Antidepressant treatments in the 21st century

Biological Psychiatry

Volumn 44, Issue 7, 1998, Pages 526-533

  Nestler, Eric J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antidepressants; G Protein coupled receptors; Intracellular messengers; Neurotrophins; Stress; trk receptors

Indexed keywords

ANTIDEPRESSANT AGENT; BUSPIRONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; METYRAPONE; NEUROTROPHIN; PINDOLOL; RU 489; SEROTONIN; UNCLASSIFIED DRUG;

ARTICLE; DEPRESSION; DRUG INDUSTRY; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEUROTRANSMISSION; NORADRENERGIC SYSTEM; PATHOGENESIS; PRIORITY JOURNAL; SEROTONINERGIC TRANSMISSION;

EID: 0032191019     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00095-X     Document Type: Review

References (32)

1. Caamano CA, Morano MI, Dalman FC, Hoversten MT, Watson SJ, Pratt WB, et al (1995): Point mutations in the 90-kDa heat shock protein binding region of the glucocorticoid receptor affect the functional characteristics of the receptor. Ann N Y Acad Sci 761:403-404.
2. Carlezon WA Jr, Boundy VA, Haile CN, Kalb RG, Neve R, Nestler EJ (1997): Sensitization to morphine induced by viral-mediated gene transfer. Science 277:812-814.
3. Chen JS, Kelz MB, Zeng GQ, Sakai N, Steffen C, Shockett PE, Picciotto M, Duman RS, and Nestler EJ (1998): Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol in press.
4. DeRisi J, Penland L, Brown PO, Bittner ML, Meltzer PS, Ray M, et al (1996): Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet 14:457-460.
5. Duman RS, Heninger GR, Nestler EJ (1997): A molecular and cellular hypothesis of depression. Arch Gen Psychiatry 54: 597-606.
6. Ghadirian AM, Engelsmann F, Dhar V, Filipini D, Keller R, Chouinard G, et al (1995): The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment. Biol Psychiatry 37:369-375.
7. Glatt CF, Snyder SH (1993): Cloning and expression of an adenylyl cyclase localized to the corpus striatum. Nature 361:536-538.
8. Gold SJ, Ni YG, Dohlman H, Nestler EJ (1997): Regulators of G protein signaling: Region-specific expression of nine subtypes in rat brain. J Neurosci 17:8024-8037.
9. Heim C, Owens MJ, Plotsky PM, Nemeroff CB (1997): The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor. Ann NY Acad Sci 82:194-207.
10. Hemmings HC Jr, Nairn AC, McGuinnes TL, Huganir RL, Greengard P (1989): Role of protein phosphorylation in neuronal signal transduction. FASEB J 3:1583-1592.
11. Heninger GR (1997): Serotonin, sex, and psychiatric illness. Proc Natl Acad Sci USA 94:4823-4824.
12. Heninger GR, Delgado PL, Charney DS (1995): The revised monoamine theory of depression: A modulatory role for monoamines, based on new findings from monoamine depletion experiments in humans. Pharmacopsychiatry 29:2-11.
13. Hyman SE, Nestler EJ (1993): The Molecular Foundations of Psychiatry. Washington, DC: American Psychiatric Press.
14. Hyman SE, Nestler EJ (1996): Initiation and adaptation: A paradigm for understanding psychotropic drug action. Am J Psychiatry 153:151-162.
15. Ip NY, Yancopoulos GD (1996): The neurotrophins and CNTF: Two families of collaborative neurotrophic factors. Annu Rev Neurosci 19:491-516.
16. Kantor DB, Lanzrein M, Stary SJ, Sandoval GM, Smith WB, Sullivan BM, et al (1996): A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue. Science 274:1744-1748.
17. Lewin GR, Barde Y-A (1996): Physiology of the neurotrophins. Annu Rev Neurosci 19:289-318.
18. Lindsay RM (1996): Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases. Ciba Found Symp 196:39-48.
19. Manji HK, Potter WZ, Lenox RH (1995): Signal transduction pathways. Molecular targets for lithium's actions. Arch Gen Psychiatry 52:531-543.
20. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER (1996): Control of memory formation through regulated expression of a CaMKII transgene. Science 274: 1678-1683.
21. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, et al (1996): In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272:263-267.
22. Nemeroff CB (1996): The corticotropin-releasing factor (CRF) hypothesis of depression: New findings and new directions. Mol Psychiatry 1:336-342.
23. Newman-Tancredi A, Conte C, Chaput C, Verriele L, Millan MJ (1997): Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT1A receptors as a function of receptor: G-protein stoichiometry. Neuropharmacology 36:451-459.
24. Rossby SP, Nalepa I, Huang M, Perrin C, Burt AM, Schmidt DE, et al (1995): Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant. Brain Res 687:79-82.
25. Rothschild AJ, Samson JA, Bond TC, Luciana MM, Schildkraut JJ, Schatzberg AF (1993): Hypothalamic-pituitary-adrenal axis activity and 1-year outcome in depression. Biol Psychiatry 34:392-400.
26. Segal RA, Greenberg ME (1996): Intracellular signaling pathways activated by neurotrophic factors. Annu Rev Neurosci 19:463-490.
27. Smith MA (1996): Hippocampal vulnerability to stress and aging: Possible role of neurotrophic factors. Behav Brain Res 78:25-36.
28. Thakore JH, Dinan TG (1995): Cortisol synthesis inhibition: A new treatment strategy for the clinical and endocrine manifestations of depression. Biol Psychiatry 37:364-368.
29. Tsien JZ, Chen DF, Gerber D, Tom C, Mercer EH, Anderson DJ, et al (1996): Subregion-and cell type-restricted gene knockout in mouse brain. Cell 87:1317-1326.
30. Vaidya VA, Siuciak J, Du F, Duman RS (1998): Mossy fiber sprouting and synaptic reorganization induced by chronic administration of electroconvulsive seizure: Role of BDNF. Neuroscience in press.
31. Wolkowitz OM, Reus VI, Manfredi F, Ingbar J, Brizendine L, Weingartner H (1993): Ketoconazole administration in hypercortisolemic depression. Am J Psychiatry 150:810-812.
32. Young EA, Vazquez D (1996): Hypercortisolemia, hippocampal glucocorticoid receptors, and fast feedback. Mol Psychiatry 1:149-159.