IL-4 plays ,a crucial role in regulating oxidative damage in the liver during schistosomiasis

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1903-1911

  La Flamme, A C ^a   Patton, E A ^a   Bauman, B ^a   Pearce, E J ^a  

^a Animal Health Diagnostic Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 4; NITRIC OXIDE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; EXPERIMENTAL MODEL; GENE EXPRESSION; HOST RESISTANCE; LIVER CELL; LIVER DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

EID: 0035253583     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1903     Document Type: Article

References (62)

1. Immunity and morbidity in human schistosomiasis mansoni
2. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs
3. IL-4 protects against TNF-α-mediated cachexia and death during acute schistosomiasis
4. High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-γ but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni
5. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
6. Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth. Schistosoma mansoni
7. + Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage
8. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
9. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
10. Schistosoma mansoni in IL-4-deficient mice
11. Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
12. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
13. Schistosoma mansoni infections in T-cell deprived mice, and the ameliorating effect of administering homologous chronic infection serum. II. Pathology
14. Tumour necrosis factor alpha restores granulomas and induces parasite egg-laying in schistosome-infected SCID mice
15. Constructing polycompetitor cDNAs for quantitative PCR
16. Complete cDNA and 5′ genomic sequences and multilevel regulation of the mouse catalase gene
17. cDNA and deduced amino acid sequence of murine Cu-Zn superoxide dismutase
18. Sequence of a cDNA coding for mouse manganese superoxide dismutase
19. Eosinophils from schistosome-induced hepatic granulomas produce superoxide and hydroxyl radical
20. 15N]nitrate in biological fluids
21. Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes
22. Extracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-κB activation
23. Superoxide dismutase assays
24. 2 mixed-function oxidation system
25. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis
26. Beneficial effects of inducible nitric oxide synthase inhibitor on reperfusion injury in the pig liver
27. A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock
28. Nitric oxide suppresses human T lymphocyte proliferation through IFN-γ-dependent and IFN-γ-independent induction of apoptosis
29. Activation and regulation of the nitric oxide-cyclic GMP signal transduction pathway by oxidative stress
30. Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection
31. Inducible nitric oxide synthase in the liver: Regulation and function
32. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages
33. Involvement of interleukin-4 and -10 in inflammatory bowel disease
34. Suppression of superoxide anion production by interleukin-10 is accompanied by a downregulation of the genes for subunit proteins of NADPH oxidase
35. Interleukin-4 suppresses anti-fungal activity of human mononuclear phagocytes against Candida albicans in association with decreased uptake of blastoconidia
36. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis
37. Oxidative stress and antioxidant status in mouse liver: Effects of dietary lipid, vitamin E and iron
38. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice
39. Peroxynitrite and cell signaling
40. Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: Attenuation by L-ascorbic acid
41. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy
42. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
43. Immunohistochemical localization of nitric oxide synthase and the oxidant peroxynitrite in lung transplant recipients with obliterative bronchiolitis
44. 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation
45. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria: Prevention by antioxidant vitamins
46. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
47. Role of oxygen reactive species in Schistosoma mansoni egg-induced granulomatous inflammation
48. Physiologic oxygen tensions limit oxidant-mediated killing of schistosome eggs by inflammatory cells and isolated granulomas
49. Role of IL-4 and IFN-γ in Schistosoma mansoni egg-induced hypersensitivity granuloma formation: Orchestration, relative contribution, and relationship to macrophage function
50. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni
51. IL-10 exerts suppressive and enhancing effects on antifungal activity of mononuclear phagocytes against Asperigillus fumigatus
52. The multiplex function of nitric oxide in (auto)immunity
53. Nitric oxide (NO) protects against cellular damage by reactive oxygen species
54. Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoni
55. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
56. The murine interleukin-4 receptor: Molecular cloning and characterization of secreted and membrane bound forms
57. Up-regulation of glutathione S-transferases α by interleukin 4 in human hepatocytes in primary culture
58. Interleukin 4 inhibits the production of some acute-phase proteins by human hepatocytes in primary culture
59. Regulation by cytokines of extracellular superoxide dismutase and other superoxide dismutase isoenzymes in fibroblasts
60. Tumor necrosis factor alpha and interleukin-1β regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-β and NF-κB
61. A nitric oxide-releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of superoxide dismutases mRNA in the murine macrophage cell line RAW264-7