Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1318-1322

  Yu, Younong ^a   Dwyer, Michael P ^a   Chao, Jianping ^a   Aki, Cynthia ^a   Chao, Jianhua ^a   Purakkattle, Biju ^a   Rindgen, Diane ^a   Bond, Richard ^a   Mayer Ezel, Rosemary ^a   Jakway, James ^a   Qiu, Hongchen ^a   Hipkin, R William ^a   Fossetta, James ^a   Gonsiorek, Waldemar ^a   Bian, Hong ^a   Fan, Xuedong ^a   Terminelli, Carol ^a   Fine, Jay ^a   Lundell, Daniel ^a   Merritt, J Robert ^b   He, Zhenmin ^b   Lai, Gaifa ^b   Wu, Minglang ^b   Taveras, Arthur ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b PHARMACOPEIA INC   (United States)

Author keywords

3,4 Diaminocyclobut 3 ene 1,2 dione class of CXCR2 CXCR1 receptor antagonists; CXCR1 receptor; CXCR2 receptor; Interleukin 8

Indexed keywords

3,4 DIAMINO 3 CYCLOBUT 3 ENE 1,2 DIONE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; HETEROCYCLIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; NONHUMAN; PROTEIN BINDING; PROTEIN FUNCTION; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; CELL LINE; CYCLOBUTANES; DIAMINES; HETEROCYCLIC COMPOUNDS; MICE; RECEPTORS, INTERLEUKIN-8A; RECEPTORS, INTERLEUKIN-8B; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 38949192884     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.024     Document Type: Article

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