Molecular dynamics simulations and experimental studies of binding and mobility of 7-tert-butyldimethylsilyl-10-hydroxycamptothecin and its 20(S)-4-aminobutyrate ester in DMPC membranes

Molecular Pharmaceutics

Volumn 3, Issue 5, 2006, Pages 589-600

  Xiang, Tian Xiang ^a   Jiang, Zhi Qiang ^a   Song, Lin ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

Anticancer drugs; Camptothecins; DB 67; DMPC; Fluorescence; Lactone hydrolysis; Lipid bilayers; Liposomes; Membrane binding; Molecular dynamics simulation; Prodrugs

Indexed keywords

4 AMINOBUTYRATE ESTER; 7 TERT BUTYLDIMETHYLSILYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; ESTER DERIVATIVE; LACTONE; LIPID; LIPOSOME; PHOSPHATE; SOLVENT; SURFACE WATER; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; BINDING AFFINITY; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; KINETICS; MOLECULAR DYNAMICS; PH MEASUREMENT; PRIORITY JOURNAL; STEADY STATE; ULTRACENTRIFUGATION;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CAMPTOTHECIN; COMPUTER SIMULATION; DIMYRISTOYLPHOSPHATIDYLCHOLINE; ESTERS; KINETICS; LACTONES; LIPID BILAYERS; LIPOSOMES; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; ORGANOSILICON COMPOUNDS;

EID: 33750401902     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp0600081     Document Type: Article

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