메뉴 건너뛰기




Volumn 111, Issue 2, 2008, Pages 135-147

The relative importance of genetics and phenotypic plasticity in dictating bone morphology and mechanics in aged mice: Evidence from an artificial selection experiment

Author keywords

Artificial selection; Body mass; Bone morphometrics; Exercise; Mechanical loading

Indexed keywords

ADAPTATION; ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BODY SIZE; BODY WEIGHT; BONE; BONE DENSITY; BREEDING; FEMALE; FEMUR NECK; GENETIC SELECTION; GENETICS; HISTOLOGY; MOUSE; MOUSE STRAIN; PHENOTYPE; PHYLOGENY; PHYSIOLOGY; RANDOMIZATION; RUNNING;

EID: 39649085556     PISSN: 09442006     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.zool.2007.06.003     Document Type: Article
Times cited : (23)

References (108)
  • 3
    • 11944265977 scopus 로고    scopus 로고
    • Bone intrinsic material properties in three inbred mouse strains
    • Akhter M.P., Fan Z., and Rho J.Y. Bone intrinsic material properties in three inbred mouse strains. Calcif. Tissue 75 (2004) 416-420
    • (2004) Calcif. Tissue , vol.75 , pp. 416-420
    • Akhter, M.P.1    Fan, Z.2    Rho, J.Y.3
  • 7
    • 0029922240 scopus 로고    scopus 로고
    • The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins
    • Arden N.K., Baker J., Hogg C., Baan K., and Spector T.D. The heritability of bone mineral density, ultrasound of the calcaneus and hip axis length: a study of postmenopausal twins. J. Bone Miner. Res. 11 (1996) 530-534
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 530-534
    • Arden, N.K.1    Baker, J.2    Hogg, C.3    Baan, K.4    Spector, T.D.5
  • 8
    • 0029841074 scopus 로고    scopus 로고
    • Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell
    • Augat P., Reeb H., and Claes L.E. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J. Bone Miner. Res. 11 (1996) 1356-1363
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 1356-1363
    • Augat, P.1    Reeb, H.2    Claes, L.E.3
  • 9
    • 0029794958 scopus 로고    scopus 로고
    • Histo-anatomy of the proximal femur in rats: impact of ovariectomy on bone mass, structure, and stiffness
    • Bagi C.M., DeLeon E., Ammann P., Rizzoli R., and Miller S.C. Histo-anatomy of the proximal femur in rats: impact of ovariectomy on bone mass, structure, and stiffness. Anat. Rec. 245 (1996) 633-644
    • (1996) Anat. Rec. , vol.245 , pp. 633-644
    • Bagi, C.M.1    DeLeon, E.2    Ammann, P.3    Rizzoli, R.4    Miller, S.C.5
  • 10
    • 0030823898 scopus 로고    scopus 로고
    • Morphological and structural characteristics of the proximal femur in human and rat
    • Bagi C.M., Wilkie D., Georgelos K., Williams D., and Bertolini D. Morphological and structural characteristics of the proximal femur in human and rat. Bone 21 (1997) 261-267
    • (1997) Bone , vol.21 , pp. 261-267
    • Bagi, C.M.1    Wilkie, D.2    Georgelos, K.3    Williams, D.4    Bertolini, D.5
  • 12
    • 0020730233 scopus 로고
    • Locomotory stresses in the limb bones of two small mammals: the ground squirrel and chipmunk
    • Biewener A.A. Locomotory stresses in the limb bones of two small mammals: the ground squirrel and chipmunk. J. Exp. Biol. 103 (1983) 131-154
    • (1983) J. Exp. Biol. , vol.103 , pp. 131-154
    • Biewener, A.A.1
  • 14
    • 0020970421 scopus 로고
    • Bone stress in the horse forelimb during locomotion at different gaits: a comparison of two experimental methods
    • Biewener A.A., Thomason J.J., Goodship A.E., and Lanyon L.E. Bone stress in the horse forelimb during locomotion at different gaits: a comparison of two experimental methods. J. Biomech. 16 (1983) 565-576
    • (1983) J. Biomech. , vol.16 , pp. 565-576
    • Biewener, A.A.1    Thomason, J.J.2    Goodship, A.E.3    Lanyon, L.E.4
  • 15
    • 13844316300 scopus 로고    scopus 로고
    • Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children
    • Binkley T., and Specker B. Increased periosteal circumference remains present 12 months after an exercise intervention in preschool children. Bone 35 (2004) 1383-1388
    • (2004) Bone , vol.35 , pp. 1383-1388
    • Binkley, T.1    Specker, B.2
  • 17
    • 33748175583 scopus 로고    scopus 로고
    • The evolution of aging and age-related physical decline in mice selectively bred for high voluntary exercise
    • Bronikowski A.M., Morgan T.J., Garland Jr. T., and Carter P.A. The evolution of aging and age-related physical decline in mice selectively bred for high voluntary exercise. Evolution 60 (2006) 1494-1508
    • (2006) Evolution , vol.60 , pp. 1494-1508
    • Bronikowski, A.M.1    Morgan, T.J.2    Garland Jr., T.3    Carter, P.A.4
  • 19
    • 2942640248 scopus 로고    scopus 로고
    • Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women
    • Center J.R., Nguyen T.V., Pocock N.A., and Eisman J.A. Volumetric bone density at the femoral neck as a common measure of hip fracture risk for men and women. J. Clin. Endocr. Metab. 89 (2004) 2776-2782
    • (2004) J. Clin. Endocr. Metab. , vol.89 , pp. 2776-2782
    • Center, J.R.1    Nguyen, T.V.2    Pocock, N.A.3    Eisman, J.A.4
  • 20
    • 0033985865 scopus 로고    scopus 로고
    • Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls
    • Ciarelli T.E., Fyhrie D.P., Schaffler M.B., and Goldstein S.A. Variations in three-dimensional cancellous bone architecture of the proximal femur in female hip fractures and in controls. J. Bone Miner. Res. 15 (2000) 32-40
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 32-40
    • Ciarelli, T.E.1    Fyhrie, D.P.2    Schaffler, M.B.3    Goldstein, S.A.4
  • 21
    • 84995146452 scopus 로고
    • Long-bone fracture in large animals - a retrospective study
    • Crawford W.H., and Fretz P.B. Long-bone fracture in large animals - a retrospective study. Vet. Surg. 14 (1985) 295-302
    • (1985) Vet. Surg. , vol.14 , pp. 295-302
    • Crawford, W.H.1    Fretz, P.B.2
  • 25
    • 0033305396 scopus 로고    scopus 로고
    • Genetics of osteoporosis
    • Eisman J.A. Genetics of osteoporosis. Endocr. Rev. 20 (1999) 788-804
    • (1999) Endocr. Rev. , vol.20 , pp. 788-804
    • Eisman, J.A.1
  • 26
    • 84995132424 scopus 로고
    • Physeal fractures in the horse. 1. Classification and incidence
    • Embertson R.M., Bramlage L.R., Herring D.S., and Gabel A.A. Physeal fractures in the horse. 1. Classification and incidence. Vet. Surg. 15 (1986) 223-229
    • (1986) Vet. Surg. , vol.15 , pp. 223-229
    • Embertson, R.M.1    Bramlage, L.R.2    Herring, D.S.3    Gabel, A.A.4
  • 28
    • 0000663324 scopus 로고
    • Crouched posture and high fulcrum, a principle in the locomotion of small mammals: the example of the rock hyrax (Procavia capensis) (Mammalia: Hyracoidea)
    • Fischer M.S. Crouched posture and high fulcrum, a principle in the locomotion of small mammals: the example of the rock hyrax (Procavia capensis) (Mammalia: Hyracoidea). J. Hum. Evol. 26 (1994) 501-524
    • (1994) J. Hum. Evol. , vol.26 , pp. 501-524
    • Fischer, M.S.1
  • 30
    • 0002520137 scopus 로고    scopus 로고
    • Selection experiments: an under-utilized tool in biomechanics and organismal biology
    • Bels V.L., Gasc J.-P., and Casinos A. (Eds), BIOS Scientific Publishers, Oxford
    • Garland Jr. T. Selection experiments: an under-utilized tool in biomechanics and organismal biology. In: Bels V.L., Gasc J.-P., and Casinos A. (Eds). Vertebrate Biomechanics and Evolution (2003), BIOS Scientific Publishers, Oxford 23-56
    • (2003) Vertebrate Biomechanics and Evolution , pp. 23-56
    • Garland Jr., T.1
  • 31
    • 24644513791 scopus 로고    scopus 로고
    • Selective breeding for high endurance running increases hindlimb symmetry
    • Garland Jr. T., and Freeman P.W. Selective breeding for high endurance running increases hindlimb symmetry. Evolution 59 (2005) 1851-1854
    • (2005) Evolution , vol.59 , pp. 1851-1854
    • Garland Jr., T.1    Freeman, P.W.2
  • 32
    • 33746022362 scopus 로고    scopus 로고
    • Phenotypic plasticity and experimental evolution
    • Garland Jr. T., and Kelly S.A. Phenotypic plasticity and experimental evolution. J. Exp. Biol. 209 (2006) 2344-2361
    • (2006) J. Exp. Biol. , vol.209 , pp. 2344-2361
    • Garland Jr., T.1    Kelly, S.A.2
  • 33
    • 0029928837 scopus 로고    scopus 로고
    • Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis
    • Garnero P., Sornay-Rendu E., Chapuy M.-C., and Delmas P.D. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J. Bone Miner. Res. 11 (1996) 337-349
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 337-349
    • Garnero, P.1    Sornay-Rendu, E.2    Chapuy, M.-C.3    Delmas, P.D.4
  • 34
    • 0032790857 scopus 로고    scopus 로고
    • Geometry of proximal femur in the prediction of hip fracture in osteoporotic women
    • Gnudi S., Ripamonti C., Gualtieri G., and Malavolta N. Geometry of proximal femur in the prediction of hip fracture in osteoporotic women. Brit. J. Radiol. 72 (1999) 729-733
    • (1999) Brit. J. Radiol. , vol.72 , pp. 729-733
    • Gnudi, S.1    Ripamonti, C.2    Gualtieri, G.3    Malavolta, N.4
  • 35
    • 0036173632 scopus 로고    scopus 로고
    • Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women
    • Gnudi S., Ripamonti C., Lisi L., Fini M., Giardino R., and Giavaresi G. Proximal femur geometry to detect and distinguish femoral neck fractures from trochanteric fractures in postmenopausal women. Osteop. Int. 13 (2002) 69-73
    • (2002) Osteop. Int. , vol.13 , pp. 69-73
    • Gnudi, S.1    Ripamonti, C.2    Lisi, L.3    Fini, M.4    Giardino, R.5    Giavaresi, G.6
  • 36
    • 0024853107 scopus 로고
    • Structural alterations and breaking strength of mouse femora exposed to three activity regimes
    • Gordon K.R., Perl M., and Levy C. Structural alterations and breaking strength of mouse femora exposed to three activity regimes. Bone 10 (1989) 303-312
    • (1989) Bone , vol.10 , pp. 303-312
    • Gordon, K.R.1    Perl, M.2    Levy, C.3
  • 37
    • 0020615526 scopus 로고
    • Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice
    • Gosden R.G., Laing S.C., Felicio L.S., Nelson J.F., and Finch C.E. Imminent oocyte exhaustion and reduced follicular recruitment mark the transition to acyclicity in aging C57BL/6J mice. Biol. Reprod. 28 (1983) 255-260
    • (1983) Biol. Reprod. , vol.28 , pp. 255-260
    • Gosden, R.G.1    Laing, S.C.2    Felicio, L.S.3    Nelson, J.F.4    Finch, C.E.5
  • 40
    • 0038016417 scopus 로고    scopus 로고
    • Common long bone fracture in small animal practice - part 2
    • Harasen G. Common long bone fracture in small animal practice - part 2. Can. Vet. J. 44 (2003) 503-504
    • (2003) Can. Vet. J. , vol.44 , pp. 503-504
    • Harasen, G.1
  • 41
    • 0030769326 scopus 로고    scopus 로고
    • Bone dimensional change with age: interactions of genetic, hormonal, and body size variables
    • Heaney R.P., Barger-Lux M.J., Davies K.M., Ryan R.A., Johnson M.L., and Gong G. Bone dimensional change with age: interactions of genetic, hormonal, and body size variables. Osteop. Int. 7 (1997) 426-431
    • (1997) Osteop. Int. , vol.7 , pp. 426-431
    • Heaney, R.P.1    Barger-Lux, M.J.2    Davies, K.M.3    Ryan, R.A.4    Johnson, M.L.5    Gong, G.6
  • 43
    • 0034873223 scopus 로고    scopus 로고
    • Effect of high-impact and low-repetition training on bones in ovariectomized rats
    • Honda A., Umemura Y., and Nagasawa S. Effect of high-impact and low-repetition training on bones in ovariectomized rats. J. Bone Miner. Res. 16 (2001) 1688-1693
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1688-1693
    • Honda, A.1    Umemura, Y.2    Nagasawa, S.3
  • 45
    • 0033104182 scopus 로고    scopus 로고
    • Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat
    • Iwamoto J., Yeh J.K., and Aloia J.F. Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat. Bone 24 (1999) 163-169
    • (1999) Bone , vol.24 , pp. 163-169
    • Iwamoto, J.1    Yeh, J.K.2    Aloia, J.F.3
  • 47
    • 0030804099 scopus 로고    scopus 로고
    • Strain gradients correlate with site of exercise-induced bone-forming surfaces in the adult skeleton
    • Judex S., Gross T.S., and Zernicke R.F. Strain gradients correlate with site of exercise-induced bone-forming surfaces in the adult skeleton. J. Bone Miner. Res. 12 (1997) 1737-1745
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 1737-1745
    • Judex, S.1    Gross, T.S.2    Zernicke, R.F.3
  • 50
    • 33845998528 scopus 로고    scopus 로고
    • Effects of physical activity on evolution of proximal femur structure in a younger elderly population
    • Kaptoge S., Jakes R.W., Dalzell N., Wareham N., Khaw K.T., Loveridge N., Beck T.J., and Reeve J. Effects of physical activity on evolution of proximal femur structure in a younger elderly population. Bone 40 (2006) 506-515
    • (2006) Bone , vol.40 , pp. 506-515
    • Kaptoge, S.1    Jakes, R.W.2    Dalzell, N.3    Wareham, N.4    Khaw, K.T.5    Loveridge, N.6    Beck, T.J.7    Reeve, J.8
  • 51
    • 33645554074 scopus 로고    scopus 로고
    • Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice
    • Kelly S.A., Czech P.P., Wight J.T., Blank K.M., and Garland Jr. T. Experimental evolution and phenotypic plasticity of hindlimb bones in high-activity house mice. J. Morphol. 267 (2006) 360-374
    • (2006) J. Morphol. , vol.267 , pp. 360-374
    • Kelly, S.A.1    Czech, P.P.2    Wight, J.T.3    Blank, K.M.4    Garland Jr., T.5
  • 52
    • 27544499571 scopus 로고    scopus 로고
    • Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains
    • Kesavan C., Mohan S., Oberholtzer S., Wergedal J.E., and Baylink D.J. Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains. J. Appl. Physiol. 99 (2005) 1951-1957
    • (2005) J. Appl. Physiol. , vol.99 , pp. 1951-1957
    • Kesavan, C.1    Mohan, S.2    Oberholtzer, S.3    Wergedal, J.E.4    Baylink, D.J.5
  • 53
    • 33746628135 scopus 로고    scopus 로고
    • Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross
    • Kesavan C., Mohan S., Srivastava A.K., Kapoor S., Wergedal J.E., Yu H.R., and Baylink D.J. Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross. Bone 39 (2006) 634-643
    • (2006) Bone , vol.39 , pp. 634-643
    • Kesavan, C.1    Mohan, S.2    Srivastava, A.K.3    Kapoor, S.4    Wergedal, J.E.5    Yu, H.R.6    Baylink, D.J.7
  • 55
    • 0347768067 scopus 로고    scopus 로고
    • Artificial selection for intrinsic aerobic endurance running capacity in rats
    • Koch L.G., and Britton S.L. Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol. Genom. 5 (2001) 45-52
    • (2001) Physiol. Genom. , vol.5 , pp. 45-52
    • Koch, L.G.1    Britton, S.L.2
  • 56
    • 0034017485 scopus 로고    scopus 로고
    • Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J but not in C3H/HeJ mice
    • Kodama Y., Umemura Y., Nagasawa S., Beamer W.G., Donahue L.R., Rosen C.R., Baylink D.J., and Farley J.R. Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J but not in C3H/HeJ mice. Calcif. Tissue 66 (2000) 298-306
    • (2000) Calcif. Tissue , vol.66 , pp. 298-306
    • Kodama, Y.1    Umemura, Y.2    Nagasawa, S.3    Beamer, W.G.4    Donahue, L.R.5    Rosen, C.R.6    Baylink, D.J.7    Farley, J.R.8
  • 58
    • 33646902229 scopus 로고    scopus 로고
    • Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear
    • Lau K.H.W., Kapur S., Kesavan C., and Baylink D.J. Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL/6J osteoblasts as opposed to C3H/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear. J. Biol. Chem. 281 (2006) 9576-9588
    • (2006) J. Biol. Chem. , vol.281 , pp. 9576-9588
    • Lau, K.H.W.1    Kapur, S.2    Kesavan, C.3    Baylink, D.J.4
  • 60
    • 0141789708 scopus 로고    scopus 로고
    • Optimization of bone growth and remodeling in response to loading in tapered mammalian limbs
    • Lieberman D.E., Pearson O.M., Polk J.D., Demes B., and Crompton A.W. Optimization of bone growth and remodeling in response to loading in tapered mammalian limbs. J. Exp. Biol. 206 (2003) 3125-3138
    • (2003) J. Exp. Biol. , vol.206 , pp. 3125-3138
    • Lieberman, D.E.1    Pearson, O.M.2    Polk, J.D.3    Demes, B.4    Crompton, A.W.5
  • 61
    • 1642539154 scopus 로고    scopus 로고
    • Predicting long bone loading from cross-sectional geometry
    • Lieberman D.E., Polk J.D., and Demes B. Predicting long bone loading from cross-sectional geometry. Am. J. Phys. Anthropol. 123 (2004) 156-171
    • (2004) Am. J. Phys. Anthropol. , vol.123 , pp. 156-171
    • Lieberman, D.E.1    Polk, J.D.2    Demes, B.3
  • 62
    • 0017074482 scopus 로고
    • The biomechanical analysis of bone strength: a method and its application to platycnemia
    • Lovejoy C.O., Burstein A.H., and Heiple K.G. The biomechanical analysis of bone strength: a method and its application to platycnemia. Am. J. Phys. Anth. 44 (1976) 489-506
    • (1976) Am. J. Phys. Anth. , vol.44 , pp. 489-506
    • Lovejoy, C.O.1    Burstein, A.H.2    Heiple, K.G.3
  • 63
    • 33845919736 scopus 로고    scopus 로고
    • Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high voluntary wheel running
    • Malisch J.L., Saltzman W., Gomes F.R., Rezende E.L., Jeske D.R., and Garland Jr. T. Baseline and stress-induced plasma corticosterone concentrations of mice selectively bred for high voluntary wheel running. Physiol. Biochem. Zool. 80 (2007) 146-156
    • (2007) Physiol. Biochem. Zool. , vol.80 , pp. 146-156
    • Malisch, J.L.1    Saltzman, W.2    Gomes, F.R.3    Rezende, E.L.4    Jeske, D.R.5    Garland Jr., T.6
  • 64
    • 33744945021 scopus 로고    scopus 로고
    • Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of aging
    • McNamara L.M., Ederveen A.G.H., Lyons C.G., Price C., Schaffler M.B., Weinans H., and Prendergast P.J. Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of aging. Bone 39 (2006) 392-400
    • (2006) Bone , vol.39 , pp. 392-400
    • McNamara, L.M.1    Ederveen, A.G.H.2    Lyons, C.G.3    Price, C.4    Schaffler, M.B.5    Weinans, H.6    Prendergast, P.J.7
  • 65
    • 0242499885 scopus 로고    scopus 로고
    • Ontogenies in mice selected for high voluntary wheel-running activity. I. Mean ontogenies
    • Morgan T.J., Garland Jr. T., and Carter P.A. Ontogenies in mice selected for high voluntary wheel-running activity. I. Mean ontogenies. Evolution 57 (2003) 646-657
    • (2003) Evolution , vol.57 , pp. 646-657
    • Morgan, T.J.1    Garland Jr., T.2    Carter, P.A.3
  • 66
    • 0024893152 scopus 로고
    • Sex differences in age-related loss of vertebral trabecular bone mass and structure - biomechanical consequences
    • Mosekilde L. Sex differences in age-related loss of vertebral trabecular bone mass and structure - biomechanical consequences. Bone 10 (1989) 425-432
    • (1989) Bone , vol.10 , pp. 425-432
    • Mosekilde, L.1
  • 67
    • 0032188873 scopus 로고    scopus 로고
    • Growth hormone increases vertebral and femoral bone strength in osteoporotic, ovariectomized, aged rats in a dose-dependent and site-specific manner
    • Mosekilde L., Thomsen J.S., Orhii P.B., and Kalu D.N. Growth hormone increases vertebral and femoral bone strength in osteoporotic, ovariectomized, aged rats in a dose-dependent and site-specific manner. Bone 23 (1998) 343-352
    • (1998) Bone , vol.23 , pp. 343-352
    • Mosekilde, L.1    Thomsen, J.S.2    Orhii, P.B.3    Kalu, D.N.4
  • 68
    • 0032190413 scopus 로고    scopus 로고
    • Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats
    • Mosley J.R., and Lanyon L.E. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone 23 (1998) 313-318
    • (1998) Bone , vol.23 , pp. 313-318
    • Mosley, J.R.1    Lanyon, L.E.2
  • 69
    • 0036139736 scopus 로고    scopus 로고
    • Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical stress
    • Mosley J.R., and Lanyon L.E. Growth rate rather than gender determines the size of the adaptive response of the growing skeleton to mechanical stress. Bone 30 (2002) 314-319
    • (2002) Bone , vol.30 , pp. 314-319
    • Mosley, J.R.1    Lanyon, L.E.2
  • 70
    • 5344254567 scopus 로고    scopus 로고
    • Adaptation of mechanical, morphological, and biochemical properties of the rat growth plate to dose-dependent voluntary exercise
    • Niehoff A., Kersting U.G., Zaucke F., Morlock M.M., and Brüggemann G.-P. Adaptation of mechanical, morphological, and biochemical properties of the rat growth plate to dose-dependent voluntary exercise. Bone 35 (2004) 899-908
    • (2004) Bone , vol.35 , pp. 899-908
    • Niehoff, A.1    Kersting, U.G.2    Zaucke, F.3    Morlock, M.M.4    Brüggemann, G.-P.5
  • 72
    • 0028146984 scopus 로고
    • The mechanical strength of bone in different rat models of experimental osteoporosis
    • Peng Z., Tuukkanen J., Zhang H., Jämsä T., and Väänänen H.K. The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15 (1994) 523-532
    • (1994) Bone , vol.15 , pp. 523-532
    • Peng, Z.1    Tuukkanen, J.2    Zhang, H.3    Jämsä, T.4    Väänänen, H.K.5
  • 73
    • 39649089232 scopus 로고    scopus 로고
    • R Development Core Team, 2007. R: A Language and Environment for Statistical Computing. Vienna, Austria. R Foundation for Statistical Computing. 〈http://r-project.org〉.
    • R Development Core Team, 2007. R: A Language and Environment for Statistical Computing. Vienna, Austria. R Foundation for Statistical Computing. 〈http://r-project.org〉.
  • 74
    • 0025161874 scopus 로고
    • Bone mechanical properties after exercise training in young and old rats
    • Raab D.M., Smith E.L., Crenshaw T.D., and Thomas D.P. Bone mechanical properties after exercise training in young and old rats. J. Appl. Physiol. 68 (1990) 130-134
    • (1990) J. Appl. Physiol. , vol.68 , pp. 130-134
    • Raab, D.M.1    Smith, E.L.2    Crenshaw, T.D.3    Thomas, D.P.4
  • 75
    • 21444435672 scopus 로고    scopus 로고
    • Neurobiology of mice selected for high voluntary wheel-running activity
    • Rhodes J.S., Gammie S.C., and Garland Jr. T. Neurobiology of mice selected for high voluntary wheel-running activity. Integr. Comp. Biol. 45 (2005) 438-455
    • (2005) Integr. Comp. Biol. , vol.45 , pp. 438-455
    • Rhodes, J.S.1    Gammie, S.C.2    Garland Jr., T.3
  • 77
    • 0036862205 scopus 로고    scopus 로고
    • Mechanotransduction in bone: genetic effects on mechanosensitivity in mice
    • Robling A.G., and Turner C.H. Mechanotransduction in bone: genetic effects on mechanosensitivity in mice. Bone 31 (2002) 562-569
    • (2002) Bone , vol.31 , pp. 562-569
    • Robling, A.G.1    Turner, C.H.2
  • 78
    • 0037315858 scopus 로고    scopus 로고
    • Evidence for a skeletal mechanosensitivity gene on mouse Chromosome 4
    • Robling A.G., Li J., Shultz K.L., Beamer W.G., and Turner C.H. Evidence for a skeletal mechanosensitivity gene on mouse Chromosome 4. FASEB J. 17 (2003) 324-326
    • (2003) FASEB J. , vol.17 , pp. 324-326
    • Robling, A.G.1    Li, J.2    Shultz, K.L.3    Beamer, W.G.4    Turner, C.H.5
  • 80
    • 0021322767 scopus 로고
    • Regulation of bone formation by applied dynamic loads
    • Rubin C.T., and Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. 66 (1984) 397-402
    • (1984) J. Bone Joint Surg. , vol.66 , pp. 397-402
    • Rubin, C.T.1    Lanyon, L.E.2
  • 81
    • 0027195461 scopus 로고
    • Postcranial robusticity in Homo. I: Temporal trends and mechanical interpretation
    • Ruff C.B., Trinkaus E., Walker A., and Larsen C.S. Postcranial robusticity in Homo. I: Temporal trends and mechanical interpretation. Am. J. Phys. Anthropol. 91 (1993) 21-53
    • (1993) Am. J. Phys. Anthropol. , vol.91 , pp. 21-53
    • Ruff, C.B.1    Trinkaus, E.2    Walker, A.3    Larsen, C.S.4
  • 84
    • 0028201749 scopus 로고
    • Reduced femoral neck bone density in the daughters of women with hip fractures: the role of peak bone density in the pathogenesis of osteoporosis
    • Seeman E., Tsalamandris C., Formica C., Hopper J.L., and McKay J. Reduced femoral neck bone density in the daughters of women with hip fractures: the role of peak bone density in the pathogenesis of osteoporosis. J. Bone Miner. Res. 9 (1994) 739-743
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 739-743
    • Seeman, E.1    Tsalamandris, C.2    Formica, C.3    Hopper, J.L.4    McKay, J.5
  • 85
    • 0023236362 scopus 로고
    • Mechanical, morphological and biochemical adaptations of bone and muscle to hindlimb suspension and exercise
    • Shaw S.R., Zernicke R.F., Vailas A.C., DeLuna D., Thomason D.B., and Baldwin K.M. Mechanical, morphological and biochemical adaptations of bone and muscle to hindlimb suspension and exercise. J. Biomech. 20 (1987) 225-234
    • (1987) J. Biomech. , vol.20 , pp. 225-234
    • Shaw, S.R.1    Zernicke, R.F.2    Vailas, A.C.3    DeLuna, D.4    Thomason, D.B.5    Baldwin, K.M.6
  • 86
    • 0030869475 scopus 로고    scopus 로고
    • Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in microstructure
    • Silva M.J., and Gibson L.J. Modeling the mechanical behavior of vertebral trabecular bone: effects of age-related changes in microstructure. Bone 21 (1997) 191-199
    • (1997) Bone , vol.21 , pp. 191-199
    • Silva, M.J.1    Gibson, L.J.2
  • 87
    • 4544246824 scopus 로고    scopus 로고
    • Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6
    • Silva M.J., Brodt M.D., Fan Z., and Rho J.-Y. Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6. J. Biomech. 37 (2004) 1639-1646
    • (2004) J. Biomech. , vol.37 , pp. 1639-1646
    • Silva, M.J.1    Brodt, M.D.2    Fan, Z.3    Rho, J.-Y.4
  • 88
    • 0022363775 scopus 로고
    • Multiple regression for physiological data analysis: the problem of multicollinearity
    • Slinker B.K., and Glantz S.A. Multiple regression for physiological data analysis: the problem of multicollinearity. Am. J. Physiol. Regul. Integr. Comput. Physiol. 248 (1985) R1-R12
    • (1985) Am. J. Physiol. Regul. Integr. Comput. Physiol. , vol.248
    • Slinker, B.K.1    Glantz, S.A.2
  • 89
    • 0000533762 scopus 로고
    • Femoral expansion in aging women: implications for osteoporosis and fractures
    • Smith Jr. R.W., and Walker R.R. Femoral expansion in aging women: implications for osteoporosis and fractures. Science 145 (1964) 156-157
    • (1964) Science , vol.145 , pp. 156-157
    • Smith Jr., R.W.1    Walker, R.R.2
  • 91
    • 0028202863 scopus 로고
    • Long-term exercise of young and adult female rates: effects on femoral biomechanical competence and bone structure
    • Søgaard C.H., Danielsen C.C., Thorling E.B., and Mosekilde L. Long-term exercise of young and adult female rates: effects on femoral biomechanical competence and bone structure. J. Bone Miner. Res. 9 (1994) 409-416
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 409-416
    • Søgaard, C.H.1    Danielsen, C.C.2    Thorling, E.B.3    Mosekilde, L.4
  • 92
    • 13844309259 scopus 로고    scopus 로고
    • Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading
    • Squire M., Donahue L.R., Rubin C., and Judex S. Genetic variations that regulate bone morphology in the male mouse skeleton do not define its susceptibility to mechanical unloading. Bone 35 (2004) 1353-1360
    • (2004) Bone , vol.35 , pp. 1353-1360
    • Squire, M.1    Donahue, L.R.2    Rubin, C.3    Judex, S.4
  • 93
    • 0036020892 scopus 로고    scopus 로고
    • A direct approach to false discovery rates
    • Storey J.D. A direct approach to false discovery rates. J. R. Stat. Soc. B 64 (2002) 479-498
    • (2002) J. R. Stat. Soc. B , vol.64 , pp. 479-498
    • Storey, J.D.1
  • 94
    • 21444445184 scopus 로고    scopus 로고
    • Selection experiments as a tool in evolutionary and comparative physiology: insights into complex traits - an introduction to the symposium
    • Swallow J.G., and Garland Jr. T. Selection experiments as a tool in evolutionary and comparative physiology: insights into complex traits - an introduction to the symposium. Integr. Comput. Biol. 45 (2005) 387-390
    • (2005) Integr. Comput. Biol. , vol.45 , pp. 387-390
    • Swallow, J.G.1    Garland Jr., T.2
  • 95
    • 0031838608 scopus 로고    scopus 로고
    • Artificial selection for increased wheel-running behavior in house mice
    • Swallow J.G., Carter P.A., and Garland Jr. T. Artificial selection for increased wheel-running behavior in house mice. Behav. Genet. 28 (1998) 227-237
    • (1998) Behav. Genet. , vol.28 , pp. 227-237
    • Swallow, J.G.1    Carter, P.A.2    Garland Jr., T.3
  • 96
    • 0033198850 scopus 로고    scopus 로고
    • Artificial selection for increased wheel-running activity in house mice results in decreased body mass at maturity
    • Swallow J.G., Koteja P., Carter P.A., and Garland Jr. T. Artificial selection for increased wheel-running activity in house mice results in decreased body mass at maturity. J. Exp. Biol. 202 (1999) 2513-2520
    • (1999) J. Exp. Biol. , vol.202 , pp. 2513-2520
    • Swallow, J.G.1    Koteja, P.2    Carter, P.A.3    Garland Jr., T.4
  • 97
    • 0030693793 scopus 로고    scopus 로고
    • Appendicular robusticity and the paleobiology of modern human emergence
    • Trinkaus E. Appendicular robusticity and the paleobiology of modern human emergence. Proc. Natl. Acad. Sci. 94 (1997) 13367-13373
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 13367-13373
    • Trinkaus, E.1
  • 98
    • 38849110337 scopus 로고    scopus 로고
    • Experimental techniques for bone mechanics
    • Cowin S.C. (Ed), CRC Press, Boca Raton
    • Turner C.H., and Burr D.B. Experimental techniques for bone mechanics. In: Cowin S.C. (Ed). The Bone Mechanics Handbook (2001), CRC Press, Boca Raton 7.1-7.35
    • (2001) The Bone Mechanics Handbook
    • Turner, C.H.1    Burr, D.B.2
  • 101
    • 0023182649 scopus 로고
    • Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging
    • Weinstein R.S., and Hutson M.S. Decreased trabecular width and increased trabecular spacing contribute to bone loss with aging. Bone 8 (1987) 137-142
    • (1987) Bone , vol.8 , pp. 137-142
    • Weinstein, R.S.1    Hutson, M.S.2
  • 102
    • 7244244130 scopus 로고    scopus 로고
    • Adaptations to free-fall impact are different in the shafts and bone ends of rat forelimbs
    • Welch J.M., Weaver C.M., and Turner C.H. Adaptations to free-fall impact are different in the shafts and bone ends of rat forelimbs. J. Appl. Physiol. 97 (2004) 1859-1865
    • (2004) J. Appl. Physiol. , vol.97 , pp. 1859-1865
    • Welch, J.M.1    Weaver, C.M.2    Turner, C.H.3
  • 103
    • 12344331677 scopus 로고    scopus 로고
    • Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density
    • Wergedal J.E., Sheng M.H.-C., Ackert-Bicknell C.L., Beamer W.G., and Baylink D.J. Genetic variation in femur extrinsic strength in 29 different inbred strains of mice is dependent on variations in femur cross-sectional geometry and bone density. Bone 36 (2005) 111-122
    • (2005) Bone , vol.36 , pp. 111-122
    • Wergedal, J.E.1    Sheng, M.H.-C.2    Ackert-Bicknell, C.L.3    Beamer, W.G.4    Baylink, D.J.5
  • 106
    • 3042523543 scopus 로고    scopus 로고
    • Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice
    • Wu J., Wang X., Chiba H., Higuchi M., Nakatani T., Ezaki O., Cui H., Yamada K., and Ishimi Y. Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53 (2004) 942-948
    • (2004) Metabolism , vol.53 , pp. 942-948
    • Wu, J.1    Wang, X.2    Chiba, H.3    Higuchi, M.4    Nakatani, T.5    Ezaki, O.6    Cui, H.7    Yamada, K.8    Ishimi, Y.9
  • 107
    • 0029100046 scopus 로고
    • Bone histomorphometric changes in the femoral neck of aging and ovariectomized rats
    • Yamamoto N., Jee W.S.S., and Ma Y.F. Bone histomorphometric changes in the femoral neck of aging and ovariectomized rats. Anat. Rec. 243 (1995) 175-185
    • (1995) Anat. Rec. , vol.243 , pp. 175-185
    • Yamamoto, N.1    Jee, W.S.S.2    Ma, Y.F.3
  • 108
    • 0034012105 scopus 로고    scopus 로고
    • Epidemiology of cervical and trochanteric fractures of the proximal femur in 1994 in Tangshan, China
    • Zhang L., Cheng A., Bai Z., Lu Y., Endo N., Dohmae Y., and Takahashi H.E. Epidemiology of cervical and trochanteric fractures of the proximal femur in 1994 in Tangshan, China. J. Bone Miner. Metab. 18 (2000) 84-88
    • (2000) J. Bone Miner. Metab. , vol.18 , pp. 84-88
    • Zhang, L.1    Cheng, A.2    Bai, Z.3    Lu, Y.4    Endo, N.5    Dohmae, Y.6    Takahashi, H.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.