3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 14, 2007, Pages 3864-3867

  Wang, Yonghui ^a   Busch Petersen, Jakob ^a   Wang, Feng ^a   Ma, Lanping ^b   Fu, Wei ^a   Kerns, Jeffrey K ^a   Jin, Jian ^a   Palovich, Michael R ^a   Shen, Jing Kang ^b   Burman, Miriam ^a   Foley, James J ^a   Schmidt, Dulcie B ^a   Hunsberger, Gerald E ^a   Sarau, Henry M ^a   Widdowson, Katherine L ^a  

^a GLAXOSMITHKLINE   (United States)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Chemokines; CXCR2 antagonists; Cyclic sulfonamides; Inflammation; Interleukin 8

Indexed keywords

1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG CLEARANCE; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; REDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

BENZOTHIADIAZINES; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250317293     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.011     Document Type: Article

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