Design and synthesis of benzo-lipoxin A4 analogs with enhanced stability and potent anti-inflammatory properties

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1382-1387

  Petasis, Nicos A ^a   Keledjian, Raquel ^a   Sun, Yee Ping ^b   Nagulapalli, Kalyan C ^a   Tjonahen, Eric ^b   Yang, Rong ^a,b   Serhan, Charles N ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Anti inflammatory agents; Benzo analogs; Eicosanoid oxido reductase; Heck reaction; Inflammation; Lipid mediators; Lipoxin analogs; Neutrophil infiltration; Palladium; Suzuki coupling

Indexed keywords

2 [9,10] BENZO 11E,15 EPILIPOXIN A4 METHYLESTER; 2 [9,12] BENZO 15 DEOXYLIPOXIN A4 METHYLESTER; 2 [9,12] BENZO 15 EPILIPOXIN A4 METHYLESTER; 2 [9,14] BENZOLIPOXIN A4 METHYLESTER; 3 [9,12] BENZO 15 EPILIPOXIN A4 METHYLESTER; ICOSANOID; INDOMETACIN; LIPOXIN A; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CELL INFILTRATION; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; INFLAMMATION; MALE; MOLECULAR MODEL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; POLYMORPHONUCLEAR CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZENE DERIVATIVES; DRUG DESIGN; DRUG STABILITY; LIPOXINS; MICE; NEUTROPHIL INFILTRATION; OXIDOREDUCTASES; PERITONITIS;

EID: 38949153410     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.013     Document Type: Article

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