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Volumn 17, Issue 9, 1998, Pages 2619-2628

A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host

Author keywords

Attenuated strain; Cell division; Deletion mutant; Leishmania mexicana; Mitogen activated protein kinase

Indexed keywords

ACID PHOSPHATASE; GENE PRODUCT; MITOGEN ACTIVATED PROTEIN KINASE;

EID: 0032080107     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.9.2619     Document Type: Article
Times cited : (146)

References (40)
  • 1
    • 0025903513 scopus 로고
    • Phosphorylation differences among proteins of bloodstream developmental stages of Trypanosoma brucei brucei
    • Aboagye-Kwarteng, T., Ole-Moiyoi, O.K. and Lonsdale-Eccles, J.D. (1991) Phosphorylation differences among proteins of bloodstream developmental stages of Trypanosoma brucei brucei. Biochem. J., 275, 7-14.
    • (1991) Biochem. J. , vol.275 , pp. 7-14
    • Aboagye-Kwarteng, T.1    Ole-Moiyoi, O.K.2    Lonsdale-Eccles, J.D.3
  • 2
    • 0026533657 scopus 로고
    • The interaction of Leishmania species with macrophages
    • Alexander, J. and Russell, D.G. (1992) The interaction of Leishmania species with macrophages. Adv. Parasitol, 31, 175-254.
    • (1992) Adv. Parasitol , vol.31 , pp. 175-254
    • Alexander, J.1    Russell, D.G.2
  • 3
    • 0026543392 scopus 로고    scopus 로고
    • Estimation of population at risk of infection and number of cases of Leishmaniasis
    • Ashford, R. W., Desjeux, P. and de Raadt, P. (1996) Estimation of population at risk of infection and number of cases of Leishmaniasis. Parasitol. Today, 8, 104-105.
    • (1996) Parasitol. Today , vol.8 , pp. 104-105
    • Ashford, R.W.1    Desjeux, P.2    De Raadt, P.3
  • 4
    • 0027509513 scopus 로고
    • Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana
    • Bahr, V., Stierhof, Y.-D., Ilg, T., Demar, M., Quinten, M. and Overath, P. (1993) Expression of lipophosphoglycan, high-molecular weight phosphoglycan and glycoprotein 63 in promastigotes and amastigotes of Leishmania mexicana. Mol. Biochem. Parasitol, 58, 107-122.
    • (1993) Mol. Biochem. Parasitol , vol.58 , pp. 107-122
    • Bahr, V.1    Stierhof, Y.-D.2    Ilg, T.3    Demar, M.4    Quinten, M.5    Overath, P.6
  • 5
    • 0026674542 scopus 로고
    • Axenic cultivation and characterization of Leishmania mexicana amastigote- Like forms
    • Bates, P.A., Robertson, C.D., Tetley, L. and Coombs, G.H. (1992) Axenic cultivation and characterization of Leishmania mexicana amastigote- like forms. Parasitology, 105, 193-202.
    • (1992) Parasitology , vol.105 , pp. 193-202
    • Bates, P.A.1    Robertson, C.D.2    Tetley, L.3    Coombs, G.H.4
  • 6
    • 0002004179 scopus 로고    scopus 로고
    • Protein phosphorylation and protein kinases in Trypanosomatids
    • Hide, G., Mottram, J.C., Coombs, G.H. and Holmes, P.H. (eds), CAB International, Wallingford, UK
    • Boshart, M. and Mottram, J.C. (1997) Protein phosphorylation and protein kinases in Trypanosomatids. In Hide, G., Mottram, J.C., Coombs, G.H. and Holmes, P.H. (eds), Trypanosomiasis and Leishmaniasis. CAB International, Wallingford, UK, pp. 227-244.
    • (1997) Trypanosomiasis and Leishmaniasis , pp. 227-244
    • Boshart, M.1    Mottram, J.C.2
  • 7
    • 0025823448 scopus 로고
    • ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
    • Boulton, T.G. et al. (1991) ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell, 65, 663-675.
    • (1991) Cell , vol.65 , pp. 663-675
    • Boulton, T.G.1
  • 8
    • 0025086308 scopus 로고
    • Molecular determinants of Leishmania virulence
    • Chang, K.-P., Chaudhuri, G. and Fong, D. (1990) Molecular determinants of Leishmania virulence. Annu. Rev. Microbiol., 44, 499-529.
    • (1990) Annu. Rev. Microbiol. , vol.44 , pp. 499-529
    • Chang, K.-P.1    Chaudhuri, G.2    Fong, D.3
  • 9
    • 0024442034 scopus 로고
    • A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S.cerevisiae
    • Courchesne, W.E., Kunisawa, R. and Thorner, J.W. (1989) A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S.cerevisiae. Cell, 58, 1107-1119.
    • (1989) Cell , vol.58 , pp. 1107-1119
    • Courchesne, W.E.1    Kunisawa, R.2    Thorner, J.W.3
  • 10
    • 0028228861 scopus 로고
    • Stage-specific regulation of protein phosphorylation in Leishmania major
    • Dell, K.R. and Engel, J.N. (1994) Stage-specific regulation of protein phosphorylation in Leishmania major. Mol. Biochem. Parasitol., 64, 283-292.
    • (1994) Mol. Biochem. Parasitol. , vol.64 , pp. 283-292
    • Dell, K.R.1    Engel, J.N.2
  • 11
    • 0021760092 scopus 로고
    • A comprehensive set of sequence analysis programs for the VAX
    • Devereux, J., Haeberli, P. and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res., 12, 387-395.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 387-395
    • Devereux, J.1    Haeberli, P.2    Smithies, O.3
  • 12
    • 0027442471 scopus 로고
    • Two more independent selectable markers for stable transfection of Leishmania
    • Freedman, D.J. and Beverley, S.M. (1993) Two more independent selectable markers for stable transfection of Leishmania. Mol. Biochem. Parasitol., 62, 37-44.
    • (1993) Mol. Biochem. Parasitol. , vol.62 , pp. 37-44
    • Freedman, D.J.1    Beverley, S.M.2
  • 13
    • 0019518610 scopus 로고
    • A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers
    • Hart, D.T., Vickerman, K. and Coombs, G.H. (1981) A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers. Parasitology, 82, 345-355.
    • (1981) Parasitology , vol.82 , pp. 345-355
    • Hart, D.T.1    Vickerman, K.2    Coombs, G.H.3
  • 14
    • 0028279936 scopus 로고
    • Differential accumulation of a protein kinase homolog in Trypanosoma brucei
    • Hua, S.B. and Wang, C.C. (1994) Differential accumulation of a protein kinase homolog in Trypanosoma brucei. J. Cell. Biochem., 54, 20-31.
    • (1994) J. Cell. Biochem. , vol.54 , pp. 20-31
    • Hua, S.B.1    Wang, C.C.2
  • 15
    • 0025939205 scopus 로고
    • Secreted acid phosphatase of Leishmania mexicana: A filamentous phosphoglycoprotein polymer
    • Ilg, T., Stierhof, Y.-D., Etges, R., Adrian, M., Harbecke, D. and Overath, P. (1991) Secreted acid phosphatase of Leishmania mexicana: a filamentous phosphoglycoprotein polymer. Proc. Natl Acad. Sci. USA, 88, 8774-8778.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 8774-8778
    • Ilg, T.1    Stierhof, Y.-D.2    Etges, R.3    Adrian, M.4    Harbecke, D.5    Overath, P.6
  • 16
    • 0027520399 scopus 로고
    • Monoclonal antibodies directed against Leishmania secreted acid phosphatase and lipophosphoglycan. Partial characterization of private and public epitopes
    • Ilg, T., Harbecke, D., Wiese, M. and Overath, P. (1993) Monoclonal antibodies directed against Leishmania secreted acid phosphatase and lipophosphoglycan. Partial characterization of private and public epitopes. Eur. J. Biochem., 217, 603-615.
    • (1993) Eur. J. Biochem. , vol.217 , pp. 603-615
    • Ilg, T.1    Harbecke, D.2    Wiese, M.3    Overath, P.4
  • 17
    • 0000237298 scopus 로고
    • Leishmania mexicana: The epidemiology of dermal Leishmaniasis in British Honduras. I. the human disease
    • Lainson, R. and Strangeways, J. (1963) Leishmania mexicana: the epidemiology of dermal Leishmaniasis in British Honduras. I. The human disease. Trans. R. Soc. Trop. Med. Hyg., 57, 242-265.
    • (1963) Trans. R. Soc. Trop. Med. Hyg. , vol.57 , pp. 242-265
    • Lainson, R.1    Strangeways, J.2
  • 18
    • 0024397165 scopus 로고
    • Trans splicing in trypanosomes - Archaism or adaptation
    • Laird, P.W. (1989) Trans splicing in trypanosomes - archaism or adaptation. Trends Genet., 5, 204-208.
    • (1989) Trends Genet. , vol.5 , pp. 204-208
    • Laird, P.W.1
  • 19
    • 0027193605 scopus 로고
    • Coupling of poly(A) site selection and trans-splicing in Leishmania
    • LeBowitz, J.H., Smith, H.Q., Rusche, L. and Beverley, S.M. (1993) Coupling of poly(A) site selection and trans-splicing in Leishmania. Genes Dev., 7, 996-1007.
    • (1993) Genes Dev. , vol.7 , pp. 996-1007
    • LeBowitz, J.H.1    Smith, H.Q.2    Rusche, L.3    Beverley, S.M.4
  • 20
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee, J.C. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1
  • 21
    • 0022992957 scopus 로고
    • Comparison of extracellular acid phosphatases from various isolates of Leishmania
    • Lovelace, J.K. and Gottlieb, M. (1986) Comparison of extracellular acid phosphatases from various isolates of Leishmania. Am. J. Trop. Med. Hyg., 35, 1121-1128.
    • (1986) Am. J. Trop. Med. Hyg. , vol.35 , pp. 1121-1128
    • Lovelace, J.K.1    Gottlieb, M.2
  • 22
    • 0027257177 scopus 로고
    • The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes
    • McConville, M.J. and Ferguson, M.A.J. (1993) The structure, biosynthesis and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem. J., 294, 305-324.
    • (1993) Biochem. J. , vol.294 , pp. 305-324
    • McConville, M.J.1    Ferguson, M.A.J.2
  • 23
    • 0025876922 scopus 로고
    • Purification and characterization of a membrane-bound acid phosphatase of Leishmania mexicana
    • Menz, B., Winter, G., Ilg, T., Lottspeich, F. and Overath, P. (1991) Purification and characterization of a membrane-bound acid phosphatase of Leishmania mexicana. Mol. Biochem. Parasitol., 47, 101-108.
    • (1991) Mol. Biochem. Parasitol. , vol.47 , pp. 101-108
    • Menz, B.1    Winter, G.2    Ilg, T.3    Lottspeich, F.4    Overath, P.5
  • 25
    • 0023796278 scopus 로고
    • Comparison of the protein kinase and acid phosphatase activities of five species of Leishmania
    • Mukhopadhyay, N.K., Saha, A.K., Lovelace, J.K., Da Silva, R., Sacks, D.L. and Glew.R.H. (1988) Comparison of the protein kinase and acid phosphatase activities of five species of Leishmania. J. Protozool., 35, 601-607.
    • (1988) J. Protozool. , vol.35 , pp. 601-607
    • Mukhopadhyay, N.K.1    Saha, A.K.2    Lovelace, J.K.3    Da Silva, R.4    Sacks, D.L.5    Glew, R.H.6
  • 26
    • 0026101645 scopus 로고
    • Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei
    • Parsons, M., Valentine, M., Deans, J., Schieven, G.L. and Ledbetter, J.A. (1991) Distinct patterns of tyrosine phosphorylation during the life cycle of Trypanosoma brucei. Mol. Biochem. Parasitol., 45, 241-248.
    • (1991) Mol. Biochem. Parasitol. , vol.45 , pp. 241-248
    • Parsons, M.1    Valentine, M.2    Deans, J.3    Schieven, G.L.4    Ledbetter, J.A.5
  • 27
    • 0027459506 scopus 로고
    • Protein kinases in divergent eukaryotes: Identification of protein kinase activities regulated during trypanosome development
    • Parsons, M., Valentine, M. and Carter, V. (1993) Protein kinases in divergent eukaryotes: identification of protein kinase activities regulated during trypanosome development. Proc. Natl Acad. Sci. USA, 90, 2656-2660.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2656-2660
    • Parsons, M.1    Valentine, M.2    Carter, V.3
  • 28
    • 0029015336 scopus 로고
    • Trypanosoma congolense: Developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle
    • Parsons, M., Carter, V., Muthiani, A. and Murphy, N. (1995) Trypanosoma congolense: developmental regulation of protein kinases and tyrosine phosphorylation during the life cycle. Exp. Parasitol, 80, 507-514.
    • (1995) Exp. Parasitol , vol.80 , pp. 507-514
    • Parsons, M.1    Carter, V.2    Muthiani, A.3    Murphy, N.4
  • 29
    • 0027583888 scopus 로고
    • MAP kinase and the activation of quiescent cells
    • Ruderman, J.V. (1993) MAP kinase and the activation of quiescent cells. Curr. Opin. Cell Biol., 5, 207-213.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 207-213
    • Ruderman, J.V.1
  • 33
    • 0029935418 scopus 로고    scopus 로고
    • Regulation of transcription by MAP kinase cascades
    • Treisman, R. (1996) Regulation of transcription by MAP kinase cascades. Curr. Opin. Cell Biol., 8, 205-215.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 205-215
    • Treisman, R.1
  • 35
    • 0028823892 scopus 로고
    • Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
    • Waskiewicz, A.J. and Cooper, J.A. (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell Biol., 7, 798-805.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 798-805
    • Waskiewicz, A.J.1    Cooper, J.A.2
  • 36
    • 0028959440 scopus 로고
    • Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase
    • Wiese, M., Ilg, T., Lottspeich, F. and Overath, P. (1995) Ser/Thr-rich repetitive motifs as targets for phosphoglycan modifications in Leishmania mexicana secreted acid phosphatase. EMBO J., 14, 1067-1074.
    • (1995) EMBO J. , vol.14 , pp. 1067-1074
    • Wiese, M.1    Ilg, T.2    Lottspeich, F.3    Overath, P.4
  • 37
    • 12644277392 scopus 로고    scopus 로고
    • The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
    • Wilson, K.P. et al. (1997) The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase. Chem. Biol., 4, 423-431.
    • (1997) Chem. Biol. , vol.4 , pp. 423-431
    • Wilson, K.P.1
  • 38
    • 0027931677 scopus 로고
    • Surface antigens of Leishmania mexicana amastigotes: Characterization of glycoinositol phospholipids and a macrophagederived glycosphingolipid
    • Winter, G., Fuchs, M., McConville, MJ., Stierhof, Y.-D. and Overath, P. (1994) Surface antigens of Leishmania mexicana amastigotes: characterization of glycoinositol phospholipids and a macrophagederived glycosphingolipid. J. Cell Sci., 107, 2471-2482.
    • (1994) J. Cell Sci. , vol.107 , pp. 2471-2482
    • Winter, G.1    Fuchs, M.2    McConville, M.J.3    Stierhof, Y.-D.4    Overath, P.5
  • 39
    • 0028157664 scopus 로고
    • Atomic structure of the MAP kinase ERK2 at 2.3 Åresolution
    • Zhang, F., Strand, A., Robbins, D., Cobb, M.H. and Goldsmith, E.J. (1994) Atomic structure of the MAP kinase ERK2 at 2.3 Åresolution. Nature, 367, 704-711.
    • (1994) Nature , vol.367 , pp. 704-711
    • Zhang, F.1    Strand, A.2    Robbins, D.3    Cobb, M.H.4    Goldsmith, E.J.5
  • 40
    • 0026739802 scopus 로고
    • Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei
    • Ziegelbauer, K., Multhaup, G. and Overath, P. (1992) Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei. J. Biol. Chem., 267, 10797-10803.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10797-10803
    • Ziegelbauer, K.1    Multhaup, G.2    Overath, P.3


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