The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage

Blood

Volumn 89, Issue 9, 1997, Pages 3199-3204

  Sanz, Cristina ^a   Benito, Adalberto ^a   Silva, Maite ^a   Albella, Beatriz ^a   Richard, Carlos ^b   Segovia, Jose Carlos ^b   Insunza, Andres ^b   Bueren, Juan Antonio ^a   Fernández Luna, Jose Luis ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b CIEMAT   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; STEM CELL FACTOR;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; GRANULOCYTE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MACROPHAGE ACTIVATION; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STEM CELL;

EID: 0031007772     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.9.3199     Document Type: Article

References (30)

1. Hockenbery DM, Zutter M, Hickey W, Nahm M, Korsmeyer SJ: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sei USA 88:6961, 1991
2. Delia D, Aiello A, Soligo D, Fontanella E, Melani C, Pezzella F, Pierotti MA, Delia Porta G: Bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood 79:1291, 1992
3. Benito A, Grillot D, Nunez G, Femandez-Luna JL: Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells. Am J Pathol 146:481, 1995
4. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB: Bcl-x, a Bcl-2related gene that functions as a dominant regulator of apoptotic cell death. Cell 74:597, 1993
5. Park JR, Bernstein ID, Hockenbery DM: Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood 86:868, 1995
6. Krajewski S, Krajewska M, Shabaik A, Wang H-G, Irie S, Fong L, Reed JC: Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Res 54:5501, 1994
7. Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K-I, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, Loh DY: Massive cell death of immature hematopoietic cells and neurons in Bcl-xdeficient mice. Science 267:1506, 1995
8. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ: Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys and hypopigmented hair. Cell 75:229, 1993
9. Lubbert M, Herrmann F, Koeffler HP: Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells. Blood 77:909, 1991
10. Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM: Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74:1563, 1989
11. Andrews RG, Singer JW, Bernstein ID: Human hematopoietic precursors in long term culture: Single CD34+ cells that lack detectable T cell, B cell, and myeloid antigens produce multiple colonyforming cells when cultured with marrow stromal cells. J Exp Med 172:355, 1990
12. Egeland T, Steen R, Quarsten H, Gaudemack G, Yang Y-C, Thorsby E: Myeloid differentiation of purified CD34+ cells after stimulation with recombinant human GM-CSF, G-CSF, M-CSF, and IL-3. Blood 78:3192, 1991
13. Lubbert M, Brugger W, Mertelsmann R, Kanz L: Developmental regulation of myeloid gene expression and demethylation during ex vivo culture of peripheral blood progenitor cells. Blood 87:447, 1996
14. L. Blood 87:3837, 1996
15. Brugger W, Mocklin.W, Heimfeld S, Berenson RJ, Mertelsmann R, Kantz L: Ex vivo expansion of enriched peripheral blood CD34+ progenitor cells by stem cell factor, interleukin-1β (IL-1β), IL-6 and IL-3, interferon-a, and erythropoietin. Blood 81:2579, 1993
16. Rapoport AP, Abboud CN, DiPersio JF: Granulocyte-macrophage colony-stimulating factor (G-CSF): Receptor biology, signal transduction, and neutrophil activation. Blood Rev 6:43, 1992
17. Metcalf D, Burgess AW: Clonal analysis of progenitor cell commitment of granulocyte or macrophage production. J Cell Physiol 111:275, 1982
18. Griffin JD, Linch D, Sabbath P, Larcom P, Schlossman SF: A monoclonal antibody reactive with normal and leukemic myeloid progenitor cells. Leuk Res 8:521, 1984
19. Liebermann D, Hoffman-Liebermann B: Genetic programs of myeloid cell differentiation. Curr Opin Hematol 1:24, 1994
20. Scheinecker C, Strobl H, Fritsch G, Csmarits B, Krieger O, Majdic O, Knapp W: Granulomonocyte-associated lysosomal protein expression during in vitro expansion and differentiation of CD34+ hematopoietic progenitor cells. Blood 86:4115, 1995
21. + cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines. Blood 82:2664, 1993
22. + cells into the myeloid lineage. Blood 80:1405, 1992
23. Berliner N, Hsing A, Granbert T, Sigurdsson F, Zain M, Bruno E, Huffman R: Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophilspecific gene expression. Blood 85:799, 1995
24. Nunez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ: Deregulated bcl-2 expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol 144:3602, 1990
25. Collins SJ: The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression. Blood 70:1233, 1987
26. Winzen R, Wallach D, Engelmann H, Nophar Y, Brakebusch C, Kemper O, Resch K, Holtmann H: Selective decrease in cell surface expression and mRNA level of the 55-kDa tumor necrosis factor receptor during differentiation of HL-60 cells into macrophage-like but not granulocyte-like cells. J Immunol 148:3454, 1992
27. Kizaki M, Ikeda Y, Tanosaki R, Nakajima H, Morikawa M, Sakashita A, Koeffler HP: Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-a and retinoid x receptor-α RNA by HL-60 cells. Blood 82:3592, 1993
28. L. J Biol Chem 271:6306, 1996
29. L and Bcl-2. Blood 88:1576, 1996
30. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76, 1990