Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 640, Issue 1-2, 2008, Pages 131-138

  van Zeeland, Albert A ^a   de Groot, Anton J L ^a   Mohn, Georges R ^b   van Steeg, Harry ^a,b   van Oostrom, Conny ^b   van Duijn Goedhart, Anne Marie ^a   Mullenders, Leon F H ^a   Jansen, Jacob G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

Chronic treatment; Low dose rate; Mutation induction; N metyl N nitrosourea; Rat

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASE PAIRING; COMPARATIVE STUDY; CONTROLLED STUDY; DNA REPAIR; DNA SEQUENCE; GENE; HPRT GENE; IN VIVO STUDY; MALE; METHYLATION; MUTAGENESIS; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SEQUENCE ANALYSIS; SPLEEN CELL; T LYMPHOCYTE; VALIDATION STUDY;

ALKYLATING AGENTS; ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; METHYLATION; METHYLNITROSOUREA; MUTAGENESIS; RATS; RATS, WISTAR; SPLEEN; TIME FACTORS;

RATTUS;

EID: 40649096072     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2007.12.011     Document Type: Article

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