Connexin 43 expression in human and mouse testes with impaired spermatogenesis

European Journal of Histochemistry

Volumn 51, Issue 4, 2007, Pages 261-268

  Kotula Balak, M ^a   Hejmej, A ^a   Sadowska, J ^a   Bilinska, Barbara ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

Connexin 43; Klinefelter syndrome; Mutant mice; Testis

Indexed keywords

CONNEXIN 43; BIOLOGICAL MARKER; GJA1 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ADULT; ANIMAL TISSUE; ARTICLE; CASE REPORT; CELL METABOLISM; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KLINEFELTER SYNDROME; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SPERMATOGENESIS; TESTIS BIOPSY; ANIMAL; CHEMISTRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE DELETION; GENETICS; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SEMINIFEROUS TUBULE; SEX CHROMOSOME ABERRATION; TESTIS; WESTERN BLOTTING; Y CHROMOSOME;

MUS;

ADULT; ANIMALS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CONNEXIN 43; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; KLINEFELTER SYNDROME; LEYDIG CELLS; MALE; MICE; MICE, MUTANT STRAINS; SEMINIFEROUS TUBULES; SEQUENCE DELETION; SEX CHROMOSOME ABERRATIONS; SPERMATOGENESIS; TESTIS; Y CHROMOSOME;

EID: 40449107383     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Batias C, Defamie N, Lablack A, Thepot D, Fenichel P, Segretain D, et al. Modified expression of testicular gap-junction connexin 43 during normal spermatogenic cycle and in altered spermatogenesis. Cell Tissue Res 1999; 298:113-21.
2. Batias C, Siffroi JP, Fenichel P, Pointis G. Segretain D. Connexin43 gene expression and regulation in the rodent seminiferous epithelium. J Histochem Cytochem 2000; 48:793-805.
3. Bigliardi E, Vegni-Talluri M. Gap junctions between Sertoli cells in the infertile human testis. Fertil Setril 1977; 28:755-8.
4. Bravo-Moreno JF, Diaz-Sanchez V, Montova-Flores JG, Lamovi E, Saez JC, Perez-Armendariz EM. Expression of connexin43 in mouse Leydig, Sertoli, and germinal cells at different stages of postnatal development. Anat Rec 2001; 264:13-24.
5. Brehm R, Zeiler M, Rüttinger, Herde K, Kibschull M, Winterhager E, et al. A Sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis. Amer J Pathol 2007; doi:10.2353/ajpath.2007.061171.
6. Brehm R, Marks A Rey R, Kliesch S, Bergmann M, Steger K. Altered expression of connexins 26 and 43 in Sertoli cells in seminiferous tubules infiltrated with carcinoma in situ or seminoma. J Pathol 2002; 197:647-53.
7. Bruzzone R, White TW, Paul DL. Connections with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 1996; 238:1-27.
8. Chang M, Werner R, Dahl G. A role for an inhibitory connexin in testis? Dev Biol 1996;175:50-6.
9. Decrouy X, Gasc J-M, Pointis G, Segretain D. Functional characterization of Cx43 based gap junctions during spermatogenesis. J Cell Physiol 2004; 200:146-54.
10. Defamie N, Berthaut I, Mograbi B, Chevallier D, Dadoune JP, Fenichel P, et al. Impaired gap junction connexin43 in Sertoli cells of patients with secretory azoospermia: a marker of undifferentiated Sertoli cells. Lab Invest 2003; 83:449-56.
11. Evans WH, Martin PEM. Gap junctions: structure and function. Mol Membr Biol 2002; 19:121-36.
12. Fiorini C, Tilloy-Ellul A, Chevalier S, Charuel C, Pointis G. Sertoli cell junctional proteins as early targets for different classes of reproductive toxicants. Reprod Toxicol 2004; 18:413-21.
13. Gilleron J, Nebout M, Scarabelli L, Senegas-Balas F, Palmero S, Segretain D, et al. A potential novel mechanism involving connexin 43 gap junction for control of Sertoli cell proliferation by thyroid hormones. J Cell Physiol 2006; 209:153-61.
14. Gitshier J, Motaff B, Reilly D, Wood WI, Fairbrother WJ. Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase. Nature Struct Biol 1998; 5:47-54.
15. Hejmej A. Gorazd M, Kosiniak-Kamysz K, Wiszniewska B, Sadowska J, Bilinska B. Expression of aromatase and estrogen receptors in the reproductive tissues of the stallion and cryptorchid visualised by means of immunohistochemistry. Dom Anim Endocrinol 2005; 29:534-47.
16. Herve JC, Pluciennik F, Verrecchia F, Bastide B, Delage B, Joffre M, et al. Influence of the molecular structure of steroids on their ability to interrupt gap junctional communication. J Membrane Biol 1996; 149:179-87.
17. Izzo G, d'Istria M, Ferrara D, Serino I, Aniello F, Minucci S. Connexin 43 expression in the testis of the frog Rana esculenta. Zygote 2006; 14:349-57.
18. Juneja SC, Barr KJ, Enders GC, Kidder GM. Defects in the germ line and gonads of mice lacking connexin 43. Biol Reprod 1999; 60:1263-70.
19. Kahiri CN, Khalil MW, Tekpetey F, Kidder GM. Leydig cell function in mice lacking connexin 43. Reproduction 2006; 132:607-16.
20. Kotula-Balak M., Grzmil P, Styrna J, Bilinska B. Immunodetection of aromatase in mice with a partial deletion in the long arm of the Y chromosome. Acta histochem 2004a; 106:55-64.
21. Kotula-Balak M, Bablok L, Fràcki S, Jankowska A, Bilinska B. Immunoexpression of androgen receptors and aromatase in testes of patient with Klinefelter's syndrome. Folia Histochem Cytobiol 2004b; 42:215-20.
22. mo-ms). Theriogenology 2007; 67:423-34.
23. Krzanowska H. New mutation. Mouse News Lett 1966; 35:34-5.
24. Lablack A, Bourdon V, Defamie N, Batias C, Mesnil M, Fenichel P, et al. Ultrastructural and biochemical evidence for gap junction and connexin 43 expression in a clonal Sertoli cell line: a potential model in the study of junctional complex formation. Cell Tissue Res 1998; 294:279-87.
25. Lee NPY, Leung K-W, Wo JY, Tam P-Ch, Yeung WSB, Luk JM. Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium. Apoptosis 2006; 11:1215-29.
26. Levallet J, Bilinska B, Mittre H, Genissel C, Fresnel J, Carreau S. Expression and immunolocalization of functional cytochrome P450 aromatase in mature rat testicular cells. Biol Reprod 1998; 58:919-26.
27. Munari-Silem Y, Rousset B. Gap junction-mediated cell-to-cell communication in endocrine glands. Molecular and functional aspects: a review Eur J Endocrinol 1996; 135:251-64.
28. Nagano T, Suzuki F. Freeze-fracture observations on the intercellular junctions of Sertoli cells and of Leydig cells in the human testis. Cell Tissue Res 1976; 166:37-48.
29. Palmiero C, Ferrara D, De Rienzo G, d'Istria M, Minucci S. Ethane 1,2-dimethane sulphonate is a useful tool for studying cell-to-cell interactions in the testis of the frog, Rana esculenta. Gen Comp Endocrinol 2003; 131:38-47.
30. Paul DL. New functions for gap junctions. Curr Opinion Cell Biol 1995; 7:665-72.
31. Pelletier RM. The distribution of connexin 43 is associated with the germ cell differentiation and with the modulation of the Sertoli cell junctional barrier in continual (guinea pig) and seasonal breeders' (mink) testes. J Androl 1995; 16:400-9.
32. Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, et al. Unique and shared functions of different connexins in mice. Curr Biol 2000; 10:1083-91.
33. Perez-Armendariz EM, Luna J, Miranda C, Talavera D, Romano MC. Luteinizing and human chorionic gonadotropin hormones increase intercellular communication and gap junctions in cultured mouse Leydig cells. Endocrine 1996; 4:141-50.
34. Pointis G, Segretain D. Role of connexin-based gap junction channels in testis. Trends Endocrinol Metab 2005; 16:300-6.
35. Pointis G, Fiorini C, Defamie N, Segretain D. Gap junction communication in the male reproductive system. Biochim Biophys Acta 2005; 1719:102-16.
36. Risley MS, Tan IP, Roy C, Saez JC. Cell-, age- and stage-dependent distribution of connexin 43 gap junctions in testes. J Cell Sci 1992; 103:81-96.
37. Risley MS. Connexin gene expression in seminiferous tubules of the Spraque-Dawley rat. Biol Reprod 2000; 62:748-54.
38. Roger C, Mograbi B, Chevalier D, Michiels JF, Tanaka H, Segretain D, et al. Disruptred traffic of connexin 43 in human testicular seminoma cell: overexpression of Cx43 induces membrane location and cell proliferative decrease. J Pathol 2004; 202:241-6.
39. Roscoe WA, Barr KJ, Mhawi AA, Pomerantz DK, Kidder GM. Failure of spermatogenesis in mice lacking connexin 43. Biol Reprod 2001; 65:829-38.
40. Saez JC, Berthoud VM, Branes MC, Martinez AD, Bneyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 2003; 83:1359-400.
41. Segeratin D, Fiorini C, Decrouy X, Defamie N, Prat JR, Pointis G. A proposed role for ZO-1 in targeting connexion 43 gap junctions to the endocytic pathway. Biochimie 2004; 86:241-4.
42. Simon AM, Goodenough DA. Diverse functions of vertebrate gap junctions. Trends Cell Biol 1998; 8:477-83.
43. Sridharan S, Simon L, Meiling DD, Cyr DG, Gutstein DE, Fishman GI, Guillou F, Cooke PS. Proliferation of adult Sertoli cells following conditional knockout of the gap junctional protein GJA1 (connexin 43) in mice. Biol Reprod 2007; 76:804-12.
44. Steger K, Tetens F, Bergmann M. Expression of connexin 43 in human testis. Histochem Cell Biol 1999; 112:215-20.
45. Styrna J, Bilinska B, Krzanowska H. The effect of partial Y chromosome deletion in B10. BR-Ydel mice on testis morphology, sperm quality and efficiency of fertilization. Reprod Fertil Dev 2002; 14:101-8.
46. You S, Li W, Lin T. Expression and regulation of connexin43 in rat Leydig cells. J Endocrinol 2000; 166:447-53.