Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition

Experimental Biology and Medicine

Volumn 233, Issue 3, 2008, Pages 344-355

  Ronis, Martin J J ^a,b   Butura, Angelica ^c   Korourian, Soheila ^a,b   Shankar, Kartik ^a,b   Simpson, Pippa ^d   Badeaux, Jamie ^b   Albano, Emanuele ^e   Ingelman Sundberg, Magnus ^c   Badger, Thomas M ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d University A Avogadro of East Piedmont ^*  (United States)

^e UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Alcohol; Cytokine; IL 4; Proliferation; TNF

Indexed keywords

ALCOHOL; CHEMOKINE; CXCL2 CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; STAT4 PROTEIN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DEATH; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENTERIC FEEDING; FATTY LIVER; HEPATITIS; INFLAMMATION; INNATE IMMUNITY; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOLOGY; PROTEIN EXPRESSION; RAT; TH1 CELL; TH2 CELL;

ALCOHOL DEHYDROGENASE; ANIMALS; CELL PROLIFERATION; CYTOCHROME P-450 CYP2E1; CYTOKINES; DISEASE MODELS, ANIMAL; ENTERAL NUTRITION; ETHANOL; GENE EXPRESSION REGULATION; HEPATITIS; HEPATOCYTES; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 40149085591     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0707-RM-203     Document Type: Article

References (48)

1. Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 343:1147-1476, 2000.
2. Thiele GM, Freeman TL, Klassen LW. Immunologic mechanisms of alcoholic liver injury. Semin Liver Dis 24:273-287, 2004.
3. Nanji AA, Zhao S, Sadrazadeh SMH, Waxman DJ. Use of reverse transcription polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods. Hepatology 19:1483-1487, 1994.
4. Kamimura S, Tsukomoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 21:1304-1309, 1995.
5. Fang C, Lindros KO, Badger TM, Ronis MJJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor chlormethiazole. Hepatology 27:1304-1310, 1998.
6. Neuman MG. Cytokines - central factors in alcoholic liver disease. Alcohol Res & Health 27:307-315, 2003.
7. McClain CJ, Brave S, Deacluc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 19:205-219, 1999.
8. Crews FT, Bachara R, Brown LA, Guidot DM, Mandrekar P, Oak S, Qin L, Szabo G, Wheeler M, Zou J. Cytokines and alcohol. Alcohol Clin Exp Res 30:720-730, 2006.
9. Nanji AA, Jokelainen K, Rahemtulla A, Miao L, Fogt F, Matsumoto H, Tahan SR, Su GL. Activation of nuclear factor kappa B and cytokine inbalance in experimental alcoholic liver disease in the rat. Hepatology 30:934-943, 1999.
10. Kremer M, Hines IN, Milton RJ, Wheeler MD. Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Hepatology 44:216-227, 2006.
11. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc Natl Acad Sci USA 94:1441-1446, 1997.
12. Isayama F, Froh M, Yin M, Conzelmann LO, Milton RJ, McKim SE, Wheeler MD. TNFα-induced Ras activation due to ethanol promotes hepatocyte proliferation independently of liver injury in the mouse. Hepatology 39:721-731, 2004.
13. Chiu H, Gardner CR, Dambach DM, Durham SK, Brittingham JA, Laskin JD, Laskin DL. Role of tumor necrosis factor receptor 1 (P55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice. Toxicol Appl Pharmacol 193:218-227, 2003.
14. Thiele GM, Mandreckar P, Zakhari S, Hoek J, Cook RT, Ray NB, Happel KI, Kolls JK, Kovaks EJ, Szabo G. RSA 2004: combined basic research satellite symposium - mechanisms of alcohol mediated organ and tissue damage. Alcohol Clin Exp Res 29:1735-1743, 2005.
15. Bautista AP. Impact of alcohol on the ability of Kupffer cells to produce chemokines and its role in alcoholic liver disease. J Gastrointest Hepatol 15:349-356, 2000.
16. Fisher NC, Neil DA, Williams A, Adams DH. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1 alpha in alcoholic liver disease. Gut 45:416-420, 1999.
17. Nanji AA, Jokelainen K, Fotouhninia M, Rahemtulla A, Thomas P, Tiptoe GI, Su G, Dannenberg AJ. Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin and chemokines. Am J Physiol Gastrointest Liver Physiol 281:G1348-G1356, 2001.
18. Jaeschke H. Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 27:23-27, 2002.
19. Keegan A, Martini R, Batey R. Ethanol-induced liver injury in the rat: a model of steatosis, inflammation and pericentral fribrosis. J Hepatol 23:591-600, 1995.
20. Ronis MJJ, Lumpkin CK, Ingelman-Sundberg M, Badger TM. Effects of short term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition. Alcohol Clin Exp Res 15:693-699, 1991.
21. Badger TM, Ronis MJJ, Lumpkin CK, Valentine CR, Shahare M, Irby D, Huang J, Mercado C, Thomas PE, Ingelman-Sundberg M, Crouch J. Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J Pharmacol Exp Ther 264:438-447, 1993.
22. Korourian S, Hakkak R, Ronis MJJ, Shelnutt SR, Waldren J, Ingelman-Sundberg M, Badger TM. Diet and the risk of ethanol-induced hepatotoxicity: carbohydrate-fat relationships in rats. Toxicol Sci 47:110-117, 1999.
23. Ronis MJJ, Hakkak R, Korourian S, Albano E, Yoon S, Ingelman-Sundberg M, Lindros KO, Badger TM. Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate diets. Exp Biol Med 229:351-360, 2003.
24. Ronis MJJ, Korourian S, Yoon S, Ingelman-Sundberg M, Albano E, Lindros KO, Badger TM. Lack of sexual dimorphism in alcohol-induced liver damage (ALD) in rats treated chronically with ethanol-containing low carbohydrate diets: the role of ethanol metabolism and endotoxin. Life Sci 75:469-483, 2004.
25. Ronis MJJ, Butura A, Sampey BP, Shankar S, Prior RL, Korourian S, Albano E, Ingelman-Sundberg M, Petersen DR, Badger TM. Effects of N-acetlycysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radic Biol Med 39:619-630, 2005.
26. Badger TM, Hoog J-O, Svensson S, McGehee RE Jr, Ronis MJJ, Ingelman-Sundberg, M. Cyclic variation in class I alcohol dehydrogenase in male rats treated with ethanol. Biochem Biophys Res Commun 274:684-688, 2000.
27. Greenwell A, Foley JF, Maronpot RR. An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues. Cancer Lett 54:251-256, 1991.
28. Tsukamoto H, French SW, Reidelberger RD, Largman C. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcohol Clin Exp Res 9:31-37, 1985.
29. Badger TM, Crouch J, Irby D, Hakkak R, Shahare M. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the rat: continuous vs. cyclic ethanol and nutrient infusions. J Pharmacol Exp Ther 264:938-943, 1993.
30. Badger TM, Ronis MJJ, Ingelman-Sundberg M, Hakkak R. Inhibition of CYP 2E1 activity does not abolish pulsatile urine alcohol concentrations during alcohol infusions. Eur J Biochem 230:914-919, 1995.
31. Arteel GE. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124:779-790, 2003.
32. Lin HZ, Yang SG, Zeidin G, Diehl AM. Chronic ethanol consumption induces the production of tumor necrosis factor-α and related cytokines in liver and adipose tissue. Alcohol Clin Exp Res (5 Suppl.) 231S-237S, 1998.
33. Pritchard MT, Nagy LE. Ethanol-induced liver injury: potential role for Egr-1. Alcohol Clin Exp Res 29:146S-150S, 2005.
34. Thurman RG. Mechanisms of hepatic toxicity II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol Gastrointest Liver Physiol 275: G605-G611, 1998.
35. Minagawa M, Deng Q, Liu Z-X, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-α during alcohol consumption. Gastroenterology 126:1387-1399, 2004.
36. Batey RG, Cao Q, Gould B. Lymphocyte-mediated liver injury in alcohol-related hepatitis. Alcohol 27:37-41, 2002.
37. Roncarolo MG, Baccetta R, Bordignon C, Narula S, Levings MK. Type 1 regulatory T cells. Immunol Rev 182:68-79, 2001.
38. Laso FJ, Vaquero JM, Almeida J, Marcos M, Orfao A. Production of inflammatory cytokines by peripheral blood monocytes in chronic alcoholism: relationship with ethanol intake and liver disease. Cytometry B Clin Cytom 72:408-415, 2007.
39. Mottaran E, Stewart SF, Rolla R, Vay D, Cipriani V, Moretti M, Vidali M et al. Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. Free Radic Biol Med 32:38-45, 2002.
40. Kato A, Yoshidome H, Edwards MJ, Lentsch AB. Reduced hepatic ischemia/reperfusion injury by IL-4: a potential anti-inflammatory role for STAT6. Inflamm Res 2000; 49:275-279.
41. La Flamme AC, Patton EA, Bauman B, Pearce EJ. IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasis. J Immunol 166:1903-1911, 2001.
42. Tsukamoto H, Towner SJ, Ciofalo LM, French SW. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6:814-822, 1986.
43. Joshi-Barve S, Barve SS, Butt W, Klein J, McClain CJ. Inhibition of proteasome function leads to NF-κB-independent IL-8 expression in human hepatocytes. Hepatology 38:1178-1187, 2003.
44. Jerva LF, Sullivan G, Lolis E. Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes. Protein Sci 6:1643-1652, 1997.
45. Yamada Y, Fausto N. Deficient liver regeneration after carbon tetrachloride injury in mice lacking type I but not type 2 tumor necrosis factor receptor. Am J Pathol 152:1577-1589, 1998.
46. Baumgardner JN, Shankar K, Korourian S, Badger TM, Ronis MJJ. Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition. Am J Physiol 293:G355-G364, 2007.
47. Apte UM, McRee R, Ramaiah SK. Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver disease. Toxicol Pathol 32:567-576, 2004.
48. Apte UM, Limaye L, Ramaiah SK, Vaidya VS, Bucci TJ, Warbritton A, Mehandale HM. Upregulated promitogenic signalling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon hepatic challenge. Toxicol Sci 69:448-459, 2002.