Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-κB and p38 MAPK in mouse skin

BioFactors

Volumn 21, Issue 1-4, 2004, Pages 27-31

  Sue, Ok Kim ^a   Chun, Kyung Soo ^a   Kundu, Joydeb Kumar ^a   Surh, Young Joon ^a  

^a Seoul National University   (South Korea)

Author keywords

Chemoprevention; Cyclooxygenase 2; Mouse skin; NF B; p38 MAPK; 6 gingerol

Indexed keywords

(6) GINGEROL; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; ANTINEOPLASTIC AGENT; FATTY ALCOHOL; GINGEROL; PROSTAGLANDIN SYNTHASE;

BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; GINGER; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PHOSPHORYLATION; TOPICAL DRUG ADMINISTRATION;

ZINGIBER OFFICINALE; ZINGIBERACEAE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTICARCINOGENIC AGENTS; CYCLOOXYGENASE 2; ENZYME ACTIVATION; FATTY ALCOHOLS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GINGER; MICE; MICE, INBRED ICR; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SKIN; TETRADECANOYLPHORBOL ACETATE;

EID: 21544454944     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.552210107     Document Type: Conference Paper

References (24)

1. Y.-J. Surh, Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review, Food Chem Toxicol 40 (2002), 1091-1097.
2. M.M. Manson, A. Gescher, E.A. Hudson, S.M. Plummer, M.S. Squires and S.A. Prigent, Blocking and suppressing mechanisms of chemoprevention by dietary constituents, Toxicol Lett 112-113 (2000), 499-505.
3. A.C. Bharti and B.B. Aggarwal, Nuclear factor-κB and cancer: its role in prevention and therapy, Biochem Pharmacol 64 (2002), 883-888.
4. P. Bremner and M. Heinrich, Natural products as targeted modulators of the nuclear factor-κB pathway, J Pharm Pharmacol 54 (2002), 453-472.
5. A.A. Beg and D. Baltimore, An essential role for NF-κB in preventing TNF-α-induced cell death, Science 274 (1996), 782-784.
6. C.Y. Wang, M.W. Mayo, R.G. Korneluk, D.V. Goeddel, A.S. Baldwin Jr., NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation, Science 281 (1998), 1680-1683.
7. R. Visconti, J. Cerutti, S. Battista, M. Fedele, F. Trapasso, K. Zeki, M. P. Miano, F. de Nigris, L. Casalino, F. Curcio, M. Santoro and A. Fusco, Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression, Oncogene 15 (1997), 1987-1994.
8. A.M. Bode, W.Y. Ma, Y.-J. Surh and Z. Dong, Inhibition of epidermal growth factor-induced cell transformation and activator protein-1 activation by [6]-gingerol, Cancer Res 61 (2001), 850-853.
9. N.R. Bhat, D.L. Feinstein, Q. Shen and A.N. Bhat, p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription factor-2, J Biol Chem 277 (2002), 29584-29592.
10. H.F. Cheng and R.C. Harris, Cyclooxygenase-2 expression in cultured cortical thick ascending limb of Henle increases in response to decreased extracellular ionic content by both transcriptional and post-transcriptional mechanisms. Role of p38-mediated pathways, J Biol Chem 277 (2002), 45638-45643.
11. M. Tamura, S. Sebastian, S. Yang, B. Gurates, Z. Fang and S.E. Bulun, Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2, J Clin Endocrinol Metab 87 (2002), 3263-3273.
12. M. Lasa, K.R. Mahtani, A. Finch, G. Brewer, J. Saklatvala and A.R. Clark, Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade, Mol Cell Biol 20 (2000), 4265-4274.
13. C.H. Lin, C.H. Wu, W.Y. Thum, Y.S. Ho and H.M. Lee, Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression, Eur J Pharmacol 438 (2002), 143-152.
14. C.A. Singer, K.J. Baker, A. McCaffrey, D.P. AuCoin, M.A. Dechert and W.T. Gerthoffer, p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes, Am J Physiol Lung Cell Mol Physiol 285 (2003), E1087-E1098.
15. J.K. Kundu, H.-K. Na, K.-S. Chun, Y.-K. Kim, S.J. Lee, S.S. Lee, O.-S. Lee, Y.-C. Sim and Y.-J. Surh, Inhibition of phorbol ester-induced COX-2 expression by epigallocatechin gallate in mouse skin and cultured human mammary epithelial cells, J Nutr 133 (2003), 3805S-3810S.
16. S. Wesselborg, M.K. Bauer, M. Vogt, M.L. Schmitz and K. Schulze-Osthoff, Activation of transcription factor NF-κB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways, J Biol Chem 272 (1997), 12422-12429.
17. Y.-J. Surh, Cancer chemoprevention with dietary phytochemicals, Nature Rev Cancer 3 (2003), 768-780.
18. S.S. Han, Y-S. Keum, H.-J. Seo, K.-S. Chun, S.S. Lee and Y.-J. Surh, Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis, Cancer Lett 164 (2001), 119-126.
19. H. Sano, Y. Kawahito, R.L. Wilder, A. Hashiramoto, S. Mukai, K. Asai, S. Kimura, H. Kato, M. Kondo and T. Hla, Expression of cyclooxygenase-1 and -2 in human colorectal cancer, Cancer Res 55 (1995), 3785-3789.
20. L.R. Howe, K. Subbaramaiah, A.M. Brown and A.J. Dannenberg, Cyclooxygenase-2: a target for the prevention and treatment of breast cancer, Endocr Relat Cancer 8 (2001), 97-114.
21. Y.-J. Surh, Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances, Mutat Res 428 (1999), 305-327.
22. K.-K. Park, K.-S. Chun, J.M. Lee, S.S. Lee and Y-J. Surh, Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice, Cancer Lett 129 (1998), 139-144.
23. K.-S. Chun, Y.-S. Keum, S.S. Han, Y.-S. Song, S.-H. Kim and Y.-J. Surh, Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation, Carcinogenesis 24 (2003), 1515-1524.
24. J.L. Lee, H. Mukhtar, D.R. Bickers, L. Kopelovich and M. Athar, Cyclooxygenases in the skin: pharmacological and toxicological implications, Toxicol Appl Pharmacol 192 (2003), 294-306.