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Volumn 237, Issue 3, 2008, Pages 649-658

The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death

Author keywords

AER; Apical ectodermal ridge; Cell death; Fgf8; Oligodactyly; Pattern formation

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CRE RECOMBINASE; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 8;

EID: 40849124152     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.21452     Document Type: Article
Times cited : (11)

References (47)
  • 1
    • 4344622095 scopus 로고    scopus 로고
    • The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth
    • Boulet AM, Moon AM, Arenkiel BR, Capecchi MR. 2004. The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth. Dev Biol 273:361-372.
    • (2004) Dev Biol , vol.273 , pp. 361-372
    • Boulet, A.M.1    Moon, A.M.2    Arenkiel, B.R.3    Capecchi, M.R.4
  • 2
    • 0028946304 scopus 로고
    • Fibroblast growth factors induce additional limb development from the flank of chick embryos
    • Cohn MJ, Izpisua-Belmonte JC, Abud H, Heath JK, Tickle C. 1995. Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80:739-746.
    • (1995) Cell , vol.80 , pp. 739-746
    • Cohn, M.J.1    Izpisua-Belmonte, J.C.2    Abud, H.3    Heath, J.K.4    Tickle, C.5
  • 3
    • 0035937405 scopus 로고    scopus 로고
    • Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    • Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. 2001. Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104:875-889.
    • (2001) Cell , vol.104 , pp. 875-889
    • Colvin, J.S.1    Green, R.P.2    Schmahl, J.3    Capel, B.4    Ornitz, D.M.5
  • 4
    • 0028959288 scopus 로고
    • The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
    • Crossley PH, Martin GR. 1995. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121:439-451.
    • (1995) Development , vol.121 , pp. 439-451
    • Crossley, P.H.1    Martin, G.R.2
  • 5
    • 0030034731 scopus 로고    scopus 로고
    • Roles for FGF8 in the induction, initiation, and maintenance of chick limb development
    • Crossley PH, Minowada G, MacArthur CA, Martin GR. 1996. Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84:127-136.
    • (1996) Cell , vol.84 , pp. 127-136
    • Crossley, P.H.1    Minowada, G.2    MacArthur, C.A.3    Martin, G.R.4
  • 6
    • 0028298335 scopus 로고
    • Cell-type-specific nuclear translocation of fibroblast growth factor-2 isoforms during chicken kidney and limb morphogenesis
    • Dono R, Zeller R. 1994. Cell-type-specific nuclear translocation of fibroblast growth factor-2 isoforms during chicken kidney and limb morphogenesis. Dev Biol 163:316-330.
    • (1994) Dev Biol , vol.163 , pp. 316-330
    • Dono, R.1    Zeller, R.2
  • 7
    • 0036682108 scopus 로고    scopus 로고
    • A re-examination of proximodistal patterning during vertebrate limb development
    • Dudley AT, Ros MA, Tabin CJ. 2002. A re-examination of proximodistal patterning during vertebrate limb development. Nature 418:539-544.
    • (2002) Nature , vol.418 , pp. 539-544
    • Dudley, A.T.1    Ros, M.A.2    Tabin, C.J.3
  • 9
  • 10
    • 33748335734 scopus 로고    scopus 로고
    • Birth and death of cells in limb development: A mapping study
    • Fernandez-Teran MA, Hinchliffe JR, Ros MA. 2006. Birth and death of cells in limb development: a mapping study. Dev Dyn 235:2521-2537.
    • (2006) Dev Dyn , vol.235 , pp. 2521-2537
    • Fernandez-Teran, M.A.1    Hinchliffe, J.R.2    Ros, M.A.3
  • 12
    • 0028598747 scopus 로고
    • The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest
    • Graham A, Francis-West P, Brickell P, Lumsden A. 1994. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature 372:684-686.
    • (1994) Nature , vol.372 , pp. 684-686
    • Graham, A.1    Francis-West, P.2    Brickell, P.3    Lumsden, A.4
  • 13
    • 0036382871 scopus 로고    scopus 로고
    • In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb
    • Guha U, Gomes WA, Kobayashi T, Pestell RG, Kessler JA. 2002. In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol 249:108-120.
    • (2002) Dev Biol , vol.249 , pp. 108-120
    • Guha, U.1    Gomes, W.A.2    Kobayashi, T.3    Pestell, R.G.4    Kessler, J.A.5
  • 14
    • 4043070783 scopus 로고    scopus 로고
    • Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
    • Hayashi S, Lewis P, Pevny L, McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119(Suppl 1):S97-S101.
    • (2002) Mech Dev , vol.119 , Issue.SUPPL. 1
    • Hayashi, S.1    Lewis, P.2    Pevny, L.3    McMahon, A.P.4
  • 17
    • 33745632810 scopus 로고    scopus 로고
    • Dix homeobox gene control of mammalian limb and craniofacial development
    • Kraus P, Lufkin T. 2006. Dix homeobox gene control of mammalian limb and craniofacial development. Am J Med Genet A 140:1366-1374.
    • (2006) Am J Med Genet A , vol.140 , pp. 1366-1374
    • Kraus, P.1    Lufkin, T.2
  • 18
    • 4744339897 scopus 로고    scopus 로고
    • Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse
    • Kurose H, Bito T, Adachi T, Shimizu M, Noji S, Ohuchi H. 2004. Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse. Gene Expr Patterns 4:687-693.
    • (2004) Gene Expr Patterns , vol.4 , pp. 687-693
    • Kurose, H.1    Bito, T.2    Adachi, T.3    Shimizu, M.4    Noji, S.5    Ohuchi, H.6
  • 19
    • 0033673531 scopus 로고    scopus 로고
    • Fgf8 signalling from the AER is essential for normal limb development
    • Lewandoski M, Sun X, Martin GR. 2000. Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26:460-463.
    • (2000) Nat Genet , vol.26 , pp. 460-463
    • Lewandoski, M.1    Sun, X.2    Martin, G.R.3
  • 20
    • 28044454317 scopus 로고    scopus 로고
    • FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis
    • Li C, Xu X, Nelson DK, Williams T, Kuehn MR, Deng CX. 2005. FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis. Development 132:4755-4764.
    • (2005) Development , vol.132 , pp. 4755-4764
    • Li, C.1    Xu, X.2    Nelson, D.K.3    Williams, T.4    Kuehn, M.R.5    Deng, C.X.6
  • 21
    • 4043118339 scopus 로고    scopus 로고
    • Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    • Lu CC, Robertson EJ. 2004. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol 273:149-159.
    • (2004) Dev Biol , vol.273 , pp. 149-159
    • Lu, C.C.1    Robertson, E.J.2
  • 22
    • 31644445191 scopus 로고    scopus 로고
    • Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function
    • Lu P, Minowada G, Martin GR. 2006. Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. Development 133:33-42.
    • (2006) Development , vol.133 , pp. 33-42
    • Lu, P.1    Minowada, G.2    Martin, G.R.3
  • 24
    • 2642595047 scopus 로고    scopus 로고
    • The roles of FGFs in the early development of vertebrate limbs
    • Martin GR. 1998. The roles of FGFs in the early development of vertebrate limbs. Genes Dev 12:1571-1586.
    • (1998) Genes Dev , vol.12 , pp. 1571-1586
    • Martin, G.R.1
  • 25
    • 0031916557 scopus 로고    scopus 로고
    • An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
    • Meyers EN, Lewandoski M, Martin GR. 1998. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet 18:136-141.
    • (1998) Nat Genet , vol.18 , pp. 136-141
    • Meyers, E.N.1    Lewandoski, M.2    Martin, G.R.3
  • 27
    • 0033662330 scopus 로고    scopus 로고
    • Fgf8 is required for outgrowth and patterning of the limbs
    • Moon AM, Capecchi MR. 2000. Fgf8 is required for outgrowth and patterning of the limbs. Nat Genet 26:455-459.
    • (2000) Nat Genet , vol.26 , pp. 455-459
    • Moon, A.M.1    Capecchi, M.R.2
  • 28
    • 0037306472 scopus 로고    scopus 로고
    • Pattern formation: Old models out on a limb
    • Niswander L. 2003. Pattern formation: old models out on a limb. Nat Rev Genet 4:133-143.
    • (2003) Nat Rev Genet , vol.4 , pp. 133-143
    • Niswander, L.1
  • 29
    • 0027436330 scopus 로고
    • FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb
    • Niswander L, Tickle C, Vogel A, Booth I, Martin GR. 1993. FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell 75:579-587.
    • (1993) Cell , vol.75 , pp. 579-587
    • Niswander, L.1    Tickle, C.2    Vogel, A.3    Booth, I.4    Martin, G.R.5
  • 30
    • 34347329271 scopus 로고    scopus 로고
    • BMP signals control limb interdigital programmed cell death by regulating FGF signaling
    • Pajni-Underwood S, Wilson CP, Elder C, Mishina Y, Lewandoski M. 2007. BMP signals control limb interdigital programmed cell death by regulating FGF signaling. Development 134:2359-2368.
    • (2007) Development , vol.134 , pp. 2359-2368
    • Pajni-Underwood, S.1    Wilson, C.P.2    Elder, C.3    Mishina, Y.4    Lewandoski, M.5
  • 31
    • 0035281514 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    • Revest JM, Spencer-Dene B, Kerr K, De Moerlooze L, Rosewell I, Dickson C. 2001. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol 231:47-62.
    • (2001) Dev Biol , vol.231 , pp. 47-62
    • Revest, J.M.1    Spencer-Dene, B.2    Kerr, K.3    De Moerlooze, L.4    Rosewell, I.5    Dickson, C.6
  • 32
    • 0026470925 scopus 로고
    • Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds
    • Ros MA, Lyons G, Kosher RA, Upholt WB, Coelho CN, Fallon JF. 1992. Apical ridge dependent and independent mesodermal domains of GHox-7 and GHox-8 expression in chick limb buds. Development 116:811-818.
    • (1992) Development , vol.116 , pp. 811-818
    • Ros, M.A.1    Lyons, G.2    Kosher, R.A.3    Upholt, W.B.4    Coelho, C.N.5    Fallon, J.F.6
  • 33
    • 0020118107 scopus 로고
    • The proximodistal determination of skeletal parts in the developing chick leg
    • Rowe DA, Fallon JF. 1982. The proximodistal determination of skeletal parts in the developing chick leg. J Embryol Exp Morphol 68:1-7.
    • (1982) J Embryol Exp Morphol , vol.68 , pp. 1-7
    • Rowe, D.A.1    Fallon, J.F.2
  • 34
    • 0020324086 scopus 로고
    • Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal
    • Rowe DA, Cairns JM, Fallon JF. 1982. Spatial and temporal patterns of cell death in limb bud mesoderm after apical ectodermal ridge removal. Dev Biol 93:83-91.
    • (1982) Dev Biol , vol.93 , pp. 83-91
    • Rowe, D.A.1    Cairns, J.M.2    Fallon, J.F.3
  • 35
    • 0032534275 scopus 로고    scopus 로고
    • Saunders JW, Jr. The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. 1948. J Exp Zool 282:628-668.
    • Saunders JW, Jr. The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. 1948. J Exp Zool 282:628-668.
  • 36
    • 0032534275 scopus 로고    scopus 로고
    • Re-published 1998 J Exp Zool 282:628-668
    • Re-published 1998 J Exp Zool 282:628-668
  • 38
    • 0037452624 scopus 로고    scopus 로고
    • Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain
    • Storm EE, Rubenstein JL, Martin GR. 2003. Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci USA 100:1757-1762.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1757-1762
    • Storm, E.E.1    Rubenstein, J.L.2    Martin, G.R.3
  • 39
    • 0016309037 scopus 로고
    • A quantitative analysis of the effect of excision of the AER from the chick limb-bud
    • Summerbell D. 1974. A quantitative analysis of the effect of excision of the AER from the chick limb-bud. J Embryol Exp Morphol 32:651-660.
    • (1974) J Embryol Exp Morphol , vol.32 , pp. 651-660
    • Summerbell, D.1
  • 40
    • 0015803611 scopus 로고
    • Positional information in chick limb morphogenesis
    • Summerbell D, Lewis JH, Wolpert L. 1973. Positional information in chick limb morphogenesis. Nature 244:492-496.
    • (1973) Nature , vol.244 , pp. 492-496
    • Summerbell, D.1    Lewis, J.H.2    Wolpert, L.3
  • 41
    • 0036682468 scopus 로고    scopus 로고
    • Functions of FGF signalling from the apical ectodermal ridge in limb development
    • Sun X, Mariani FV, Martin GR. 2002. Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature 418:501-508.
    • (2002) Nature , vol.418 , pp. 501-508
    • Sun, X.1    Mariani, F.V.2    Martin, G.R.3
  • 42
    • 0034114458 scopus 로고    scopus 로고
    • Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
    • Tallquist MD, Soriano P. 2000. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis 26:113-115.
    • (2000) Genesis , vol.26 , pp. 113-115
    • Tallquist, M.D.1    Soriano, P.2
  • 43
    • 0036401138 scopus 로고    scopus 로고
    • Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development
    • Tumpel S, Sanz-Ezquerro JJ, Isaac A, Eblaghie MC, Dobson J, Tickle C. 2002. Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development. Dev Biol 250:251-262.
    • (2002) Dev Biol , vol.250 , pp. 251-262
    • Tumpel, S.1    Sanz-Ezquerro, J.J.2    Isaac, A.3    Eblaghie, M.C.4    Dobson, J.5    Tickle, C.6
  • 44
    • 27644470220 scopus 로고    scopus 로고
    • Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning
    • Verheyden JM, Lewandoski M, Deng C, Harfe BD, Sun X. 2005. Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning. Development 132:4235-4245.
    • (2005) Development , vol.132 , pp. 4235-4245
    • Verheyden, J.M.1    Lewandoski, M.2    Deng, C.3    Harfe, B.D.4    Sun, X.5
  • 45
    • 0034023520 scopus 로고    scopus 로고
    • Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
    • Xu J, Liu Z, Ornitz DM. 2000. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development 127:1833-1843.
    • (2000) Development , vol.127 , pp. 1833-1843
    • Xu, J.1    Liu, Z.2    Ornitz, D.M.3
  • 46
    • 0031459462 scopus 로고    scopus 로고
    • Regulation of number and size of digits by posterior Hox genes: A dose-dependent mechanism with potential evolutionary implications
    • Zakany J, Fromental-Ramain C, Warot X, Duboule D. 1997. Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanism with potential evolutionary implications. Proc Natl Acad Sci USA 94:13695-13700.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13695-13700
    • Zakany, J.1    Fromental-Ramain, C.2    Warot, X.3    Duboule, D.4
  • 47
    • 15944364455 scopus 로고    scopus 로고
    • Programmed cell death in the embryonic vertebrate limb
    • Zuzarte-Luis V, Hurle JM. 2005. Programmed cell death in the embryonic vertebrate limb. Semin Cell Dev Biol 16:261-269.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 261-269
    • Zuzarte-Luis, V.1    Hurle, J.M.2


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