The inhibitory effect of TMK688, a novel anti-allergic drug having both 5-lipoxygenase inhibitory activity and anti-histamine activity, against bronchoconstriction, leukotriene production and inflammatory cell infiltration in sensitized guinea pigs

Clinical and Experimental Allergy

Volumn 27, Issue 1, 1997, Pages 110-118

  Tohda, Y ^a   Nakajima, S ^a   Shizawa, T ^b   Maeda, Kazuha ^b   Ohmori, S ^b   Satoh, H ^b   Ishii, T ^b   Kamitani, T ^b  

^a KINKI UNIVERSITY   (Japan)

^b TERUMO CORPORATION   (Japan)

Author keywords

5 Lipoxygenase inhibitor; Histamine antagonist; TMK688

Indexed keywords

ANTIALLERGIC AGENT; ANTIHISTAMINIC AGENT; ARACHIDONATE 5 LIPOXYGENASE; AZELASTINE; KETOTIFEN; LEUKOTRIENE; LINAZOLAST; OXATOMIDE; PRANLUKAST;

ANIMAL EXPERIMENT; ARTICLE; ASTHMA; BRONCHOSPASM; CELL INFILTRATION; CONTROLLED STUDY; GUINEA PIG; INFLAMMATORY CELL; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ANIMALS; ANTI-ALLERGIC AGENTS; ASTHMA; BRONCHOCONSTRICTION; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; GRANULOCYTES; GUINEA PIGS; HISTAMINE ANTAGONISTS; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; LUNG; MALE; OVALBUMIN; PIPERIDINES; SERINE PROTEINASE INHIBITORS;

EID: 0031016085     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1997.tb00680.x     Document Type: Article

References (37)

1. Murphy RC, Hammarstrom S, Samuelsson B. Leukotriene C, a slow-reacting substance from murine mastocytoma cells. Proc Natl Acad Sci USA 1979; 76:4275-9.
2. Hammarstrom S, Samuelsson B, Clark DA et al. Stereochemistry of leukotriene C-1. Biochem Biophys Res Commun 1980; 92:946-53.
3. Morris HR, Taylor GW, Piper PJ, Tippins JR. Structure of slow-reacting substance of anaphylaxis from guinea pig lung. Nature 1980; 285:104-6.
4. Barnes PJ, Chung KF, Page CP. Inflammatory mediators and asthma. Pharmacol Rev 1988; 40:49-84.
5. Goetzl E. Mediators of immediate hypersensitivity derived from arachidonic acid. N Eng J Med 1980; 303:822-5.
6. White MV, Kaliner MA. Mediators of allergic rhinitis. J Allergy Clin Immunol 1992; 90:699-704.
7. Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 1983; 220:568-75.
8. Drazen JM, Austen KF, Lewis RA et al. Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci USA 1980; 77: 4354-8.
9. 4 and histamine in normal human subjects. Thorax 1984; 39:500-4.
10. Holroyde MC, Altounyan REC, Cole M, Dixon M, Eliott EV. Bronchoconstriction produced in man by leukotrienes C and D. Lancet 1981; 2:17-18.
11. Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 1980; 286:264-5.
12. Czarnetzki BM, Mertensmeier R. In vitro and in vivo chemotaxis of guinea pig leukocytes toward leukotriene B4 and its w-oxidation products. Prostaglandins 1985; 30: 5-11.
13. 4 and structure-function relationships for chemotaxis of human neutrophils. J. Immunol 1984; 133: 1477-82.
14. 4 and 8(S), 15(S)-dihydroxy-5,9,11,13(Z,E, Z,E)-eicosatetraenoic acid. J Immunol 1991; 147:2276-83.
15. Holgate ST, Finnerty JP. Antihistamines in asthma. J Allergy Clin Immunol 1989; 83:537-47.
16. Koshihara Y, Neichi T, Murota S et al. Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochim Biophys Acta 1984; 792:92-7.
17. Murota S, Koshihara Y, Wakabayashi T, Arai J. Anti-allergic action of inhibitors of leukotriene biosynthesis. Adv Prostaglandin Thromboxane Leukotriene Res 1985; 15:221-3.
18. Murota S, Tomioka H, Ozawa S, Suzuki T, Wakabayashi T. Development of an orally active antiallergic drug: TMK688. In: Zor U, Naor Z, Danon A., eds. Leukotrienes and prostanoids in health and disease. New trends in lipid mediatores research. Basel: Karger, 1989; 3:56-61.
19. Konzett H, Rössler R. Versuchsanordnung zu untersuchungen an der bronchialmuskulatur. Arch Exp Pathol Pharmakol 1940; 195:71-4.
20. Sasaki H, Yanai M, Shimura S et al. Late asthmatic response to ascaris antigen challenge in dogs treated with metyrapone. Am Rev Respir Dis 1987; 136:1459-65.
21. Robert C, Haynes J. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones. In: Goodman Gilman A, Rall TW, Nies AS, Taylor P, eds. Goodman and Gilman's the pharmacological basis of therapeutics, 8th edn. New York: Maxwell Macmillan Pergamon 1990: 1431-59.
22. Iijima H, Isii M, Yamauchi K. Bronchoalveolar lavage and histologie characterization of late asthmatic response in guinea-pigs. Am Rev Respir Dis 1987; 136:922-9.
23. Murlas CG, Roum JH. Sequence of pathologic change in the airway mucosa of guinea-pigs during ozone-induced bronchial hyperreactivity. Am Rev Respir Dis 1985; 131: 314-20.
24. Yeadon M, Wilkinson D, Darley-Usmar V, O'Leary J, Payne AN. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulmon Pharmacol 1992; 5:39-50.
25. Tatsumi K, Ou T, Yamada H, Yoshimura H. Studies on metabolic fate of a new antiallergic agent, Azelastine (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)-1-(2-H)-phthalazinone hydrochloride). Japan J Pharmacol 1980; 30: 37-48.
26. Martin U, Römer D. The pharmacological properties of a new, orally active antianaphylactic compound: Ketotifen. a benzocycloheptathiophene. Arzneim Forsch/Drug Res 1978; 28:770-82.
27. Ohmori K, Ishii H, Hirayama, T, Shuto K, Nakamizo N. Pharmacological studies on oxatomide (KW-4354): (1) Effect on passive cutaneous anaphylaxis (PCA) in rat and guinea pigs. Folia Pharmacol Japon 1982; 80:251-60 (Abstract in English.)
28. Nakagawa N, Obata T, Kobayashi T et al. Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma. Eur J Pharmacol 1993; 235:211-9.
29. Zechel HJ, Brock N, Lenke D, Achterrath-Tuckermann U. Pharmacological and toxicological properties of Azelastine, a novel antiallergic agent. Arzneim Forsch/Drug Res 1981; 31:1184-92.
30. Ritchie DM, Sierchio JN, Capetola RJ, Rosenthale ME. SRSA-mediated bronchospasm by pharmacologie modification of lung anaphylaxis in vivo. Agents and Actions 1981; 11:396-401.
31. Collier HOJ, James GWL. Humoral factors affecting pulmonary inflation during acute anaphylaxis in the guinea pig in vivo. Br J Pharmacol Chemother 1967; 30:283-301.
32. Broder I, Rogers S, Chamberlain DW, Milne ENC. Model of allergic bronchoconstriction in the guinea pig. Clin Immun Immunopathol 1978; 9:1-15.
33. Nakagawa N, Obata T, Kobayashi T et al. In vivo pharmacologic profile of ONO-1078: a potent, selective and orally active peptide leukotriene (LT) antagonist. Japan J Pharmacol 1992; 60:217-25.
34. 4 to airway inflammation and the effect of antagonists. Ann NY Acad Sci 1991; 629:274-87.
35. 4 antagonist U-75302 on antigen-induced bronchopulmonary eosinophilia in sensitized guinea pigs. Am Rev Respir Dis 1989; 140:1712-6.
36. Foster A, Chan CC. Peptide leukotriene involvement in pulmonary eosinophil migration upon antigen challenge in the actively sensitized buinea pig. Int Arch Allergy Appl Immunol 1991; 96:279-84.
37. 4 induces interleukin 5 generation from human T lymphocytes. Eur J Immunol 1993; 23:2392-8.