메뉴 건너뛰기




Volumn 81, Issue 15, 2007, Pages 8041-8049

CCR5Δ32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CCR5; VIRUS ENVELOPE PROTEIN;

EID: 34547123541     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00068-07     Document Type: Article
Times cited : (20)

References (40)
  • 1
    • 33744765246 scopus 로고    scopus 로고
    • Anti-HIV therapy: Current and future directions
    • Agrawal, L., X. Lu, Q. Jin, and G. Alkhatib. 2006. Anti-HIV therapy: current and future directions. Curr. Pharm. Des. 12:2031-2055.
    • (2006) Curr. Pharm. Des , vol.12 , pp. 2031-2055
    • Agrawal, L.1    Lu, X.2    Jin, Q.3    Alkhatib, G.4
  • 3
    • 0029984987 scopus 로고    scopus 로고
    • Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages
    • Alkhatib, G., C. C. Broder, and E. A. Berger. 1996. Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J. Virol. 70:5487-5494.
    • (1996) J. Virol , vol.70 , pp. 5487-5494
    • Alkhatib, G.1    Broder, C.C.2    Berger, E.A.3
  • 4
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958.
    • (1996) Science , vol.272 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3    Feng, Y.4    Kennedy, P.E.5    Murphy, P.M.6    Berger, E.A.7
  • 5
    • 0030749666 scopus 로고    scopus 로고
    • HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: Independence from G protein signaling and importance of coreceptor downmodulation
    • Alkhatib, G., M. Locati, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1997. HIV-1 coreceptor activity of CCR5 and its inhibition by chemokines: independence from G protein signaling and importance of coreceptor downmodulation. Virology 234:340-348.
    • (1997) Virology , vol.234 , pp. 340-348
    • Alkhatib, G.1    Locati, M.2    Kennedy, P.E.3    Murphy, P.M.4    Berger, E.A.5
  • 7
    • 0030712312 scopus 로고    scopus 로고
    • Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32
    • Benkirane, M., D. Y. Jin, R. F. Chun, R. A. Koup, and K. T. Jeang. 1997. Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32. J. Biol. Chem. 272:30603-30606.
    • (1997) J. Biol. Chem , vol.272 , pp. 30603-30606
    • Benkirane, M.1    Jin, D.Y.2    Chun, R.F.3    Koup, R.A.4    Jeang, K.T.5
  • 9
    • 0031051739 scopus 로고    scopus 로고
    • HIV-1 infection in an individual homozygous for the CCR5 deletion allele
    • Biti, R., R. Ffrench, J. Young, B. Bennetts, G. Stewart, and T. Liang. 1997. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nat. Med. 3:252-253.
    • (1997) Nat. Med , vol.3 , pp. 252-253
    • Biti, R.1    Ffrench, R.2    Young, J.3    Bennetts, B.4    Stewart, G.5    Liang, T.6
  • 11
    • 0030444052 scopus 로고    scopus 로고
    • Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung
    • Braciak, T. A., K. Bacon, Z. Xing, D. J. Torry, F. L. Graham, T. J. Schall, C. D. Richards, K. Croitoru, and J. Gauldie. 1996. Overexpression of RANTES using a recombinant adenovirus vector induces the tissue-directed recruitment of monocytes to the lung. J. Immunol. 157:5076-5084.
    • (1996) J. Immunol , vol.157 , pp. 5076-5084
    • Braciak, T.A.1    Bacon, K.2    Xing, Z.3    Torry, D.J.4    Graham, F.L.5    Schall, T.J.6    Richards, C.D.7    Croitoru, K.8    Gauldie, J.9
  • 12
    • 0035861556 scopus 로고    scopus 로고
    • Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor
    • Chelli, M., and M. Alizon. 2001. Determinants of the trans-dominant negative effect of truncated forms of the CCR5 chemokine receptor. J. Biol. Chem. 276:46975-46982.
    • (2001) J. Biol. Chem , vol.276 , pp. 46975-46982
    • Chelli, M.1    Alizon, M.2
  • 13
    • 0034065231 scopus 로고    scopus 로고
    • Selective HIV-1-induced downmodulation of CD4 and coreceptors
    • Chenine, A. L., Q. Sattentau, and M. Moulard. 2000. Selective HIV-1-induced downmodulation of CD4 and coreceptors. Arch. Virol. 145:455-471.
    • (2000) Arch. Virol , vol.145 , pp. 455-471
    • Chenine, A.L.1    Sattentau, Q.2    Moulard, M.3
  • 16
    • 0001633495 scopus 로고    scopus 로고
    • Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, S. J. O'Brien, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862. (Erratum, 274:1069.)
    • Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, S. J. O'Brien, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862. (Erratum, 274:1069.)
  • 18
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149-1158.
    • (1996) Cell , vol.85 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3    Smyth, R.J.4    Samson, M.5    Peiper, S.C.6    Parmentier, M.7    Collman, R.G.8    Doms, R.W.9
  • 20
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
    • (1996) Science , vol.272 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 21
    • 0037341625 scopus 로고    scopus 로고
    • Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein
    • Gibellini, D., M. C. Re, F. Vitone, N. Rizzo, C. Maldini, M. La Placa, and G. Zauli. 2003. Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein. Clin. Exp. Immunol. 131:428-435.
    • (2003) Clin. Exp. Immunol , vol.131 , pp. 428-435
    • Gibellini, D.1    Re, M.C.2    Vitone, F.3    Rizzo, N.4    Maldini, C.5    La Placa, M.6    Zauli, G.7
  • 25
    • 24644465001 scopus 로고    scopus 로고
    • Combined effect of CCR5-Δ32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission
    • Hladik, F., H. Liu, E. Speelmon, D. Livingston-Rosanoff, S. Wilson, P. Sakchalathorn, Y. Hwangbo, B. Greene, T. Zhu, and M. J. McElrath. 2005. Combined effect of CCR5-Δ32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. J. Virol. 79:11677-11684.
    • (2005) J. Virol , vol.79 , pp. 11677-11684
    • Hladik, F.1    Liu, H.2    Speelmon, E.3    Livingston-Rosanoff, D.4    Wilson, S.5    Sakchalathorn, P.6    Hwangbo, Y.7    Greene, B.8    Zhu, T.9    McElrath, M.J.10
  • 26
    • 0028293288 scopus 로고
    • Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1
    • Kabat, D., S. L. Kozak, K. Wehrly, and B. Chesebro. 1994. Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1. J. Virol. 68:2570-2577.
    • (1994) J. Virol , vol.68 , pp. 2570-2577
    • Kabat, D.1    Kozak, S.L.2    Wehrly, K.3    Chesebro, B.4
  • 27
    • 0031031452 scopus 로고    scopus 로고
    • CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1
    • Kozak, S. L., E. J. Platt, N. Madani, F. E. Ferro, Jr., K. Peden, and D. Kabat. 1997. CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1. J. Virol. 71:873-882.
    • (1997) J. Virol , vol.71 , pp. 873-882
    • Kozak, S.L.1    Platt, E.J.2    Madani, N.3    Ferro Jr., F.E.4    Peden, K.5    Kabat, D.6
  • 28
    • 0033941573 scopus 로고    scopus 로고
    • Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1
    • Kuhmann, S. E., E. J. Platt, S. L. Kozak, and D. Kabat. 2000. Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1. J. Virol. 74:7005-7015.
    • (2000) J. Virol , vol.74 , pp. 7005-7015
    • Kuhmann, S.E.1    Platt, E.J.2    Kozak, S.L.3    Kabat, D.4
  • 29
    • 0032968822 scopus 로고    scopus 로고
    • An HIV-1-infected individual homozygous for the CCR-5 Δ32 allele and the SDF-1 3′A allele
    • Kuipers, H., C. Workman, W. Dyer, A. Geczy, J. Sullivan, and R. Oelrichs. 1999. An HIV-1-infected individual homozygous for the CCR-5 Δ32 allele and the SDF-1 3′A allele. AIDS 13:433-434.
    • (1999) AIDS , vol.13 , pp. 433-434
    • Kuipers, H.1    Workman, C.2    Dyer, W.3    Geczy, A.4    Sullivan, J.5    Oelrichs, R.6
  • 33
    • 0036121120 scopus 로고    scopus 로고
    • A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4
    • Naif, H. M., A. L. Cunningham, M. Alali, S. Li, N. Nasr, M. M. Buhler, D. Schols, E. de Clercq, and G. Stewart. 2002. A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Δ32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4. J. Virol. 76:3114-3124.
    • (2002) J. Virol , vol.76 , pp. 3114-3124
    • Naif, H.M.1    Cunningham, A.L.2    Alali, M.3    Li, S.4    Nasr, N.5    Buhler, M.M.6    Schols, D.7    de Clercq, E.8    Stewart, G.9
  • 34
    • 0033647217 scopus 로고    scopus 로고
    • The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS
    • O'Brien, S. J., and J. P. Moore. 2000. The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS. Immunol. Rev. 177:99-111.
    • (2000) Immunol. Rev , vol.177 , pp. 99-111
    • O'Brien, S.J.1    Moore, J.P.2
  • 39
    • 34547120215 scopus 로고    scopus 로고
    • Reduced cell surface expression of CCR5 in CCR5δ32 heterozygotes is mediated by gene dosage, not by receptor sequestration
    • Venkatesan, S., A. Petrovic, D. I. Van Ryk, M. Locati, D. Weissman, and P. M. Murphy. 2001. Reduced cell surface expression of CCR5 in CCR5δ32 heterozygotes is mediated by gene dosage, not by receptor sequestration. J. Biol. Chem. 16:16.
    • (2001) J. Biol. Chem , vol.16 , pp. 16
    • Venkatesan, S.1    Petrovic, A.2    Van Ryk, D.I.3    Locati, M.4    Weissman, D.5    Murphy, P.M.6
  • 40
    • 8244227329 scopus 로고    scopus 로고
    • Zimmerman, P. A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam, M. Vaccarezza, P. E. Kennedy, V. Kumaraswami, J. V. Giorgi, R. Detels, J. Hunter, M. Chopek, E. A. Berger, A. S. Fauci, T. B. Nutman, and P. M. Murphy. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies of populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:23-36.
    • Zimmerman, P. A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam, M. Vaccarezza, P. E. Kennedy, V. Kumaraswami, J. V. Giorgi, R. Detels, J. Hunter, M. Chopek, E. A. Berger, A. S. Fauci, T. B. Nutman, and P. M. Murphy. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies of populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol. Med. 3:23-36.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.