Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB1 receptor

European Journal of Medicinal Chemistry

Volumn 43, Issue 3, 2008, Pages 513-539

  Moloney, Gerard P ^a   Angus, James A ^b   Robertson, Alan D ^c   Stoermer, Martin J ^a   Robinson, Michael ^a   Wright, Christine E ^b   McRae, Ken ^a   Christopoulos, Arthur ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Zenyth Therapeutics Limited Australia   (Australia)

Author keywords

Aminoalkylindoles; Cannabinoid CB1 receptors; CB1 agonists; Design; Pain control; Synthesis

Indexed keywords

(1H INDOL 3 YL)(3 PHENYL 1,2,4 OXADIAZOL 5 YL)METHANONE; (3 BENZYL 1,2,4 OXADIAZOL 5 YL)[1 (2 MORPHOLINOETHYL) 1H INDOL 3 YL)METHANONE; (3 BENZYL [1,2,4]OXADIAZOL 5 YL)(1H INDOL 3 YL)METHANONE; (3 NAPHTHALEN 2 YLMETHYL) 5 [1 [2 (PYRROLIDINE 1 YL) ETHYL] 1H INDOL 3 YL] 1,2,4 OXADIAZOLE; 1 MORPHOLINO 2 (3 PHENYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 1 YL ETHANONE; 2 [3 (3 BENZYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 1 YL] 1 MORPHOLINOETHANONE; 3 (2 CHLOROBENZYL) 5 (1H INDOL 3 YL) 1,2,4 OXADIAZOLE; 3 (4 BROMOBENZYL) 5 (1H INDOL 3 YL) 1,2,4 OXADIAZOLE; 3 (BIPHENYL 4 YL) 5 (1H INDOL 3 YL) 1,2,4 OXADIAZOLE; 3 BENZYL 5 (1 PENTYL 1H INDOL 3 YL) 1,2,4 OXADIAZOLE; 3 BENZYL 5 (1H INDOL 3 YL) 1,2,4 OXADIAZOLE; 3 BENZYL 5 [1 (2 PYRROLIDIN 1 YL)ETHYL 1H INDOL 3 YL] 1,2,4 OXADIAZOLE; 4 [2 [3 (3 BENZYL [1,2,4]OXADIAZOL 5 YL) 1H INDOL 1 YL]ETHYL]MORPHOLINE; 4 [2 [3 (3 BIPHENYL 4 YL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 1 YL]ETHYL]MORPHOLINE; 4 [2 [3 (3 PHENYL 1,2,4 OXADIAZOL 5 YL) 1H INDOL 1 YL]ETHYL]MORPHOLINE; 4 [2 [3 [3 (NAPHTHALENE 2 YLMETHYL) 1,2,4 OXADIAZOL 5 YL] 1H INDOL 1 YL]ETHYL]MORPHOLINE; 5 (1H IMIDAZOL 4 YL) 3 (THIOPHEN 2 YLMETHYL) 1,2,4 OXADIAZOLE; 5 (1H INDOL 3 YL) 3 (4 METHOXYBENZYL) 1,2,4 OXADIAZOLE; 5 (1H INDOL 3 YL) 3 (NAPHTHALENE 2 YLMETHYL) 1,2,4 OXADIAZOLE; 5 (1H INDOL 3 YL) 3 (THIOPHEN 2 YLMETHYL) 1,2,4 OXADIAZOLE; 5 (1H INDOL 3 YL) 3 PHENETHYL 1,2,4 OXADIAZOLE; 5 (1H INDOL 3 YL) 3 PHENYL 1,2,4 OXADIAZOLE; 5 [3 [3 (NAPHTHALENE 2 YLMETHYL) 1,2,4 OXADIAZOL 5 YL] 1H INDOL 1 YL]PENTANOIC ACID; ANANDAMIDE; CANNABINOID 1 RECEPTOR AGONIST; DEXANABINOL; ETHYL 5 [3 [3 (NAPHTHALEN 2 YLMETHYL) 1,2,4 OXADIAZOL 5 YL] 1H INDOL 1 YL]PENTANOATE; OXADIAZOLE DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; RAT;

EID: 40149100335     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.04.007     Document Type: Article

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