Gene organization and promoter function for CC chemokine receptor 5 (CCR5)

Journal of Immunology

Volumn 160, Issue 2, 1998, Pages 985-992

  Guignard, Florence ^b   Combadiere, Christophe ^b   Tiffany, H Lee ^b   Murphy, Philip M ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOATTRACTANT; CHEMOKINE RECEPTOR; DNA FRAGMENT;

ANIMAL CELL; ARTICLE; CELL CULTURE; DNA DETERMINATION; DNA FLANKING REGION; DNA SEQUENCE; ENHANCER REGION; EXON; GENE DELETION; GENE EXPRESSION; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMEDIATE EARLY GENE; LEUKOCYTE ACTIVATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RNA ANALYSIS; T LYMPHOCYTE; TATA BOX;

BASE SEQUENCE; CELL LINE; HUMANS; JURKAT CELLS; LYMPHOCYTES, TUMOR-INFILTRATING; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RECEPTORS, CCR5; REGULATORY SEQUENCES, NUCLEIC ACID; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TRANSFECTION;

EID: 0031963655     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Baggiolini, M., B. Dewald, and B. Moser. 1994. Interleukin-8 and related chemotactic cytokines: CXC and CC chemokines. Adv. Immunol. 55:97.
2. Broxmeyer, H. E., B. Sherry, S. Cooper, L. Lu, R. Maze, M. P. Beckmann, A. Cerami, and P. Ralph. 1993. Comparative analysis of the human macrophage inflammatory protein family of cytokines (chemokines) on proliferation of human myeloid progenitor cells Interacting effects involving suppression, synergistic suppression, and blocking of suppression. J. Immunol. 150:3448.
3. Strieter, R. M., P. J. Polverini, D. A. Arenberg, A. Walz, G. Opdenakker, J. Van Damme, and S. L. Kunkel. 1995. Role of C-X-C chemokines as regulators of angiogenesis in lung cancer. J. Leukocyte Biol. 57:752.
4. Springer, T. A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301.
5. Cook, D. N., M. A. Beck, T. M. Coffman, S. L. Kirby, J. F. Sheridan, I. B. Pragnell, and O. Smithies. 1995. Requirement of MIP-1α for an inflammatory response to viral infection. Science 269:1583.
6. Murphy, P. M. 1996. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Fact. Rev. 7:47.
7. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry co-factor: functional cDNA cloning of a seven-transmembrane G-protein coupled receptor. Science 272:872.
8. Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1b receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955.
9. + cells is mediated by the chemokine receptor CC CKR-5. Nature 381:667.
10. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. DiMarzio, S. Marmon, R. E. Sutton, C. M. Hill, D. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661.
11. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. J. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. P. Gerard, C. Gerard, and J. Sodroski. 1996. The b-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV isolates. Cell 85:1135.
12. Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual tropic primary HIV-1 isolate that uses fusin and the b-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion co-factors. Cell 85:1149.
13. Bleul, C. C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829.
14. Oberlin, E., A. Amara, F. Bacherlerie, C. Bessia, J.-L. Virelizier, F. Arenzana-Seisdedos, O. Schwarta, J.-M. Heard, I. Clark-Lewis, D. F. Legler, M. Loetscher, M. Baggiolini, B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833.
15. Zhang, L., Y. Huang, T. He, Y. Cao, and D. D. Ho. 1996. HIV-1 subtype and second-receptor use. Nature 383:768.
16. Alkhatib, G., E. A. Berger, P. M. Murphy, and J. Pease. 1997. Determinants of HIV-1 coreceptor function on CC chemokine receptor 3: importance of both extracellular and transmembrane/cytoplasmic domains. J. Biol. Chem. 272:20420.
17. Dittmar, M. T., A. McKnight, G. Simmons, P. R. Clapham, R. A. Weiss, and P. Simmonds. 1997. HIV-1 tropism and co-receptor use. Nature 385:495.
18. Liu, R., W. A. Paxton, S. Choe, D. Ceradini, S. R. Martin, R. Horuk, M. E. MacDonald, H. Stuhlman, R. A. Koup, and N. R. Landau. 1996. Homozyaous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367.
19. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C.-M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonbuy, M. Georges, T. Imai, S. Rana, Y. Yi, R. J. Smyth, R. G. Collman, R. W. Doms, G. Vassart, and M. Parmentier. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382:722.
20. Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE, and S. J. O'Brien. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856.
21. Zimmerman, P. A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam, M. Vaccarezza, P. E. Kennedy, V. Kumaraswami, J. V. Giorgi, R. Detels, J. Hunter, M. Chopek, E. A. Berger, A. S. Fauci, T. B. Nutman, and P. M. Murphy. 1997. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background and quantified risk. Mol. Med. 3:23.
22. Huang, Y., W. A. Paxton, S. M. Wolinsky, A. U. Neumann, L. Zhang, T. He, S. Kang, D. Ceradini, Z. Jin, K. Yazdanbakhsh, K. Kunstman, D. Erickson, E. Dragon, N. R. Landau, J. Phair, D. D. Ho, and R. A. Koup. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2:1240.
23. + T cells. Science 270:1811.
24. Combadiere, C., S. K. Ahuja, H. L. Tiffany, and P. M. Murphy. 1996. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1b, and RANTES. J. Leukocyte Biol. 60:147.
25. He, J., Y. Chen, M. Farzan, H. Choe, A. Ohagen, S. Gartner, J. Susciglio, X. Yang, W. Hofmann, W. Newman, C. R. Mackay, J. Sodroski, and D. Gabuzda. 1997. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385:645.
26. Bleul, C. C., L. Wu, J. A. Hoxie, T. A. Springer, and C. R. Mackay. 1997. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA 94:1925.
27. + T cells. Science 276:273.
28. Yannelli, J. R. 1991. The preparation of effector cells for use in the adoptive cellular immunotherapy of human cancer. J. Immunol. Methods 139:1.
29. Liao, F., R. L. Rabin, J. R. Yannelli, L. G. Koniaris, P. Vanguri, and J. M. Farber. 1995. Human Mig chemokine: biochemical and functional characterization. J. Exp. Med. 182:1301.
30. Raport, C. J., J. Gosling, V. L. Schweickart, P. W. Gray, and I. F. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J. Biol. Chem. 271: 17161.
31. Combadiere, C., S. K. Ahuja, and P. M. Murphy. 1995. Cloning, chromosomal localization and RNA expression of a novel human b chemokine receptor-like gene. DNA Cell Biol. 14:673.
32. Devereux, J., P. Haeberli, and O. Smithies. 1984. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:389.
33. Ahuja, S. K., A. Shetty, H. L. Tiffany, and P. M. Murphy. 1994. Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B. J. Biol. Chem. 269:26381.
34. Lloyd, A. R., A. Biragyn, J. A. Johnston, D. D. Taub, L. Xu, D. Michiel, H. Sprenger, J. J. Oppenheim, and D. J. Kelvin. 1995. Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J. Biol. Chem. 270:28188.
35. Sprenger, H., A. R. Lloyd, R. G. Meyer, J. A. Johnston, and D. J. Kelvin. 1994. Genomic structure, characterization, and identification of the promoter of the human IL-8 receptor A gene. J. Immunol. 153:2524.
36. Murphy, P. M., H. L. Tiffany, D. McDermott, and S. K. Ahuja. 1993. Sequence and organization of the human N-formyl peptide receptor-encoding gene. Gene 133:285.
37. Raport, C. J., V. L. Schweickart, D. Chantry, R. L. Eddy, Jr., T. B. Shows, R. Godiska, and P. W. Gray. 1996. New members of the chemokine receptor gene family. J. Leukocyte Biol. 59:18.
38. Gao, J.-L., D. B. Kuhns, H. L. Tiffany, D. McDermott, X. Li, U. Francke, and P. M. Murphy. 1993. Structure and functional expression of the human macrophage inflammatory protein-1α/RANTES receptor. J. Exp. Med. 177:1421.
39. Mutoh, H., H. Bito, M. Minami, M. Nakamura, Z. Honda, T. Izumi, R. Nakata, Y. Kurachi, A. Terano, and T. Shimizu. 1993. Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor. FEBS Lett. 322:129.
40. Marchese, A., M. Heiber, T. Nguyen, H. H. Q. Heng, V. R. Saldivia, R. Cheng, P. M. Murphy, L.-C. Tsui, X. Shi, P. Gregor, S. R. George, B. F. O'Dowd, and J. M. Docherty. 1995. Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors. Genomics 29:335.
41. Charo, I., S. J. Myers, A. Herman, C. Franci, A. J. Connolly, and S. R. Coughlin. 1994. Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. USA 91:2752.
42. Gerard, N. P., L. Bao, X.-P. He, R. L. Eddy, Jr., T. B. Shows, and C. Gerard. 1993. Human chemotactic receptor genes cluster at 19q13.3/13.4: characterization of the human C5a receptor gene. Biochemistry 32:1243.
43. Samson, M., O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC chemokine receptor gene. Biochemistry 35:3363.
44. Ahuja, S. K., T. Ozcelik, A. Milatovich, U. Francke, and P. M. Murphy. 1992. Molecular evolution of the interleukin-8 receptor gene cluster. Nat. Genet. 2:31.
45. Horuk, R., C. Chitnis, W. Darbonne, T. Colby, A. Rybicki, T. Hadley, and L. Miller. 1993. The erythrocyte chemokine receptor is a receptor for the malarial parasite Plasmodium vivax. Science 261:1182.
46. Tournamille, C., Y. Colin, J. P. Cartron, and C. Le Van Kim. 1995. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. Nat. Genet. 10:224.