The BCL2 rheostat in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia

Leukemia

Volumn 22, Issue 2, 2008, Pages 370-377

  Ploner, C ^a   Rainer, J ^b   Niederegger, H ^b   Eduardoff, M ^b   Villunger, A ^a   Geley, S ^a   Kofler, R ^a,b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; BIM PROTEIN; GLUCOCORTICOID; PROTEIN BCL 2; PROTEIN NOXA; RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LENTIVIRINAE; LYMPHOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 39149095948     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2405039     Document Type: Article

References (40)

1. Pui CH, Relling MV, Downing JR. Acute lymphoblastic leukemia. N Engl J Med 2004; 350: 1535-1548.
2. Laudet V, Gronemeyer H. The Nuclear Receptor Facts Book. Academic Press: London, 2002, 354-376.
3. Schmidt S, Rainer J, Ploner C, Presul E, Riml S, Kofler R. Glucticorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ 2004; 11 (Suppl 1): S45-S55.
4. Schmidt S, Rainer J, Riml S, Ploner C, Jesacher S, Achmüller C et al. Identification of glucocorticoid response genes in children with acute lymphoblastic leukemia. Blood 2006; 107: 2061-2069.
5. Tissing WJ, den Boer ML, Meijerink JP, Menezes RX, Swagemakers S, van der Spek PJ et al. Genome-wide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood 2007; 109: 3929-3935.
6. Distelhorst CW. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ 2002; 9: 6-19.
7. Schaaf MJ, Cidlowski JA. Molecular mechanisms of glucocorticoid action and resistance. J Steroid Biochem Mol Biol 2002; 83: 37-48.
8. Planey SL, Litwack G. Glucocorticoid-induced apoptosis in lymphocytes. Biochem Biophys Res Commun 2000; 279: 307-312.
9. Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 2005; 5: 189-200.
10. Ranger AM, Malynn BA, Korsmeyer SJ. Mouse models of cell death. Nat Genet 2001; 28: 113-118.
11. Almawi WY, Melemedjian OK, Jaoude MM. On the link between Bcl-2 family proteins and glucocorticoid-induced apoptosis. J Leukoc Biol 2004; 76: 7-14.
12. Labi V, Erlacher M, Kiessling S, Villunger A. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ 2006; 13: 1325-1338.
13. Hartmann BL, Geley S, Löffler M, Hattmannstorfer R, Strasser-Wozak EMC, Auer B et al. Bcl-2 interferes with the execution phase, but not upstream events, in glucocorticoid-induced leukemia apoptosis. Oncogene 1999; 18: 713-719.
14. Abrams MT, Robertson NM, Yoon K, Wickstrom E. Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM with siRNA and shRNA. J Biol Chem 2004; 279: 55809-55817.
15. Lu J, Quearry B, Harada H. p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells. FEBS Lett 2006; 580: 3539-3544.
16. Salomons GS, Brady HJM, Verwijs-Janssen M, Van den Borg JD, Hart AAM, Van den Berg H et al. The Baxα:BCl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. Int J Cancer 1997; 71: 959-965.
17. Wei G, Twomey D, Lamb J, Schlis K, Agarwal J, Stam RW et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006; 10: 331-342.
18. Wang Z, Malone MH, He H, McColl KS, Distelhorst CW. Microarray analysis uncovers the induction of the pro-apoptotic BH3-only protein Bim in multiple models of glucocorticoid induced apoptosis. J Biol Chem 2003; 278: 23861-23867.
19. Iglesias-Serret D, de FM, Santidrian AF, Coll-Mulet L, Cosialls AM, Barragan M et al. Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells. Leukemia 2007; 21: 281-287.
20. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ et al Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci USA 2001; 98: 11318-11323.
21. Casale F, Addeo R, D'Angelo V, Indolfi P, Poggi V, Morgera C et al Determination of the in vivo effects of prednisone on Bcl-2 family protein expression in childhood acute lymphoblastic leukemia. Int J Oncol 2003; 22: 123-128.
22. Löffler M, Tonko M, Hartmann BL, Bernhard D, Geley S, Helmberg A et al. c-myc does not prevent glucocorticoid-induced apoptosis of human leukemic lymphoblasts. Oncogene 1999; 18: 4626-4631.
23. Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DCS et al Structural insights into the degradation of Mcl-1 induced by BH3 domains. Proc Natl Acad Sci USA 2007; 104: 6217-6222.
24. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005; 19: 1294-1305.
25. Claudio JO, Masih-Khan E, Tang H, Goncalves J, Voralia M, Li ZH et al A molecular compendium of genes expressed in multiple myeloma. Blood 2002; 100: 2175-2186.
26. Green DR. Apoptotic pathways: Ten minutes to dead. Cell 2005; 121: 671-674.
27. Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ et al. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 2006; 8: 1348-1358.
28. Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856-859.
29. Willis SN, Adams JIM. Life in the balance: How BH3-only proteins induce apoptosis. Curr Opin Cell Biol 2005; 17: 617-625.
30. Certo M, Del GMV, Nishino M, Wei G, Korsmeyer S, Armstrong SA et al Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 2006; 9: 351-365.
31. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 2005; 17: 393-403.
32. Villunger A, Michalak EM, Coultas L, Mullauer F, Bock G, Ausserlechner MJ et al. p53- and-drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 2003; 302: 1036-1038.
33. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, Coultas L et al. BH3-only proteins Puma and Bim are rate-limiting for {gamma} -radiation and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 2005; 106: 4131-4138.
34. Rhein P, Scheid S, Ratei R, Hagemeier C, Seeger K, Kirschner-Schwabe R et al. Gene expression shift towards normal B cells, decreased proliferative capacity and distinct surface receptors characterize leukemic blasts persisting during induction therapy in childhood acute lymphoblastic leukemia. Leukemia 2007; 21: 897-905.
35. Alves NL, van Lier RA, Eldering E. Withdrawal symptoms on display: Bcl-2 members under investigation. Trends Immunol 2007; 28: 26-32.
36. Herr I, Gassler N, Friess H, Buchler MW. Regulation of differential pro- and anti-apoptotic signaling by glucocorticoids. Apoptosis 2007; 12: 271-291.
37. Schmidt S, Irving JA, Minto L, Matheson E, Nicholson L, Ploner A et al. Glucocorticoid resistance in two key models of acute lymphoblastic leukemia occurs at the level of the glucocorticoid receptor. FASEB J 2006; 20: 2600-2602.
38. Wang Z, Chen W, Kono E, Dang T, Garabedian MJ. Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol 2007; 21: 625-634.
39. Szatmary Z, Garabedian MJ, Vilcek J. Inhibition of Glucocorticoid Receptor-mediated Transcriptional Activation by p38 Mitogen activated Protein (MAP) Kinase. J Biol Chem 2004; 279: 43708-43715.
40. Bodwell JE, Webster JC, Jewell CM, Cidlowski JA, Hu JM, Munck A. Glucocorticoid-receptor phosphorylation: Overview, function and cell cycle-dependence J Steroid Biochem Mol Biol 1998; 65: 91-99.