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Volumn 82, Issue 5, 2008, Pages 2418-2426

CCR5Δ32 59537-G/A promoter polymorphism is associated with low translational efficiency and the loss of CCR5Δ32 protective effects

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; MESSENGER RNA;

EID: 39749084581     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01596-07     Document Type: Article
Times cited : (21)

References (42)
  • 1
    • 34547123541 scopus 로고    scopus 로고
    • CCR5Δ32 protein expression and stability are critical for resistance to HIV-1 in vivo
    • Agrawal, L., Q. Jin, J. Altenburg, L. Meyer, R. Tubiana, I. Theodorou, and G. Alkhatib. 2007. CCR5Δ32 protein expression and stability are critical for resistance to HIV-1 in vivo. J. Virol. 81:8041-8049.
    • (2007) J. Virol , vol.81 , pp. 8041-8049
    • Agrawal, L.1    Jin, Q.2    Altenburg, J.3    Meyer, L.4    Tubiana, R.5    Theodorou, I.6    Alkhatib, G.7
  • 3
    • 0029984987 scopus 로고    scopus 로고
    • Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages
    • Alkhatib, G., C. C. Broder, and E. A. Berger. 1996. Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J. Virol. 70:5487-5494.
    • (1996) J. Virol , vol.70 , pp. 5487-5494
    • Alkhatib, G.1    Broder, C.C.2    Berger, E.A.3
  • 4
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3    Feng, Y.4    Kennedy, P.E.5    Murphy, P.M.6    Berger, E.A.7
  • 6
    • 0030712312 scopus 로고    scopus 로고
    • Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32
    • Benkirane, M., D. Y. Jin, R. F. Chun, R. A. Koup, and K. T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32. J. Biol. Chem. 272:30603-30606.
    • (1997) J. Biol. Chem , vol.272 , pp. 30603-30606
    • Benkirane, M.1    Jin, D.Y.2    Chun, R.F.3    Koup, R.A.4    Jeang, K.T.5
  • 7
    • 0031051739 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for the CCR5 deletion allele
    • Biti, R., R. Ffrench, J. Young, B. Bennetts, G. Stewart, and T. Liang. 1997. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat. Med. 3:252-253.
    • (1997) Nat. Med , vol.3 , pp. 252-253
    • Biti, R.1    Ffrench, R.2    Young, J.3    Bennetts, B.4    Stewart, G.5    Liang, T.6
  • 8
    • 0030444052 scopus 로고    scopus 로고
    • Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung
    • Braciak, T. A., K. Bacon, Z. Xing, D. J. Torry, F. L. Graham, T. J. Schall, C. D. Richards, K. Croitoru, and J. Gauldie. 1996. Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung. J. Immunol. 157:5076-5084.
    • (1996) J. Immunol , vol.157 , pp. 5076-5084
    • Braciak, T.A.1    Bacon, K.2    Xing, Z.3    Torry, D.J.4    Graham, F.L.5    Schall, T.J.6    Richards, C.D.7    Croitoru, K.8    Gauldie, J.9
  • 9
    • 0035861556 scopus 로고    scopus 로고
    • Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor
    • Chelli, M., and M. Alizon. 2001. Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor. J. Biol. Chem. 276:46975-46982.
    • (2001) J. Biol. Chem , vol.276 , pp. 46975-46982
    • Chelli, M.1    Alizon, M.2
  • 12
    • 39749139640 scopus 로고    scopus 로고
    • (Comment, Science 273:1797-1798; erratum, Science 274:1069.)
    • (Comment, Science 273:1797-1798; erratum, Science 274:1069.)
  • 14
    • 39749090655 scopus 로고    scopus 로고
    • (Comment, Nature 381:647-648.)
    • (Comment, Nature 381:647-648.)
  • 15
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3    Smyth, R.J.4    Samson, M.5    Peiper, S.C.6    Parmentier, M.7    Collman, R.G.8    Doms, R.W.9
  • 19
    • 0031963655 scopus 로고    scopus 로고
    • Gene organization and promoter function for CC chemokine receptor 5 (CCR5)
    • Guignard, F., C. Combadiere, H. L. Tiffany, and P. M. Murphy. 1998. Gene organization and promoter function for CC chemokine receptor 5 (CCR5). J. Immunol. 160:985-992.
    • (1998) J. Immunol , vol.160 , pp. 985-992
    • Guignard, F.1    Combadiere, C.2    Tiffany, H.L.3    Murphy, P.M.4
  • 20
    • 24644465001 scopus 로고    scopus 로고
    • Combined effect of CCR5-Δ32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission
    • Hladik, F., H. Liu, E. Speelmon, D. Livingston-Rosanoff, S. Wilson, P. Sakchalathorn, Y. Hwangbo, B. Greene, T. Zhu, and M. J. McElrath. 2005. Combined effect of CCR5-Δ32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J. Virol. 79:11677-11684.
    • (2005) J. Virol , vol.79 , pp. 11677-11684
    • Hladik, F.1    Liu, H.2    Speelmon, E.3    Livingston-Rosanoff, D.4    Wilson, S.5    Sakchalathorn, P.6    Hwangbo, Y.7    Greene, B.8    Zhu, T.9    McElrath, M.J.10
  • 22
    • 0036021444 scopus 로고    scopus 로고
    • Emerging links between initiation of translation and human diseases
    • Kozak, M. 2002. Emerging links between initiation of translation and human diseases. Mamm. Genome 13:401-410.
    • (2002) Mamm. Genome , vol.13 , pp. 401-410
    • Kozak, M.1
  • 23
    • 0030213227 scopus 로고    scopus 로고
    • Interpreting cDNA sequences: Some insights from studies on translation
    • Kozak, M. 1996. Interpreting cDNA sequences: some insights from studies on translation. Mamm. Genome 7:563-574.
    • (1996) Mamm. Genome , vol.7 , pp. 563-574
    • Kozak, M.1
  • 24
    • 0032968822 scopus 로고    scopus 로고
    • An HIV-1-infected individual homozygous for the CCR-5 delta32 allele and the SDF-1 3′ A allele
    • Kuipers, H., C. Workman, W. Dyer, A. Geczy, J. Sullivan, and R. Oelrichs. 1999. An HIV-1-infected individual homozygous for the CCR-5 delta32 allele and the SDF-1 3′ A allele. AIDS 13:433-434.
    • (1999) AIDS , vol.13 , pp. 433-434
    • Kuipers, H.1    Workman, C.2    Dyer, W.3    Geczy, A.4    Sullivan, J.5    Oelrichs, R.6
  • 32
    • 0030679633 scopus 로고    scopus 로고
    • The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons
    • Mummidi, S., S. S. Ahuja, B. L. McDaniel, and S. K. Ahuja. 1997. The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5′-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons. J. Biol. Chem. 272:30662-30671.
    • (1997) J. Biol. Chem , vol.272 , pp. 30662-30671
    • Mummidi, S.1    Ahuja, S.S.2    McDaniel, B.L.3    Ahuja, S.K.4
  • 33
    • 0036121120 scopus 로고    scopus 로고
    • A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4
    • Naif, H. M., A. L. Cunningham, M. Alali, S. Li, N. Nasr, M. M. Buhler, D. Schols, E. de Clercq, and G. Stewart. 2002. A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4. J. Virol. 76:3114-3124.
    • (2002) J. Virol , vol.76 , pp. 3114-3124
    • Naif, H.M.1    Cunningham, A.L.2    Alali, M.3    Li, S.4    Nasr, N.5    Buhler, M.M.6    Schols, D.7    de Clercq, E.8    Stewart, G.9
  • 34
    • 0033647217 scopus 로고    scopus 로고
    • The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
    • O'Brien, S. J., and J. P. Moore. 2000. The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol. Rev. 177:99-111.
    • (2000) Immunol. Rev , vol.177 , pp. 99-111
    • O'Brien, S.J.1    Moore, J.P.2
  • 36
    • 39749103673 scopus 로고    scopus 로고
    • Comment, Lancet 350:742
    • (Comment, Lancet 350:742.)
  • 38
    • 0035958521 scopus 로고    scopus 로고
    • A somatic mutation in the 5′UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency
    • Signori, E., C. Bagni, S. Papa, B. Primerano, M. Rinaldi, F. Amaldi, and V. M. Fazio. 2001. A somatic mutation in the 5′UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency. Oncogene 20:4596-4600.
    • (2001) Oncogene , vol.20 , pp. 4596-4600
    • Signori, E.1    Bagni, C.2    Papa, S.3    Primerano, B.4    Rinaldi, M.5    Amaldi, F.6    Fazio, V.M.7
  • 39
    • 0030976601 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for CCR5 delta 32
    • Theodorou, I., L. Meyer, M. Magierowska, C. Katlama, C. Rouzioux, et al. 1997. HIV-1 infection in an individual homozygous for CCR5 delta 32. Lancet 349:1219-1220.
    • (1997) Lancet , vol.349 , pp. 1219-1220
    • Theodorou, I.1    Meyer, L.2    Magierowska, M.3    Katlama, C.4    Rouzioux, C.5
  • 40
    • 39749145265 scopus 로고    scopus 로고
    • Comment, Lancet 350:742
    • (Comment, Lancet 350:742.)
  • 41
    • 34547120215 scopus 로고    scopus 로고
    • Reduced cell surface expression of CCR5 in CCR5{DELTA}32 heterozygotes is mediated by gene dosage, not by receptor sequestration
    • Venkatesan, S., A. Petrovic, D. I. Van Ryk, M. Locati, D. Weissman, and P. M. Murphy. 2001. Reduced cell surface expression of CCR5 in CCR5{DELTA}32 heterozygotes is mediated by gene dosage, not by receptor sequestration. J. Biol. Chem. 16:16.
    • (2001) J. Biol. Chem , vol.16 , pp. 16
    • Venkatesan, S.1    Petrovic, A.2    Van Ryk, D.I.3    Locati, M.4    Weissman, D.5    Murphy, P.M.6
  • 42
    • 8244227329 scopus 로고    scopus 로고
    • Zimmerman, P. A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam, M. Vaccarezza, P. E. Kennedy, V. Kumaraswami, J. V. Giorgi, R. Detels, J. Hunter, M. Chopek, E. A. Berger, A. S. Fauci, T. B. Nutman, and P. M. Murphy. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:23-36.
    • Zimmerman, P. A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam, M. Vaccarezza, P. E. Kennedy, V. Kumaraswami, J. V. Giorgi, R. Detels, J. Hunter, M. Chopek, E. A. Berger, A. S. Fauci, T. B. Nutman, and P. M. Murphy. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:23-36.


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