Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A 2 receptor, on airway obstruction in guinea pigs

British Journal of Pharmacology

Volumn 153, Issue 4, 2008, Pages 669-675

  Ishimura, M ^a   Suda, M ^a   Morizumi, K ^b   Kataoka, S ^a   Maeda, T ^a   Kurokawa, S ^a   Hiyama, Y ^a  

^a KAKEN PHARMACEUTICAL CO LTD   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Bronchoconstriction; Dual antagonist; Guinea pig; Leukotriene D 4; Thromboxane A 2

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANTIGEN; CYSTEINYL LEUKOTRIENE RECEPTOR 1; CYSTEINYL LEUKOTRIENE RECEPTOR 1 BLOCKING AGENT; KP 496; LEUKOTRIENE D4; MONTELUKAST; OVALBUMIN; SERATRODAST; THROMBOXANE A2 RECEPTOR; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOSPASM; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; GUINEA PIG; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETATES; ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; AIRWAY OBSTRUCTION; ANIMALS; ANTI-ASTHMATIC AGENTS; BENZOATES; BENZOQUINONES; BRONCHOCONSTRICTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; GUINEA PIGS; HEPTANOIC ACIDS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE D4; LUNG; MALE; MEMBRANE PROTEINS; OVALBUMIN; PROSTAGLANDIN ANTAGONISTS; QUINOLINES; RECEPTORS, LEUKOTRIENE; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; RESPIRATORY HYPERSENSITIVITY; THIAZOLES; TIME FACTORS;

EID: 39449134944     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707602     Document Type: Article

References (35)

1. Abraham WM, Ahmed A, Cortes A, Sielczak M, Hallmon J (1993). The effects of a cysteinyl leukotriene antagonist (ONO-1078) on antigen-induced responses in allergic sheep. Prostaglandins Leukot Essent Fatty Acids 48: 233-239.
2. 4-induced smooth muscle contraction in guinea-pig lung parenchyma, but not in trachea. Prostaglandins Leukot Essent Fatty Acids 55: 437-440.
3. 2 antagonist on airway hyperresponsiveness, exhaled nitric oxide, and induced sputum eosinophils in asthmatics. Prostaglandins Leukot Essent Fatty Acids 59: 185-190.
4. Aoki Y, Ishiwara M, Koda A, Takagaki H (2000). Inhibitory effect of a novel quinolinone derivative, TA-270, on asthmatic inflammatory responses in sensitized guinea pigs. Eur J Pharmacol 409: 325-330.
5. 2 receptor antagonist on mediator-controlled resistance in guinea pigs. Eur J Pharmacol 403: 169-179.
6. Arakida Y, Ohga K, Suwa K, Okada Y, Morio H, Yokota M et al. (2000b). Effect of YM158, a dual lipid mediator antagonist, on immediate and late asthmatic responses, and on airway hyperresponsiveness in guinea pigs. Jpn J Pharmacol 82: 287-294.
7. 1 antagonist, pranlukast, in Japanese patients with moderate asthma. Pharmacogenetics 12: 565-570.
8. Ashida Y, Matsumoto T, Kuriki H, Shiraishi M, Kato K, Terao S (1989). A novel antiasthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38: 91-112.
9. Bernstein DI, Ploysongsang Y, Mittman RJ, Piyamahunt A, Bernstein IL (1992). The relationship between airway responsiveness measured before and after the allergen-induced late asthmatic response. Chest 101: 437-441.
10. 4. Br J Pharmacol 80: 497-502.
11. Cartier A, Thomson NC, Frith PA, Roberts R, Hargreave FE (1982). Allergen-induced increase in bronchial responsiveness to histamine: relationship to the late asthmatic response and change in airway caliber. J Allergy Clin Immunol 70: 170-177.
12. 4 on glycoprotein and lysozyme secretion by human bronchial mucosa. Prostaglandins 25: 155-170.
13. Creticos PS, Peters SP, Adkinson Jr NF, Naclerio RM, Hayes EC, Norman PS et al. (1984). Peptide leukotriene release after antigen challenge in patients sensitive to ragweed. N Engl J Med 310: 1626-1630.
14. Dahlen SE, Hedqvist P, Hammarstrom S, Samuelsson B (1980). Leukotrienes are potent constrictors of human bronchi. Nature 288: 484-486.
15. De Monchy JG, Kauffman HF, Venge P, Koeter GH, Jansen HM, Sluiter HJ et al. (1985). Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions. Am Rev Respir Dis 131: 373-376.
16. Drazen JM, Yandava CN, Dube L, Szczerback N, Hippensteel R, Pillari A et al. (1999). Pharmacogenetic association between ALOX5 promoter genotype and the response to antiasthma treatment. Nat Genet 22: 168-170.
17. Fujimura M, Sasaki F, Nakatsumi Y, Takahashi Y, Hifumi S, Taga K et al. (1986). Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax 41: 955-959.
18. Ihaku D, Cameron L, Suzuki M, Molet S, Martin J, Hamid Q (1999). Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats. J Allergy Clin Immunol 104: 1147-1154.
19. 2 mimetic, in inducing airflow obstruction and airway microvascular leakage in guinea pigs. Pharmacology 65: 62-68.
20. 2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergol Int 55: 403-410.
21. 4 receptor antagonist. Can J Physiol Pharmacol 73: 191-201.
22. Kagoshima M, Tomomatsu N, Iwahisa Y, Yamaguchi S, Kawakami Y, Terasawa M (1997). Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. Pharmacology 54: 261-270.
23. 2 mimetic) induces airflow obstruction and airway plasma extravasation in the guinea pig: the role of histamine, cyclooxygenase metabolites, leukotrienes and PAF. J Pharmacol Exp Ther 278: 268-276.
24. Konzett H, Rössler R (1940). Versuchsanordhung zu Untersuchungen an der Bronchialmuskultur. Arch Exp Path Pharmacol 195: 71-77.
25. Krell RD, Aharony D, Buckner CK, Keith RA, Kusner EJ, Snyder DW et al. (1990). The preclinical pharmacology of ICI 204,219. A peptide leukotriene antagonist. Am Rev Respir Dis 141: 978-987.
26. 2 receptor (TP), on porcine pancreas elastase induced emphysema in mice. J Allergy Clin Immunol 119: S245.
27. Matsumoto T, Ashida Y, Tsukuda R (1994). Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig. J Pharmacol Exp Ther 269: 1236-1244.
28. Obata T, Okada Y, Motoishi M, Nakagawa N, Terawaki T, Aishita H (1992). In vitro antagonism of ONO-1078, a newly developed antiasthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol 60: 227-237.
29. Pepys J, Hutchcroft BJ (1975). Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 112: 829-859.
30. Sakurai T, Yamaguchi S, Iwama T, Nagai H (1994). Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs. Prostaglandins Leukot Essent Fatty Acids 51: 95-99.
31. Smith HR, Larsen GL, Cherniack RM, Wenzel SE, Voelkel NF, Westcott JY et al. (1992). Inflammatory cells and eicosanoid mediators in subjects with late asthmatic responses and increases in airway responsiveness. J Allergy Clin Immunol 89: 1076-1084.
32. 2: effects on airway and vascular smooth muscle. Prostaglandins 14: 425-436.
33. 2 receptor antagonist in asthmatic patients? Respir Med 93: 891-897.
34. Tohda Y, Nakajima S, Shizawa T, Maeda K, Ohmori S, Satoh H et al. (1997). The inhibitory effect of TMK688, a novel antiallergic drug having both 5-lipoxygenase inhibitory activity and antihistamine activity, against bronchoconstriction, leukotriene production and inflammatory cell infiltration in sensitized guinea pigs. Clin Exp Allergy 27: 110-118.
35. 2 dual receptor antagonist, on asthmatic responses in guinea pigs. Pharmacology 69: 51-58.