Growth hormone increases vertebral and femoral bone strength in osteopenic, ovariectomized, aged rats in a dose-dependent and site-specific manner

Bone

Volumn 23, Issue 4, 1998, Pages 343-352

  Mosekilde, Li ^a   Thomsen, J S ^a   Orhii, P B ^b   Kalu, D N ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Bone mass; Bone strength; Growth hormone; Osteopenia; Ovariectomy; Rat model

Indexed keywords

GROWTH HORMONE; RECOMBINANT GROWTH HORMONE;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MASS; BONE STRENGTH; CONTROLLED STUDY; FEMALE; FEMUR; NONHUMAN; OSTEOPENIA; OVARIECTOMY; RAT;

AGING; ANIMALS; BONE DISEASES, METABOLIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FEMUR; GROWTH HORMONE; HORMONE REPLACEMENT THERAPY; HUMANS; LUMBAR VERTEBRAE; OVARIECTOMY; RATS; RATS, INBRED F344; STRESS, MECHANICAL; WEIGHT-BEARING;

EID: 0032188873     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/S8756-3282(98)00107-0     Document Type: Article

References (55)

1. Andreassen T.T., Jørgensen P.H., Flyvbjerg A., Ørskov H., Oxlund H. Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J Bone Miner Res. 10:1995;1057-1067.
2. Andreassen T.T., Melsen F., Oxlund H. The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats. J Bone Miner Res. 11:1996;1094-1102.
3. Bagi C.M., Ammann P., Rizzoli R., Miller S.C. Effect of estrogen deficiency on cancellous and cortical bone structure and strength of the femoral neck in rats. Calcif Tissue Int. 61:1997;336-344.
4. Bak B., Jørgensen P.H., Andreassen T.T. Dose response of growth hormone on fracture healing in the rat. Acta Orthop Scand. 61:1990;54-57.
5. Brixen K., Kassem M., Nielsen H.K., Loft A.G., Flyvbjerg A., Mosekilde L.E. Short-term treatment with growth hormone stimulates osteoblastic and osteoclastic activity in osteopenic postmenopausal women A dose response study . J Bone Miner Res. 10:1995;1865-1874.
6. Brixen K., Nielsen H.K., Mosekilde L.E., Flyvbjerg A. A short course of recombinant human growth hormone treatment stimulates osteoblasts and activates bone remodelling in human volunteers. J Bone Miner Res. 5:1990;609-618.
7. Conover W.J. Practical Nonparametric Statistics. 1980;229-237 Wiley, New York.
8. Eschen C., Andreassen T.T. Growth hormone normalizes vertebral strength on ovariectomized rats. Calcif Tissue Int. 57:1995;392-396.
9. Gasser J.A. Assessing bone quality by pQCT. Bone. 17:(Suppl.):1995;145S-154S.
10. Gasser J.A. Quantitative assessment of bone mass and geometry by pQCT in rats in vivo and site specificity of changes at different skeletal sites. J Jpn Soc Bone Morphol. 7:1997;107-114.
11. Guidelines for Preclinical and Clinical Evaluation of Agents Used in the Prevention or Treatment of Postmenopausal Osteoporosis (Draft). Washington, DC: Division of Metabolism and Endocrine Drug Products, Food and Drug Administration, April 1994.
12. Gunness-Hey M., Hock J.M. Increased trabecular bone mass in rats treated with human synthetic parathyroid hormone. Metab Bone Dis Rel Res. 5:1984;177-181.
13. Gunness-Hey M., Hock J.M. Loss of anabolic effect of parathyroid hormone on bone after discontinuation of hormone in rats. Bone. 10:1989;447-452.
14. Harrigan T.P., Jasty M., Mann R.W., Harris W.H. Limitations of the continuum assumption in cancellous bone. J Biomech. 21:1998;269-275.
15. Hvid I., Andersen K., Olesen S. Cancellous bone strength measurements with the osteopenetrometer. Eng Med. 13:1984;73-78.
16. Jørgensen P.H., Andreassen T.T. Influence of biosynthetic human growth hormone on biomechanical properties of rat skin incisional wounds. Acta Chir Scand. 154:1988;623-626.
17. Kalu D.N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15:1991;175-192.
18. Kalu D.N., Echen R., Hollis B.V. Modulation of ovariectomy-related bone loss by parathyroid hormone in rats. Mech Ageing Dev. 56:1990;49-62.
19. Kalu D.N., Pennock J., Doyle F.H., Foster G.V. Parathyroid hormone and experimental osteosclerosis. Lancet. i:1970;1363-1366.
20. Lafage M.-H., Balena R., Battle M.A., Shea M., Seedor J.G., Klein H., Hayes W.C., Rodan G.A. Comparison of Alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs A one year study . J Clin Invest. 95:1995;2127-2133.
21. L. I M. Mosekilde, L. I. , Søgaard, C. H., and Wronski, T. J. Parathyroid hormone monotherapy and cotherapy with antiresorptive agents restore vertebral bone mass and strength in aged ovariectomized rats. Bone. 16:1995;629-635.
22. Liu C.C., Kalu D.N. Human parathyroid hormone-(1-34) prevents bone loss and augments bone formation in sexually mature ovariectomized rats. J Bone Miner Res. 5:1990;973-982.
23. Liu C.C., Kalu D.N., Salerno E., Echen R., Hollis B.W., Ray M. Pre-existing bone loss associated with ovariectomy in rats is reversed by parathyroid hormone. J Bone Miner Res. 6:1991;1071-1080.
24. Marcus R., Butterfield G., Holloway L., Gilliland L., Baylink D.J., Hintz R.L., Sherman B.M. Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrin Metab. 70:1990;519-527.
25. Mosekilde L.I. Assessing bone quality - animal models in preclinical osteoporosis research. Bone. 17:(Suppl.):1995;343S-352S.
26. Mosekilde L.I. Osteoporosis Mechanisms and models . Whitfield J.F., Morley P. Anabolic Treatments for Osteoporosis. 1998;31-58 CRC, Boca Raton, FL.
27. Mosekilde L.I., Bak B. The effect of growth hormone on fracture healing in rats - a histological investigation. Bone. 14:1993;19-27.
28. Mosekilde L.I., Danielsen C.C., Gasser J.A. The effect on vertebral bone mass and strength of long term treatment with antiresorptive agents (estrogen and calcitonin), human parathyroid hormone (1-38), and combination therapy, assessed in aged ovariectomized rats. Endocrinology. 134:1994;2126-2134.
29. Mosekilde L.I., Danielsen C.C., Knudsen U.B. The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats. Bone. 14:1993;1-6.
30. Mosekilde L.I., Danielsen C.C., Søgaard C.H., McOsker J.E., Wronski T.J. The anabolic effects of parathyroid hormone on cortical bone mass, dimensions and strength - assessed in a sexually mature, ovariectomized rat model. Bone. 16:1995;223-230.
31. Mosekilde L.I., Danielsen C.C., Søgaard C.H., Thorling E.B. The effect of long-term exercise on vertebral and femoral bone mass, dimensions and strength - assessed in a rat model. Bone. 15:1994;293-301.
32. Mosekilde L.I., Kragstrup J., Richards A. Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs. Calcif Tissue Int. 40:1987;318-322.
33. Mosekilde L.I., Søgaard C.H., McOsker J.E., Wronski T.J. PTH has a more pronounced effect on vertebral bone mass and biomechanical competence than antiresorptive agents (estrogen and bisphosphonate) - assessed in sexually mature, ovariectomized rats. Bone. 15:1994;401-408.
34. Mosekilde L.I., Søgaard C.H., Danielsen C.C., Tørring O., Nilsson M.H.L. The anabolic effect of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing A comparison study between hPTH(1-34) and hPTH(1-84) . Endocrinology. 129:1991;421-428.
35. Noland K.A., Orhii P.B., Kalu D.N. Growth hormone therapy restores cancellous bone following loss due to ovariectomy in aged rats. J Bone Miner Res. 12:(Suppl. 1):1997;S240.
36. Orhii P.B., Noland K.A., Kalu D.N. Growth hormone therapy restores cortical bone following loss due to ovariectomy in aged rats. J Bone Miner Res. 12:(Suppl. 1):1997;S240.
37. Pead M.J., Skerry T.M., Lanyon L.E. Direct transformation from quiescence to bone formation in the adult periosteum following a single brief period of bone loading. J Bone Miner Res. 3:1988;647-656.
38. Podbesek R., Edouard C., Meunier P.J., Parsons J.A., Reeve J., Stevenson R.W., Zanelli J.M. Effects of two treatment regimes with synthetic human parathyroid hormone fragment on bone formation and the tissue balance of trabecular bone in greyhounds. Endocrinology. 112:1983;1000-1005.
39. Qui H. , L. I, M., and Wronski, T. J. A comparison of the anabolic effects of parathyroid hormone at skeletal sites with moderate and severe osteopenia in aged ovariectomized rats. J Bone Miner Res. 10:1995;948-955.
40. Søgaard C.H., Danielsen C.C., Thorling E.B., Mosekilde L.I. Long-term exercise of young and adult female rats Effect on femoral neck biomechanical competence and bone structure . J Bone Miner Res. 9:1994;409-416.
41. Søgaard C.H., Mosekilde L.I., Schwartz W., Leidig G., Minne H.W., Ziegler R. Effects of fluoride on rat vertebral body biomechanical competence and bone mass. Bone. 16:1995;163-169.
42. Søgaard C.H., Mosekilde L.I., Thomsen J.S., Richards A., McOsker J.E. A comparison of the effects of two anabolic agents (Fluoride and PTH) on ash density and bone strength assessed in an osteopenic rat model. Bone. 20:1997;439-449.
43. Søgaard C.H., Wronski T.J., McOsker J.E., Mosekilde L.I. The positive effect of parathyroid hormone on femoral neck bone strength in ovariectomized rats is more pronounced than that of estrogen or bisphosphonates. Endocrinology. 134:1994;650-657.
44. Takahashi H.E., Tanizawa T., Hori M., Uzawa T. Effect of intermittent administration of human parathyroid hormone (1-34) on experimental osteoporosis in rats induced by ovariectomy The aged rat model for bone biology studies . Cells Mater. (Suppl. 1):1991;113-117.
45. Thomsen J.S., Ebbesen E.N., Mosekilde L.I. Relationships between static histomorphometry and bone strength measurements in human iliac crest bone biopsies. Bone. 22:1998;153-163.
46. Thomsen, J. S., Gasser, J. A., and Mosekilde, L. I. Long term therapy of OVX-induced osteopenia with PTH analog SDZ PTS893 and maintenance in retired breeder rats. Bone. In press.
47. Turner C.H., Burr D.B. Basic biomechanical measurements of bone A tutorial . Bone. 14:1993;595-608.
48. Turner C.H., Garetto L.P., Dunipace A.J., Zhang W., Wilson M.E., Grynpas M.D., Chachra D., McClintock R., Peacock M., Stookey G.K. Fluoride treatment increased serum IGF-1, bone turnover and bone mass, but not bone strength, in rabbits. Calcif Tissue Int. 61:1997;77-83.
49. Turner C.H., Hasegawa K., Zhang W., Wilson M., Dunipace A.J. Fluoride reduces bone strength in older rats. J Dent Res. 74:1995;1475-1481.
50. Tuukkanen J., Wallmarl B., Jalovaara P., Takala T., Väänänen K. Changes induced in growing rat bone by immobilization and remobilization. Bone. 12:1991;113-118.
51. Verhaeghe J., Van Bree R., Van Herck E., Thomas H., Skottner A., Dequeker J., Mosekilde L.I., Einhorn T.A., Bouillon R. Effects of recombinant human growth hormone and insulin-like growth factor-I, with or without 17β-estradiol, on bone and mineral homeostasis of aged ovariectomized rats. J Bone Miner Res. 11:1996;1723-1735.
52. Wronski T.J., Yen C.-F. Anabolic effects of parathyroid hormone on cortical bone in ovariectomized rats. Bone. 15:1994;51-58.
53. Wronski T.J., Yen C.-F., Dann L.M. Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats. Endocrinology. 132:1993;823-831.
54. Yeh J.K., Aloia J.F., Chen M. Growth hormone administration potentiates the effect of treadmill exercise on log bone formation but not on vertebrae in middle aged rats. Calcif Tissue Int. 54:1994;38-43.
55. Zhang L., Takahashi H.E., Inoue J., Tanizawa T., Endo N., Yamamoto N., Hori M. Effects of intermittent administration of low dose human PTH(1-34) on cancellous and cortical bone of lumbar vertebral bodies in adult beagles. Bone. 21:1997;501-506.