Adoptive transfer of CD4+ T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling

Infection and Immunity

Volumn 69, Issue 3, 2001, Pages 1714-1721

  Lucas, B ^a   Bumann, D ^a   Walduck, A ^a   Koesling, J ^a   Develioglu, L ^a   Meyer, T F ^a   Aebischer, T ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; HELICOBACTER PYLORI VACCINE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UREASE;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; CELL PROTECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HELICOBACTER PYLORI; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; T LYMPHOCYTE SUBPOPULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; INTERLEUKIN-4; MALE; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-13; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; SPLEEN; STOMACH; UREASE;

EID: 0035112343     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.3.1714-1721.2001     Document Type: Article

References (44)

1. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
2. Host response and vaccine development to Helicobacter pylori infection
3. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice
4. Influence of the antigen delivery system on immunoglobulin isotype selection and cytokine production in response to influenza A nucleoprotein
5. MHCPEP, a database of MHC-binding peptides: Update 1997
6. Oral immunizatian with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice
7. c expressing urease A and B subunits
8. Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets
9. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization
10. An empirical method for the prediction of T-cell epitopes
11. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer
12. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses
13. Recombinant antigens prepared from the urease subunits of Helicobacter spp.: Evidence of protection in a mouse model of gastric infection
14. The groES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice
15. Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection
16. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B
17. The response of cells from low-grade B-cell gastric lymphomas of mucosa-assoelated lymphoid tissue to Helicobacter pylori
18. Therapeutic oral vaccination induces mucosal immune response sufficient to eliminate long-term Helicobacter pylori infection
19. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis
20. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys
21. Immunity to Salmonella
22. Development of a mouse model of Helicobacter pylori infection that mimics human disease
23. Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes from Mycobacterium tubercalosis and HIV protein sequences
24. Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T Iymphocytes and immune protection against Helicobacter infection in mice
25. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease
26. Helicobacter-specific cell-mediated immune responses display a predominant Th1 pheno-type and promote a delayed-type hypersensitivity response in the stomachs of mice
27. Murine CD4 T-cell response to Helicobacter infection: Th1 cells enhance gastritis and Th2 cells reduce bacterial load
28. Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
29. + cells secreting interleukin-4
30. + cells correlate with resolution of lesions in murine cutaneous leishmaniasis
31. + T cell IL-4 production is revealed in IL-4 receptor-deficient mice
32. Helicobacter pylori infection in immunized mice lacking major histocompatibility complex class I and class II functions
33. Helicobacter pylori infection and gastric lymphoma
34. Constructing polycompetitor cDNAs for quantitative PCR
35. Inhibition of B lymphocyte activation by interferon-gamma
36. Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection
37. Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model
38. Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice
39. + lymphocytes in Helicobacter pylori gastritis display a Th1 phenotype
40. Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella
41. Proliferative and T-cell specific interleukin (IL-2/IL-4) production responses in spleen cells from mice vaccinated with aroA live attenuated Salmonella vaccines
42. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori
43. Oral Salmonella typhimurium (aroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis
44. Naturally acquired human immune responses against Helicobacter pylori and implications for vaccine development