Metal imbalance and compromised antioxidant function are early changes in prion disease

Biochemical Journal

Volumn 362, Issue 1, 2002, Pages 253-258

  Thackray, Alana M ^a   Knight, Robert ^a   Haswell, Stephen J ^a   Bujdoso, Raymond ^a   Brown, David R ^a  

^a University of Bath   (United Kingdom)

Author keywords

Copper; Manganese; Neurodegeneration; Scrapie; Superoxide

Indexed keywords

ANTIOXIDANTS; BRAIN; CHEMICAL BONDS; COPPER; DISEASES; MANGANESE; METABOLISM; PATHOLOGY; PROTEINS; TRACE ELEMENTS;

METAL IMBALANCE;

BIOCHEMISTRY;

COPPER; MANGANESE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; FEMALE; MALE; METAL BINDING; MOUSE; NONHUMAN; PATHOGENESIS; PRION DISEASE; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; BRAIN; COPPER; ENDOPEPTIDASE K; FEMALE; MALE; MANGANESE; MICE; MICE, INBRED C57BL; PRION DISEASES; PRIONS; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0037083888     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3620253     Document Type: Article

References (22)

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21. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
22. Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie