Endurance training and obesity: Effect on substrate metabolism and insulin sensitivity

Medicine and Science in Sports and Exercise

Volumn 40, Issue 3, 2008, Pages 495-502

  Venables, Michelle C ^a   Jeukendrup, Asker E ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Exercise intensity; Fat oxidation; Glucose tolerance; Insulin signaling

Indexed keywords

CARBOHYDRATE; FAT; PROTEIN;

ADULT; ANALYSIS OF VARIANCE; ANTHROPOMETRY; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; DISEASE ASSOCIATION; ENDURANCE; ENZYME METABOLISM; EXERCISE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; OBESITY; SITTING; STATISTICAL SIGNIFICANCE; STEADY STATE; TRAINING; WAIST HIP RATIO;

ADIPOSE TISSUE; ADULT; BODY COMPOSITION; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 2; DIET; ENERGY METABOLISM; EXERCISE THERAPY; GREAT BRITAIN; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; OXYGEN CONSUMPTION; PHYSICAL ENDURANCE;

EID: 39749099343     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e31815f256f     Document Type: Article

References (48)

1. Achten J, Gleeson M, Jeukendrup AE. Determination of the exercise intensity that elicits maximal fat oxidation. Med Sci Sports Exerc. 2002;34(1):92-7.
2. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription, 6th ed. Philadelphia (PA): Lippincott Williams and Wilkins; 2000.
3. Belfort R, Mandarino L, Kashyap S, et al. Dose-response effect of elevated plasma free fatty acid on insulin signaling. Diabetes. 2005;54:1640-8.
4. Bergman BC, Brooks GA. Respiratory gas-exchange ratios during graded exercise in fed and fasted trained and untrained men. J Appl Physiol. 1999;86:479-87.
5. Bezaire V, Bruce CR, Heigenhauser GJ, et al. Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation. Am J Physiol Endocrinol Metab. 2006;290:E509-15.
6. Boden G, Lebed B, Schatz M, Homko C, Lemieux S. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes. 2001;50:1612-7.
7. Bonen A, Ball-Burnett M, Russel C. Glucose tolerance is improved after low- and high-intensity exercise in middle-age men and women. Can J Appl Physiol. 1998;23:583-93.
8. Borghouts LB, Backx K, Mensink MF, Keizer HA. Effect of training intensity on insulin sensitivity as evaluated by insulin tolerance test. Eur J Appl Physiol Occup Physiol. 1999;80:461-6.
9. Bruce CR, Thrush AB, Mertz VA, et al. Endurance training in obese humans improves glucose tolerance, mitochondrial fatty acid oxidation and alters muscle lipid content. Am J Physiol Endocrinol Metab. 2006;291:E99-107.
10. Burgomaster KA, Cermak NM, Phillips SM, Benton CR, Bonen A, Gibala MJ. Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. Am J Physiol Regul Integr Comp Physiol. 2007;292:R1970-6.
11. Colberg SR, Simoneau JA, Thaete FL, Kelley DE. Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest. 1995;95:1846-53.
12. Crampes F, Marion-Latard F, Zakaroff-Girard A, et al. Effects of a longitudinal training program on responses to exercise in overweight men. Obes Res. 2003;11:247-56.
13. Durnin JV, Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974;32:77-97.
14. Gollnick PD, Saltin B. Significance of skeletal muscle oxidative enzyme enhancement with endurance training. Clin Physiol. 1982;2:1-12.
15. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes. 1999;48:839-47.
16. Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism. 2000;49:467-72.
17. Gulve EA, Spina RJ. Effect of 7-10 days of cycle ergometer exercise on skeletal muscle GLUT-4 protein content. J Appl Physiol. 1995;79:1562-6.
18. Houmard JA, Tanner CJ, Slentz CA, Duscha BD, McCartney JS, Kraus WE. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol. 2004;96:101-6.
19. Hulver MW, Berggren JR, Cortright RN, et al. Skeletal muscle lipid metabolism with obesity. Am J Physiol Endocrinol Metab. 2003;284:E741-7.
20. Jeukendrup AE, Wallis GA. Measurement of substrate oxidation during exercise by means of gas exchange measurements. Int J Sports Med. 2005;26(Suppl. 1):S28-37.
21. Jong-Yeon K, Hickner RC, Dohm GL, Houmard JA. Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle. Metabolism. 2002;51:460-4.
22. Kang J, Robertson RJ, Hagberg JM, et al. Effect of exercise intensity on glucose and insulin metabolism in obese individuals and obese NIDDM patients. Diabetes Care. 1996;19:341-9.
23. Kelley DE, Goodpaster B, Wing RR, Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol. 1999;277:E1130-41.
24. Kim JK, Gimeno RE, Higashimori T, et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest. 2004;113:756-63.
25. Kim JY, Hickner RC, Cortright RL, Dohm GL, Houmard JA. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab. 2000;279:E1039-44.
26. Kraegen EW, Saha AK, Preston E, et al. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab. 2006;290:E471-9.
27. Larsen JJ, Dela F, Madsbad S, Galbo H. The effect of intense exercise on postprandial glucose homeostasis in type II diabetic patients. Diabetologia. 1999;42:1282-92.
28. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22:1462-70.
29. Oshida Y, Yamanouchi K, Hayamizu S, Sato Y. Long-term mild jogging increases insulin action despite no influence on body mass index or VO2 max. J Appl Physiol. 1989;66:2206-10.
30. Pan DA, Lillioja S, Kriketos AD, et al. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes. 1997;46:983-8.
31. Perseghin G, Price TB, Petersen KF, et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med. 1996;335:1357-62.
32. Perseghin G, Scifo P, De Cobelli F, et al. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 1999;48:1600-6.
33. Phillips DI, Caddy S, Ilic V, et al. Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism. 1996;45:947-50.
34. Ranneries C, Bulow J, Buemann B, Christensen NJ, Madsen J, Astrup A. Fat metabolism in formerly obese women. Am J Physiol. 1998;274:E155-61.
35. Romijn JA, Coyle EF, Sidossis LS, et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J Physiol. 1993;265:E380-91.
36. Santomauro AT, Boden G, Silva ME, et al. Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects. Diabetes. 1999;48:1836-41.
37. Schenk S, Horowitz JF. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab. 2006;291:E254-60.
38. Schrauwen P, van Aggel-Leijssen DP, Hul G, et al. The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression. Diabetes. 2002;51:2220-6.
39. Seals DR, Hagberg JM, Hurley BF, Ehsani AA, Holloszy JO. Effects of endurance training on glucose tolerance and plasma lipid levels in older men and women. JAMA. 1984;252:645-9.
40. Segal KR, Edano A, Abalos A, et al. Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men. J Appl Physiol. 1991;71:2402-11.
41. Sidossis LS, Gastaldelli A, Klein S, Wolfe RR. Regulation of plasma fatty acid oxidation during low- and high-intensity exercise. Am J Physiol. 1997;272:E1065-70.
42. Simoneau JA, Colberg SR, Thaete FL, Kelley DE. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. FASEB J. 1995;9:273-8.
43. Starritt EC, Howlett RA, Heigenhauser GJ, Spriet LL. Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle. Am J Physiol Endocrinol Metab. 2000;278:E462-8.
44. Talanian JL, Galloway SD, Heigenhauser GJ, Bonen A, Spriet LL. Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women. J Appl Physiol. 2007;102:1439-47.
45. van Aggel-Leijssen DP, Saris WH, Wagenmakers AJ, Hul GB, van Baak MA. The effect of low-intensity exercise training on fat metabolism of obese women. Obes Res. 2001;9:86-96.
46. van Aggel-Leijssen DP, Saris WH, Wagenmakers AJ, Senden JM, van Baak MA. Effect of exercise training at different intensities on fat metabolism of obese men. J Appl Physiol. 2002;92:1300-9.
47. Venables MC, Achten J, Jeukendrup AE. Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Physiol. 2005;98:160-7.
48. Yu C, Chen Y, Cline GW, et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)- associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem. 2002;277:50230-6.