Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl) -1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 6, 2005, Pages 1989-2007

  Dong, Chang Zhi ^a   Ahamada Himidi, Azali ^a   Plocki, Stéphanie ^a   Aoun, Darina ^a   Touaibia, Mohamed ^a   Meddad Bel Habich, Nadia ^a   Huet, Jack ^a   Redeuilh, Catherine ^a   Ombetta, Jean Edouard ^a   Godfroid, Jean Jacques ^a   Massicot, France ^a,b   Heymans, Françoise ^a  

^a Laboratoire de Pharmacochimie   (France)

^b Centre Universitaire des Saints Pères   (France)

Author keywords

Oxadiazolone; Phospholipase A2; SAR; Specific inhibitor

Indexed keywords

3 (3 HEPTANOYL 4 HEPTYLOXYBENZYL) 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 (3 HEPTYL 4 HEPTYLOXYBENZYL) 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 (4 DECYLOXYBENZYL) 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 (4 DODECYLOXYBENZYL) 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 (4 HEXADECYLOXYBENZYL) 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 HEPTADECYL 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 (13 CARBOXYTRIDECYLOXY)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 (N TERT BUTYLOXYCARBONYL N TETRADECYLAMINO)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 (N,N DIHEPTYLAMINO)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 (N,N DIOCTYLAMINO)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 (N,N DITETRADECYLAMINO)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 HEPTYLOXY 3 (2 HEXYL 1,3 DIOXOLAN 2 YL)BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 [2 [2 [2 (2 ETHOXYETHOXY)ETHOXY]ETHOXY]ETHOXY]BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 3 [4 [8 (2 ETHOXYETHOXY)OCTYL]BENZYL] 4,5 DIHYDRO 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 2 METHYL 3 (4 TETRADECYLOXYBENZYL) 2H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (2 TETRADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 OCTADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 OCTYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 TETRADECYLCYCLOXYPHENETHYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 TETRADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 TETRADECYLSULFONYLBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (4 TETRADECYLTHIOBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (ALPHA METHYL 4 TETRADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 (ALPHA,ALPHA DIMETHYL 4 TETRADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 [4 (14 HYDROXYTETRADECYLOXY)BENZYL] 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 3 [4 (N TETRADECYLAMINO)BENZYL] 4H 1,2,4 OXADIAZOL 5 ONE; 4,5 DIHYDRO 4 METHYL 3 (4 TETRADECYLOXYBENZYL) 4H 1,2,4 OXADIAZOL 5 ONE; LY 311727; OXADIAZOLE DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; PMS 1062; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; SWINE;

SUIDAE;

EID: 13844307284     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.01.016     Document Type: Article

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