Leptin receptor signaling is required for vaccine-induced protection against Helicobacter pylori

Helicobacter

Volumn 13, Issue 2, 2008, Pages 94-102

  Wehrens, Andrea ^a   Aebischer, Toni ^a,b   Meyer, Thomas F ^a   Walduck, Anna K ^a,c  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Immunization; Mouse; Transcription profile

Indexed keywords

BACTERIUM LYSATE; CHOLERA TOXIN; LEPTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; BACTERIAL COLONIZATION; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GASTRITIS; GENE EXPRESSION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNE RESPONSE; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; STOMACH MUCOSA; T LYMPHOCYTE; VACCINATION;

ANIMALS; BACTERIAL VACCINES; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; LEPTIN; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; RECEPTORS, CELL SURFACE; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION;

ANIMALIA; BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; MUS;

EID: 40449103208     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2008.00591.x     Document Type: Article

References (51)

1. Ferrero RL, Thiberge J-M, Huerre M, Labigne A. Immune responses of specific-pathogen-free mice to chronic Helicobacter pylori (strain SS1) infection. Infect Immun 1998 66: 1349 55.
2. Hatz RA, Meimarakis G, Bayerdorffer E, Stolte M, Kirchner T, Enders G. Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis. Scand J Gastroenterol 1996 31: 222 8.
3. Aebischer T, Schmitt A, Walduck AK, Meyer TF. Helicobacter pylori vaccine development: facing the challenge. Int J Med Microbiol 2005 295: 343 53.
4. + T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling. Infect Immun 2001 69: 1714 21.
5. Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn SJ. Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 1997 113 AB (6): 1848 57.
6. Velin D, Bachmann D, Bouzourene H, Michetti P. Mast cells are critical mediators of vaccine-induced Helicobacter clearance in the mouse model. Gastroenterology 2005 129: 142 55.
7. Ermak TH, Giannasca PJ, Nichols R, et al. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J Exp Med 1998 188: 2277 88.
8. Pappo J, Torrey D, Castriotta L, Savinainen A, Kabok Z, Ibraghimov A. Helicobacter pylori infection in immunised mice lacking major histocompatibility complex class 1 and class II functions. Infect Immun 1999 67: 337 41.
9. Garhart CA, Heinzel FP, Czinn SJ, Nedrud JG. Vaccine-induced reduction of Helicobacter pylori colonization in mice is interleukin-12 dependent but gamma interferon and inducible nitric oxide synthase independent. Infect Immun 2003 71: 910 21.
10. Akhiani AA, Pappo J, Kabok Z, Schon K, Gao W, Franzen LE, Lycke N. Protection against Helicobacter pylori infection following immunization is IL-12-dependent and mediated by Th1 cells. J Immunol 2002 169: 6977 84.
11. Panthel K, Faller G, Haas R. Colonization of C57BL/6J and BALB/c wild-type and knockout mice with Helicobacter pylori: effect of vaccination and implications for innate and acquired immunity. Infect Immun 2003 71: 794 800.
12. Rahn W, Redline RW, Blanchard TG. Molecular analysis of Helicobacter pylori-associated gastric inflammation in naive versus previously immunized mice. Vaccine 2004 23: 807 18.
13. Walduck A, Schmitt A, Lucas B, Aebischer T, Meyer TF. Transcription profiling analysis of the mechanisms of vaccine-induced protection against H. pylori. FASEB J 2004 18: 1955 7.
14. Mueller A, O'Rourke J, Chu P, Kim CC, Sutton P, Lee A, Falkow S. Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc Natl Acad Sci USA 2003 100: 12289 94.
15. Friedman JM. Leptin, leptin receptors, and the control of body weight. Nutr Rev 1998 56: s38 46 Discussion s54-75.
16. Brzozowski T, Konturek PC, Pajdo R, et al. Brain-gut axis in gastroprotection by leptin and cholecystokinin against ischemia-reperfusion induced gastric lesions. J Physiol Pharmacol 2001 52: 583 602.
17. Elefteriou F, Takeda S, Ebihara K, et al. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci USA 2004 101: 3258 63.
18. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000 68: 437 46.
19. Lord G. Role of leptin in immunology. Nutr Rev 2002 60: S35 8 Discussion S68-84, 5-7.
20. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006 176: 7745 52.
21. Smythies LE, Chen JA, Lindsey JR, Ghiara P, Smith PD, Waites KB. Quantitative analysis of Helicobacter pylori infection in a mouse model. J Immunol Methods 2000 242: 67 78.
22. Lee A, O'Rourke J, De Ungria MC, Robertson B, Daskalopoulos G, Dixon MF. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 1997 112: 1386 97.
23. Gomez-Duarte OG, Lucas B, Yan ZX, Panthel K, Haas R, Meyer TF. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine 1998 16: 460 71.
24. Dixon MF, Genta RM, Yardley JH, Correa P. Histological classification of gastritis and Helicobacter pylori infection: an agreement at last? The International Workshop on the Histopathology of Gastritis. Helicobacter 1997 2: S17 24.
25. Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 1998 95: 14863 8.
26. Mueller A, O'Rourke J, Chu P, Kim CC, Sutton P, Lee A, Falkow S. Protective immunity against Helicobacter is characterized by a unique transcriptional signature. Proc Natl Acad Sci USA 2003 100: 12289 94.
27. Nishi Y, Isomoto H, Uotani S, et al. Enhanced production of leptin in gastric fundic mucosa with Helicobacter pylori infection. World J Gastroenterol 2005 11: 695 9.
28. Cho I, Blaser MJ, Francois F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2005 162: 579 84.
29. Azuma T, Suto H, Ito Y, Ohtani M, Dojo M, Kuriyama M, Kato T. Gastric leptin and Helicobacter pylori infection. Gut 2001 49: 324 9.
30. Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000 199: 15 24.
31. Raso GM, Pacilio M, Esposito E, Coppola A, Di Carlo R, Meli R. Leptin potentiates IFN-gamma-induced expression of nitric oxide synthase and cyclo-oxygenase-2 in murine macrophage J774A.1. Br J Pharmacol 2002 137: 799 804.
32. Aebischer T, Laforsch S, Hurwitz R, Brombacher F, Meyer TF. Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice. Infect Immun 2001 69: 556 8.
33. Court M, Robinson P, Dixon M, Jeremy A, Crabtree J. The effect of gender on Helicobacter felis-mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse model. J Pathol 2003 201: 303 11.
34. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998 394: 897 901.
35. Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999 104: 1051 9.
36. Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr., Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet 1996 14: 95 7.
37. Hosoi T, Okuma Y, Nomura Y. Leptin regulates interleukin-1beta expression in the brain via the STAT3-independent mechanisms. Brain Res 2002 949: 139 46.
38. Siegmund B, Lehr HA, Fantuzzi G. Leptin: a pivotal mediator of intestinal inflammation in mice. Gastroenterology 2002 122: 2011 25.
39. Siegmund B, Lear-Kaul KC, Faggioni R, Fantuzzi G. Leptin deficiency, not obesity, protects mice from Con A-induced hepatitis. Eur J Immunol 2002 32: 552 60.
40. Naggert JK, Mu JL, Frankel W, Bailey DW, Paigen B. Genomic analysis of the C57BL/Ks mouse strain. Mamm Genome 1995 6: 131 3.
41. Petkov PM, Ding Y, Cassell MA, et al. An efficient SNP system for mouse genome scanning and elucidating strain relationships. Genome Res 2004 14: 1806 11.
42. Chen H, Charlat O, Tartaglia LA, et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996 84: 491 5.
43. Garris DR, Garris BL. Cytochemical analysis of pancreatic islet hypercytolipidemia following diabetes (db/db) and obese (ob/ob) mutation expression: influence of genomic background. Pathobiology 2004 71: 231 40.
44. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006 17: 4 12.
45. Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J, Bastard JP. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord 2004 28: 993 7.
46. Akhiani AA, Stensson A, Schon K, Lycke NY. IgA antibodies impair resistance against Helicobacter pylori infection: studies on immune evasion in IL-10-deficient mice. J Immunol 2005 174: 8144 53.
47. Gruen ML, Hao M, Piston D, Hasty AH. Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. Am J Physiol Cell Physiol 2007.
48. Montecucco F, Bianchi G, Gnerre P, Bertolotto M, Dallegri F, Ottonello L. Induction of neutrophil chemotaxis by leptin: crucial role for p38 and Src kinases. Ann N Y Acad Sci 2006 1069: 463 71.
49. Zarkesh-Esfahani H, Pockley AG, Wu Z, Hellewell PG, Weetman AP, Ross RJ. Leptin indirectly activates human neutrophils via induction of TNF-alpha. J Immunol 2004 172: 1809 14.
50. Bjorbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997 272: 32686 95.
51. Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969 217: 1298 304.