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Volumn 115, Issue 3, 2008, Pages 431-441

Pharmacological treatment of Parkinson's disease: Life beyond dopamine D2/D3 receptors?

Author keywords

Animal models; Levodopa induced dyskinesias; Non dopaminergic drugs; Parkinson's disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ADENOSINE; AMANTADINE; BACLOFEN; BUSPIRONE; CANNABINOID; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; ENADOLINE; ETIRACETAM; FIPAMEZOLE; GLUTAMIC ACID; IDAZOXAN; ISTRADEFYLLINE; LEVODOPA; NORADRENALIN; OPIATE; RIMONABANT; SARIZOTAN; SEROTONIN; SPIRADOLINE; ZONISAMIDE;

EID: 40949126492     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-007-0852-z     Document Type: Review
Times cited : (10)

References (93)
  • 1
    • 0025099820 scopus 로고
    • The efficacy of levodopa treatment declines in the course of Parkinson's disease: Do nondopaminergic lesions play a role?
    • Y Agid AM Graybiel M Ruberg E Hirsch J Blin B Dubois F Javoy-Agid 1990 The efficacy of levodopa treatment declines in the course of Parkinson's disease: do nondopaminergic lesions play a role? Adv Neurol 53 83 100
    • (1990) Adv Neurol , vol.53 , pp. 83-100
    • Agid, Y.1    Graybiel, A.M.2    Ruberg, M.3    Hirsch, E.4    Blin, J.5    Dubois, B.6    Javoy-Agid, F.7
  • 4
    • 0026665712 scopus 로고
    • Partial dopamine agonist therapy of levodopa-induced dyskinesias
    • F Baronti MM Mouradian KE Conant 1992 Partial dopamine agonist therapy of levodopa-induced dyskinesias Neurology 42 1241 1243
    • (1992) Neurology , vol.42 , pp. 1241-1243
    • Baronti, F.1    Mouradian, M.M.2    Conant, K.E.3
  • 6
    • 0035344211 scopus 로고    scopus 로고
    • Experimental models of Parkinson's disease
    • MF Beal 2001 Experimental models of Parkinson's disease Nat Rev Neurosci 2 325 332
    • (2001) Nat Rev Neurosci , vol.2 , pp. 325-332
    • Beal, M.F.1
  • 7
    • 0027941178 scopus 로고
    • Suppression of dyskinesias in advanced Parkinson's disease: Moderate daily clozapine doses provide long-term dyskinesia reduction
    • JP Bennett Jr ER Landow S Dietrich LA Schuh 1994 Suppression of dyskinesias in advanced Parkinson's disease: moderate daily clozapine doses provide long-term dyskinesia reduction Mov Disord 9 409 414
    • (1994) Mov Disord , vol.9 , pp. 409-414
    • Bennett Jr., J.P.1    Landow, E.R.2    Dietrich, S.3    Schuh, L.A.4
  • 8
    • 0038579160 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    • E Bezard S Ferry U Mach 2003 Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function Nat Med 9 762 777
    • (2003) Nat Med , vol.9 , pp. 762-777
    • Bezard, E.1    Ferry, S.2    MacH, U.3
  • 9
    • 0035960558 scopus 로고    scopus 로고
    • Serotonin 5HT1A agonist improves motor complications in rodent and primate parkinsonian models
    • F Bibbiani JD Oh TN Chase 2001 Serotonin 5HT1A agonist improves motor complications in rodent and primate parkinsonian models Neurology 57 1829 1834
    • (2001) Neurology , vol.57 , pp. 1829-1834
    • Bibbiani, F.1    Oh, J.D.2    Chase, T.N.3
  • 11
    • 4544226873 scopus 로고    scopus 로고
    • The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: Final results of a 5-year, double-blind, levodopa-controlled study
    • PKDS009 Study Group
    • F Bracco A Battaglia C Chouza PKDS009 Study Group 2004 The long-acting dopamine receptor agonist cabergoline in early Parkinson's disease: final results of a 5-year, double-blind, levodopa-controlled study CNS Drugs 18 733 746
    • (2004) CNS Drugs , vol.18 , pp. 733-746
    • Bracco, F.1    Battaglia, A.2    Chouza, C.3
  • 12
    • 1442300051 scopus 로고    scopus 로고
    • Effect of riluzole on dyskinesia and duration of the on state in Parkinson's disease patients: A double-blind, placebo-controlled pilot study
    • CA Braz V Borges HB Ferraz 2004 Effect of riluzole on dyskinesia and duration of the on state in Parkinson's disease patients: a double-blind, placebo-controlled pilot study Clin Neuropharmacol 27 25 29
    • (2004) Clin Neuropharmacol , vol.27 , pp. 25-29
    • Braz, C.A.1    Borges, V.2    Ferraz, H.B.3
  • 13
    • 0037303024 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor signalling in Parkinson's disease
    • JM Brotchie 2003 CB1 cannabinoid receptor signalling in Parkinson's disease Curr Opin Pharmacol 3 54 61
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 54-61
    • Brotchie, J.M.1
  • 14
    • 0346218258 scopus 로고    scopus 로고
    • Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease
    • F Calon AH Rajput O Hornykiewicz PJ Bedard T Di Paolo 2003 Levodopa-induced motor complications are associated with alterations of glutamate receptors in Parkinson's disease Neurobiol Dis 14 404 416
    • (2003) Neurobiol Dis , vol.14 , pp. 404-416
    • Calon, F.1    Rajput, A.H.2    Hornykiewicz, O.3    Bedard, P.J.4    Di Paolo, T.5
  • 15
    • 20844441058 scopus 로고    scopus 로고
    • Cannabis for dyskinesia in Parkinson disease: A randomized double-blind crossover study
    • CB Carroll PG Bain L Teare 2004 Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study Neurology 63 1245 1250
    • (2004) Neurology , vol.63 , pp. 1245-1250
    • Carroll, C.B.1    Bain, P.G.2    Teare, L.3
  • 16
    • 0036637271 scopus 로고    scopus 로고
    • Animal models of neurological deficits: How relevant is the rat?
    • MA Cenci IQ Whishaw T Schallert 2002 Animal models of neurological deficits: how relevant is the rat? Nat Rev Neurosci 3 574 579
    • (2002) Nat Rev Neurosci , vol.3 , pp. 574-579
    • Cenci, M.A.1    Whishaw, I.Q.2    Schallert, T.3
  • 17
    • 0030819940 scopus 로고    scopus 로고
    • Gabapentin and motor fluctuations in Parkinson's disease
    • P Chaná A de Marinis N Barrientos 1997 Gabapentin and motor fluctuations in Parkinson's disease Mov Disord 12 608
    • (1997) Mov Disord , vol.12 , pp. 608
    • Chaná, P.1    De Marinis, A.2    Barrientos, N.3
  • 18
    • 0034105156 scopus 로고    scopus 로고
    • Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications
    • Suppl 1
    • TN Chase JD Oh 2000 Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications Ann Neurol 47 Suppl 1 S122 S130
    • (2000) Ann Neurol , vol.47
    • Chase, T.N.1    Oh, J.D.2
  • 19
    • 18844447522 scopus 로고    scopus 로고
    • Short-term paroxetine treatment does not alter the motor response to levodopa in PD
    • KA Chung NE Carlson JG Nutt 2005 Short-term paroxetine treatment does not alter the motor response to levodopa in PD Neurology 64 1797 1798
    • (2005) Neurology , vol.64 , pp. 1797-1798
    • Chung, K.A.1    Carlson, N.E.2    Nutt, J.G.3
  • 20
    • 33646823604 scopus 로고    scopus 로고
    • Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome
    • Suppl 1
    • MO Collins H Husi L Yu 2006 Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome J Neurochem 97 Suppl 1 16 23
    • (2006) J Neurochem , vol.97 , pp. 16-23
    • Collins, M.O.1    Husi, H.2    Yu, L.3
  • 21
    • 0037465371 scopus 로고    scopus 로고
    • Tremor in Parkinson's disease and serotoninergic dysfunction: An (11)C-WAY 100635 PET study
    • M Doder EA Rabiner N Turjanski Aj Lees DJ Brooks 2003 Tremor in Parkinson's disease and serotoninergic dysfunction: an (11)C-WAY 100635 PET study Neurology 60 601 605
    • (2003) Neurology , vol.60 , pp. 601-605
    • Doder, M.1    Rabiner, E.A.2    Turjanski, N.3    Aj, L.4    Brooks, D.J.5
  • 22
    • 0029431964 scopus 로고
    • Levodopa-induced dyskinesias are improved by fluoxetine
    • F Durif M Vidailhet AM Bonnet 1995 Levodopa-induced dyskinesias are improved by fluoxetine Neurology 45 1855 1858
    • (1995) Neurology , vol.45 , pp. 1855-1858
    • Durif, F.1    Vidailhet, M.2    Bonnet, A.M.3
  • 23
    • 1042299831 scopus 로고    scopus 로고
    • Clozapine improves dyskinesias in Parkinson disease: A double-blind, placebo-controlled study
    • F Durif B Debilly M Galitzky 2004 Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study Neurology 62 381 388
    • (2004) Neurology , vol.62 , pp. 381-388
    • Durif, F.1    Debilly, B.2    Galitzky, M.3
  • 24
    • 33947359691 scopus 로고    scopus 로고
    • Istradefylline for the treatment of motor response complications on levodopa in PD: Results of the KW-6002-US-018 study focusing on functional and notor improvement
    • Suppl 15
    • HH Fernandez 2006 Istradefylline for the treatment of motor response complications on levodopa in PD: results of the KW-6002-US-018 study focusing on functional and notor improvement Mov Disord 21 Suppl 15 S642
    • (2006) Mov Disord , vol.21 , pp. 642
    • Fernandez, H.H.1
  • 25
    • 0035412923 scopus 로고    scopus 로고
    • Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: Evidence from the effects of the alpha-2 adrenoceptor antagonist idazoxan
    • SH Fox B Henry MP Hill 2001 Neural mechanisms underlying peak-dose dyskinesia induced by levodopa and apomorphine are distinct: evidence from the effects of the alpha-2 adrenoceptor antagonist idazoxan Mov Disord 16 642 650
    • (2001) Mov Disord , vol.16 , pp. 642-650
    • Fox, S.H.1    Henry, B.2    Hill, M.P.3
  • 26
    • 33750990196 scopus 로고    scopus 로고
    • Translation of nondopaminergic treatments for levodopa-induced dyskinesia from MPTP-lesioned nonhuman primates to phase Iia clinical studies: Keys to success and roads to failure
    • SH Fox AE Lang JM Brotchie 2006 Translation of nondopaminergic treatments for levodopa-induced dyskinesia from MPTP-lesioned nonhuman primates to phase Iia clinical studies: keys to success and roads to failure Mov Disord 21 1578 1594
    • (2006) Mov Disord , vol.21 , pp. 1578-1594
    • Fox, S.H.1    Lang, A.E.2    Brotchie, J.M.3
  • 27
    • 0036159538 scopus 로고    scopus 로고
    • Brasofensine treatment for Parkinson's disease in combination with levodopa/carbidopa
    • EJ Frackiewicz SS Jhee TM Shiovitz 2002 Brasofensine treatment for Parkinson's disease in combination with levodopa/carbidopa Ann Pharmacother 36 225 230
    • (2002) Ann Pharmacother , vol.36 , pp. 225-230
    • Frackiewicz, E.J.1    Jhee, S.S.2    Shiovitz, T.M.3
  • 29
    • 0027384928 scopus 로고
    • Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys
    • B Gomez-Mancilla PJ Bedard 1993 Effect of nondopaminergic drugs on L-dopa-induced dyskinesias in MPTP-treated monkeys Clin Neuropharmacol 16 418 427
    • (1993) Clin Neuropharmacol , vol.16 , pp. 418-427
    • Gomez-Mancilla, B.1    Bedard, P.J.2
  • 30
    • 40949083686 scopus 로고    scopus 로고
    • Efficacy of istradefylline in Parkinson's disease patients treated with levodopa with motor response complications: Primary efficacy results of the KW-6002-US-018 study
    • Suppl 15
    • M Guttman 2006 Efficacy of istradefylline in Parkinson's disease patients treated with levodopa with motor response complications: primary efficacy results of the KW-6002-US-018 study Mov Disord 21 Suppl 15 S585
    • (2006) Mov Disord , vol.21 , pp. 585
    • Guttman, M.1
  • 31
    • 40949156450 scopus 로고    scopus 로고
    • Efficacy of istradefylline in levodopa-treated Parkinson's disease patients with motor response complications: Secondary efficacy results of the KW-6002-US-013 study
    • Suppl 15
    • RA Hauser 2006 Efficacy of istradefylline in levodopa-treated Parkinson's disease patients with motor response complications: secondary efficacy results of the KW-6002-US-013 study Mov Disord 21 Suppl 15 S510
    • (2006) Mov Disord , vol.21 , pp. 510
    • Hauser, R.A.1
  • 32
    • 0043126954 scopus 로고    scopus 로고
    • Randomized trial of the Adenosine A2A receptor antagonist istradefylline in advanced PD
    • the Istradefylline US-001 Study Group
    • R Hauser JP Hubble DD Truong the Istradefylline US-001 Study Group 2003 Randomized trial of the Adenosine A2A receptor antagonist istradefylline in advanced PD Neurology 61 297 303
    • (2003) Neurology , vol.61 , pp. 297-303
    • Hauser, R.1    Hubble, J.P.2    Truong, D.D.3
  • 33
    • 0032588996 scopus 로고    scopus 로고
    • The alpha 2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of levodopa in the MPTP-lesioned primate model of Parkinson's disease
    • B Henry SH Fox D Peggs 1999 The alpha 2-adrenergic receptor antagonist idazoxan reduces dyskinesia and enhances anti-parkinsonian actions of levodopa in the MPTP-lesioned primate model of Parkinson's disease Mov Disord 14 744 753
    • (1999) Mov Disord , vol.14 , pp. 744-753
    • Henry, B.1    Fox, S.H.2    Peggs, D.3
  • 34
    • 0034851915 scopus 로고    scopus 로고
    • Mu- and delta-Opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
    • B Henry SH Fox AR Crossman JM Brotchie 2001 Mu- and delta-Opioid receptor antagonists reduce levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease Exp Neurol 171 139 146
    • (2001) Exp Neurol , vol.171 , pp. 139-146
    • Henry, B.1    Fox, S.H.2    Crossman, A.R.3    Brotchie, J.M.4
  • 35
    • 0031951172 scopus 로고    scopus 로고
    • Kappa-opioid receptor agonists increase locomotor activity in the monoamine depleted rat model of parkinsonism
    • NR Hughes AT McKnight GN Woodruff 1998 Kappa-opioid receptor agonists increase locomotor activity in the monoamine depleted rat model of parkinsonism Mov Disord 13 228 233
    • (1998) Mov Disord , vol.13 , pp. 228-233
    • Hughes, N.R.1    McKnight, A.T.2    Woodruff, G.N.3
  • 36
    • 0033993550 scopus 로고    scopus 로고
    • Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the macaque monkey
    • C Imbert E Bezard S Guitraud T Boraud CE Gross 2000 Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the macaque monkey J Neurosci Meth 96 71 76
    • (2000) J Neurosci Meth , vol.96 , pp. 71-76
    • Imbert, C.1    Bezard, E.2    Guitraud, S.3    Boraud, T.4    Gross, C.E.5
  • 37
    • 0037269421 scopus 로고    scopus 로고
    • The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease
    • P Jenner 2003 The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease Parkinsonism Relat D 9 131 137
    • (2003) Parkinsonism Relat D , vol.9 , pp. 131-137
    • Jenner, P.1
  • 39
    • 0031594271 scopus 로고    scopus 로고
    • Adenosine A2A antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys
    • T Kanda MJ Jackson LA Smith 1998 Adenosine A2A antagonist: a novel antiparkinsonian agent that does not provoke dyskinesia in parkinsonian monkeys Ann Neurol 43 507 513
    • (1998) Ann Neurol , vol.43 , pp. 507-513
    • Kanda, T.1    Jackson, M.J.2    Smith, L.A.3
  • 40
    • 0842309193 scopus 로고    scopus 로고
    • Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: A double blind cross over study
    • R Katzenschlager AJ Manson A Evans H Watt AJ Lees 2004 Low dose quetiapine for drug induced dyskinesias in Parkinson's disease: a double blind cross over study J Neurol Neurosurg Psychiatry 75 295 297
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 295-297
    • Katzenschlager, R.1    Manson, A.J.2    Evans, A.3    Watt, H.4    Lees, A.J.5
  • 41
    • 0036387577 scopus 로고    scopus 로고
    • Naloxone reduces levodopa-induced dyskinesias and apomorphine-induced rotations in primate models of parkinsonism
    • R Klintenberg P Svenningsson L Gunne PE Andren 2002 Naloxone reduces levodopa-induced dyskinesias and apomorphine-induced rotations in primate models of parkinsonism J Neural Transm 109 1295 1307
    • (2002) J Neural Transm , vol.109 , pp. 1295-1307
    • Klintenberg, R.1    Svenningsson, P.2    Gunne, L.3    Andren, P.E.4
  • 42
    • 0027453787 scopus 로고
    • Toward an understanding of the role of glutamate in experimental parkinsonism: Agonist-sensitive sites in the basal ganglia
    • T Klockgether L Turski 1993 Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia Ann Neurol 34 585 593
    • (1993) Ann Neurol , vol.34 , pp. 585-593
    • Klockgether, T.1    Turski, L.2
  • 44
    • 4344688188 scopus 로고    scopus 로고
    • Recent failures of new potential symptomatic treatments for Parkinson's disease: Causes and solutions
    • G Linazasoro 2004 Recent failures of new potential symptomatic treatments for Parkinson's disease: causes and solutions Mov Disord 19 743 754
    • (2004) Mov Disord , vol.19 , pp. 743-754
    • Linazasoro, G.1
  • 45
    • 0036768049 scopus 로고    scopus 로고
    • Physiologic studies in the human brain in movement disorders
    • AM Lozano F Carella 2002 Physiologic studies in the human brain in movement disorders Parkinsonism Relat Disord 8 455 458
    • (2002) Parkinsonism Relat Disord , vol.8 , pp. 455-458
    • Lozano, A.M.1    Carella, F.2
  • 46
    • 33746405294 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia
    • KE Lyons R Pahwa 2006 Efficacy and tolerability of levetiracetam in Parkinson disease patients with levodopa-induced dyskinesia Clin Neuropharmacol 29 148 153
    • (2006) Clin Neuropharmacol , vol.29 , pp. 148-153
    • Lyons, K.E.1    Pahwa, R.2
  • 48
    • 0034123913 scopus 로고    scopus 로고
    • Idazoxan is ineffective for levodopa-induced dyskinesias in Parkinson's disease
    • AJ Manson E Iakovidou AJ Lees 2000 Idazoxan is ineffective for levodopa-induced dyskinesias in Parkinson's disease Mov Disord 15 336 337
    • (2000) Mov Disord , vol.15 , pp. 336-337
    • Manson, A.J.1    Iakovidou, E.2    Lees, A.J.3
  • 50
    • 20544476874 scopus 로고    scopus 로고
    • The 'magic' of l-dopa: Why is it the gold standard Parkinson's disease therapy?
    • NB Mercuri G Bernardi 2005 The 'magic' of l-dopa: why is it the gold standard Parkinson's disease therapy? Trends Pharmacol Sci 26 341 344
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 341-344
    • Mercuri, N.B.1    Bernardi, G.2
  • 51
    • 0032730121 scopus 로고    scopus 로고
    • Effect of memantine (NMDA antagonist) on Parkinson's disease: A double-blind crossover randomized study
    • M Merello MI Nouzeilles A Cammarota R Leiguarda 1999 Effect of memantine (NMDA antagonist) on Parkinson's disease: a double-blind crossover randomized study Clin Neuropharmacol 22 273 276
    • (1999) Clin Neuropharmacol , vol.22 , pp. 273-276
    • Merello, M.1    Nouzeilles, M.I.2    Cammarota, A.3    Leiguarda, R.4
  • 52
    • 0033594792 scopus 로고    scopus 로고
    • Riluzole for levodopa-induced dyskinesias in advanced Parkinson's disease
    • D Merims I Ziv R Djaldetti 1999 Riluzole for levodopa-induced dyskinesias in advanced Parkinson's disease Lancet 353 1764 1765
    • (1999) Lancet , vol.353 , pp. 1764-1765
    • Merims, D.1    Ziv, I.2    Djaldetti, R.3
  • 53
    • 2942597453 scopus 로고    scopus 로고
    • Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson's disease
    • V Mesnage JL Houeto AM Bonnet 2004 Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson's disease Clin Neuropharmacol 27 108 110
    • (2004) Clin Neuropharmacol , vol.27 , pp. 108-110
    • Mesnage, V.1    Houeto, J.L.2    Bonnet, A.M.3
  • 54
    • 0035656346 scopus 로고    scopus 로고
    • Zonisamide has beneficial effects on Parkinson's disease patients
    • M Murata E Horiuchi I Kanazawa 2001 Zonisamide has beneficial effects on Parkinson's disease patients Neurosci Res 41 397 399
    • (2001) Neurosci Res , vol.41 , pp. 397-399
    • Murata, M.1    Horiuchi, E.2    Kanazawa, I.3
  • 55
    • 33846054367 scopus 로고    scopus 로고
    • Zonisamide improves motor function in Parkinson's disease. a randomized, double-blind study
    • The Japan Zonisamide on PD Study Group
    • M Murata K Hasegawa I Kanazawa The Japan Zonisamide on PD Study Group 2007 Zonisamide improves motor function in Parkinson's disease. A randomized, double-blind study Neurology 68 45 50
    • (2007) Neurology , vol.68 , pp. 45-50
    • Murata, M.1    Hasegawa, K.2    Kanazawa, I.3
  • 56
    • 0036801619 scopus 로고    scopus 로고
    • PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease
    • NF Nichols MG Cimini JV Haas 2002 PNU-96391A (OSU6162) antagonizes the development of behavioural sensitization induced by dopamine agonists in a rat model for Parkinson's disease Neuropharmacology 43 817 824
    • (2002) Neuropharmacology , vol.43 , pp. 817-824
    • Nichols, N.F.1    Cimini, M.G.2    Haas, J.V.3
  • 57
    • 2342450729 scopus 로고    scopus 로고
    • Multicenter, open-label, trial of sarizotan in Parkinson's disease patients with levodopa-induced dyskinesias (the SPLENDID study)
    • CW Olanow P Damier CG Goetz 2004 Multicenter, open-label, trial of sarizotan in Parkinson's disease patients with levodopa-induced dyskinesias (the SPLENDID study) Clin Neuropharmacol 27 58 62
    • (2004) Clin Neuropharmacol , vol.27 , pp. 58-62
    • Olanow, C.W.1    Damier, P.2    Goetz, C.G.3
  • 58
    • 0031048102 scopus 로고    scopus 로고
    • Gabapentin for parkinsonism: A double-blind, placebo-controlled, crossover trial
    • WL Olson M Gruenthal ME Mueller WH Olson 1997 Gabapentin for parkinsonism: a double-blind, placebo-controlled, crossover trial Am J Med 102 60 66
    • (1997) Am J Med , vol.102 , pp. 60-66
    • Olson, W.L.1    Gruenthal, M.2    Mueller, M.E.3    Olson, W.H.4
  • 59
    • 0034684139 scopus 로고    scopus 로고
    • Pramipexole vs levodopa as initial therapy for Parkinson's disease: A randomized controlled trial
    • Parkinson Study Group
    • Parkinson Study Group 2000 Pramipexole vs levodopa as initial therapy for Parkinson's disease: a randomized controlled trial JAMA 284 1931 1938
    • (2000) JAMA , vol.284 , pp. 1931-1938
  • 60
    • 0035957065 scopus 로고    scopus 로고
    • A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease
    • Parkinson Study Group
    • Parkinson Study Group 2001 A randomized, controlled trial of remacemide for motor fluctuations in Parkinson's disease Neurology 56 455 462
    • (2001) Neurology , vol.56 , pp. 455-462
  • 61
    • 40949100638 scopus 로고    scopus 로고
    • Safety and tolerability of istradefylline in Parkinson's disease with motor response complications: Results of the KW-6002-US-018 study
    • Suppl 15
    • E Pourcher 2006 Safety and tolerability of istradefylline in Parkinson's disease with motor response complications: results of the KW-6002-US-018 study Mov Disord 21 Suppl 15 S508
    • (2006) Mov Disord , vol.21 , pp. 508
    • Pourcher, E.1
  • 62
    • 33947252912 scopus 로고    scopus 로고
    • Debates on translational research: A balancing act
    • J Qiu 2007 Debates on translational research: a balancing act Lancet Neurol 6 208 209
    • (2007) Lancet Neurol , vol.6 , pp. 208-209
    • Qiu, J.1
  • 63
    • 0027958852 scopus 로고
    • Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease
    • O Rascol N Fabre O Blin 1994 Naltrexone, an opiate antagonist, fails to modify motor symptoms in patients with Parkinson's disease Mov Disord 9 437 440
    • (1994) Mov Disord , vol.9 , pp. 437-440
    • Rascol, O.1    Fabre, N.2    Blin, O.3
  • 64
    • 0033019985 scopus 로고    scopus 로고
    • ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease
    • O Rascol O Blin C Thalamas 1999 ABT-431, a D1 receptor agonist prodrug, has efficacy in Parkinson's disease Ann Neurol 45 736 741
    • (1999) Ann Neurol , vol.45 , pp. 736-741
    • Rascol, O.1    Blin, O.2    Thalamas, C.3
  • 65
    • 0034682308 scopus 로고    scopus 로고
    • A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa
    • O Rascol DJ Brooks AD Korczyn PP De Deyn CE Clarke AE Lang 2000 A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa N Eng J Med 342 1484 1491
    • (2000) N Eng J Med , vol.342 , pp. 1484-1491
    • Rascol, O.1    Brooks, D.J.2    Korczyn, A.D.3    De Deyn, P.P.4    Clarke, C.E.5    Lang, A.E.6
  • 66
    • 0035412888 scopus 로고    scopus 로고
    • Idazoxan, an α-2 antagonist, and L-dopa-induced dyskinesias in patients with Parkinson's disease
    • O Rascol I Arnulf PH Peyro-Saint 2001a Idazoxan, an α-2 antagonist, and L-dopa-induced dyskinesias in patients with Parkinson's disease Mov Disord 16 708 713
    • (2001) Mov Disord , vol.16 , pp. 708-713
    • Rascol, O.1    Arnulf, I.2    Peyro-Saint, P.H.3
  • 67
    • 0034745615 scopus 로고    scopus 로고
    • Induction by D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson's disease
    • O Rascol J Nutt O Blin 2001b Induction by D1 receptor agonist ABT-431 of dyskinesia similar to levodopa in patients with Parkinson's disease Arch Neurol 58 249 254
    • (2001) Arch Neurol , vol.58 , pp. 249-254
    • Rascol, O.1    Nutt, J.2    Blin, O.3
  • 68
    • 40949104553 scopus 로고    scopus 로고
    • NS2330, a dopamine reuptake inhibitor, in levodopa-treated patients with Parkinson's disease and motor fluctuations: The Phase II ADVANS study
    • Suppl 15
    • O Rascol AJ Lees W Poewe L Stalin 2006 NS2330, a dopamine reuptake inhibitor, in levodopa-treated patients with Parkinson's disease and motor fluctuations: the Phase II ADVANS study Mov Disord 21 Suppl 15 S515
    • (2006) Mov Disord , vol.21 , pp. 515
    • Rascol, O.1    Lees, A.J.2    Poewe, W.3    Stalin, L.4
  • 69
    • 0032949690 scopus 로고    scopus 로고
    • Do serotonin reuptake inhibitor antidepressants worsen Parkinson's disease? a retrospective case series
    • IH Richard A Maughn R Kurlan 1999 Do serotonin reuptake inhibitor antidepressants worsen Parkinson's disease? A retrospective case series Mov Disord 14 155 157
    • (1999) Mov Disord , vol.14 , pp. 155-157
    • Richard, I.H.1    Maughn, A.2    Kurlan, R.3
  • 70
    • 0030611334 scopus 로고    scopus 로고
    • Adenosine A2a receptor antagonists as new agents for the treatment of Parkinson's disease
    • PJ Richardson H Kase PG Jenner 1997 Adenosine A2a receptor antagonists as new agents for the treatment of Parkinson's disease Trends Pharmacol Sci 18 338 344
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 338-344
    • Richardson, P.J.1    Kase, H.2    Jenner, P.G.3
  • 71
    • 0142122419 scopus 로고    scopus 로고
    • Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: Interaction between dopamine and opioid systems
    • P Samadi L Gregoire PJ Bedard 2003 Opioid antagonists increase the dyskinetic response to dopaminergic agents in parkinsonian monkeys: interaction between dopamine and opioid systems Neuropharmacology 45 954 963
    • (2003) Neuropharmacology , vol.45 , pp. 954-963
    • Samadi, P.1    Gregoire, L.2    Bedard, P.J.3
  • 72
    • 0022567868 scopus 로고
    • Naloxone treatment of L-dopa-induced dyskinesias in Parkinson's disease
    • R Sandyk SR Snider 1986 Naloxone treatment of L-dopa-induced dyskinesias in Parkinson's disease Am J Psychiatry 143 118
    • (1986) Am J Psychiatry , vol.143 , pp. 118
    • Sandyk, R.1    Snider, S.R.2
  • 73
    • 0033538482 scopus 로고    scopus 로고
    • Motor actions of cannabinoids in the basal ganglia output nuclei
    • MC Sañudo-Pena K Tsou JM Walker 1999 Motor actions of cannabinoids in the basal ganglia output nuclei Life Sci 65 703 713
    • (1999) Life Sci , vol.65 , pp. 703-713
    • Sañudo-Pena, M.C.1    Tsou, K.2    Walker, J.M.3
  • 74
    • 0042474326 scopus 로고    scopus 로고
    • Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease
    • JM Savola M Hill M Engstrom 2003 Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease Mov Disord 18 872 883
    • (2003) Mov Disord , vol.18 , pp. 872-883
    • Savola, J.M.1    Hill, M.2    Engstrom, M.3
  • 78
    • 0035846577 scopus 로고    scopus 로고
    • Cannabinoids reduce levodopa-induced dyskinesias in Parkinson's disease: A pilot study
    • KA Sieradzan SH Fox MP Hill 2001 Cannabinoids reduce levodopa-induced dyskinesias in Parkinson's disease: a pilot study Neurology 57 2108 2111
    • (2001) Neurology , vol.57 , pp. 2108-2111
    • Sieradzan, K.A.1    Fox, S.H.2    Hill, M.P.3
  • 80
    • 0036764831 scopus 로고    scopus 로고
    • The hyperkinetic abnormal movements scale: A tool for measuring levodopa-induced abnormal movements in squirrel monkeys
    • LC Tan PH Protell JW Langston DM Togasaki 2002 The hyperkinetic abnormal movements scale: a tool for measuring levodopa-induced abnormal movements in squirrel monkeys Mov Disord 17 902 909
    • (2002) Mov Disord , vol.17 , pp. 902-909
    • Tan, L.C.1    Protell, P.H.2    Langston, J.W.3    Togasaki, D.M.4
  • 82
    • 40949138041 scopus 로고    scopus 로고
    • Efficacy of istradefylline in levodopa-treated Parkinson's disease patients with motor response complications: Primary efficacy results of the KW-6002-US-013 study
    • Suppl 15
    • JM Trugman 2006 Efficacy of istradefylline in levodopa-treated Parkinson's disease patients with motor response complications: primary efficacy results of the KW-6002-US-013 study Mov Disord 21 Suppl 15 S513
    • (2006) Mov Disord , vol.21 , pp. 513
    • Trugman, J.M.1
  • 83
    • 0026556044 scopus 로고
    • Gamma vinyl GABA in the treatment of levodopa-induced dyskinesias
    • N Turjanski AJ Lees 1992 Gamma vinyl GABA in the treatment of levodopa-induced dyskinesias J Neurol Neurosurg Psychiatry 55 413
    • (1992) J Neurol Neurosurg Psychiatry , vol.55 , pp. 413
    • Turjanski, N.1    Lees, A.J.2
  • 84
    • 0042520948 scopus 로고    scopus 로고
    • Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures
    • Y Ueda T Doi J Tokumaru LJ Willmore 2003 Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures Brain Res Mol Brain Res 116 1 6
    • (2003) Brain Res Mol Brain Res , vol.116 , pp. 1-6
    • Ueda, Y.1    Doi, T.2    Tokumaru, J.3    Willmore, L.J.4
  • 85
    • 2942556503 scopus 로고    scopus 로고
    • Effects of gabapentin on the motor response to levodopa: A double-blind, placebo-controlled, crossover study in patients with complicated Parkinson's disease
    • N Van Blercom A Lasa K Verger 2004 Effects of gabapentin on the motor response to levodopa: a double-blind, placebo-controlled, crossover study in patients with complicated Parkinson's disease Clin Neuropharmacol 27 124 128
    • (2004) Clin Neuropharmacol , vol.27 , pp. 124-128
    • Van Blercom, N.1    Lasa, A.2    Verger, K.3
  • 86
    • 0031945065 scopus 로고    scopus 로고
    • A trial of dextromethorphan in parkinsonian patients with motor response complications
    • L Vergahen Metman PJ Blanchet P van den Munckhof 1998a A trial of dextromethorphan in parkinsonian patients with motor response complications Mov Disord 13 414 417
    • (1998) Mov Disord , vol.13 , pp. 414-417
    • Vergahen Metman, L.1    Blanchet, P.J.2    Van Den Munckhof, P.3
  • 87
    • 0006647256 scopus 로고    scopus 로고
    • Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
    • L Vergahen Metman P Del Dotto P van den Munckhof 1998b Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease Neurology 50 1323 1326
    • (1998) Neurology , vol.50 , pp. 1323-1326
    • Vergahen Metman, L.1    Del Dotto, P.2    Van Den Munckhof, P.3
  • 88
    • 0032706028 scopus 로고    scopus 로고
    • Amantadine for levodopa-induced dyskinesias: A 1-year follow-up study
    • L Verhagen Metman P Del Dotto K LePoole 1999 Amantadine for levodopa-induced dyskinesias: a 1-year follow-up study Arch Neurol 56 1383 1386
    • (1999) Arch Neurol , vol.56 , pp. 1383-1386
    • Verhagen Metman, L.1    Del Dotto, P.2    Lepoole, K.3
  • 89
    • 33845189050 scopus 로고    scopus 로고
    • Pharmacological characterization of psychosis-like behaviour in the MPTP-lesioned nonhuman primate model of Parkinson's disease
    • NP Visanji J Gómez-Ramírez TH Johnston D Pires V Voon JM Brotchie SH Fox 2006 Pharmacological characterization of psychosis-like behaviour in the MPTP-lesioned nonhuman primate model of Parkinson's disease Mov Disord 21 1879 1891
    • (2006) Mov Disord , vol.21 , pp. 1879-1891
    • Visanji, N.P.1    Gómez-Ramírez, J.2    Johnston, T.H.3    Pires, D.4    Voon, V.5    Brotchie, J.M.6    Fox, S.H.7
  • 90
    • 0031225736 scopus 로고    scopus 로고
    • Improved therapies for Parkinson's disease: Life beyond dopamine D2/D3 receptor agonists
    • M Williams S Wright GK Lloyd 1997 Improved therapies for Parkinson's disease: life beyond dopamine D2/D3 receptor agonists Trends Pharmacol Sci 18 307 310
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 307-310
    • Williams, M.1    Wright, S.2    Lloyd, G.K.3
  • 91
    • 27944490384 scopus 로고    scopus 로고
    • Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors
    • S Yoshida M Okada G Zhu S Kaneko 2005 Effects of zonisamide on neurotransmitter exocytosis associated with ryanodine receptors Epilepsy Res 67 153 162
    • (2005) Epilepsy Res , vol.67 , pp. 153-162
    • Yoshida, S.1    Okada, M.2    Zhu, G.3    Kaneko, S.4
  • 92
    • 23644462322 scopus 로고    scopus 로고
    • Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease
    • TA Zesiewicz KL Sullivan JL Maldonado WO Tatum RA Hauser 2005 Open-label pilot study of levetiracetam (Keppra) for the treatment of levodopa-induced dyskinesias in Parkinson's disease Mov Disord 20 1205 1209
    • (2005) Mov Disord , vol.20 , pp. 1205-1209
    • Zesiewicz, T.A.1    Sullivan, K.L.2    Maldonado, J.L.3    Tatum, W.O.4    Hauser, R.A.5
  • 93
    • 0023235711 scopus 로고
    • Therapeutic response to progabide in neuroleptic- and L-dopa-induced dyskinesias
    • M Ziegler V Fournier N Bathien 1987 Therapeutic response to progabide in neuroleptic- and L-dopa-induced dyskinesias Clin Neuropharmacol 10 238 246
    • (1987) Clin Neuropharmacol , vol.10 , pp. 238-246
    • Ziegler, M.1    Fournier, V.2    Bathien, N.3


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