MGMT expression in murine bone marrow is a major determinant of animal survival after alkylating agent exposure

Journal of Hematotherapy and Stem Cell Research

Volumn 10, Issue 1, 2001, Pages 115-123

  Reese, J S ^a   Qin, X ^a   Ballas, C B ^a   Sekiguchi, M ^b   Gerson, S L ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; ALKYLATING AGENT; GENE PRODUCT; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; BONE MARROW SUPPRESSION; BONE MARROW TOXICITY; BONE MARROW TRANSPLANTATION; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DRUG EXPOSURE; HEMATOPOIESIS; HYPERSENSITIVITY; KNOCKOUT MOUSE; METHYLATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALKYLATING AGENTS; ANIMALS; BONE MARROW; BONE MARROW TRANSPLANTATION; DNA REPAIR; HEMATOPOIESIS; METHYLNITROSOUREA; MICE; MICE, KNOCKOUT; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SURVIVAL RATE;

EID: 0035081485     PISSN: 15258165     EISSN: None     Source Type: Journal    
DOI: 10.1089/152581601750098354     Document Type: Article

References (21)

1. Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase
2. Mammalian O6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
3. 6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
4. 6-benzylguanine plus BCNU
5. The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase
6. Retroviral transduction and expression of the human alkyltransferase cDNA provides nitrosourea resistance to hematopoietic cells
7. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea
8. 6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea
9. Retrovirus-mediated expression of a DNA repair protein in bone marrow protects hematopoietic cells from nitrosourea-induced toxicity in vitro and in vivo
10. Increasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agent
11. Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide
12. Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent
13. DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
14. 6-methylguanine residues in E. coli DNA
15. Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes
16. Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells
17. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta
18. Kinetics of central nervous system microglial and macrophage engraftment: Analysis using a transgenic bone marrow transplantation model
19. Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: Variations in yield, growth, and differentiation
20. Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice
21. The secondary leukemias: Challenges and future research directions