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Volumn 15, Issue 6, 2007, Pages 246-251

Proteinase-activated receptors in the gastrointestinal system: A functional linkage to prostanoids

Author keywords

Epithelial cell; Gastrointestinal system; Prostaglandin E2; Prostanoid; Proteinase activated receptor (PAR)

Indexed keywords

ANTIINFLAMMATORY AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN; PROSTANOID; PROTEINASE ACTIVATED RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 AGONIST; PROTEINASE ACTIVATED RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 38849114241     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-007-1591-3     Document Type: Review
Times cited : (17)

References (50)
  • 1
    • 0036793557 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway
    • Buresi, M. C., Buret, A. G., Hollenberg, M. D. et al. (2002) Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway, Faseb J 16, 1515-1525.
    • (2002) Faseb J , vol.16 , pp. 1515-1525
    • Buresi, M.C.1    Buret, A.G.2    Hollenberg, M.D.3
  • 3
    • 0033545627 scopus 로고    scopus 로고
    • A protective role for protease-activated receptors in the airways
    • Cocks, T. M., Fong, B., Chow, J. M. et al. (1999a) A protective role for protease-activated receptors in the airways, Nature 398, 156-160.
    • (1999) Nature , vol.398 , pp. 156-160
    • Cocks, T.M.1    Fong, B.2    Chow, J.M.3
  • 4
    • 0032971765 scopus 로고    scopus 로고
    • Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle
    • Cocks, T. M., Sozzi, V., Moffatt, J. D. et al. (1999b) Protease-activated receptors mediate apamin-sensitive relaxation of mouse and guinea pig gastrointestinal smooth muscle, Gastroenterology 116, 586-592.
    • (1999) Gastroenterology , vol.116 , pp. 586-592
    • Cocks, T.M.1    Sozzi, V.2    Moffatt, J.D.3
  • 6
    • 0030979972 scopus 로고    scopus 로고
    • Protease-activated receptor 3 is a second thrombin receptor in humans
    • Ishihara, H., Connolly, A. J., Zeng, D. et al. (1997) Protease-activated receptor 3 is a second thrombin receptor in humans, Nature 386, 502-506.
    • (1997) Nature , vol.386 , pp. 502-506
    • Ishihara, H.1    Connolly, A.J.2    Zeng, D.3
  • 7
    • 0032514474 scopus 로고    scopus 로고
    • A dual thrombin receptor system for platelet activation
    • Kahn, M. L., Zheng, Y. W., Huang, W. et al. (1998) A dual thrombin receptor system for platelet activation, Nature 394, 690-694.
    • (1998) Nature , vol.394 , pp. 690-694
    • Kahn, M.L.1    Zheng, Y.W.2    Huang, W.3
  • 8
    • 1542648400 scopus 로고    scopus 로고
    • PAR-2: Structure, function and relevance to human diseases of the gastric mucosa
    • Kawabata, A. (2002) PAR-2: structure, function and relevance to human diseases of the gastric mucosa, Expert Rev. Mol. Med. 2002, 1-17.
    • (2002) Expert Rev. Mol. Med , vol.2002 , pp. 1-17
    • Kawabata, A.1
  • 9
    • 33646760967 scopus 로고    scopus 로고
    • Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: Involvement of endogenous bradykinin
    • Kawabata, A., Kawao, N., Kitano, T. et al. (2006a) Colonic hyperalgesia triggered by proteinase-activated receptor-2 in mice: Involvement of endogenous bradykinin, Neurosci Lett 402, 167-172.
    • (2006) Neurosci Lett , vol.402 , pp. 167-172
    • Kawabata, A.1    Kawao, N.2    Kitano, T.3
  • 10
    • 0034983372 scopus 로고    scopus 로고
    • The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection
    • Kawabata, A., Kinoshita, M., Nishikawa, H. et al. (2001a) The protease-activated receptor-2 agonist induces gastric mucus secretion and mucosal cytoprotection, J Clin Invest 107, 1443-1450.
    • (2001) J Clin Invest , vol.107 , pp. 1443-1450
    • Kawabata, A.1    Kinoshita, M.2    Nishikawa, H.3
  • 11
    • 4644282618 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: Signal transduction mechanisms and distinct agonist sensitivity
    • Kawabata, A., Kubo, S., Ishiki, T. et al. (2004a) Proteinase-activated receptor-2-mediated relaxation in mouse tracheal and bronchial smooth muscle: signal transduction mechanisms and distinct agonist sensitivity, J Pharmacol Exp Ther 311, 402-410.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 402-410
    • Kawabata, A.1    Kubo, S.2    Ishiki, T.3
  • 12
    • 0033771536 scopus 로고    scopus 로고
    • Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): A novel role for PAR-4 as opposed to PAR-1
    • Kawabata, A., Kuroda, R., Kuroki, N. et al. (2000a) Dual modulation by thrombin of the motility of rat oesophageal muscularis mucosae via two distinct protease-activated receptors (PARs): a novel role for PAR-4 as opposed to PAR-1, Br. J. Pharmacol. 131, 578-584.
    • (2000) Br. J. Pharmacol , vol.131 , pp. 578-584
    • Kawabata, A.1    Kuroda, R.2    Kuroki, N.3
  • 13
    • 0034872420 scopus 로고    scopus 로고
    • In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse
    • Kawabata, A., Kuroda, R., Nagata, N. et al. (2001b) In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse, Br J Pharmacol 133, 1213-1218.
    • (2001) Br J Pharmacol , vol.133 , pp. 1213-1218
    • Kawabata, A.1    Kuroda, R.2    Nagata, N.3
  • 14
    • 0037019916 scopus 로고    scopus 로고
    • Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion
    • Kawabata, A., Kuroda, R., Nishida, M. et al. (2002) Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion, Life Sci 71, 2435-2446.
    • (2002) Life Sci , vol.71 , pp. 2435-2446
    • Kawabata, A.1    Kuroda, R.2    Nishida, M.3
  • 15
    • 0032695476 scopus 로고    scopus 로고
    • Modulation by protease-activated receptors of the rat duodenal motility in vitro: Possible mechanisms underlying the evoked contraction and relaxation
    • Kawabata, A., Kuroda, R., Nishikawa, H. et al. (1999) Modulation by protease-activated receptors of the rat duodenal motility in vitro: possible mechanisms underlying the evoked contraction and relaxation, Br J Pharmacol 128, 865-872.
    • (1999) Br J Pharmacol , vol.128 , pp. 865-872
    • Kawabata, A.1    Kuroda, R.2    Nishikawa, H.3
  • 16
    • 33646430025 scopus 로고    scopus 로고
    • Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice
    • Kawabata, A., Matsunami, M., Tsutsumi, M. et al. (2006b) Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice, Br J Pharmacol 148, 54-60.
    • (2006) Br J Pharmacol , vol.148 , pp. 54-60
    • Kawabata, A.1    Matsunami, M.2    Tsutsumi, M.3
  • 17
    • 0034595060 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland
    • Kawabata, A., Morimoto, N., Nishikawa, H. et al. (2000b) Activation of protease-activated receptor-2 (PAR-2) triggers mucin secretion in the rat sublingual gland, Biochem Biophys Res Commun 270, 298-302.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 298-302
    • Kawabata, A.1    Morimoto, N.2    Nishikawa, H.3
  • 18
    • 4544250027 scopus 로고    scopus 로고
    • Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms
    • Kawabata, A., Nakaya, Y., Ishiki, T. et al. (2004b) Receptor-activating peptides for PAR-1 and PAR-2 relax rat gastric artery via multiple mechanisms, Life Sci 75, 2689-2702.
    • (2004) Life Sci , vol.75 , pp. 2689-2702
    • Kawabata, A.1    Nakaya, Y.2    Ishiki, T.3
  • 19
    • 0141923076 scopus 로고    scopus 로고
    • Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats
    • Kawabata, A., Nakaya, Y., Kuroda, R. et al. (2003) Involvement of EDHF in the hypotension and increased gastric mucosal blood flow caused by PAR-2 activation in rats, Br J Pharmacol 140, 247-254.
    • (2003) Br J Pharmacol , vol.140 , pp. 247-254
    • Kawabata, A.1    Nakaya, Y.2    Kuroda, R.3
  • 20
    • 9144246209 scopus 로고    scopus 로고
    • A protective role of protease-activated receptor 1 in rat gastric mucosa
    • Kawabata, A., Nishikawa, H., Saitoh, H. et al. (2004c) A protective role of protease-activated receptor 1 in rat gastric mucosa, Gastroenterology 126, 208-219.
    • (2004) Gastroenterology , vol.126 , pp. 208-219
    • Kawabata, A.1    Nishikawa, H.2    Saitoh, H.3
  • 21
    • 20844435292 scopus 로고    scopus 로고
    • 2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice
    • 2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice, Br J Pharmacol 144, 212-219.
    • (2005) Br J Pharmacol , vol.144 , pp. 212-219
    • Kawabata, A.1    Oono, Y.2    Yonezawa, D.3
  • 22
    • 0346099140 scopus 로고    scopus 로고
    • The PAR-1-activating peptide facilitates pepsinogen secretion in rats
    • Kawao, N., Hiramatsu, K., Inoi, N. et al. (2003) The PAR-1-activating peptide facilitates pepsinogen secretion in rats, Peptides 24, 1449-1451.
    • (2003) Peptides , vol.24 , pp. 1449-1451
    • Kawao, N.1    Hiramatsu, K.2    Inoi, N.3
  • 23
    • 1842732512 scopus 로고    scopus 로고
    • Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2
    • Kawao, N., Ikeda, H., Kitano, T. et al. (2004) Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2, J Pharmacol Sci 94, 277-285.
    • (2004) J Pharmacol Sci , vol.94 , pp. 277-285
    • Kawao, N.1    Ikeda, H.2    Kitano, T.3
  • 24
    • 27144516847 scopus 로고    scopus 로고
    • Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells
    • Kawao, N., Nagataki, M., Nagasawa, K. et al. (2005) Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells, J Pharmacol Exp Ther 315, 576-589.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 576-589
    • Kawao, N.1    Nagataki, M.2    Nagasawa, K.3
  • 25
    • 0036196473 scopus 로고    scopus 로고
    • Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: Immunolocalization and facilitation of pepsin/pepsinogen secretion
    • Kawao, N., Sakaguchi, Y., Tagome, A. et al. (2002) Protease-activated receptor-2 (PAR-2) in the rat gastric mucosa: immunolocalization and facilitation of pepsin/pepsinogen secretion, Br J Pharmacol 135, 1292-1296.
    • (2002) Br J Pharmacol , vol.135 , pp. 1292-1296
    • Kawao, N.1    Sakaguchi, Y.2    Tagome, A.3
  • 26
    • 0030741026 scopus 로고    scopus 로고
    • Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2
    • Kong, W., McConalogue, K., Khitin, L. M. et al. (1997) Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2, Proc Natl Acad Sci U S A 94, 8884-8889.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 8884-8889
    • Kong, W.1    McConalogue, K.2    Khitin, L.M.3
  • 27
    • 38849109526 scopus 로고    scopus 로고
    • Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues
    • in press
    • Kubo, S., Ishiki, T., Doe, I. et al. Distinct activity of peptide mimetic intracellular ligands (pepducins) for proteinase-activated receptor-1 in multiple cells/tissues, Ann NY Acad Sci, in press.
    • Ann NY Acad Sci
    • Kubo, S.1    Ishiki, T.2    Doe, I.3
  • 28
    • 0034923238 scopus 로고    scopus 로고
    • Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion
    • Lourbakos, A., Potempa, J., Travis, J. et al. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion, Infect Immun 69, 5121-5130.
    • (2001) Infect Immun , vol.69 , pp. 5121-5130
    • Lourbakos, A.1    Potempa, J.2    Travis, J.3
  • 29
    • 0034681427 scopus 로고    scopus 로고
    • Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2
    • Miyata, S., Koshikawa, N., Yasumitsu, H. et al. (2000) Trypsin stimulates integrin alpha(5)beta(1)-dependent adhesion to fibronectin and proliferation of human gastric carcinoma cells through activation of proteinase-activated receptor-2, J Biol Chem 275, 4592-4598.
    • (2000) J Biol Chem , vol.275 , pp. 4592-4598
    • Miyata, S.1    Koshikawa, N.2    Yasumitsu, H.3
  • 30
    • 0038002035 scopus 로고    scopus 로고
    • Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle
    • Mule, F., Baffi, M. C., Capparelli, A. et al. (2003) Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle, Br J Pharmacol 139, 598-604.
    • (2003) Br J Pharmacol , vol.139 , pp. 598-604
    • Mule, F.1    Baffi, M.C.2    Capparelli, A.3
  • 31
    • 1642574390 scopus 로고    scopus 로고
    • Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon
    • Mule, F., Pizzuti, R., Capparelli, A. et al. (2004) Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon, Gut 53, 229-234.
    • (2004) Gut , vol.53 , pp. 229-234
    • Mule, F.1    Pizzuti, R.2    Capparelli, A.3
  • 32
    • 0037292257 scopus 로고    scopus 로고
    • Protease-activated receptor-2-mediated contraction in the rat urinary bladder: The role of urinary bladder mucosa
    • Nakahara, T., Kubota, Y., Mitani, A. et al. (2003) Protease-activated receptor-2-mediated contraction in the rat urinary bladder: the role of urinary bladder mucosa, Naunyn Schmiedebergs Arch Pharmacol 367, 211-213.
    • (2003) Naunyn Schmiedebergs Arch Pharmacol , vol.367 , pp. 211-213
    • Nakahara, T.1    Kubota, Y.2    Mitani, A.3
  • 33
    • 0034611727 scopus 로고    scopus 로고
    • PAR3 is a cofactor for PAR4 activation by thrombin
    • Nakanishi-Matsui, M., Zheng, Y. W., Sulciner, D. J. et al. (2000) PAR3 is a cofactor for PAR4 activation by thrombin, Nature 404, 609-613.
    • (2000) Nature , vol.404 , pp. 609-613
    • Nakanishi-Matsui, M.1    Zheng, Y.W.2    Sulciner, D.J.3
  • 34
    • 0032896792 scopus 로고    scopus 로고
    • Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2
    • Nguyen, T. D., Moody, M. W., Steinhoff, M. et al. (1999) Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2, J. Clin. Invest. 103, 261-269.
    • (1999) J. Clin. Invest , vol.103 , pp. 261-269
    • Nguyen, T.D.1    Moody, M.W.2    Steinhoff, M.3
  • 35
    • 0037188756 scopus 로고    scopus 로고
    • Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats
    • Nishikawa, H., Kawai, K., Nishimura, S. et al. (2002) Suppression by protease-activated receptor-2 activation of gastric acid secretion in rats, Eur J Pharmacol 447, 87-90.
    • (2002) Eur J Pharmacol , vol.447 , pp. 87-90
    • Nishikawa, H.1    Kawai, K.2    Nishimura, S.3
  • 36
    • 0027933068 scopus 로고
    • Molecular cloning of a potential proteinase activated receptor
    • Nystedt, S., Emilsson, K., Wahlestedt, C. et al. (1994) Molecular cloning of a potential proteinase activated receptor, Proc. Natl. Acad. Sci. U. S. A. 91, 9208-9212.
    • (1994) Proc. Natl. Acad. Sci. U. S. A , vol.91 , pp. 9208-9212
    • Nystedt, S.1    Emilsson, K.2    Wahlestedt, C.3
  • 37
    • 33745664539 scopus 로고    scopus 로고
    • Kallikrein-mediated cell signalling: Targeting proteinase-activated receptors (PARs)
    • Oikonomopoulou, K., Hansen, K. K., Saifeddine, M. et al. (2006) Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs), Biol Chem 387, 817-824.
    • (2006) Biol Chem , vol.387 , pp. 817-824
    • Oikonomopoulou, K.1    Hansen, K.K.2    Saifeddine, M.3
  • 38
    • 1642279517 scopus 로고    scopus 로고
    • Protease-activated receptors: Contribution to physiology and disease
    • Ossovskaya, V. S. and Bunnett, N. W. (2004) Protease-activated receptors: contribution to physiology and disease, Physiol. Rev. 84, 579-621.
    • (2004) Physiol. Rev , vol.84 , pp. 579-621
    • Ossovskaya, V.S.1    Bunnett, N.W.2
  • 39
    • 0030008482 scopus 로고    scopus 로고
    • Rat proteinase-activated receptor-2 (PAR-2): CDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue
    • Saifeddine, M., al-Ani, B., Cheng, C. H. et al. (1996) Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue, Br J Pharmacol 118, 521-530.
    • (1996) Br J Pharmacol , vol.118 , pp. 521-530
    • Saifeddine, M.1    al-Ani, B.2    Cheng, C.H.3
  • 41
    • 30944449423 scopus 로고    scopus 로고
    • Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro
    • Sekiguchi, F., Hasegawa, N., Inoshita, K. et al. (2006) Mechanisms for modulation of mouse gastrointestinal motility by proteinase-activated receptor (PAR)-1 and -2 in vitro, Life Sci 78, 950-957.
    • (2006) Life Sci , vol.78 , pp. 950-957
    • Sekiguchi, F.1    Hasegawa, N.2    Inoshita, K.3
  • 42
    • 21044458180 scopus 로고    scopus 로고
    • Protease-activated receptors (PARs) as therapeutic targets: Development of agonists/antagonists and modulation of gastrointestinal functions
    • Sekiguchi, F. and Kawabata, A. (2004) Protease-activated receptors (PARs) as therapeutic targets: development of agonists/antagonists and modulation of gastrointestinal functions., Drug Des. Rev.-Online 1, 287-296.
    • (2004) Drug Des. Rev.-Online , vol.1 , pp. 287-296
    • Sekiguchi, F.1    Kawabata, A.2
  • 43
    • 34447617716 scopus 로고    scopus 로고
    • Intracellular signaling for prostaglandin E2 production caused by activation of the thrombin receptor, PAR-1, in the rat gastric mucosal epithelial cells
    • 108P
    • Sekiguchi, F., Saito, S., Nagataki, M. et al. (2005) Intracellular signaling for prostaglandin E2 production caused by activation of the thrombin receptor, PAR-1, in the rat gastric mucosal epithelial cells, J Pharmacol Sci 97 (Suppl. I), 108P.
    • (2005) J Pharmacol Sci , vol.97 , Issue.SUPPL. I
    • Sekiguchi, F.1    Saito, S.2    Nagataki, M.3
  • 44
    • 0037904503 scopus 로고    scopus 로고
    • 2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1)
    • 2+ mobilization in human gingival fibroblasts is mediated by protease-activated receptor-1 (PAR-1), Life Sci 73, 301-310.
    • (2003) Life Sci , vol.73 , pp. 301-310
    • Tanaka, N.1    Morita, T.2    Nezu, A.3
  • 45
    • 0035223826 scopus 로고    scopus 로고
    • Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder
    • Tognetto, M., Trevisani, M., Maggiore, B. et al. (2000) Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder, Br J Pharmacol 131, 689-694.
    • (2000) Br J Pharmacol , vol.131 , pp. 689-694
    • Tognetto, M.1    Trevisani, M.2    Maggiore, B.3
  • 46
    • 0037365240 scopus 로고    scopus 로고
    • Expression and cytoprotective effect of protease-activated receptor-1 in gastric epithelial cells
    • Toyoda, N., Gabazza, E. C., Inoue, H. et al. (2003) Expression and cytoprotective effect of protease-activated receptor-1 in gastric epithelial cells, Scand J Gastroenterol 38, 253-259.
    • (2003) Scand J Gastroenterol , vol.38 , pp. 253-259
    • Toyoda, N.1    Gabazza, E.C.2    Inoue, H.3
  • 47
    • 2442526798 scopus 로고    scopus 로고
    • Modulation of visceral pain and inflammation by protease-activated receptors
    • Vergnolle, N. (2004) Modulation of visceral pain and inflammation by protease-activated receptors, Br. J. Pharmacol. 141, 1264-1274.
    • (2004) Br. J. Pharmacol , vol.141 , pp. 1264-1274
    • Vergnolle, N.1
  • 48
    • 0032560576 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2 (PAR2)-activating peptides: Identification of a receptor distinct from PAR2 that regulates intestinal transport
    • Vergnolle, N., Macnaughton, W. K., Al-Ani, B. et al. (1998) Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport, Proc Natl Acad Sci U S A 95, 7766-7771.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7766-7771
    • Vergnolle, N.1    Macnaughton, W.K.2    Al-Ani, B.3
  • 49
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu, T. K., Hung, D. T., Wheaton, V. I. et al. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation, Cell 64, 1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3
  • 50
    • 0032499696 scopus 로고    scopus 로고
    • Cloning and characterization of human protease-activated receptor 4
    • Xu, W. F., Andersen, H., Whitmore, T. E. et al. (1998) Cloning and characterization of human protease-activated receptor 4, Proc. Natl. Acad. Sci. U. S. A. 95, 6642-6646.
    • (1998) Proc. Natl. Acad. Sci. U. S. A , vol.95 , pp. 6642-6646
    • Xu, W.F.1    Andersen, H.2    Whitmore, T.E.3


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