Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro

Neuroscience Letters

Volumn 434, Issue 3, 2008, Pages 299-303

  Yang, Hui wen ^a   Liu, Hai yan ^a   Liu, Xiang ^a   Zhang, Dong mei ^a   Liu, Yu chun ^a   Liu, Xiao dong ^a   Wang, Guang ji ^a   Xie, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antiepileptic drugs; Blood brain barrier; Induction; P glycoprotein; Rat brain microvascular endothelial cells

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CYCLOSPORIN A; GLYCOPROTEIN P; PHENOBARBITAL; PHENYTOIN; RHODAMINE 123; RIFAMPICIN; VALPROIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; IN VITRO STUDY; LONG TERM EXPOSURE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RAT; WESTERN BLOTTING;

ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; BRAIN; CARBAMAZEPINE; CELLS, CULTURED; CEREBRAL ARTERIES; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIAL CELLS; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; MICROCIRCULATION; P-GLYCOPROTEIN; PHENOBARBITAL; PHENYTOIN; RATS; RHODAMINE 123; SODIUM CHANNEL BLOCKERS; TIME; UP-REGULATION; VALPROIC ACID; VERAPAMIL;

EID: 40849094137     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.01.071     Document Type: Article

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