Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study)

Biophysical Chemistry

Volumn 134, Issue 1-2, 2008, Pages 93-100

  Ibrahim, Bashar ^a,b   Dittrich, Peter ^a,b   Diekmann, Stephan ^c   Schmitt, Eberhard ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Jena Centre for Bioinformatics JCB   (Germany)

^c FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

Cdc20 sequestering; Exchange model; Kinetochore modeling; Mitotic control; p31comet inhibition; Template model

Indexed keywords

CELL CYCLE PROTEIN 20; PROTEIN MAD2;

ANAPHASE; ARTICLE; CENTROMERE; COMPLEX FORMATION; DYNAMICS; MATHEMATICAL MODEL; METAPHASE; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIMULATION;

ANAPHASE; CELL CYCLE PROTEINS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; KINETICS; METAPHASE; MITOSIS; MODELS, BIOLOGICAL; PROTEIN BINDING; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 39749168956     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2008.01.007     Document Type: Article

References (35)

1. Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8 (2007) 379-393
2. Kim M., and Kao G.D. Newly identified roles for an old guardian: profound deficiency of the mitotic spindle checkpoint protein BubR1 leads to early aging and infertility. Cancer Biol. Ther. 4 (2005) 164-165
3. Steuerwald N. Meiotic spindle checkpoints for assessment of aneuploid oocytes. Cytogenet. Genome Res. 111 (2005) 256-259
4. Compton D.A. Chromosomes walk the line. Nat. Cell Biol. 8 (2006) 308-310
5. Gupta A., Inaba S., Wong O.K., Fang G., and Liu J. Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1. Oncogene 22 (2003) 7593-7599
6. Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Curr. Opin. Cell Biol. 14 (2002) 706-714
7. Peters J.-M. The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9 (2002) 931-943
8. May K.M., and Hardwick K.G. The spindle checkpoint. J. Cell Sci. 119 (2006) 4139-4142
9. Yu H., and Tang Z. Bub1 multitasking in mitosis. Cell Cycle 4 (2005) 262-265
10. Chen R.H., Brady D.M., Smith D., Murray A.W., and Hardwick K.G. The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins. Mol. Biol. Cell 10 (1999) 2607-2618
11. Luo X., Tang Z., Xia G., Wassmann K., Matsumoto T., Rizo J., and Yu H. The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat. Struct. Mol. Biol. 11 (2004) 338-345
12. DeAntoni A., Pearson C.G., Cimini D., Canman J.C., Sala V., Nezi L., Mapelli M., Sironi L., Faretta M., Salmon E.D., and Musacchio A. The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint. Curr. Biol. 15 (2005) 214-225
13. Lenart P., and Peters J.-M. Checkpoint activation: do not get mad too much. Curr. Biol. 16 (2006) R412-R414
14. Hardwick K.G. Checkpoint signalling: Mad2 conformers and signal propagation. Curr. Biol. 15 (2005) R122-R124
15. DeAntoni A., Sala V., and Musacchio A. Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2. Philos. Trans. R. Soc. Lond., B Biol. Sci. 360 (2005) 637-648
16. Fang G. Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex. Mol. Biol. Cell 13 (2002) 755-766
17. Mapelli M., Filipp F.V., Rancati G., Massimiliano L., Nezi L., Stier G., Hagan R.S., Confalonieri S., Piatti S., Sattler M., and Musacchio A. Determinants of conformational dimerization of Mad2 and its inhibition by p31comet. EMBO J. 25 (2006) 1273-1284
18. Nezi L., Rancati G., DeAntoni A., Pasqualato S., Piatti S., and Musacchio A. Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae. J. Cell Biol. 174 (2006) 39-51
19. Vink M., Simonetta M., Transidico P., Ferrari K., Mapelli M., Antoni A.D., Massimiliano L., Ciliberto A., Faretta M., Salmon E.D., and Musacchio A. In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics. Curr. Biol. 16 (2006) 755-766
20. Ibrahim B., Dittrich P., Diekmann S., and Schmitt E. Stochastic effects in a compartmental model for mitotic checkpoint regulation. J. Integr. Bioinformatics 4 3 (2007) 66. http://journal.imbio.de/index.php?paper_id=66 Online Journal: http://journal.imbio.de/index.php?paper_id=66
21. Toth A., Queralt E., Uhlmann F., and Novak B. Mitotic exit in two dimensions. J. Theor. Biol. 248 (2007) 560-573
22. Queralt E., Lehane C., Novak B., and Uhlmann F. Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast. Cell 125 (2006) 719-732
23. Sironi L., Melixetian M., Faretta M., Prosperini E., Helin K., and Musacchio A. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint. EMBO J. 20 (2001) 6371-6382
24. Luo X., Tang Z., Rizo J., and Yu H. The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol. Cell 9 (2002) 59-71
25. Campbell M.S., Chan G.K., and Yen T.J. Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J. Cell Sci. 114 (2001) 953-963
26. Lampson M.A., and Kapoor T.M. The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments. Nat. Cell Biol. 7 (2005) 93-98
27. Habu T., Kim S.H., Weinstein J., and Matsumoto T. Identification of a MAD2-binding protein, CMT2, and its role in mitosis. EMBO J. 21 (2002) 6419-6428
28. Xia G., Luo X., Habu T., Rizo J., Matsumoto T., and Yu H. Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J. 23 (2004) 3133-3143
29. Sudakin V., Chan G.K., and Yen T.J. Checkpoint inhibition of the APC/C in heLa cells is mediated by a complex of BubR1, Bub3, Cdc20, and Mad2. J. Cell Biol. 154 (2001) 925-936
30. Tang Z., Bharadwaj R., Li B., and Yu H. Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. Dev. Cell 1 (2001) 227-237
31. Yu H. Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 Template model. J. Cell Biol. 173 (2006) 153-157
32. Doncic A., Ben-Jacob E., and Barkai N. Evaluating putative mechanisms of the mitotic spindle checkpoint. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6332-6337
33. Sear R.P., and Howard M. Modeling dual pathways for the metazoan spindle assembly checkpoint. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 16758-16763
34. Howell B.J., Hoffman D.B., Fang G., Murray A.W., and Salmon E.D. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J. Cell Biol. 150 (2000) 1233-1250
35. Hansen N., Muller S.D., and Koumoutsakos P. Reducing the time complexity of the derandomized evolution strategy with covariance matrix adaptation (CMA-ES). Evol. Comput. 11 (2003) 1-18