Disruption of PDGFRα-initiated PI3K activation and migration of somite derivatives leads to spina bifida

Development

Volumn 135, Issue 3, 2008, Pages 589-598

  Pickett, Elizabeth A ^a   Olsen, Gregory S ^a   Tallquist, Michelle D ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cell migration; Chick; Mouse; PAK1; PDGF; PI3 kinase; S6K1; Spina bifida

Indexed keywords

IMATINIB; MUTANT PROTEIN; P21 ACTIVATED KINASE 1; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOSERINE; PIPERAZINE DERIVATIVE; PROTEIN KINASE B; PYRIMIDINE DERIVATIVE; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIRTH DEFECT; BONE DEVELOPMENT; CARTILAGE CELL; CELL MIGRATION; CONTROLLED STUDY; DERMATOME; DISEASE COURSE; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; MESENCHYME CELL; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN LOCALIZATION; SCLEROTOME; SIGNAL TRANSDUCTION; SOMITE; SPINA BIFIDA; TISSUE SPECIFICITY; ANIMAL; CARTILAGE; CELL MOTION; CHICKEN; CHONDROGENESIS; CONGENITAL MALFORMATION; DRUG EFFECT; EMBRYO (ANATOMY); ENZYMOLOGY; GENETICS; MESODERM; METABOLISM; MUTATION; PATHOLOGY; SPINAL DYSRAPHISM; SPINE;

MUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARTILAGE; CELL MOVEMENT; CHICKENS; CHONDROGENESIS; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MESODERM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; PHENOTYPE; PHOSPHOSERINE; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RAS PROTEINS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SIGNAL TRANSDUCTION; SOMITES; SPINAL DYSRAPHISM; SPINE;

EID: 39749148788     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.013763     Document Type: Article

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