Formulated antidiabetic preparation Syndrex® has a strong antioxidant activity

European Journal of Pharmacology

Volumn 581, Issue 1-2, 2008, Pages 216-225

  Dixit, Priyanjali P ^a   Devasagayam, Thomas P A ^b   Ghaskadbi, Saroj ^a  

^a UNIVERSITY OF PUNE   (India)

^b BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Antidiabetic preparation; Antioxidant activity; Islets; Protein carbonyls; Syndrex ; Thiobarbituric acid reactive substances

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIDIABETIC AGENT; FERRYLMYOGLOBIN; FLAVONOID; GALLIC ACID; HERBACEOUS AGENT; PHENOL; QUERCETIN; STREPTOZOCIN; SYNDREX; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG INHIBITION; DRUG SYNTHESIS; FEMALE; FENUGREEK; FRACTIONATION; IN VITRO STUDY; INSULIN RELEASE; LIPID PEROXIDATION; LIVER; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PULSE RADIOLYSIS; RAT;

ANIMALS; ANTIOXIDANTS; CATALASE; FEMALE; GLUTATHIONE REDUCTASE; HYPOGLYCEMIC AGENTS; INSULIN; ISLETS OF LANGERHANS; LIPID PEROXIDATION; MALE; MICE; PLANT EXTRACTS; RATS; RATS, WISTAR; STREPTOZOCIN; TRIGONELLA;

EID: 38949102653     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.11.052     Document Type: Article

References (48)

1. Aebi H.E. Catalase. In: Bermeyer H.U. (Ed). Methods of Enzymatic Analysis vol. 3 (1983), Verlag Chemie GmbH, Weinheim 277-282
2. .+ assay. Food Sci. Technol. Res. 7 (2001) 141-144
3. Aquino R., Morelli S., Lauro M.R., Abdo S., Saija A., and Tomaino A. Phenolic constituents and antioxidant activity of an extract of Anthurium versicolor leaves. J. Nat. Prod. 64 (2001) 1019-1023
4. Assaf-Al S., Navaratnam S., Parsons B.J., and Phillips G.O. Chain scission hyaluronan by carbonate and dichloride radicals anions: potential reactive oxygen species in inflammation? Free Rad. Biol. Med. 40 (2006) 2018-2027
5. Basch E. Therapeutic applications of fenugreek. Altern. Med. Rev. 8 (2003) 20-27
6. Bandyopadhyay U., Das D., and Banerjee R.K. Reactive oxygen specie: oxidative damage and pathogenesis. Curr. Sci. 77 (1999) 658-666
7. Beauchamp C., and Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44 (1971) 276-287
8. Block G., Patterson B., and Subar A. Fruits, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer 18 (1992) 1-29
9. Burns J., Gardner P.T., O, ' Neil J., Crawford S., Morecroft I., McPhail D.B., Lister C., Matthews D., MacLean M.R., Lean M.E.L., Duthie G.G., and Crozier A. Relationship among Antioxidant Activity, vasodilation capacity, and phenolic content of red wines. J. Agric. Food Chem. 48 (2000) 220-230
10. Cook N.C., and Samman S. Flavonoids - chemistry, metabolism, cardioprotective effects, and dietary sources. Nutr. Biochem. 7 (1996) 66-76
11. Crow J. Dichlorodihydrofluorescein and DHR123 are sensitive indicators of peroxynirite in vitro: implications for intracellular measurement of reactive oxygen/nitrogen species. Nitric Oxide Biol. Chem. 1 (1997) 145-147
12. Dalle-Donne I., Rossi R., Giustarini D., Milzani A., and Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin. Chim. Acta 329 (2003) 23-28
13. Devasagayam T.P.A. Lipid peroxidation in rat uterus. Biochim. Biophys. Acta 876 (1986) 507-514
14. Dixit P., Ghaskadbi S., Hari M., and Devasagayam T.P.A. Antioxidant properties of germinated fenugreek seeds. Phytother. Res. 19 (2005) 977-983
15. Goldberg D.M., and Spooner R.J. Glutathione reductase. In: Bermeyer H.U. (Ed). Methods of Enzymatic Analysis vol. 3 (1983), Verlag Chemie GmbH, Weinheim 258-265
16. Halliwell B., and Gutteridge J.M.C. Antioxidant defenses. Free Radicals in Biology and Medicine. 3rd edn (1999), Oxford University Press, Oxford 146-148
17. Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species play a causal role in multiple forms of insulin resistance. Nature 440 (2006) 944-948
18. Johansen J.S., Harris A.K., Rychly D.J., and Ergul A. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc. Diabetol. 4 (2005) 5
19. Kajimoto Y., and Kaneto H. Role of oxidative stress in pancreatic β-cell dysfunction. Ann. N. Y. Acad. Sci. 1011 (2004) 168-176
20. Kamat J.P., Boloor K.K., and Devasagayam T.P.A. Chlorophyllin as an effective antioxidant against membrane damage in vitro and in vivo. Biochim. Biophys. Acta 1487 (2000) 113-127
21. Kaneto H., Katakami N., Kawamori D., Miyatsuka K., Matsuoka T., Matsuhika M., and Yamasaki Y. Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid. Redox Signal. 9 (2007) 355-366
22. Kimoto K., Suzuki K., Kizaki T., Hitomi Y., Ishida H., Katsuta H., Ookawara T., Suzuki K., Honke K., and Ohno H. Gliclazide protects pancreatic beta cells from damage by hydrogen peroxide. Biochem. Biophys. Res. Comm. 303 (2003) 112-119
23. Lacy P.E., and Kostianovsky M. Method for the isolation of islet of Langerhans from the rat pancreas. Diabetes 16 (1967) 35-39
24. Lawrence R.A., and Burk R.F. Glutathione peroxidase activity in selenium deficient rat liver. Biochem. Biophys. Res. Commun. 71 (1976) 952-958
25. Lefevre G., Beljean-Leymarie M., Beyerle F., Bonnefont-Rousselot D., Cristol J.P., Therond P., and Torreilles J. Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances. Ann. Biol. Clin. (Paris) 56 (1998) 305-319
26. Luximon-Ramma A., Bahorun T., Soobrattee M.A., and Aruoma O.I. Antioxidant activities of phenolic, proantocyanidin and flavonoid components in extracts of Cassia fistula. J. Agric. Food Chem. 50 (2002) 5042-5047
27. Maritim A.C., Sanders R.A., and Watkins III J.B. Diabetes, oxidative stress, and antioxidants: a review. J. Biochem. Molec. Toxicol. 17 (2003) 24-38
28. Noiri E., and Tsukahara H. Parameters for measurement of oxidative stress in diabetes mellitus: applicability of enzyme-linked immunosorbent assay for clinical evaluation. J. Investig. Med. 53 (2005) 167-175
29. Nourooz-Zadeh J., Jajaddini-Sarmadi J., Ling K.L., and Wolff S.P. Low-density lipoprotein is the major carrier of lipid hydroperoxides in plasma. Relevance to determination of total plasma lipid hydroperoxide concentrations. Biochem. J. 313 (1996) 781-786
30. Pannala A.S., Rice-Evans C., Sampson J., and Singh S. Interaction of peroxynitrite with carotenoides and tocopherols within low density lipoprotein. FEBS. Lett. 423 (1998) 297-301
31. Pulido R., Bravo L., and Saura-Calixto F. Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing antioxidant power assay. J Agric. Food Chem. 46 (2000) 3396-3402
32. Qian F.Y., Ouyang F., Fu D.X., and Ren T.R. Establishment and application of the model of islet impaired by NO free radical released from streptozotocin. Sheng Wu Gng Cheng Xue Bao 19 (2003) 349-352
33. Rahimi R., Shekoufeh N., Bagher L., and Mohammad A.A. Review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother 59 (2005) 365-373
34. Ribes G., Sauvaire Y., Da Costa C., Baccou J.C., and Loubatieres-Mariani M.M. Antidiabetic effects of subfractions from fenugreek seeds in diabetic dogs. Proc. Soc. Exp. Biol. Med. 182 (1986) 159-166
35. Robertson R.P., Tanaka Y., Takahashi H., Tran P.O., and Harmon J.S. Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic islets. Ann. N. Y. Acad. Sci. 1043 (2005) 513-520
36. Rodney C.R., and McDonald R.B. Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes. J. Am. Coll. Nutr. 20 (2001) 363S-369S
37. Rolo A.P., and Palmeira C.M. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol. Appl. Pharmacol. 212 (2006) 167-178
38. Samual A.C., Kermit M.B., Sandra S.D., Thelma C.R., and William L.L. Staining and in vitro toxicity of dithiozone with canine porcine and bovine islets. Cell Transplant 3 (1994) 299-306
39. Schwarz M.A., Lazo J.S., Yalowich J.C., Reynolds I., Kagan V.E., Tyurin V., Kim Y.M., Watkins S.C., and Pitt B.R. Cytoplasmic metallothionein overexpression protects NIH3T3 cells from tert-butyl hydroperoxide toxicity. J. Biol. Chem. 269 (1994) 15238-15243
40. Shao Z.H., Xi J.T., Terry L., Hoek V., Mehendale S., Aung H., Li C.O., Oin Y., Schumacker P.T., Becker L.B., and Yuan C.S. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress. Biochim. Biophys. Acta 1670 (2004) 165-171
41. Shewade Y., Umarani M., Bhonde, and R.R. Large-scale isolation of islets by tissue culture of adult mouse pancreas. Transplant. Proc. 31 (1999) 1721-1723
42. Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50 (2001) 536-546
43. Teixeira H.D., and Meneghini R. Chinese hamster fibroblasts overexpressing CuZn-superoxide dismutase undergo a global reduction in antioxidants and an increasing sensitivity of DNA to oxidative damage. Biochem. J. 315 (1996) 821-825
44. Tung Y., Wu J., Kuo Y., and Chang S. Antioxidant activities of natural phenolic compounds from Acacia confusa bark. Bioresour. Technol. 98 (2007) 11120-11123
45. Vijaykumar M.V., Singh S., Chhipa R.R., and Bhat M.K. The hypoglycemic activity of fenugreek extract is mediated through the stimulation of an insulin signaling pathway. British J. Pharmacol. 146 (2005) 41-48
46. Warburton S., and James R. Hemocytometer cell counts and viability studies. In: Doyle A., Griffiths J.B., and Newell D.G. (Eds). Cell and Tissue Culture: Laboratory Procedures 4B (1995), John Wiley, New York 1.1-1.5
47. Wolfe K., Wu X., and Liu R.H. Antioxidant activity of apple peels. J. Agric. Food Chem. 51 (2003) 609-614
48. Zia T., Hasnain S.N., and Hasan S.K. Evaluation of the oral hypoglycaemic effect of Trigonella foenum-graecum L. (methi) in normal mice. J. Ethnopharmacol. 75 (2001) 191-195