Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats

Neuropharmacology

Volumn 53, Issue 5, 2007, Pages 657-663

  Liu, Xiaodong ^a   Yang, Zhihong ^a   Yang, Jiansong ^b   Yang, Huiwen ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CERTARA UK LIMITED   (United Kingdom)

Author keywords

Antiepileptic drugs; Blood brain barrier; Epilepsy; Kindling; P glycoprotein; Phenobarbital

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; PENTETRAZOLE; PHENOBARBITAL; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN CORTEX; BRAIN TISSUE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; EPILEPSY; HIPPOCAMPUS; KINDLING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; CEREBRAL CORTEX; CONVULSANTS; EPILEPSY; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; HYPNOTICS AND SEDATIVES; KAINIC ACID; KINDLING, NEUROLOGIC; MALE; MUSCARINIC AGONISTS; P-GLYCOPROTEIN; PENTYLENETETRAZOLE; PHENOBARBITAL; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; UP-REGULATION;

EID: 34848911714     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.07.012     Document Type: Article

References (27)

1. Alqawi O., Bates S., and Georges E. Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding. Biochemical Journal 382 (2004) 711-716
2. Ando H., Nishio Y., Ito K., Nakao A., Takagi K.M., and Hasegawa T. Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine 123 in rats. Antimicrobial Agents and Chemotherapy 45 (2001) 3462-3467
3. Aquilante C.L., Letrent S.P., Pollack G.M., and Brouwer K.M. Increased brain P-glycoprotein in morphine tolerant rats. Life Sciences 66 (2000) 47-51
4. Brandt C., Bethmann K., Gastens A.M., and Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiology of Disease 24 (2006) 202-211
5. Brodie M.J., and Kwan P. Phenobarbital: a drug for the 21st century. Epilepsy and Behavior 5 (2004) 802-803
6. Chen Z.S., Kawabe T., Ono M., Aoki S., Sumizawa T., Furukawa T., Uchiumi T., Wada M., Kuwano M., and Akiyama S.I. Effect of multidrug resistance-reversing agents on transporting activity of human canalicular multispecific organic anion transporter. Molecular Pharmacology 56 (1999) 1219-1228
7. Dombrowski S.M., Desai S.Y., Marroni M., Cucullo L., Goodrich K., Bingaman W., Mayberg M.R., Bengez L., and Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42 (2001) 1501-1506
8. Dogan A.L., Legrand O., Faussat A.M., Perrot J.Y., and Marie J.P. Evaluation and comparison of MRP1 activity with three fluorescent dyes and three modulators. Leukemia Research 28 (2004) 619-622
9. Gerk P.M., and Vore M. Regulation of expression of the multidrug resistance associated protein 2 (MRP2) and its role in drug disposition. Journal of Pharmacology and Experimental Therapeutics 302 (2002) 407-415
10. Kageyama M., Fukushima K., Togawa T., Fujimoto K., Taki M., Nishimura A., Ito Y., Sugioka N., Shibata N., and Takada K. Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers. Biological & Pharmaceutical Bulletin 29 (2006) 779-784
11. Löscher W., and Potschka H. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. Neurotherapeutics 2 (2005) 86-98
12. Löscher W., and Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. Journal of Pharmacology and Experimental Therapeutics 301 (2002) 7-14
13. Nagatomo I., Akasaki Y., Nagase F., Nomaguchi M., and Takigawa M. Relationships between convulsive seizures and serum and brain concentrations of phenobarbital and zonisamide in mutant inbred strain EL mouse. Brain Research 731 (1996) 190-198
14. Potschka H., Fedrowitz M., and Löscher W. P-glycoprotein-mediated efflux of phenobarbital, lamotrigine and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neuroscience Letters 327 (2002) 173-176
15. Potschka H., Fedrowitz M., and Löscher W. Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity. Journal of Pharmacology and Experimental Therapeutics 306 (2003) 124-131
16. Qadir M., O'Loughlin K.L., Fricke S.M., Williamson N.A., Greco W.R., Minderman H., and Baer M.R. Cyclosporin A is a broad-spectrum multidrug resistance modulator. Clinical Cancer Research 11 (2005) 2320-2326
17. Rogawski M.A. Does P-glycoprotein play a role in pharmacoresistance to antiepileptic drugs?. Epilepsy and Behavior 3 (2002) 493-495
18. Sarro A.D., and Naccari G.D. Enhanced susceptibility of pentylenetetrazole kindled mice to quinolone effects. International Journal of Antimicrobial Agents 12 (1999) 239-244
19. Sisodiya S.M., Lin W.R., Harding B.N., Squier M.V., and Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 125 (2002) 22-31
20. Suzuki K., Omura S., Ohashi Y., Kawai M., Iwata Y., Tani K., Sekine Y., Takei N., and Mori N. FK506 facilitates chemical kindling induced by pentylenetetrazole in rat. Epilepsy Research 46 (2001) 279-282
21. van der Sandt I.C., Blom-Roosemalen M.C., de Boer A.G., and Breimer D.D. Specificity of doxorubicin verse rhodamine 123 in assessing P-glycoprotein functionality in LLC-PK1, LLC-PK1 MDR1 and Caco-2 cell. European Journal of Pharmaceutical Sciences 11 (2000) 207-214
22. Turncliff R.Z., Tian X., and Brouwer K.L. Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes. Biochemical Pharmacology 71 (2006) 1520-1529
23. Volk H.A., Burkhardt K., Potschka H., Chen J., Becker A., and Löscher W. Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures. Neuroscience 123 (2004) 751-759
24. Volk H.A., Potschka H., and Löscher W. Increase expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats. Epilepsy Research 58 (2004) 67-79
25. Volk H.A., Potschka H., and Löscher W. Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizure are sensitive to fixation and staining variables. Journal of Histochemistry and Cytochemistry 34 (2005) 517-531
26. Yang Z.H., Liu X.D., Xie L., Liang Y., and Yang H.W. Determination of phenobarbital in rat hippocampus by LC-MS. Journal of China Pharmaceutical University 37 (2006) 142-145
27. Yumoto R., Murakaki T., Nakamoto Y., Hasegawa R., Nagai J., and Takano M. Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds. Journal of Pharmacology and Experimental Therapeutics 289 (1999) 149-155