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Volumn 179, Issue 12, 2007, Pages 8519-8524

NLRP2, an inhibitor of the NF-κB pathway, is transcriptionally activated by NF-κB and exhibits a nonfunctional allelic variant

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; GENOMIC DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NLRP2 PROTEIN; NUCLEIC ACID BINDING PROTEIN; NUCLEOTIDE; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NLRP2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR RELA;

EID: 40049089542     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.12.8519     Document Type: Article
Times cited : (64)

References (38)
  • 1
    • 0031897632 scopus 로고    scopus 로고
    • NF-κ B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κ B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 2
    • 0036771830 scopus 로고    scopus 로고
    • The NF-κB signalling pathway in human diseases: From incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes
    • Smahi, A., G. Courtois, S. H. Rabia, R. Doffinger, C. Bodemer, A. Munnich, J. L. Casanova, and A. Israel. 2002. The NF-κB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes. Hum. Mol. Genet. 11: 2371-2375.
    • (2002) Hum. Mol. Genet , vol.11 , pp. 2371-2375
    • Smahi, A.1    Courtois, G.2    Rabia, S.H.3    Doffinger, R.4    Bodemer, C.5    Munnich, A.6    Casanova, J.L.7    Israel, A.8
  • 3
    • 0037108346 scopus 로고    scopus 로고
    • Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
    • Harton, J. A., M. W. Linhoff, J. Zhang, and J. P. Ting. 2002. Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J. Immunol. 169: 4088-4093.
    • (2002) J. Immunol , vol.169 , pp. 4088-4093
    • Harton, J.A.1    Linhoff, M.W.2    Zhang, J.3    Ting, J.P.4
  • 4
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
    • Ogura, Y., N. Inohara, A. Benito, F. F. Chen, S. Yamaoka, and G. Nunez. 2001. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem. 276: 4812-4818.
    • (2001) J. Biol. Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 5
    • 33344476398 scopus 로고    scopus 로고
    • CATERPILLERs, pyrin and hereditary immunological disorders
    • Ting, J. P., D. L. Kastner, and H. M. Hoffman. 2006. CATERPILLERs, pyrin and hereditary immunological disorders. Nat. Rev. Immunol. 6: 183-195.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 183-195
    • Ting, J.P.1    Kastner, D.L.2    Hoffman, H.M.3
  • 6
    • 10644258637 scopus 로고    scopus 로고
    • PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κB and caspase-1 activation in macrophages
    • Bruey, J. M., N. Bruey-Sedano, R. Newman, S. Chandler, C. Stehlik, and J. C. Reed. 2004. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-κB and caspase-1 activation in macrophages. J. Biol. Chem. 279: 51897-51907.
    • (2004) J. Biol. Chem , vol.279 , pp. 51897-51907
    • Bruey, J.M.1    Bruey-Sedano, N.2    Newman, R.3    Chandler, S.4    Stehlik, C.5    Reed, J.C.6
  • 7
    • 0346350694 scopus 로고    scopus 로고
    • Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-κB suppressive properties
    • O'Connor, W., Jr., J. A. Harton, X. Zhu, M. W. Linhoff, and J. P. Ting. 2003. Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-κB suppressive properties. J. Immunol. 171: 6329-6333.
    • (2003) J. Immunol , vol.171 , pp. 6329-6333
    • O'Connor Jr., W.1    Harton, J.A.2    Zhu, X.3    Linhoff, M.W.4    Ting, J.P.5
  • 8
    • 0037144586 scopus 로고    scopus 로고
    • A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β
    • Fiorentino, L., C. Stehlik, V. Oliveira, M. E. Ariza, A. Godzik, and J. C. Reed. 2002. A novel PAAD-containing protein that modulates NF-κB induction by cytokines tumor necrosis factor-α and interleukin-1β. J. Biol. Chem. 277: 35333-35340.
    • (2002) J. Biol. Chem , vol.277 , pp. 35333-35340
    • Fiorentino, L.1    Stehlik, C.2    Oliveira, V.3    Ariza, M.E.4    Godzik, A.5    Reed, J.C.6
  • 11
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    • Hoffman, H. M., J. L. Mueller, D. H. Broide, A. A. Wanderer, and R. D. Kolodner. 2001. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29: 301-305.
    • (2001) Nat. Genet , vol.29 , pp. 301-305
    • Hoffman, H.M.1    Mueller, J.L.2    Broide, D.H.3    Wanderer, A.A.4    Kolodner, R.D.5
  • 12
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini, L., F. Martinon, K. Burns, M. F. McDermott, P. N. Hawkins, and J. Tschopp. 2004. NALP3 forms an IL-1β-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20: 319-325.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 15
    • 20444442787 scopus 로고    scopus 로고
    • PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1β secretion
    • Kinoshita, T., Y. Wang, M. Hasegawa, R. Imamura, and T. Suda. 2005. PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1β secretion. J. Biol. Chem. 280: 21720-21725.
    • (2005) J. Biol. Chem , vol.280 , pp. 21720-21725
    • Kinoshita, T.1    Wang, Y.2    Hasegawa, M.3    Imamura, R.4    Suda, T.5
  • 16
    • 0031007772 scopus 로고    scopus 로고
    • The expression of Bcl-x is down-regulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage
    • Sanz, C., A. Benito, M. Silva, B. Albella, C. Richard, J. C. Segovia, A. Insunza, J. A. Bueren, and J. L. Fernandez-Luna. 1997. The expression of Bcl-x is down-regulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage. Blood 89: 3199-3204.
    • (1997) Blood , vol.89 , pp. 3199-3204
    • Sanz, C.1    Benito, A.2    Silva, M.3    Albella, B.4    Richard, C.5    Segovia, J.C.6    Insunza, A.7    Bueren, J.A.8    Fernandez-Luna, J.L.9
  • 17
    • 0037206950 scopus 로고    scopus 로고
    • Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells
    • Real, P. J., A. Sierra, A. De Juan, J. C. Segovia, J. M. Lopez-Vega, and J. L. Fernandez-Luna. 2002. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene 21: 7611-7618.
    • (2002) Oncogene , vol.21 , pp. 7611-7618
    • Real, P.J.1    Sierra, A.2    De Juan, A.3    Segovia, J.C.4    Lopez-Vega, J.M.5    Fernandez-Luna, J.L.6
  • 18
    • 33750054426 scopus 로고    scopus 로고
    • Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells
    • Real, P. J., C. Sanz, O. Gutierrez, C. Pipaon, A. M. Zubiaga, and J. L. Fernandez-Luna. 2006. Transcriptional activation of the proapoptotic bik gene by E2F proteins in cancer cells. FEBS Lett. 580: 5905-5909.
    • (2006) FEBS Lett , vol.580 , pp. 5905-5909
    • Real, P.J.1    Sanz, C.2    Gutierrez, O.3    Pipaon, C.4    Zubiaga, A.M.5    Fernandez-Luna, J.L.6
  • 19
    • 0035951792 scopus 로고    scopus 로고
    • Human nod1 confers responsiveness to bacterial lipopolysaccharides
    • Inohara, N., Y. Ogura, F. F. Chen, A. Muto, and G. Nunez. 2001. Human nod1 confers responsiveness to bacterial lipopolysaccharides. J. Biol. Chem. 276: 2551-2554.
    • (2001) J. Biol. Chem , vol.276 , pp. 2551-2554
    • Inohara, N.1    Ogura, Y.2    Chen, F.F.3    Muto, A.4    Nunez, G.5
  • 20
    • 0031906550 scopus 로고    scopus 로고
    • Signal transduction through NF-κB
    • May, M., and S. Ghosh. 1998. Signal transduction through NF-κB. Immunol. Today 19: 80-88.
    • (1998) Immunol. Today , vol.19 , pp. 80-88
    • May, M.1    Ghosh, S.2
  • 21
    • 0027168447 scopus 로고
    • NF-κB controls expression of inhibitor IκBα: Evidence for an inducible autoregulatory pathway
    • Sun, S. C., P. A. Ganchi, D. W. Ballard, and W. C. Greene. 1993. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259: 1912-1915.
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun, S.C.1    Ganchi, P.A.2    Ballard, D.W.3    Greene, W.C.4
  • 22
    • 0033135134 scopus 로고    scopus 로고
    • Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma
    • Sampath, D., M. Castro, D. C. Look, and M. J. Holtzman. 1999. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J. Clin. Invest. 103: 1353-1361.
    • (1999) J. Clin. Invest , vol.103 , pp. 1353-1361
    • Sampath, D.1    Castro, M.2    Look, D.C.3    Holtzman, M.J.4
  • 23
    • 0036510161 scopus 로고    scopus 로고
    • Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1
    • Karsunky, H., H. Zeng, T. Schmidt, B. Zevnik, R. Kluge, K. W. Schmid, U. Duhrsen, and T. Moroy. 2002. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat. Genet. 30: 295-300.
    • (2002) Nat. Genet , vol.30 , pp. 295-300
    • Karsunky, H.1    Zeng, H.2    Schmidt, T.3    Zevnik, B.4    Kluge, R.5    Schmid, K.W.6    Duhrsen, U.7    Moroy, T.8
  • 24
    • 0037312509 scopus 로고    scopus 로고
    • NALPs: A novel protein family involved in inflammation
    • Tschopp, J., F. Martinon, and K. Burns. 2003. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4: 95-104.
    • (2003) Nat. Rev. Mol. Cell Biol , vol.4 , pp. 95-104
    • Tschopp, J.1    Martinon, F.2    Burns, K.3
  • 25
    • 0242626505 scopus 로고    scopus 로고
    • Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2
    • Albrecht, M., F. S. Domingues, S. Schreiber, and T. Lengauer. 2003. Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2. FEBS Lett. 554: 520-528.
    • (2003) FEBS Lett , vol.554 , pp. 520-528
    • Albrecht, M.1    Domingues, F.S.2    Schreiber, S.3    Lengauer, T.4
  • 26
    • 19344374949 scopus 로고    scopus 로고
    • IκB kinase (IKK) β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    • Ruocco, M. G., S. Maeda, J. M. Park, T. Lawrence, L. C. Hsu, Y. Cao, G. Schett, E. F. Wagner, and M. Karin. 2005. IκB kinase (IKK) β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 201: 1677-1687.
    • (2005) J. Exp. Med , vol.201 , pp. 1677-1687
    • Ruocco, M.G.1    Maeda, S.2    Park, J.M.3    Lawrence, T.4    Hsu, L.C.5    Cao, Y.6    Schett, G.7    Wagner, E.F.8    Karin, M.9
  • 27
    • 0038644731 scopus 로고    scopus 로고
    • Differential STAT3, STAT5, and NF-κB activation in human hematopoietic progenitors by endogenous interleukin-15: Implications in the expression of functional molecules
    • Giron-Michel, J., A. Caignard, M. Fogli, D. Brouty-Boye, D. Briard, M. van Dijk, R. Meazza, S. Ferrini, C. Lebousse-Kerdiles, D. Clay, et al. 2003. Differential STAT3, STAT5, and NF-κB activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules. Blood 102: 109-117.
    • (2003) Blood , vol.102 , pp. 109-117
    • Giron-Michel, J.1    Caignard, A.2    Fogli, M.3    Brouty-Boye, D.4    Briard, D.5    van Dijk, M.6    Meazza, R.7    Ferrini, S.8    Lebousse-Kerdiles, C.9    Clay, D.10
  • 28
    • 0141780826 scopus 로고    scopus 로고
    • NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
    • Sitcheran, R., P. C. Cogswell, and A. S. Baldwin, Jr. 2003. NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. Genes Dev. 17: 2368-2373.
    • (2003) Genes Dev , vol.17 , pp. 2368-2373
    • Sitcheran, R.1    Cogswell, P.C.2    Baldwin Jr., A.S.3
  • 29
    • 0037883685 scopus 로고    scopus 로고
    • Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA
    • Giri, R. K., S. K. Selvaraj, and V. K. Kalra. 2003. Amyloid peptide-induced cytokine and chemokine expression in THP-1 monocytes is blocked by small inhibitory RNA duplexes for early growth response-1 messenger RNA. J. Immunol. 170: 5281-5294.
    • (2003) J. Immunol , vol.170 , pp. 5281-5294
    • Giri, R.K.1    Selvaraj, S.K.2    Kalra, V.K.3
  • 30
    • 24744443536 scopus 로고    scopus 로고
    • Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart
    • Chen, Y., and R. W. Currie. 2005. Heat shock treatment suppresses angiotensin II-induced SP-1 and AP-1 and stimulates Oct-1 DNA-binding activity in heart. Inflamm. Res. 54: 338-343.
    • (2005) Inflamm. Res , vol.54 , pp. 338-343
    • Chen, Y.1    Currie, R.W.2
  • 31
    • 0037053315 scopus 로고    scopus 로고
    • Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase
    • Shuto, T., A. Imasato, H. Jono, A. Sakai, H. Xu, T. Watanabe, D. Rixter, H. Kai, A. Andalibi, F. Linthicum, et al. 2002. Glucocorticoids synergistically enhance nontypeable Haemophilus influenzae-induced toll-like receptor 2 expression via a negative cross-talk with p38 MAP kinase. J. Biol. Chem. 277: 17263-17270.
    • (2002) J. Biol. Chem , vol.277 , pp. 17263-17270
    • Shuto, T.1    Imasato, A.2    Jono, H.3    Sakai, A.4    Xu, H.5    Watanabe, T.6    Rixter, D.7    Kai, H.8    Andalibi, A.9    Linthicum, F.10
  • 32
    • 33745465017 scopus 로고    scopus 로고
    • NOD2: Ethnic and geographic differences
    • Cavanaugh, J. 2006. NOD2: ethnic and geographic differences. World J. Gastroenterol. 12: 3673-3677.
    • (2006) World J. Gastroenterol , vol.12 , pp. 3673-3677
    • Cavanaugh, J.1
  • 33
    • 0036745064 scopus 로고    scopus 로고
    • Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis
    • Aganna, E., F. Martinon, P. N. Hawkins, J. B. Ross, D. C. Swan, D. R. Booth, H. J. Lachmann, A. Bybee, R. Gaudet, P. Woo, et al. 2002. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum. 46: 2445-2452.
    • (2002) Arthritis Rheum , vol.46 , pp. 2445-2452
    • Aganna, E.1    Martinon, F.2    Hawkins, P.N.3    Ross, J.B.4    Swan, D.C.5    Booth, D.R.6    Lachmann, H.J.7    Bybee, A.8    Gaudet, R.9    Woo, P.10
  • 35
    • 33750454819 scopus 로고    scopus 로고
    • Mutations in the NF-κB signaling pathway: Implications for human disease
    • Courtois, G., and T. D. Gilmore. 2006. Mutations in the NF-κB signaling pathway: implications for human disease. Oncogene 25: 6831-6843.
    • (2006) Oncogene , vol.25 , pp. 6831-6843
    • Courtois, G.1    Gilmore, T.D.2


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