Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000

European Journal of Pharmaceutical Sciences

Volumn 28, Issue 1-2, 2006, Pages 67-76

  Urbanetz, Nora Anne ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Ageing; Dissolution; Nimodipine; Polyethylene glycol; Povidone; Recrystallization; Solid dispersion; Supersaturation

Indexed keywords

ACETIC ACID ETHYL ESTER; BUTYLMETHACRYLAT (2 DIMETHYLAMINOETHYL)METHACRYLAT METHYLMETHACRYLAT COPOLYMER; CETOSTEARYLIC ALCOHOL; COPOLYMER; DODECYL SULFATE SODIUM; GLYCEROL; GLYCEROL STEARATE; HYDROXYPROPYLCELLULOSE; MACROGOL; MACROGOL 2000; MACROGOL 300; MACROGOL CETOSTEARYL ETHER; MACROGOL DERIVATIVE; MACROGOL GLYCEROL MONOSTEARATE; MACROGOL STEARATE; NIMODIPINE; POLYACRYLIC ACID; POLYPROPYLENE GLYCOL; POLYSORBATE 60; POLYVINYL ALCOHOL; POVIDONE DERIVATIVE; PROPANEDIOL DERIVATIVE; SILICA GEL; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG SOLUBILITY; DRUG SOLUTION; DRUG STABILITY; DRUG STORAGE; DRUG TRANSFORMATION; PRIORITY JOURNAL; SOLID STATE;

CALCIUM CHANNEL BLOCKERS; CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; KINETICS; NIMODIPINE; POLYETHYLENE GLYCOLS; POVIDONE; SOLUBILITY; SOLVENTS; SUSPENSIONS; TEMPERATURE; X-RAY DIFFRACTION;

EID: 33644881395     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.12.009     Document Type: Article

References (25)

1. M. Aldén, J. Tegenfeldt, and E. Sjökvist Structure of solid dispersions in the system polyethylene glycol-griseofulvin with additions of sodium dodecyl sulphate Int. J. Pharm. 83 1992 47 52
2. M. Aldén, J. Tegenfeldt, and E. Sjökvist Saers Structures formed by interactions in solid dispersions of the system polyethylene glycol-griseofulvin with charged and non charged surfactants added Int. J. Pharm. 94 1993 31 38
3. M. Aldén, M. Lydén, and J. Tegenfeldt Effect of counterions on the interactions in solid dispersions between polyethylene glycol, griseofulvin and alkali dodecyl sulphates Int. J. Pharm. 110 1994 267 276
4. Cowie, J.M.G., 1997. Chemie und Physik der synthetischen Polymeren. Friedrich Vieweg & Sohn Verlagsgesellschaft mbH, Braunschweig/Wiesbaden.
5. D.Q.M. Craig A review of thermal methods used for the analysis of the crystal form, solution thermodynamics and glass transition behaviour of polyethylene glycols Thermochim. Acta 248 1995 189 203
6. D.Q.M. Craig The mechanisms of drug release from solid dispersions in water-soluble polymers Int. J. Pharm. 231 2002 131 144
7. A. Hasegawa, R. Kawamura, H. Nakagawa, and I. Sugimoto Dissolution mechanism of solid dispersions of nifedipine with enteric coating agents Yakugaku Zasshi 105 1985 586 592
8. Hoechst Aktiengesellschaft, 1992. Polyethylenglykole, Produktbeschreibung. Hoechst Aktiengesellschaft, Frankfurt am Main.
9. S.L. Law, W.Y. Lo, F.M. Lin, and C.H. Chaing Dissolution and absorption of nifedipine in polyethylene glycol solid dispersion containing phosphatidycholine Int. J. Pharm. 84 1992 161 166
10. C. Leuner, and J. Dressman Improving drug solubility for oral delivery using solid dispersions Eur. J. Pharm. 50 2000 47 60
11. P. Mura, M.T. Faucci, A. Manderioli, G. Bramanti, and P. Parrini Thermal behavior and dissolution properties of naproxen from binary and ternary solid dispersions Drug Dev. Ind. Pharm. 25 3 1999 257 264
12. A.T.M. Serajuddin Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs J. Pharm. Sci. 88 1999 1058 1066
13. E. Sjökvist, C. Nyström, and M. Aldén Physicochemical aspects of drug release. XIII. The effect of sodium dodecyl sulphate additions on the structure and dissolution of a drug in solid dispersions Int. J. Pharm. 69 1991 53 62
14. E. Sjökvist, C. Nyström, M. Aldén, and N. Caram-Lelham Physicochemical aspects of drug release. XIV. The effects of some ionic and non-ionic surfactants on properties of a sparingly soluble drug in solid dispersions Int. J. Pharm. 79 1992 123 133
15. E. Sjökvist Saers, C. Nyström, and M. Aldén Physiochemical aspects of drug release. XVI. The effect of storage on drug dissolution from solid dispersions and the influence of cooling rate and incorporation of surfactant Int. J. Pharm. 90 1993 105 118
16. M. Sugimoto, T. Okagaki, S. Narisawa, Y. Koida, and K. Nakajima Improvement of dissolution characteristics and bioavailability of poorly water-soluble drugs by novel cogrinding method using water-soluble polymer Int. J. Pharm. 160 1998 11 19
17. H. Suzuki, and H. Sunada Comparison of nicotinamide, ethylurea and polyethylene glycol as carriers for nifedipine solid dispersion systems Chem. Pharm. Bull. 45 1997 1688 1693
18. H. Suzuki, and H. Sunada Influence of water-soluble polymers on the dissolution of nifedipine solid dispersions with combined carriers Chem. Pharm. Bull. 46 1998 482 487
19. H. Suzuki, M. Ogawa, K. Hironaka, K. Ito, and H. Sunada A nifedipine coground mixture with sodium deoxycholate. II. Dissolution characteristics and stability Drug Dev. Ind. Pharm. 27 2001 951 958
20. R.W. Tejwani, H.N. Joshi, S.A. Varia, and A.T.M. Serajuddin Study of phase behavior of poly(ethylene glycol)-polysorbate 80 and poly(ethylene glycol)-polysorbate 80-water mixtures J. Pharm. Sci. 89 2000 946 950
21. N.A. Urbanetz, and B.C. Lippold Solid dispersions of nimodipine and polyethylene glycol 2000: dissolution properties and physico-chemical characterisation Eur. J. Pharm. Biopharm. 59 2005 107 118
22. G. Van den Mooter, M. Wuyts, N. Blaton, R. Busson, P. Grobet, P. Augustijns, and R. Kinget Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25 Eur. J. Pharm. Sci. 12 2001 261 269
23. M.D. Veiga, C. Escobar, and M.J. Bernad Dissolution behaviour of drugs from binary and ternary systems Int. J. Pharm. 93 1993 215 220
24. M. Wulff, and M. Aldén Phase equilibria in drug-polymer-surfactant systems Thermochim. Acta 256 1995 151 165
25. M. Wulff, M. Aldén, and D.Q.M. Craig An investigation into the critical surfactant concentration for solid solubility of hydrophobic drug in different polyethylene glycols Int. J. Pharm. 142 1996 189 198