    MICHAELI, D.3
  • 25
    • 33646358252 scopus 로고    scopus 로고
    • An open-label, multinational, multicenter study of G17DT vaccination combined with cisplatin and 5-fluorouracil in patients with untreated, advanced gastric or gastroesophageal cancer: The GC4 study
    • AJANI JA, RANDOLPH HECHT J, HO L et al.: An open-label, multinational, multicenter study of G17DT vaccination combined with cisplatin and 5-fluorouracil in patients with untreated, advanced gastric or gastroesophageal cancer: the GC4 study. Cancer (2006) 106(9):1908-1916.
    • (2006) Cancer , vol.106 , Issue.9 , pp. 1908-1916
    • AJANI, J.A.1    RANDOLPH HECHT, J.2    HO, L.3
  • 26
    • 28344451391 scopus 로고    scopus 로고
    • G17DT+ gemcitabine [gem] versus placebo+gem in untreated subjects with locally advanced, recurrent, or metastatic adenocarcinoma of the pancreas: Results of a randomised, double-blind, multinational, multicenter study
    • Abstract 4012
    • SHAPIRO J, MARSHALL J, KARASEK P et al.: G17DT+ gemcitabine [gem] versus placebo+gem in untreated subjects with locally advanced, recurrent, or metastatic adenocarcinoma of the pancreas: results of a randomised, double-blind, multinational, multicenter study. Proc. Am. Soc. Clin. Oncol. (2005) 23:Abstract 4012.
    • (2005) Proc. Am. Soc. Clin. Oncol , vol.23
    • SHAPIRO, J.1    MARSHALL, J.2    KARASEK, P.3


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