Small molecule interleukin-8 modulators

Expert Opinion on Therapeutic Patents

Volumn 11, Issue 12, 2001, Pages 1905-1910

  Li, J J ^a  

^a PFIZER INC   (United States)

Author keywords

Chemokines (cytokines); CXCR1; CXCR2; IL 8; Inflammation; P38 kinase

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; 9 CARBAZOLEPROPIONIC ACID; AROMATIC COMPOUND; CHEMOKINE; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; DF 1681; DICHLOROQUINOXALINE; IMIDAZOLE DERIVATIVE; IMMUNOMODULATING AGENT; INTERLEUKIN 8; INTERLEUKIN 8 RECEPTOR; N (2 ARYLPROPIONYL)SULFONAMIDE; N (2 HYDROXY 4 CYANOPHENYL) N (2 BROMOPHENYL)UREA; N (2 HYDROXY 4 NITROPHENYL) N (2 BROMOPHENYL)UREA; N (2 HYDROXY 4 NITROPHENYL) N PHENYLUREA; OLOPATADINE; PHOSPHOTRANSFERASE INHIBITOR; PYRIMIDINE; PYRIMIDINE DERIVATIVE; PYRIMIDYL AMIDE; QUINOXALINE DERIVATIVE; SYNAPTOPHYSIN; THIAZOLE; THIAZOLOPYRIMIDINE; U 3405; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG CONCENTRATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INFLAMMATORY DISEASE; MEDICAL DOCUMENTATION; MEDICAL LITERATURE; NONHUMAN; PATENT; PREVALENCE; PUBLICATION; REVIEW;

EID: 0035207793     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.11.12.1905     Document Type: Review

References (20)

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3. Cloning of complementary DNA encoding a functional human interleukin-8 receptor
4. Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: Partial characterization and separation from interleukin 1 (IL 1)
5. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes
6. Modulation and induction of eosinophil chemotaxis by granulocyte-macrophage colony-stimulating factor and interleukin-3
7. Neutrophil attractant/activation protein-1 (NAP-1) causes human basophil histamine release
8. Effects of the neutrophil-activating peptide NAP-2 platelet basic protein connective tissue-activating peptide III and platelet factor 4 on human neutrophils
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10. Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1
11. Identification of C5ades arg and an anionic neutrophil-activating peptide (ANAP) in psoriatic scales
12. Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells
13. Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality
14. Interleukin-8 is a major neutrophil chemotactic factor in pleural liquid of patients with empyema
15. 2 antagonist that inhibits interleukin-8-induced neutrophil migration
16. IL-8 induces neutrophil chemotaxis predominantly via Type I IL-8 receptors
17. Both interleukin-8 receptors independently mediate chemotaxis. Jurkat cells transfected with IL-8R1 or IL-8R2 migrate in response to IL-8, GROα and NAP-2
18. Bradykinin stimulates IL-6 and IL-8 production by human lung fibroblasts through ERK- and p38 MAPK-dependent mechanisms
19. Selective inhibitor of p38 mitogen-activated protein kinase inhibits lipopolysaccharide-induced interleukin-8 expression in human pulmonary vascular endothelial cells
20. Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases