Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission

British Journal of Pharmacology

Volumn 119, Issue 1, 1996, Pages 49-56

  Wright, Christine E ^a   Angus, James A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Calcium channels, N type; Calcium channels, P type; Calcium channels, Q type; Neuromuscular junction; Sympathetic neurotransmission; Voltage operated calcium channels; agatoxin IVA; conotoxin GVIA; conotoxin MVIIC

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CONOTOXIN;

ADRENERGIC TRANSMISSION; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; DIAPHRAGM; HEART RIGHT ATRIUM; MALE; MESENTERIC ARTERY; MOUSE; MUSCLE TWITCH; NERVE STIMULATION; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RAT; VAS DEFERENS;

EID: 0029791654     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15676.x     Document Type: Article

References (43)

1. ANGUS, J.A., BROUGHTON, A. & MULVANY, M.J. (1988). Role of α-adrenoceptors in constrictor responses of rat, guinea-pig and rabbit small arteries to neural activation. J. Physiol., 403, 495-510.
2. ANGUS, J.A. & HARVEY, K. (1981). Refractory period field stimulation of right atria: a method for studying presynaptic receptors in cardiac autonomic transmission. J. Pharmacol. Methods, 6, 51-64.
3. BOOT, J.R. (1994). Differential effects of ω-conotoxin GVIA and MVIIC on nerve stimulation induced contractions of guinea-pig ileum and rat vas deferens. Eur. J. Pharmacol., 258, 155-158.
4. BROCK, J.A., CUNNANE, T.C., EVANS, R.J. & ZIOGAS, J. (1989). Inhibition of transmitter release from sympathetic nerve endings by ω-conotoxin. Clin. Exp. Pharmacol. Physiol., 16, 333-339.
5. CLASBRUMMEL, B., OSSWALD, H. & ILLES, P. (1989). Inhibition of noradrenaline release by ω-conotoxin GVIA in the rat tail artery. Br. J. Pharmacol., 96, 101-110.
6. DE LUCA, A., LI, C.G., RAND, M.J., REID, J.J., THAINA, P. & WONG-DUSTING, H.K. (1990). Effects of ω-conotoxin GVIA on autonomic neuroeffector transmission in various tissues. Br. J. Pharmacol., 101, 437-447.
7. DE LUCA, A., RAND, M.J., REID, J.J. & STORY, D.F. (1991). Differential sensitivities of avian and mammalian neuromuscular junctions to inhibition of cholinergic transmission by ω-conotoxin GVIA. Toxicon, 29, 311-320.
8. FABI, F., CHIAVARELLI, M., ARGIOLAS, L., CHIAVARELLI, R. & DEL BASSO, P. (1993). Evidence for sympathetic neurotransmission through presynaptic N-type calcium channels in human saphenous vein. Br. J. Pharmacol., 110, 338-342.
9. FLINN, J.P., MURPHY, R., BOUBLIK, J.H., LEW, M.J., WRIGHT, C.E. & ANGUS, J.A. (1995). Synthesis and biological characterization of a series of analogues of ω-conotoxin GVIA. J. Peptide Sci., 1, 379-384.
10. 2+ channels. Neuron, 9, 69-77.
11. 2+ channels in evoked release of norepinephrine from sympathetic neurons. Science, 239, 57-61.
12. HONG, S.J. & CHANG, C.C. (1995). Calcium channel subtypes for the sympathetic and parasympathetic nerves of guinea-pig atria. Br. J. Pharmacol., 116, 1577-1582.
13. 2+ channels in the mammalian central nervous system. Trends Neurosci., 15, 351-355.
14. LLINÁS, R., SUGIMORI, M., LIN, J.-W. & CHERKSEY, B. (1989). Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison. Proc. Natl. Acad. Sci. U.S.A., 86, 1689-1693.
15. LUDBROOK, J. (1994). Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res., 28, 303-311.
16. LUNDY, P.M. & FREW, R. (1994). Effect of ω-agatoxin-IVA on autonomic neurotransmission. Eur. J. Pharmacol., 261, 79-84.
17. MCCLESKEY, E.W., FOX., A.P., FELDMAN, D.H., CRUZ, L.J., OLIVERA, B.M., TSIEN, R.W. & YOSHIKAMI, D. (1987). ω-Conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle. Proc. Natl. Acad. Sci. U.S.A., 84, 4327-4331.
18. MILLER, R.J. (1987). Multiple calcium channels and neuronal function. Science, 235, 46-52.
19. MINTZ, I.M., VENEMA, V.J., SWIDEREK, K.M., LEE, T.D., BEAN, B.P. & ADAMS, M.E. (1992). P-type calcium channels blocked by the spider toxin ω-Aga-IVA. Nature, 355, 827-829.
20. MONJE, V.D., HAACK, J.A., NAISBITT, S.R., MILJANICH, G., RAMACHANDRAN, J., NASDASDI, L., OLIVERA, B.M., HILLYARD, D.R. & GRAY, W.R. (1993). A new Conus peptide ligand for Ca channel subtypes. Neuropharmacology, 32, 1141-1149.
21. MORI, Y., FRIEDRICH, T., KIM, M.-S., MIKAMI, A., NAKAI, J., RUTH, P., BOSSE, E., HOFMANN, F., FLOCKERZI, V., FURUICHI, T., MIKOSHIBA, K., IMOTO, K., TANABE, T. & NUMA, S. (1991). Primary structure and functional expression from complementary DNA of a brain calcium channel. Nature, 350, 398 402.
22. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 19 26.
23. NOWYCKY, M.C., FOX, A.P. & TSIEN, R.W. (1985). Three types of neuronal calcium channel with different calcium agonist sensitivity. Nature, 316, 440-443.
24. OLIVERA, B.M., MCINTOSH, J.M., CRUZ, L.J., LUQUE, F.A. & GRAY, W.R. (1984). Purification and sequence of a presynaptic peptide toxin from Conus geographus venom. Biochemistry, 23, 5087 5090.
25. OLIVERA, B.M., MILJANICH, G.P., RAMACHANDRAN, J. & ADAMS, M.E. (1994). Calcium channel diversity and neurotransmitter release: the ω-conotoxins and ω-agatoxins. Ann. Rev. Biochem., 63, 823-867.
26. 2+ currents blocked by the spider toxin ω-Aga-IVA. Neuro Report, 5, 333-336.
27. PRUNEAU, D. & ANGUS, J.A. (1990a). ω-Conotoxin GVIA is a potent inhibitor of sympathetic neurogenic responses in rat small mesenteric arteries. Br. J. Pharmacol., 100, 180-184.
28. PRUNEAU, D. & ANGUS, J.A. (1990b). ω-Conotoxin GVIA, the N-type calcium channel inhibitor, is sympatholytic but not vagolytic: consequences for hemodynamics and autonomic reflexes in conscious rabbits. J. Cardiovasc. Pharmacol., 16, 675-680.
29. REN, L.-M., NAKANE, T. & CHIBA, S. (1994). Differential effect of ω-conotoxin GVIA and tetrodotoxin on vasoconstrictions evoked by electrical stimulation and nicotinic receptor stimulation in canine isolated, perfused splenic arteries. Br. J. Pharmacol., 111, 1321-1327.
30. ROSSONI, G., BERTI, F., LA MAESTRA, L. & CLEMENTI, F. (1994). ω-Conotoxin GVIA binds to and blocks rat neuromuscular junction. Neurosci. Lett., 176, 185-188.
31. RUSSELL, J.A., GIESE, E.C. & MOORE, T.L. (1990). Neuronal type N calcium channels mediate norepinephrine release in isolated rabbit pulmonary artery. Pulm. Pharmacol., 3, 41-46.
32. SMITH, A.B. & CUNNANE, T.C. (1996). ω-Conotoxin GVIA-resistant neurotransmitter release in postganglionic sympathetic nerve terminals. Neuroscience., 70, 817-824.
33. SNEDECOR, G.W. & COCHRAN, W.G. (1989). Statistical Methods. pp. 254-272. Ames: Iowa State University Press.
34. TSIEN, R.W., LIPSCOMBE, D., MADISON, D.V., BLEY, K.R. & FOX, A.P. (1988). Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci., 11, 431-438.
35. UCHITEL, O.D., PROTTI, D.A., SANCHEZ, V., CHERKSEY, B.D., SUGIMORI, M. & LLINÁS, R. (1992). P-type voltage-dependent calcium channel mediates presynaptic calcium influx and transmitter release in mammalian synapses. Proc. Natl. Acad. Sci. U.S.A., 89, 3330-3333.
36. VEGA, T., DE PASCUAL, R., BULBENA, O. & GARCÍA, A.G. (1995). Effects of ω-toxins on noradrenergic neurotransmission in beating guinea pig atria. Eur. J. Pharmacol., 276, 231-238.
37. 2+ channels in supporting hippocampal synaptic transmission. Science, 264, 107-111.
38. WHORLOW, S.L., ANGUS, J.A. & WRIGHT, C.E. (1996). Selectivity of ω-conotoxin GVIA for N-type calcium channels in rat isolated small mesenteric arteries. Clin. Exp. Pharmacol. Physiol., 23, 16-21.
39. 2+ channel blockade with ω-conotoxin GVIA in conscious normotensive and hypertensive rabbits. J. Cardiovasc. Pharmacol., 25, 459-468.
40. WRIGHT, C.E., ANGUS, J.A. & KORNER, P.I. (1987). Vascular amplifier properties in renovascular hypertension in conscious rabbits. Hindquarter responses to constrictor and dilator stimuli. Hypertension, 9, 122-131.
41. 2+ channels and their possible counterparts in mammalian CNS neurons. Neuropharmacology, 32, 1075-1088.
42. ZYGMUNT, P.M. & HÖGESTÄTT, E.D. (1993). Calcium channels at the adrenergic neuroeffector junction in the rabbit ear artery. Naunyn-Schmiedeberg's Arch. Pharmacol., 347, 617-623.
43. ZYGMUNT, P.M., ZYGMUNT, P.K.E., HÖGESTÄTT, E.D. & ANDERSSON, K.-E. (1993). Effects of ω-conotoxin on adrenergic, cholinergic and NANC neurotransmission in the rabbit urethra and detrusor. Br. J. Pharmacol., 110, 1285-1290.