Adenoviral vector-mediated transfer of the Indian hedgehog gene modulates lymphomyelopoiesis in vivo

Stem Cells

Volumn 26, Issue 2, 2008, Pages 534-542

  Kobune, Masayoshi ^a   Kato, Junji ^a   Kawano, Yutaka ^a   Sasaki, Katsunori ^b   Uchida, Hiroaki ^c   Takada, Kohichi ^a   Takahashi, Sho ^a   Takimoto, Rishu ^a   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adenovirus; Hedgehog; Hematopoiesis; Lymphocyte; Spleen; Thymus

Indexed keywords

ADENOVIRUS VECTOR; SONIC HEDGEHOG PROTEIN;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; GENE; HEMATOPOIESIS; HUMAN; HUMAN CELL; INDIAN HEDGEHOG GENE; LIVER; LYMPHOPOIESIS; MONONUCLEAR CELL; MOUSE; MYELOPOIESIS; NONHUMAN; SEVERE COMBINED IMMUNODEFICIENCY; SINGLE DRUG DOSE; SPLEEN; THYMUS; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BASE SEQUENCE; COLONY-FORMING UNITS ASSAY; DNA PRIMERS; GENE EXPRESSION; GENETIC VECTORS; HEDGEHOG PROTEINS; HUMANS; LYMPHOPOIESIS; MICE; MICE, INBRED BALB C; MICE, SCID; MYELOPOIESIS; NIH 3T3 CELLS; RECOMBINANT PROTEINS; SPLEEN; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; ERINACEIDAE; MUS;

EID: 40949138402     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0741     Document Type: Article

References (56)

1. Ingham PW. Hedgehog signaling: A tale of two lipids. Science 2001; 294:1879-1881.
2. Denef N, Neubuser D, Perez L et al. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 2000;102:521-531.
3. Duman-Scheel M, Weng L, Xin S et al. Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E. Nature 2002;417:299-304.
4. Bigelow RL, Chari NS, Unden AB et al. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem 2004;279:1197-1205.
5. Lai K, Kaspar BK, Gage FH et al. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci 2003;6:21-27.
6. St-Jacques B, Dassule HR, Karavanova I et al. Sonic hedgehog signaling is essential for hair development. Curr Biol 1998;8:1058-1068.
7. Spinella-Jaegle S, Rawadi G, Kawai S et al. Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci 2001;114:2085-2094.
8. Watkins DN, Berman DM, Burkholder SG et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-317.
9. Pola R, Ling LE, Aprahamian TR et al. Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 2003;108:479-485.
10. Pathi S, Pagan-Westphal S, Baker DP et al. Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev 2001;106:107-117.
11. Baron M. Induction of embryonic hematopoietic and endothelial stem/progenitor cells by hedgehog-mediated signals. Differentiation 2001;68:175-185.
12. Dyer MA, Farrington SM, Mohn D et al. Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo. Development 2001;128:1717-1730.
13. Byrd N, Becker S, Maye P et al. Hedgehog is required for murine yolk sac angiogenesis. Development 2002;129:361-372.
14. Gering M, Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell 2005;8:389-400.
15. Vortkamp A, Lee K, Lanske B et al. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science 1996;273:613-622.
16. Chung UI, Schipani E, McMahon AP et al. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest 2001;107:295-304.
17. St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 1999;13:2072-2086.
18. Kobune M, Ito Y, Kawano Y et al. Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/ SCID-beta2m-/- repopulating cells. Blood 2004;104:1002-1009.
19. Uhmann A, Dittmann K, Nitzki F et al. The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood 2007;110:1814-1823.
20. Rowbotham NJ, Hager-Theodorides AL, Cebecauer M et al. Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 2007;109:3757-3766.
21. Sacedon R, Varas A, Hernandez-Lopez C et al. Expression of hedgehog proteins in the human thymus. J Histochem Cytochem 2003;51:1557-1566.
22. El Andaloussi A, Graves S, Meng F et al. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 2006;7:418-426.
23. Outram SV, Varas A, Pepicelli CV et al. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 2000;13:187-197.
24. Varas A, Hager-Theodorides AL, Sacedon R et al. The role of morphogens in T-cell development. Trends Immunol 2003;24:197-206.
25. Shah DK, Hager-Theodorides AL, Outram SV et al. Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol 2004;172:2296-2306.
26. Hager-Theodorides AL, Dessens JT, Outram SV et al. The transcription factor Gli3 regulates differentiation of fetal CD4- CD8- double-negative thymocytes. Blood 2005;106:1296-1304.
27. Stewart GA, Lowrey JA, Wakelin SJ et al. Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells. J Immunol 2002;169:5451-5457.
28. Lowrey JA, Stewart GA, Lindey S et al. Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes. J Immunol 2002;169:1869-1875.
29. Sacedon R, Diez B, Nunez V et al. Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. J Immunol 2005;174:1456-1461.
30. Allman D, Miller JP. Common lymphoid progenitors, early B-lineage precursors, and IL-7: Characterizing the trophic and instructive signals underlying early B cell development. Immunol Res 2003;27:131-140.
31. Nakamura T, Sato K, Hamada H. Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber. J Virol 2003;77:2512-2521.
32. Pola R, Ling LE, Silver M et al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 2001;7:706-711.
33. Asai J, Takenaka H, Kusano KF et al. Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation 2006;113:2413-2424.
34. Kusano KF, Pola R, Murayama T et al. Sonic hedgehog myocardial gene therapy: Tissue repair through transient reconstitution of embryonic signaling. Nat Med 2005;11:1197-1204.
35. Dehari H, Ito Y, Nakamura T et al. Enhanced antitumor effect of RGD fiber-modified adenovirus for gene therapy of oral cancer. Cancer Gene Ther 2003;10:75-85.
36. Uchida H, Tanaka T, Sasaki K et al. Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther 2004;10:162-171.
37. Zhang WW, Koch PE, Roth JA. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. Biotechniques 1995;18:444-447.
38. Nakamura T, Sato K, Hamada H. Effective gene transfer to human melanomas via integrin-targeted adenoviral vectors. Hum Gene Ther 2002;13:613-626.
39. Mizugishi K, Aruga J, Nakata K et al. Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 2001;276:2180-2188.
40. Kobune M, Xu Y, Baum C et al. Retrovirus-mediated expression of the base excision repair proteins, formamidopyrimidine DNA glycosylase or human oxoguanine DNA glycosylase, protects hematopoietic cells from N,N′,N″-triethylenethiophosphoramide (thioTEPA)-induced toxicity in vitro and in vivo. Cancer Res 2001;61:5116-5125.
41. Yang FC, Kapur R, King AJ et al. Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells. Immunity 2000;12:557-568.
42. Bhardwaj G, Murdoch B, Wu D et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2001;2:172-180.
43. Gutierrez-Frias C, Sacedon R, Hernandez-Lopez C et al. Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells. J Immunol 2004;173:5046-5053.
44. Pepinsky RB, Rayhorn P, Day ES et al. Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem 2000;275:10995-11001.
45. Trowbridge JJ, Scott MP, Bhatia M. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A 2006;103:14134-14139.
46. Long F, Chung UI, Ohba S et al. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 2004;131:1309-1318.
47. Colnot C, de la Fuente L, Huang S et al. Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development. Development 2005;132:1057-1067.
48. Chuang PT, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999;397:617-621.
49. Mullor JL, Ruiz i Altaba A. Growth, hedgehog and the price of GAS. Bioessays 2002;24:22-26.
50. Argenti B, Gallo R, Di Marcotullio L et al. Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors. J Neurosci 2005;25:8338-8346.
51. Bulgakov OV, Eggenschwiler JT, Hong DH et al. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development 2004;131:2149-2159.
52. Yao S, Lum L, Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell 2006;125:343-357.
53. Zhang F, McLellan JS, Ayala AM et al. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry 2007;46:3933-3941.
54. Martin ST, Sato N, Dhara S et al. Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther 2005;4:728-733.
55. Olsen CL, Hsu PP, Glienke J et al. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer 2004;4:43.
56. Di Marcotullio L, Ferretti E, De Smaele E et al. REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A 2004;101:10833-10838.