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Volumn 15, Issue 3, 2008, Pages 435-442

Mutant huntingtin can paradoxically protect neurons from death

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CASEIN KINASE; CASPASE 3; CASPASE 6; CYSTATHIONINE BETA SYNTHASE; ENDOPHILIN; GLUTAMATE RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HUNTINGTIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NUCLEAR RECEPTOR COREPRESSOR; POSTSYNAPTIC DENSITY PROTEIN 95; PROLINE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P53; QUINOLINIC ACID; RAS PROTEIN;

EID: 39449105711     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402261     Document Type: Review
Times cited : (24)

References (53)
  • 1
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • The Huntington's Disease Collaborative Research Group
    • The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993; 72: 971-983.
    • (1993) Cell , vol.72 , pp. 971-983
  • 5
    • 0029152808 scopus 로고
    • Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies
    • Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR et al Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies. Proc Natl Acad Sci USA 1995; 92: 8710-8714.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8710-8714
    • Gutekunst, C.A.1    Levey, A.I.2    Heilman, C.J.3    Whaley, W.L.4    Yi, H.5    Nash, N.R.6
  • 6
    • 0030771894 scopus 로고    scopus 로고
    • Huntingtin localization in brains of normal and Huntington's disease patients
    • Sapp E, Schwarz C, Chase K, Bhide PG, Young AB, Penney J et al. Huntingtin localization in brains of normal and Huntington's disease patients. Ann Neurol 1997; 42: 604-612.
    • (1997) Ann Neurol , vol.42 , pp. 604-612
    • Sapp, E.1    Schwarz, C.2    Chase, K.3    Bhide, P.G.4    Young, A.B.5    Penney, J.6
  • 7
    • 0842322740 scopus 로고    scopus 로고
    • Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction
    • Qin ZH, Wang Y, Sapp E, Cuiffo B, Wanker E, Hayden MR et al. Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. J Neurosci 2004; 24: 269-281.
    • (2004) J Neurosci , vol.24 , pp. 269-281
    • Qin, Z.H.1    Wang, Y.2    Sapp, E.3    Cuiffo, B.4    Wanker, E.5    Hayden, M.R.6
  • 8
    • 8844220536 scopus 로고    scopus 로고
    • Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series
    • Landles C, Bates GP. Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep 2004; 5: 958-963.
    • (2004) EMBO Rep , vol.5 , pp. 958-963
    • Landles, C.1    Bates, G.P.2
  • 9
    • 7244236320 scopus 로고    scopus 로고
    • Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
    • Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 2004; 431: 805-810.
    • (2004) Nature , vol.431 , pp. 805-810
    • Arrasate, M.1    Mitra, S.2    Schweitzer, E.S.3    Segal, M.R.4    Finkbeiner, S.5
  • 10
    • 0042536473 scopus 로고    scopus 로고
    • Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    • Arundine M, Tymianski M. Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity. Cell Calcium 2003; 34: 325-337.
    • (2003) Cell Calcium , vol.34 , pp. 325-337
    • Arundine, M.1    Tymianski, M.2
  • 11
    • 0020702374 scopus 로고
    • Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
    • Schwarcz R, Whetsell Jr WO, Mangano RM. Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain. Science 1983; 219: 316-318.
    • (1983) Science , vol.219 , pp. 316-318
    • Schwarcz, R.1    Whetsell Jr, W.O.2    Mangano, R.M.3
  • 12
    • 0033587760 scopus 로고    scopus 로고
    • Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity
    • Hansson O, Petersen A, Leist M, Nicotera P, Castilho RF, Brundin P. Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci USA 1999; 96: 8727-8732.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8727-8732
    • Hansson, O.1    Petersen, A.2    Leist, M.3    Nicotera, P.4    Castilho, R.F.5    Brundin, P.6
  • 13
    • 0035783462 scopus 로고    scopus 로고
    • Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene
    • Hansson O, Guatteo E, Mercuri NB, Bernardi G, Li XJ, Castilho RF et al. Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene. Eur J Neurosci 2001; 14: 1492-1504.
    • (2001) Eur J Neurosci , vol.14 , pp. 1492-1504
    • Hansson, O.1    Guatteo, E.2    Mercuri, N.B.3    Bernardi, G.4    Li, X.J.5    Castilho, R.F.6
  • 14
    • 0027261537 scopus 로고
    • Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease
    • Snell RO, MacMillan JC, Cheadle JP, Fenton I, Lazarou LP, Davies P et al. Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease. Nat Genet 1993; 4 393-397.
    • (1993) Nat Genet , vol.4 , pp. 393-397
    • Snell, R.O.1    MacMillan, J.C.2    Cheadle, J.P.3    Fenton, I.4    Lazarou, L.P.5    Davies, P.6
  • 15
    • 1542346231 scopus 로고    scopus 로고
    • Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model
    • Jarabek BR, Yasuda RP, Wolfe BB. Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model. Brain 2004; 127: 505-516.
    • (2004) Brain , vol.127 , pp. 505-516
    • Jarabek, B.R.1    Yasuda, R.P.2    Wolfe, B.B.3
  • 16
    • 23844472610 scopus 로고    scopus 로고
    • Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions
    • Slow EJ, Graham RK, Osmand AP, Devon RS, Lu G, Deng Y et al. Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions. Proc Natl Acad Sci USA 2005; 102: 11402-11487.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11402-11487
    • Slow, E.J.1    Graham, R.K.2    Osmand, A.P.3    Devon, R.S.4    Lu, G.5    Deng, Y.6
  • 18
    • 33745003424 scopus 로고    scopus 로고
    • Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
    • Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G et al. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 2006; 125: 1179-1191.
    • (2006) Cell , vol.125 , pp. 1179-1191
    • Graham, R.K.1    Deng, Y.2    Slow, E.J.3    Haigh, B.4    Bissada, N.5    Lu, G.6
  • 19
    • 0037075624 scopus 로고    scopus 로고
    • Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitoxicity in a mouse model of Huntington's disease
    • Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P et al. Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitoxicity in a mouse model of Huntington's disease. Neuron 2002; 33: 849-860.
    • (2002) Neuron , vol.33 , pp. 849-860
    • Zeron, M.M.1    Hansson, O.2    Chen, N.3    Wellington, C.L.4    Leavitt, B.R.5    Brundin, P.6
  • 20
    • 30744437894 scopus 로고    scopus 로고
    • Striatal neurons apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
    • Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR et al. Striatal neurons apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiol Dis 2006; 21: 392-403.
    • (2006) Neurobiol Dis , vol.21 , pp. 392-403
    • Shehadeh, J.1    Fernandes, H.B.2    Zeron Mullins, M.M.3    Graham, R.K.4    Leavitt, B.R.5    Hayden, M.R.6
  • 21
    • 0032912386 scopus 로고    scopus 로고
    • Recent advances on the pathogenesis of Huntington's disease
    • Petersen A, Mani K, Brundin P. Recent advances on the pathogenesis of Huntington's disease. Exp Neurol 1999; 157: 1-18.
    • (1999) Exp Neurol , vol.157 , pp. 1-18
    • Petersen, A.1    Mani, K.2    Brundin, P.3
  • 22
    • 0034889544 scopus 로고    scopus 로고
    • Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length
    • Hansson O, Castilho RF, Korhonen L, Lindholm D, Bates GP, Brundin P. Partial resistance to malonate-induced striatal cell death in transgenic mouse models of Huntington's disease is dependent on age and CAG repeat length. J Neurochem 2001; 78: 694-703.
    • (2001) J Neurochem , vol.78 , pp. 694-703
    • Hansson, O.1    Castilho, R.F.2    Korhonen, L.3    Lindholm, D.4    Bates, G.P.5    Brundin, P.6
  • 23
    • 0035783947 scopus 로고    scopus 로고
    • Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine
    • Petersen A, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF et al. Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine. Eur J Neurosci 2001; 14: 1425-1435.
    • (2001) Eur J Neurosci , vol.14 , pp. 1425-1435
    • Petersen, A.1    Hansson, O.2    Puschban, Z.3    Sapp, E.4    Romero, N.5    Castilho, R.F.6
  • 24
    • 0033784437 scopus 로고    scopus 로고
    • Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity
    • Hickey MA, Morton AJ. Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity. J Neurochem 2000; 75: 2163-2171.
    • (2000) J Neurochem , vol.75 , pp. 2163-2171
    • Hickey, M.A.1    Morton, A.J.2
  • 25
    • 0034194616 scopus 로고    scopus 로고
    • Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity
    • Morton AJ, Leavens W. Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity. Brain Res Bull 2000; 52: 51-59.
    • (2000) Brain Res Bull , vol.52 , pp. 51-59
    • Morton, A.J.1    Leavens, W.2
  • 26
    • 0036469255 scopus 로고    scopus 로고
    • Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice
    • MacGibbon GA, Hamilton LC, Crocker SF, Costain WJ, Murphy KM, Robertson HA et al. Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice. J Neurosci Res 2002; 67: 372-378.
    • (2002) J Neurosci Res , vol.67 , pp. 372-378
    • MacGibbon, G.A.1    Hamilton, L.C.2    Crocker, S.F.3    Costain, W.J.4    Murphy, K.M.5    Robertson, H.A.6
  • 27
  • 28
    • 13944275615 scopus 로고    scopus 로고
    • Polyglutamine expansion of huntingtin impairs its nuclear export
    • Cornett J, Cao F, Wang CE, Ross CA, Bates GP, Li SH et al. Polyglutamine expansion of huntingtin impairs its nuclear export. Nat Genet 2005; 37: 198-204.
    • (2005) Nat Genet , vol.37 , pp. 198-204
    • Cornett, J.1    Cao, F.2    Wang, C.E.3    Ross, C.A.4    Bates, G.P.5    Li, S.H.6
  • 29
    • 0032186107 scopus 로고    scopus 로고
    • SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates
    • Sittler A, Walter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H et al. SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. Mol Cell 1998; 2: 427-436.
    • (1998) Mol Cell , vol.2 , pp. 427-436
    • Sittler, A.1    Walter, S.2    Wedemeyer, N.3    Hasenbank, R.4    Scherzinger, E.5    Eickhoff, H.6
  • 30
    • 0000790724 scopus 로고    scopus 로고
    • SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes
    • Liu YF, Deth RC, Devys D. SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes. J Biol Chem 1997; 272: 8121-8124.
    • (1997) J Biol Chem , vol.272 , pp. 8121-8124
    • Liu, Y.F.1    Deth, R.C.2    Devys, D.3
  • 32
    • 0036796261 scopus 로고    scopus 로고
    • PACSIN 1-interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains
    • Modregger J, DiProspero NA, Charles V, Tagle DA, Plomann M. PACSIN 1-interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brains. Hum Mol Genet 2002; 11: 2547-2558.
    • (2002) Hum Mol Genet , vol.11 , pp. 2547-2558
    • Modregger, J.1    DiProspero, N.A.2    Charles, V.3    Tagle, D.A.4    Plomann, M.5
  • 33
    • 0035816627 scopus 로고    scopus 로고
    • Polyglutemine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95
    • Sun Y, Savanenin A, Reddy PH, Liu YF. Polyglutemine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95. J Biol Chem 2001; 276: 24713-24718.
    • (2001) J Biol Chem , vol.276 , pp. 24713-24718
    • Sun, Y.1    Savanenin, A.2    Reddy, P.H.3    Liu, Y.F.4
  • 35
    • 0036850524 scopus 로고    scopus 로고
    • HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis
    • Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S et al. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet 2002; 11: 2815-2828.
    • (2002) Hum Mol Genet , vol.11 , pp. 2815-2828
    • Singaraja, R.R.1    Hadano, S.2    Metzler, M.3    Givan, S.4    Wellington, C.L.5    Warby, S.6
  • 37
    • 0034649661 scopus 로고    scopus 로고
    • FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis
    • Hattula K, Peranen J. FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. Curr Biol 2000; 10 1603-1606.
    • (2000) Curr Biol , vol.10 , pp. 1603-1606
    • Hattula, K.1    Peranen, J.2
  • 38
    • 0032833981 scopus 로고    scopus 로고
    • Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
    • Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS et al. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. Hum Mol Genet 1999; 8: 1647-1655.
    • (1999) Hum Mol Genet , vol.8 , pp. 1647-1655
    • Boutell, J.M.1    Thomas, P.2    Neal, J.W.3    Weston, V.J.4    Duce, J.5    Harper, P.S.6
  • 39
    • 0026729382 scopus 로고
    • The SH2 and SH3 domain-containing protein GRB2 links receptortyrosine kinases to ras signaling
    • Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R et al The SH2 and SH3 domain-containing protein GRB2 links receptortyrosine kinases to ras signaling. Cell 1992; 70: 431-442.
    • (1992) Cell , vol.70 , pp. 431-442
    • Lowenstein, E.J.1    Daly, R.J.2    Batzer, A.G.3    Li, W.4    Margolis, B.5    Lammers, R.6
  • 40
    • 0025177324 scopus 로고
    • Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
    • Ellis CMM, McCormick F, Pawson T. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature 1990; 343: 377-381.
    • (1990) Nature , vol.343 , pp. 377-381
    • Ellis, C.M.M.1    McCormick, F.2    Pawson, T.3
  • 41
    • 0028788570 scopus 로고
    • Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
    • Henkemeyer MAD, Holmyard DP, Puri MC, Mbamula G, Harpal K, Shih TS et al. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995; 377: 695-701.
    • (1995) Nature , vol.377 , pp. 695-701
    • Henkemeyer, M.A.D.1    Holmyard, D.P.2    Puri, M.C.3    Mbamula, G.4    Harpal, K.5    Shih, T.S.6
  • 42
    • 14644430451 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
    • Lievens JC, Rival T, Iohe M, Chneiweiss H, Birman S. Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila. Hum Mol Genet 2005; 14 713-724.
    • (2005) Hum Mol Genet , vol.14 , pp. 713-724
    • Lievens, J.C.1    Rival, T.2    Iohe, M.3    Chneiweiss, H.4    Birman, S.5
  • 43
    • 0035503713 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death
    • Peterson AA, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P et al. Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death. Brain Res Bull 2001; 56: 331-335.
    • (2001) Brain Res Bull , vol.56 , pp. 331-335
    • Peterson, A.A.1    Larsen, K.E.2    Behr, G.G.3    Romero, N.4    Przedborski, S.5    Brundin, P.6
  • 44
    • 0032764083 scopus 로고    scopus 로고
    • Effects of ciliary neurotrophic factor on excitotoxicity and calcium-ionophore A23187-induced cell death in cultured embryonic striatal neurons
    • Petersen A, Brundin P. Effects of ciliary neurotrophic factor on excitotoxicity and calcium-ionophore A23187-induced cell death in cultured embryonic striatal neurons. Exp Neurol 1999; 160: 402-412.
    • (1999) Exp Neurol , vol.160 , pp. 402-412
    • Petersen, A.1    Brundin, P.2
  • 46
    • 0032836405 scopus 로고    scopus 로고
    • NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus
    • Bond A, Lodge D, Hicks CA, Ward MA, O'Neill MJ. NMDA receptor antagonism, but not AMPA receptor antagonism attenuates induced ischaemic tolerance in the gerbil hippocampus. Eur J Pharmacol 1999; 380: 91-99.
    • (1999) Eur J Pharmacol , vol.380 , pp. 91-99
    • Bond, A.1    Lodge, D.2    Hicks, C.A.3    Ward, M.A.4    O'Neill, M.J.5
  • 47
    • 0033103342 scopus 로고    scopus 로고
    • Ischemic tolerance in murine cortical cell culture: Critical role for NMDA receptors
    • Grabb MC, Choi DW. Ischemic tolerance in murine cortical cell culture: critical role for NMDA receptors. J Neurosci 1999; 19: 1657-1662.
    • (1999) J Neurosci , vol.19 , pp. 1657-1662
    • Grabb, M.C.1    Choi, D.W.2
  • 48
    • 0026608622 scopus 로고
    • MK-801, but not anisomycin, inhibits the inducton of tolerance to ischemia in the gerbil hippocampus
    • Kato H, Liu Y, Araki T, Kogure K. MK-801, but not anisomycin, inhibits the inducton of tolerance to ischemia in the gerbil hippocampus. Neurosci Lett 1992; 139: 118-121.
    • (1992) Neurosci Lett , vol.139 , pp. 118-121
    • Kato, H.1    Liu, Y.2    Araki, T.3    Kogure, K.4
  • 49
    • 33750831549 scopus 로고    scopus 로고
    • Oral uridine pro-drug PN401 is neuroprotective in the R8/2 and N171-82O mouse models of Huntington's disease
    • Saydoff JA, Garcia RA, Browne SE, Liu L, Sheng J, Brenneman D et al Oral uridine pro-drug PN401 is neuroprotective in the R8/2 and N171-82O mouse models of Huntington's disease. Neurobiol Dis 2006; 24: 455-465.
    • (2006) Neurobiol Dis , vol.24 , pp. 455-465
    • Saydoff, J.A.1    Garcia, R.A.2    Browne, S.E.3    Liu, L.4    Sheng, J.5    Brenneman, D.6
  • 50
    • 0036315706 scopus 로고    scopus 로고
    • Mise overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid
    • Dedeoglu A, Ferrante RJ, Andreassen OA, Dillmann WH, Beal MF. Mise overexpressing 70-kDa heat shock protein show increased resistance to malonate and 3-nitropropionic acid. Exp Neurol 2002; 176: 262-265.
    • (2002) Exp Neurol , vol.176 , pp. 262-265
    • Dedeoglu, A.1    Ferrante, R.J.2    Andreassen, O.A.3    Dillmann, W.H.4    Beal, M.F.5
  • 51
    • 33745178085 scopus 로고    scopus 로고
    • Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease
    • McBride JL, Ramaswamy S, Gasmi M, Bartus RT, Herzog CD, Brandon EP et al. Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's disease. Proc Natl Acad Sci USA 2006; 103: 9345-9350.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9345-9350
    • McBride, J.L.1    Ramaswamy, S.2    Gasmi, M.3    Bartus, R.T.4    Herzog, C.D.5    Brandon, E.P.6
  • 52
    • 29144517660 scopus 로고    scopus 로고
    • FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease
    • Jin K, LaFevre-Bernt M, Sun Y, Chen S, Gafni J, Crippen D et al. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci USA 2005; 102: 18189-18194.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18189-18194
    • Jin, K.1    LaFevre-Bernt, M.2    Sun, Y.3    Chen, S.4    Gafni, J.5    Crippen, D.6
  • 53
    • 20844455450 scopus 로고    scopus 로고
    • Chemotherapy for the brain: The antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease
    • Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J et al. Chemotherapy for the brain: The antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci 2004; 24: 10335-10342.
    • (2004) J Neurosci , vol.24 , pp. 10335-10342
    • Ferrante, R.J.1    Ryu, H.2    Kubilus, J.K.3    D'Mello, S.4    Sugars, K.L.5    Lee, J.6


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